fluorouracil has been researched along with Atrophy in 12 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments." | 9.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments." | 5.12 | The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021) |
| "Hand-foot syndrome (HFS), the most common toxicity of capecitabine, is characterized by tingling, numbness, pain, erythema, dryness, rash, swelling, increased pigmentation, and/or pruritus of the palmar and/or plantar surfaces of the hands and/or feet." | 3.76 | Unilateral hand-foot syndrome: an extraordinary side effect of capecitabine. ( Abali, H; Disel, U; Gürkut, O; Kaleağasi, H; Mertsoylu, H; Ozyilkan, O; Saif, MW, 2010) |
| "Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy." | 2.82 | Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022) |
| "Surgical scars are best treated with a combination approach to address various features of the scar." | 2.53 | A Combination Approach to Surgical Scars. ( Cohen, JL; Eilers, RE; Ortiz, AE; Ross, EV, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dahlgren, D | 1 |
| Rosenqvist, E | 1 |
| Hellström, PM | 1 |
| Nygren, P | 1 |
| Kullenberg, F | 1 |
| Peters, K | 1 |
| Sjöblom, M | 1 |
| Lennernäs, H | 1 |
| Leszczynski, R | 1 |
| da Silva, CA | 1 |
| Pinto, ACPN | 1 |
| Kuczynski, U | 1 |
| da Silva, EM | 1 |
| Shindoh, J | 1 |
| Kobayashi, Y | 1 |
| Kinowaki, K | 1 |
| Mise, Y | 1 |
| Gonoi, W | 1 |
| Yoshida, S | 1 |
| Tani, K | 1 |
| Matoba, S | 1 |
| Kuroyanagi, H | 1 |
| Hashimoto, M | 1 |
| Zhuang, Z | 1 |
| Li, Y | 1 |
| Wei, X | 1 |
| Eilers, RE | 1 |
| Ross, EV | 1 |
| Cohen, JL | 1 |
| Ortiz, AE | 1 |
| Yang, GY | 1 |
| May, KS | 1 |
| Iyer, RV | 1 |
| Chandrasekhar, R | 1 |
| Wilding, GE | 1 |
| McCloskey, SA | 1 |
| Khushalani, NI | 1 |
| Yendamuri, SS | 1 |
| Gibbs, JF | 1 |
| Fakih, M | 1 |
| Thomas, CR | 1 |
| Disel, U | 1 |
| Gürkut, O | 1 |
| Abali, H | 1 |
| Kaleağasi, H | 1 |
| Mertsoylu, H | 1 |
| Ozyilkan, O | 1 |
| Saif, MW | 1 |
| FLOCH, MH | 1 |
| HELLMAN, L | 1 |
| Bai, M | 1 |
| Jiang, Z | 1 |
| Liu, Y | 1 |
| Yamano, T | 1 |
| Takayasu, Y | 1 |
| Nakao, N | 1 |
| Kubota, A | 1 |
| D'Souza, UJ | 1 |
| Narayana, K | 1 |
| Kim, CH | 1 |
3 reviews available for fluorouracil and Atrophy
| Article | Year |
|---|---|
Laser therapy for treating hypertrophic and keloid scars.
Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di | 2022 |
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.
Topics: Atrophy; Burns; Cicatrix, Hypertrophic; Culture Media; Fluorouracil; Humans; Injections, Intralesion | 2021 |
A Combination Approach to Surgical Scars.
Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Atrophy; Cicatrix; Combined Modality Thera | 2016 |
9 other studies available for fluorouracil and Atrophy
| Article | Year |
|---|---|
Evaluation and validation of chemotherapy-specific diarrhoea and histopathology in rats.
Topics: Animals; Antineoplastic Agents; Atrophy; Body Weight; Diarrhea; Doxorubicin; Fluorouracil; Idarubici | 2022 |
Dynamic Changes in Normal Liver Parenchymal Volume During Chemotherapy for Colorectal Cancer: Liver Atrophy as an Alternate Marker of Chemotherapy-Associated Liver Injury.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Bevacizumab | 2019 |
Renal atrophy secondary to chemoradiotherapy of abdominal malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; At | 2010 |
Unilateral hand-foot syndrome: an extraordinary side effect of capecitabine.
Topics: Aged; Antimetabolites, Antineoplastic; Atrophy; Capecitabine; Deoxycytidine; Dihydropyrimidine Dehyd | 2010 |
THE EFFECT OF FIVE-FLUOROURACIL ON RECTAL MUCOSA.
Topics: Atrophy; Cell Division; Drug Therapy; Epithelium; Fluorouracil; Gastrointestinal Neoplasms; Mucous M | 1965 |
[Glutamine dipeptide attenuate mucosal atrophic changes and preservation of gut barrier function following 5-FU intervention].
Topics: Animals; Atrophy; Bacterial Translocation; Dipeptides; Fluorouracil; Intestinal Mucosa; Male; Parent | 1996 |
[Evaluation of hepatic toxicity following high-dose 5-FU arterial infusion chemotherapy: analysis of 42 cases of colorectal liver metastases].
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Atrophy; Chemical and Drug Induced Liver Injury; Color | 2000 |
Induction of seminiferous tubular atrophy by single dose of 5-fluorouracil (5-FU) in Wistar rats.
Topics: Animals; Antimetabolites; Atrophy; Epididymis; Fluorouracil; Germ Cells; Male; Organ Size; Rats; Rat | 2001 |
[Effect on dentin mineralization following 5-fluorouracil administration in the rat. Fluorescence microscopy and scanning electron microscopy studies].
Topics: Animals; Atrophy; Calcium; Dentin; Fluorouracil; Microscopy, Electron, Scanning; Microscopy, Fluores | 1985 |