fluorouracil has been researched along with Auricular Cancer in 18 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-five squamous cell carcinomas, 1 melanoma, 2 basocellular carcinomas and 2 adenoid cystic carcinomas were treated." | 1.33 | [The outcome of treatments for carcinoma of the external auditory canal]. ( Delalande, C; Dumas, G; Lavieille, JP; Reyt, E; Righini, Ch; Schmerber, S; Soriano, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (61.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Means, AD | 1 |
| Leader, NF | 1 |
| Siegel, JA | 1 |
| Arron, ST | 1 |
| Walker, JL | 1 |
| Pomerantz, H | 2 |
| Beatson, M | 1 |
| Weinstock, MA | 2 |
| Maebayashi, T | 1 |
| Ishibashi, N | 1 |
| Aizawa, T | 1 |
| Sakaguchi, M | 1 |
| Ikeda, A | 1 |
| Hirai, R | 1 |
| Furusaka, T | 1 |
| Homma, T | 1 |
| Korgavkar, K | 1 |
| Lee, KC | 1 |
| Lew, R | 1 |
| Tanguay, JS | 1 |
| Shrihari, N | 1 |
| Warren, RE | 1 |
| Schmerber, S | 1 |
| Righini, Ch | 1 |
| Soriano, E | 1 |
| Delalande, C | 1 |
| Dumas, G | 1 |
| Reyt, E | 1 |
| Lavieille, JP | 1 |
| Harada, H | 1 |
| Knegt, PP | 1 |
| Ah-See, KW | 1 |
| Meeuwis, CA | 1 |
| van der Velden, LA | 1 |
| Kerrebijn, JD | 1 |
| De Boer, MF | 1 |
| Price, LA | 1 |
| Hill, BT | 1 |
| Calvert, AH | 1 |
| Shaw, HJ | 1 |
| Hughes, KB | 1 |
| Heising, RA | 1 |
| Harker, GJ | 1 |
| Stephens, FO | 1 |
| Theilen, G | 1 |
| Ammon, J | 1 |
| Giesen, M | 1 |
| Schwab, W | 1 |
| Palme, G | 1 |
| Prutkin, L | 1 |
| Nitze, HR | 2 |
| Ganzer, U | 1 |
| Vosteen, KH | 1 |
| Glupe, J | 1 |
| Kraus, H | 1 |
| Wannenmacher, E | 1 |
| Litwin, MS | 1 |
| Krementz, ET | 1 |
| Kashiwado, S | 1 |
| Sawaki, S | 1 |
| Satake, K | 1 |
| Matsui, M | 1 |
| Rosemann, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial[NCT00847912] | Phase 4 | 954 participants (Actual) | Interventional | 2009-06-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00847912)
Timeframe: date of randomization to last visit before end of study follow up (6/30/2013), assessed up to four years
| Intervention | participants (Number) |
|---|---|
| Arm 1: 5-fluorouracil | 182 |
| Arm 2: Placebo, Vehicle Control | 177 |
Diagnosis of the first Primary Basil Cell Carcinoma (BCC) or primary Squamous Cell Carcinoma (SCC) on the face or ears that was removed surgically. (NCT00847912)
Timeframe: From randomization to last visit prior to end of study date (6/30/2013), assessed up to four years
| Intervention | years (Median) |
|---|---|
| Arm 1: 5-fluorouracil | 3.37 |
| Arm 2: Placebo, Vehicle Control | 3.52 |
1 review available for fluorouracil and Auricular Cancer
| Article | Year |
|---|---|
Effectiveness of chemoradiotherapy for radiation-induced bilateral external auditory canal cancer: A case report and literature review.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cetuximab; Chemoradi | 2019 |
2 trials available for fluorouracil and Auricular Cancer
| Article | Year |
|---|---|
Rate and Proportion of Malignant Skin Biopsies for Basal Cell and Squamous Cell Carcinoma on the Face and Ears After a Single Course of Topical 5-Fluorouracil: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial.
Topics: Administration, Topical; Aged; Antimetabolites, Antineoplastic; Biopsy; Carcinoma, Basal Cell; Carci | 2021 |
Validation of Photograph-Based Toxicity Score for Topical 5-Fluorouracil Cream Application.
Topics: Administration, Cutaneous; Age Factors; Aged; Antimetabolites, Antineoplastic; Carcinoma, Squamous C | 2016 |
15 other studies available for fluorouracil and Auricular Cancer
| Article | Year |
|---|---|
Pasteurella multocida infection following cisplatin and 5-fluorouracil chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Diseas | 2003 |
[The outcome of treatments for carcinoma of the external auditory canal].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemoth | 2005 |
[Experimental studies on rat ear duct tumor. Part 2: Effects of anticancer drugs on rat ear duct tumor induced by DMBA and DAS (author's transl)].
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 9,10-Dimethyl-1,2-benzanthracene; Animal | 1980 |
Squamous carcinoma of the external auditory canal: a different approach.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Combined Modality | 2002 |
Kinetically-based multiple drug treatment for advanced head and neck cancer.
Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Ear Neopla | 1975 |
Treatment of Bowen's disease of the ear by the combined use of cryosurgery and topical 5-fluorouracil.
Topics: Administration, Topical; Bowen's Disease; Carcinoma, Squamous Cell; Cryosurgery; Ear Neoplasms; Ear, | 1979 |
Comparison of intra-arterial versus intravenous 5-fluorouracil administration on epidermal squamous cell carcinoma in sheep.
Topics: Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Drug Administration Schedule; Ear Neoplas | 1992 |
Adverse effect from use of 5% fluorouracil.
Topics: Animals; Brain; Carcinoma, Squamous Cell; Cat Diseases; Cats; Dogs; Ear Neoplasms; Ear, External; Fl | 1987 |
[Clinical results of synchronised radiotherapy on a theoretical and experimental basis (author's transl)].
Topics: Animals; Breast Neoplasms; Dose-Response Relationship, Radiation; Drosophila melanogaster; Ear Neopl | 1973 |
Antitumor activity of vitamin A acid and fluorouracil used in combination on the skin tumor, keratoacanthoma.
Topics: Animals; Antineoplastic Agents; Biopsy; Drug Combinations; Drug Synergism; Ear Neoplasms; Epithelial | 1973 |
Synchronization of human tissues and its consequences for cancer therapy in ENT. Cell kinetic and clinical studies.
Topics: Aged; Animals; Carcinoma; Carcinoma, Squamous Cell; Cell Division; DNA Replication; DNA, Neoplasm; E | 1974 |
[Combined cytostatic and irradiation treatment of head and neck tumors using the synchronization effect].
Topics: Aged; Cobalt Isotopes; Ear Neoplasms; Female; Fluorouracil; Head; Head and Neck Neoplasms; Humans; M | 1972 |
Treatment of basal and squamous cancers of the nose and ear with 5-fluorouracil cream.
Topics: Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Ear Neoplasms; Female; Fluorouracil; Follow-U | 1971 |
[Effect and limitation of antineoplastic agents in otolaryngology. 2. Effect and evaluation of intra-arterial injection therapy].
Topics: Ear Canal; Ear Neoplasms; Fluorouracil; Humans; Injections, Intra-Arterial; Maxillary Neoplasms | 1971 |
[The modification of the cell division rhythm in human tumors].
Topics: Adult; Aged; Autoradiography; Biopsy; Cell Division; Depression, Chemical; DNA, Neoplasm; Ear Neopla | 1969 |