fluorouracil has been researched along with Autoimmune Thrombocytopenia in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A colorectal cancer patient receiving chemotherapy (5-fluorouracil and oxaliplatin) plus bevacizumab developed acute, severe thrombocytopenia." | 3.78 | A rare hematological adverse event induced by bevacizumab: severe thrombocytopenia. ( Brezault, C; Chaussade, S; Coriat, R; Dhooge, M; Dior, M; Goldwasser, F; Mir, O; Perkins, G, 2012) |
| "She had been diagnosed with idiopathic thrombocytopenic purpura (ITP) in her 20s, with a platelet count maintained at approximately 1." | 1.40 | [Concomitant use of romiplostim and chemotherapy for advanced rectal cancer associated with idiopathic thrombocytopenic purpura]. ( Fujinaga, T; Hiramatsu, N; Iijima, H; Nishida, T; Shinzaki, S; Takehara, T; Tatsumi, T; Tsujii, M; Yakushijin, T; Yamada, M; Yamada, T, 2014) |
| "The patient was diagnosed as idiopathic thrombocytopenic purpura (ITP) by several examinations but medical control including steroids failed." | 1.36 | [Idiopathic thrombocytopenic purpura during chemotherapy for liver metastasis of rectal cancer]. ( Ebisui, C; Ide, Y; Kinuta, M; Mikami, K; Momozane, T; Mukai, R; Murakami, M; Murata, K; Nagase, H; Nishigaki, T; Okada, K; Owada, Y; Yamada, M; Yanagisawa, T; Yokouchi, H, 2010) |
| "Drug-induced immune thrombocytopenia (DITP) should be considered in patients who experience a sudden, isolated drop in platelet levels while being treated with chemotherapeutic agents, especially when adequate numbers of megakaryocytes are present in the bone marrow." | 1.33 | Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin. ( Aster, RH; Blank, J; Curtis, BR; Kaliszewski, J; Marques, MB; McFarland, JG; Nabelle, L; Saif, MW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamada, M | 2 |
| Shinzaki, S | 1 |
| Nishida, T | 1 |
| Yamada, T | 1 |
| Fujinaga, T | 1 |
| Yakushijin, T | 1 |
| Tatsumi, T | 1 |
| Iijima, H | 1 |
| Hiramatsu, N | 1 |
| Tsujii, M | 1 |
| Takehara, T | 1 |
| Saif, MW | 2 |
| The, A | 1 |
| Ledbetter, L | 1 |
| Murata, K | 1 |
| Mikami, K | 1 |
| Ide, Y | 1 |
| Owada, Y | 1 |
| Nishigaki, T | 1 |
| Nagase, H | 1 |
| Mukai, R | 1 |
| Momozane, T | 1 |
| Murakami, M | 1 |
| Okada, K | 1 |
| Yanagisawa, T | 1 |
| Ebisui, C | 1 |
| Yokouchi, H | 1 |
| Kinuta, M | 1 |
| Dior, M | 1 |
| Coriat, R | 1 |
| Mir, O | 1 |
| Brezault, C | 1 |
| Perkins, G | 1 |
| Dhooge, M | 1 |
| Goldwasser, F | 1 |
| Chaussade, S | 1 |
| Curtis, BR | 1 |
| Kaliszewski, J | 1 |
| Marques, MB | 1 |
| Nabelle, L | 1 |
| Blank, J | 1 |
| McFarland, JG | 1 |
| Aster, RH | 1 |
5 other studies available for fluorouracil and Autoimmune Thrombocytopenia
| Article | Year |
|---|---|
[Concomitant use of romiplostim and chemotherapy for advanced rectal cancer associated with idiopathic thrombocytopenic purpura].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Deoxycytidine; Female; Fluorou | 2014 |
Oxaliplatin-mediated autoimmune thrombocytopenia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colonic Neoplasms; Deoxycytidine; Fema | 2009 |
[Idiopathic thrombocytopenic purpura during chemotherapy for liver metastasis of rectal cancer].
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic C | 2010 |
A rare hematological adverse event induced by bevacizumab: severe thrombocytopenia.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2012 |
Immune-mediated thrombocytopenia resulting from sensitivity to oxaliplatin.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Autoantibodies; Bone M | 2006 |