fluorouracil has been researched along with B-Cell Lymphoma in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mouse body weight was monitored daily." | 5.42 | Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice. ( Alves, LA; Aquino, CC; Araújo, CV; Bertolini, LR; Brito, GA; Costa, TB; Figueiredo, IL; Lazzarotto, CR; Lima, AA; Oriá, RB; Ribeiro, RA, 2015) |
| "Chemotherapy is one of the most common treatments used for hepatocellular carcinoma (HCC), which effectively improves outcome and reduces tumor recurrence." | 5.42 | MicroRNA‑133a and microRNA‑326 co‑contribute to hepatocellular carcinoma 5‑fluorouracil and cisplatin sensitivity by directly targeting B‑cell lymphoma‑extra large. ( Guo, R; Lei, X; Ma, J; Pan, X; Peng, C; Tang, H; Wang, T; Xiang, Q; Yang, X; Yin, J; Yu, J; Zu, X, 2015) |
| "With regard to squamous cell carcinoma, treatment with 5-fluorouracil, methotrexate, interferon, and bleomycin are reviewed." | 2.47 | Intralesional agents in the management of cutaneous malignancy: a review. ( Good, LM; High, WA; Miller, MD, 2011) |
| "Mouse body weight was monitored daily." | 1.42 | Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice. ( Alves, LA; Aquino, CC; Araújo, CV; Bertolini, LR; Brito, GA; Costa, TB; Figueiredo, IL; Lazzarotto, CR; Lima, AA; Oriá, RB; Ribeiro, RA, 2015) |
| "Chemotherapy is one of the most common treatments used for hepatocellular carcinoma (HCC), which effectively improves outcome and reduces tumor recurrence." | 1.42 | MicroRNA‑133a and microRNA‑326 co‑contribute to hepatocellular carcinoma 5‑fluorouracil and cisplatin sensitivity by directly targeting B‑cell lymphoma‑extra large. ( Guo, R; Lei, X; Ma, J; Pan, X; Peng, C; Tang, H; Wang, T; Xiang, Q; Yang, X; Yin, J; Yu, J; Zu, X, 2015) |
| "5-Fluorouracil (5-FU) has long been a mainstay antimetabolite chemotherapeutic drug for the treatment of major solid tumors, particularly colorectal cancer." | 1.38 | ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity. ( Fujinaka, Y; Gillespie, DA; Iimori, M; Kakeji, Y; Kitao, H; Maehara, Y; Matsuoka, K; Morita, M; Saeki, H; Sakasai, R; Takata, M; Tuul, M; Yamamoto, K; Yoshinaga, K, 2012) |
| "5-fluorouracil (5-FU) has been successfully used to control (or cure) a variety of tumors, but has been only rarely applied to tumors of the lymphoid lineage." | 1.32 | Customized mitogen or antibody treatments enhance the sensitivity of lymphoid tumors to 5-fluorouracil in vitro and in vivo. ( D'Costa, S; Hurwitz, JL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cairo, M | 1 |
| Auperin, A | 1 |
| Perkins, SL | 1 |
| Pinkerton, R | 1 |
| Harrison, L | 1 |
| Goldman, S | 1 |
| Patte, C | 1 |
| Xia, D | 1 |
| Li, W | 1 |
| Zhang, L | 1 |
| Qian, H | 1 |
| Yao, S | 1 |
| Qi, X | 1 |
| Araújo, CV | 1 |
| Lazzarotto, CR | 1 |
| Aquino, CC | 1 |
| Figueiredo, IL | 1 |
| Costa, TB | 1 |
| Alves, LA | 1 |
| Ribeiro, RA | 1 |
| Bertolini, LR | 1 |
| Lima, AA | 1 |
| Brito, GA | 1 |
| Oriá, RB | 1 |
| Ma, J | 1 |
| Wang, T | 1 |
| Guo, R | 1 |
| Yang, X | 1 |
| Yin, J | 1 |
| Yu, J | 1 |
| Xiang, Q | 1 |
| Pan, X | 1 |
| Zu, X | 1 |
| Peng, C | 1 |
| Tang, H | 1 |
| Lei, X | 1 |
| Good, LM | 1 |
| Miller, MD | 1 |
| High, WA | 1 |
| Fujinaka, Y | 1 |
| Matsuoka, K | 1 |
| Iimori, M | 1 |
| Tuul, M | 1 |
| Sakasai, R | 1 |
| Yoshinaga, K | 1 |
| Saeki, H | 1 |
| Morita, M | 1 |
| Kakeji, Y | 1 |
| Gillespie, DA | 2 |
| Yamamoto, K | 1 |
| Takata, M | 1 |
| Kitao, H | 1 |
| Maehara, Y | 1 |
| D'Costa, S | 2 |
| Hurwitz, JL | 3 |
| D'Costa, SS | 1 |
| Robinson, HM | 1 |
| Jones, R | 1 |
| Walker, M | 1 |
| Zachos, G | 1 |
| Brown, R | 1 |
| Cassidy, J | 1 |
| Bonsignori, M | 1 |
| Surman, S | 1 |
| Zinzani, PL | 1 |
| Bendandi, M | 1 |
| Frezza, G | 1 |
| Gherlinzoni, F | 1 |
| Merla, E | 1 |
| Salvucci, M | 1 |
| Magagnoli, M | 1 |
| Babini, L | 1 |
| Tura, S | 1 |
| Martelli, MP | 1 |
| Martelli, M | 1 |
| Pescarmona, E | 1 |
| De Sanctis, V | 1 |
| Donato, V | 1 |
| Palombi, F | 1 |
| Todisco, E | 1 |
| Rendina, EA | 1 |
| Pau, FM | 1 |
| Mandelli, F | 1 |
| Yukiiri, K | 1 |
| Mizushige, K | 1 |
| Ueda, T | 1 |
| Kohno, M | 1 |
1 review available for fluorouracil and B-Cell Lymphoma
| Article | Year |
|---|---|
Intralesional agents in the management of cutaneous malignancy: a review.
Topics: Aminolevulinic Acid; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Bleomycin; Carci | 2011 |
2 trials available for fluorouracil and B-Cell Lymphoma
| Article | Year |
|---|---|
Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patients.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Therapy; Cycloph | 1996 |
MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosis.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Combined Modality Ther | 1998 |
10 other studies available for fluorouracil and B-Cell Lymphoma
| Article | Year |
|---|---|
Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: A report from the FAB/LMB 96 study group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carmustine; Child; | 2018 |
RNA interference-mediated knockdown of brain-derived neurotrophic factor (BDNF) promotes cell cycle arrest and apoptosis in B-cell lymphoma cells.
Topics: Apoptosis; Brain-Derived Neurotrophic Factor; Cell Cycle Checkpoints; Cell Line, Tumor; Fluorouracil | 2014 |
Alanyl-glutamine attenuates 5-fluorouracil-induced intestinal mucositis in apolipoprotein E-deficient mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apolipoproteins E; Apoptosis; Body Weight; Dipeptides; Fem | 2015 |
MicroRNA‑133a and microRNA‑326 co‑contribute to hepatocellular carcinoma 5‑fluorouracil and cisplatin sensitivity by directly targeting B‑cell lymphoma‑extra large.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Cell Proliferation; Cisp | 2015 |
ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.
Topics: Animals; Apoptosis; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Nucleus; Checkpoint Kina | 2012 |
Customized mitogen or antibody treatments enhance the sensitivity of lymphoid tumors to 5-fluorouracil in vitro and in vivo.
Topics: Animals; Antibodies, Monoclonal; CD40 Antigens; Cell Division; Cell Membrane; Drug Synergism; Fluoro | 2003 |
Phytohemagglutinin inhibits lymphoid tumor growth in vitro and in vivo.
Topics: Animals; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Drug Combinations; Drug | 2003 |
Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.
Topics: Cell Cycle; Cell Line, Tumor; Cell Survival; Checkpoint Kinase 1; DNA Damage; DNA Replication; Enzym | 2006 |
A combination of 5-fluorouracil and membrane-bound antibody inhibits B-cell lymphoma growth in a mouse model system.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; CD40 Antigens; Cell Membrane; Comb | 2007 |
Second primary cardiac B-cell lymphoma after radiation therapy and chemotherapy--a case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Needle; Carcinoma, Squamous Cell; Cisp | 2001 |