fluorouracil has been researched along with B-Cell Chronic Lymphocytic Leukemia in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acriflavine was active in cell spheroids, indicating good drug penetration and activity against hypoxic cells." | 5.37 | Novel activity of acriflavine against colorectal cancer tumor cells. ( Fayad, W; Felth, J; Fryknäs, M; Glimelius, B; Graf, W; Gullbo, J; Hassan, S; Larsson, R; Laryea, D; Linder, S; Mahteme, H; Nygren, P; Påhlman, L; Rickardson, L, 2011) |
| "Acriflavine was active in cell spheroids, indicating good drug penetration and activity against hypoxic cells." | 1.37 | Novel activity of acriflavine against colorectal cancer tumor cells. ( Fayad, W; Felth, J; Fryknäs, M; Glimelius, B; Graf, W; Gullbo, J; Hassan, S; Larsson, R; Laryea, D; Linder, S; Mahteme, H; Nygren, P; Påhlman, L; Rickardson, L, 2011) |
| "Patients diagnosed with Chronic Lymphocytic Leukemia (CLL) have an increased risk of developing second primary cancers." | 1.31 | Multiple neoplasms: a case report. ( Pigeaud-Klessens, ML; van der Valk, P, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chong, SJF | 1 |
| Iskandar, K | 1 |
| Lai, JXH | 1 |
| Qu, J | 1 |
| Raman, D | 1 |
| Valentin, R | 1 |
| Herbaux, C | 1 |
| Collins, M | 1 |
| Low, ICC | 1 |
| Loh, T | 1 |
| Davids, M | 1 |
| Pervaiz, S | 1 |
| Hassan, S | 1 |
| Laryea, D | 1 |
| Mahteme, H | 1 |
| Felth, J | 1 |
| Fryknäs, M | 1 |
| Fayad, W | 1 |
| Linder, S | 1 |
| Rickardson, L | 1 |
| Gullbo, J | 1 |
| Graf, W | 1 |
| Påhlman, L | 1 |
| Glimelius, B | 1 |
| Larsson, R | 1 |
| Nygren, P | 1 |
| Dreger, P | 1 |
| von Neuhoff, N | 1 |
| Kuse, R | 1 |
| Sonnen, R | 1 |
| Glass, B | 1 |
| Uharek, L | 1 |
| Schoch, R | 1 |
| Löffler, H | 1 |
| Schmitz, N | 1 |
| Pigeaud-Klessens, ML | 1 |
| van der Valk, P | 1 |
| Cavaliere, A | 1 |
| Alberti, PF | 1 |
| Vitali, R | 1 |
1 trial available for fluorouracil and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Early stem cell transplantation for chronic lymphocytic leukaemia: a chance for cure?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Cisplatin; Co | 1998 |
4 other studies available for fluorouracil and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Topics: Apoptosis; Cell Proliferation; Cisplatin; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Etopos | 2020 |
Novel activity of acriflavine against colorectal cancer tumor cells.
Topics: Acriflavine; Camptothecin; Cell Line, Tumor; Colorectal Neoplasms; DNA Topoisomerases, Type I; DNA T | 2011 |
Multiple neoplasms: a case report.
Topics: Aged; Antimetabolites, Antineoplastic; Blepharoplasty; Carcinoma in Situ; Carcinoma, Squamous Cell; | 2002 |
5-Fluorouracil carcinogenesis in BALB/c mice.
Topics: Animals; Carcinogenicity Tests; Female; Fluorouracil; Injections, Intraperitoneal; Leukemia, Lymphoc | 1990 |