fluorouracil has been researched along with Bacterial Infections in 18 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Bacterial Infections: Infections by bacteria, general or unspecified.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy." | 7.70 | Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998) |
| "In 16 advanced colorectal cancer patients with 5-fluorouracil-associated diarrhea, we evaluated the role of bacterial pathogens in the development of this adverse effect." | 7.69 | Have enteric infections a role in 5-fluorouracil-associated diarrhea? ( Cascinu, S; Catalano, G, 1995) |
| "Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue." | 7.67 | Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate. ( Aboud, A; Blumenschein, GR; Buzdar, AU; Hortobagyi, GN; Yap, HY, 1984) |
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 5.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| " We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy." | 3.70 | Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy. ( Altaras, M; Beyth, Y; Chowers, M; Fishman, A; Lang, R, 1998) |
| "In 16 advanced colorectal cancer patients with 5-fluorouracil-associated diarrhea, we evaluated the role of bacterial pathogens in the development of this adverse effect." | 3.69 | Have enteric infections a role in 5-fluorouracil-associated diarrhea? ( Cascinu, S; Catalano, G, 1995) |
| "Twenty-nine patients with metastatic breast cancer were treated with fluorouracil, adriamycin, cyclophosphamide (FAC), and methotrexate (MTX), with or without leukovorin rescue." | 3.67 | Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate. ( Aboud, A; Blumenschein, GR; Buzdar, AU; Hortobagyi, GN; Yap, HY, 1984) |
| "Bacterial infections are major life-threatening complications in patients receiving cytotoxic drugs." | 2.72 | Granulocyte function is stimulated by a novel hexapeptide, WKYMVm, in chemotherapy-treated cancer patients. ( Heo, SK; Kim, BS; Kim, H; Kim, MJ; Lee, EH; Min, YJ; Park, JH; Park, SK, 2006) |
| "Patients with cancer commonly suffer neurologic disabilities." | 2.37 | Neurologic complications of systemic cancer. ( Patchell, RA; Posner, JB, 1985) |
| "Chemotherapy is 1 method for the treatment of cancer, but serious side effects can sometimes limit the dosage given." | 1.32 | Simultaneous onset of acute inflammatory response, sepsis-like symptoms and intestinal mucosal injury after cancer chemotherapy. ( Fukushima, R; Hiki, N; Kaminishi, M; Kojima, J; Mafune, K; Mimura, Y; Nomura, S; Ogawa, T; Tsuji, E, 2003) |
| "Azotemia, body fluid insufficiency and bacterial infections were frequently found in these patients." | 1.30 | Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection. ( Chang, HK; Chen, JS; Liaw, CC; Liaw, SJ; Lin, YC; Wang, CH; Wang, HM; Yang, TS; Yeh, CT, 1999) |
| "The risk of superinfection following routine abdominal drainage after major surgery is debated." | 1.28 | Implantable drainage after major abdominal surgery in compromised patients. ( Andersson, R; Bengmark, S; Holmberg, A; Jeppsson, B, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (22.22) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 2 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Ngoc Toan, V | 1 |
| Dinh Thanh, N | 1 |
| Minh Tri, N | 1 |
| Thi Thu Huong, N | 1 |
| Mohindroo, C | 1 |
| Hasanov, M | 1 |
| Rogers, JE | 1 |
| Dong, W | 1 |
| Prakash, LR | 1 |
| Baydogan, S | 1 |
| Mizrahi, JD | 1 |
| Overman, MJ | 1 |
| Varadhachary, GR | 1 |
| Wolff, RA | 1 |
| Javle, MM | 1 |
| Fogelman, DR | 1 |
| Lotze, MT | 1 |
| Kim, MP | 1 |
| Katz, MHG | 1 |
| Pant, S | 1 |
| Tzeng, CD | 1 |
| McAllister, F | 1 |
| Shobana, S | 3 |
| Dharmaraja, J | 3 |
| Selvaraj, S | 1 |
| Subramaniam, P | 2 |
| Narayan, A | 1 |
| Mitu, L | 1 |
| Arvind Narayan, S | 1 |
| Tsuji, E | 1 |
| Hiki, N | 1 |
| Nomura, S | 1 |
| Fukushima, R | 1 |
| Kojima, J | 1 |
| Ogawa, T | 1 |
| Mafune, K | 1 |
| Mimura, Y | 1 |
| Kaminishi, M | 1 |
| Kim, H | 1 |
| Park, JH | 1 |
| Lee, EH | 1 |
| Kim, MJ | 1 |
| Park, SK | 1 |
| Heo, SK | 1 |
| Kim, BS | 1 |
| Min, YJ | 1 |
| Aboud, A | 1 |
| Buzdar, AU | 1 |
| Yap, HY | 1 |
| Hortobagyi, GN | 1 |
| Blumenschein, GR | 1 |
| Cascinu, S | 1 |
| Catalano, G | 1 |
| Konishi, F | 1 |
| Mitsuyama, M | 1 |
| Okuda, M | 1 |
| Tanaka, K | 1 |
| Hasegawa, T | 1 |
| Nomoto, K | 1 |
| Kish, JA | 1 |
| Wolf, MK | 1 |
| Schellhammer, PF | 1 |
| Hussain, MH | 1 |
| Einstein, AB | 1 |
| Crawford, ED | 1 |
| Fishman, A | 1 |
| Chowers, M | 1 |
| Altaras, M | 1 |
| Beyth, Y | 1 |
| Lang, R | 1 |
| Liaw, CC | 1 |
| Wang, HM | 1 |
| Wang, CH | 1 |
| Yang, TS | 1 |
| Chen, JS | 1 |
| Chang, HK | 1 |
| Lin, YC | 1 |
| Liaw, SJ | 1 |
| Yeh, CT | 1 |
| Boushey, RP | 1 |
| Yusta, B | 1 |
| Drucker, DJ | 1 |
| Andersson, R | 1 |
| Jeppsson, B | 1 |
| Holmberg, A | 1 |
| Bengmark, S | 1 |
| Markman, M | 1 |
| McIntyre, KW | 1 |
| Unowsky, J | 1 |
| DeLorenzo, W | 1 |
| Benjamin, W | 1 |
| Patchell, RA | 1 |
| Posner, JB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Analysis of the Effect of Teduglutide Treatment on Intestinal Malabsorption and Paneth Cell Numbers in Patients With Steroid-refractory Gastrointestinal Graft Versus Host Disease (SR-GI-GVHD).[NCT04290429] | Early Phase 1 | 6 participants (Actual) | Interventional | 2017-12-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Bacterial Infections
| Article | Year |
|---|---|
Intracavitary chemotherapy.
Topics: Absorption; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascitic | 1985 |
Neurologic complications of systemic cancer.
Topics: Arachnoid; Bacterial Infections; Brain; Brain Neoplasms; Cerebrovascular Disorders; Cisplatin; Disse | 1985 |
2 trials available for fluorouracil and Bacterial Infections
| Article | Year |
|---|---|
Granulocyte function is stimulated by a novel hexapeptide, WKYMVm, in chemotherapy-treated cancer patients.
Topics: Adult; Aged; Bacterial Infections; Blood Bactericidal Activity; Cells, Cultured; Cisplatin; Dose-Res | 2006 |
Continuous-infusion 5-fluorouracil and cisplatin for advanced/recurrent transitional cell cancer of the bladder: a Southwest Oncology Group trial.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplast | 1997 |
14 other studies available for fluorouracil and Bacterial Infections
| Article | Year |
|---|---|
Synthesis and biological screening of thiosemicarbazones of substituted 3-acetylcoumarins having d-glucose moiety.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Bacteria; Bacterial Infections; Cou | 2020 |
Antibiotic use influences outcomes in advanced pancreatic adenocarcinoma patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antineoplastic Agents; Bacterial Infections; | 2021 |
Mixed ligand complexation of some transition metal ions in solution and solid state: spectral characterization, antimicrobial, antioxidant, DNA cleavage activities and molecular modeling.
Topics: Animals; Anti-Infective Agents; Antioxidants; Bacteria; Bacterial Infections; Cattle; Copper; DNA; D | 2013 |
Morphological and pharmacological investigation on some biopotent materials derived from substituted pyrimidine and imidazole enzyme constituents.
Topics: Animals; Antimetabolites; Antioxidants; Bacteria; Bacterial Infections; Cattle; Coordination Complex | 2014 |
Synthesis, structural elucidation, biological, antioxidant and nuclease activities of some 5-Fluorouracil-amino acid mixed ligand complexes.
Topics: Amino Acids; Animals; Anti-Infective Agents; Antioxidants; Bacteria; Bacterial Infections; Cattle; D | 2015 |
Simultaneous onset of acute inflammatory response, sepsis-like symptoms and intestinal mucosal injury after cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Bacteria; Bacterial Infections; Bacterial Translocation; Digestive S | 2003 |
Combination chemotherapy for metastatic breast cancer with fluorouracil, adriamycin, cyclophosphamide, and methotrexate.
Topics: Alopecia; Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Breast Neoplasms; Cy | 1984 |
Have enteric infections a role in 5-fluorouracil-associated diarrhea?
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Colorectal Neoplasms; Diarrhea; | 1995 |
Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bacterial Infections; Bone Marrow; | 1996 |
Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aztreonam; Bacterial | 1998 |
Risk of transient hyperammonemic encephalopathy in cancer patients who received continuous infusion of 5-fluorouracil with the complication of dehydration and infection.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Bacterial Infections; Brain Diseases; Dehydration; Fem | 1999 |
Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor.
Topics: Animals; Antineoplastic Agents; Apoptosis; Bacterial Infections; Camptothecin; Cell Line; Cell Survi | 2001 |
Implantable drainage after major abdominal surgery in compromised patients.
Topics: Abdominal Neoplasms; Adult; Aged; Bacterial Infections; Drainage; Female; Fluorouracil; Humans; Immu | 1990 |
Enhancement of antibacterial resistance of neutropenic, bone marrow-suppressed mice by interleukin-1 alpha.
Topics: Adjuvants, Immunologic; Agranulocytosis; Animals; Bacterial Infections; Bone Marrow; Cyclophosphamid | 1989 |