fluorouracil has been researched along with Autosomal Chromosome Disorders in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new human colon cancer cell line (020588) has been derived by means of a combined in vitro matrix-in vivo xenograft technique." | 1.28 | A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice. ( Agrez, MV; Chua, FK; Fagan, K; Ferguson, NW; Heath, JW, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Labianca, R | 1 |
| Nordlinger, B | 1 |
| Beretta, GD | 1 |
| Mosconi, S | 1 |
| Mandalà, M | 1 |
| Cervantes, A | 1 |
| Arnold, D | 1 |
| Agrez, MV | 1 |
| Chua, FK | 1 |
| Fagan, K | 1 |
| Heath, JW | 1 |
| Ferguson, NW | 1 |
| Bridge, MF | 1 |
| Melamed, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Age, Body Mass Index and Tumor Sidedness in Metastatic Colorectal Cancer Patients as Predictive Factors for Systemic Therapy Outcome[NCT04543019] | 50 participants (Anticipated) | Observational | 2020-12-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for fluorouracil and Autosomal Chromosome Disorders
| Article | Year |
|---|---|
Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoembryoni | 2013 |
A human colon cancer cell line established from collagen matrix cultures transplanted into nude mice.
Topics: Animals; Carcinoembryonic Antigen; Cell Line; Chromosome Aberrations; Chromosome Disorders; Collagen | 1991 |
Leukocyte chromosome abnormalities in advanced nonhematopoietic cancer.
Topics: Adult; Aged; Antineoplastic Agents; Cells, Cultured; Chromosome Aberrations; Chromosome Disorders; C | 1972 |