fluorouracil has been researched along with Bacteremia in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS." | 8.87 | Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011) |
| "A 61-year-old woman with metastatic breast cancer who was undergoing treatment with capecitabine developed erythema, fissuring, and erosions over both hands and feet, consistent with HFS." | 4.87 | Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature. ( Baker, SG; Cotliar, JA; Gunawardane, ND; Hoesly, FJ, 2011) |
| "Atorvastatin prevented mucosal damage and inflammation associated with 5-FU-induced OM, but the association of a higher dose of ATV with 5-FU induced hepatotoxicity and amplified leukopenia." | 3.77 | Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis. ( Alencar, NM; Barboza, DR; Brito, GA; Gomes, AS; Leitão, RF; Macedo, RN; Medeiros, CA; Nogueira, NA; Ribeiro, RA, 2011) |
| " Subsequent dosing with 5-FU induced lethal septicaemia caused by the inoculated strains in most of these mice, whereas CY did not regularly induce septicaemia." | 1.29 | Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice. ( Furuya, N; Hirakata, Y; Matsumoto, T; Tateda, K; Yamaguchi, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Soueidy, C | 1 |
| Skaff, S | 1 |
| Stephan, F | 1 |
| Kattan, J | 1 |
| Medeiros, CA | 1 |
| Leitão, RF | 1 |
| Macedo, RN | 1 |
| Barboza, DR | 1 |
| Gomes, AS | 1 |
| Nogueira, NA | 1 |
| Alencar, NM | 1 |
| Ribeiro, RA | 1 |
| Brito, GA | 1 |
| Hoesly, FJ | 1 |
| Baker, SG | 1 |
| Gunawardane, ND | 1 |
| Cotliar, JA | 1 |
| Lieuw-a-Fa, M | 1 |
| Peringa, J | 1 |
| Leeksma, O | 1 |
| Terpstra, W | 1 |
| Hirakata, Y | 2 |
| Furuya, N | 2 |
| Matsumoto, T | 2 |
| Tateda, K | 2 |
| Yamaguchi, K | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II, Randomised Controlled Trial to Evaluate the Efficacy and Safety of Moisturising Creams With or Without Palm-oil-derived Vitamin E Concentrate in Addition to Urea-based Cream or Urea-based Cream Alone in Capecitabine-associated Palmar-Plantar E[NCT05939726] | 90 participants (Anticipated) | Interventional | 2023-05-16 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fluorouracil and Bacteremia
| Article | Year |
|---|---|
Capecitabine-induced hand-foot syndrome complicated by pseudomonal superinfection resulting in bacterial sepsis and death: case report and review of the literature.
Topics: Antimetabolites, Antineoplastic; Bacteremia; Breast Neoplasms; Capecitabine; Deoxycytidine; Fatal Ou | 2011 |
5 other studies available for fluorouracil and Bacteremia
| Article | Year |
|---|---|
Cetuximab severe cutaneous toxicity… a gateway for bacteremia: case report.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bacteremia; Cellulitis; Cetu | 2023 |
Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Atorvastatin; Bac | 2011 |
Sepsis from liver abscesses in metastatic colorectal carcinoma after chemoimmunotherapy.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2008 |
Influence of various immunosuppressive agents on the occurrence of endogenous bacteraemia in mice.
Topics: Animals; Bacteremia; Cisplatin; Cyclophosphamide; Enterobacteriaceae Infections; Fluorouracil; Immun | 1995 |
Experimental endogenous septicaemia caused by Klebsiella pneumoniae and Escherichia coli in mice.
Topics: Ampicillin; Animals; Bacteremia; Ceftazidime; Cephalosporins; Cyclophosphamide; Disease Models, Anim | 1996 |