Page last updated: 2024-10-27

fluorouracil and Atrophy

fluorouracil has been researched along with Atrophy in 12 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments."9.12The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021)
"TAC may be beneficial for the short-term treatment of hypertrophic scars and keloids; however, 5-FU, 5-FU+TAC, and verapamil may produce superior results for medium- and long-term treatments."5.12The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis. ( Li, Y; Wei, X; Zhuang, Z, 2021)
"Hand-foot syndrome (HFS), the most common toxicity of capecitabine, is characterized by tingling, numbness, pain, erythema, dryness, rash, swelling, increased pigmentation, and/or pruritus of the palmar and/or plantar surfaces of the hands and/or feet."3.76Unilateral hand-foot syndrome: an extraordinary side effect of capecitabine. ( Abali, H; Disel, U; Gürkut, O; Kaleağasi, H; Mertsoylu, H; Ozyilkan, O; Saif, MW, 2010)
"Different approaches are used aiming to improve these scars, including intralesional corticosteroids, surgery and more recently, laser therapy."2.82Laser therapy for treating hypertrophic and keloid scars. ( da Silva, CA; da Silva, EM; Kuczynski, U; Leszczynski, R; Pinto, ACPN, 2022)
"Surgical scars are best treated with a combination approach to address various features of the scar."2.53A Combination Approach to Surgical Scars. ( Cohen, JL; Eilers, RE; Ortiz, AE; Ross, EV, 2016)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's1 (8.33)18.2507
2000's2 (16.67)29.6817
2010's4 (33.33)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Dahlgren, D1
Rosenqvist, E1
Hellström, PM1
Nygren, P1
Kullenberg, F1
Peters, K1
Sjöblom, M1
Lennernäs, H1
Leszczynski, R1
da Silva, CA1
Pinto, ACPN1
Kuczynski, U1
da Silva, EM1
Shindoh, J1
Kobayashi, Y1
Kinowaki, K1
Mise, Y1
Gonoi, W1
Yoshida, S1
Tani, K1
Matoba, S1
Kuroyanagi, H1
Hashimoto, M1
Zhuang, Z1
Li, Y1
Wei, X1
Eilers, RE1
Ross, EV1
Cohen, JL1
Ortiz, AE1
Yang, GY1
May, KS1
Iyer, RV1
Chandrasekhar, R1
Wilding, GE1
McCloskey, SA1
Khushalani, NI1
Yendamuri, SS1
Gibbs, JF1
Fakih, M1
Thomas, CR1
Disel, U1
Gürkut, O1
Abali, H1
Kaleağasi, H1
Mertsoylu, H1
Ozyilkan, O1
Saif, MW1
FLOCH, MH1
HELLMAN, L1
Bai, M1
Jiang, Z1
Liu, Y1
Yamano, T1
Takayasu, Y1
Nakao, N1
Kubota, A1
D'Souza, UJ1
Narayana, K1
Kim, CH1

Reviews

3 reviews available for fluorouracil and Atrophy

ArticleYear
Laser therapy for treating hypertrophic and keloid scars.
    The Cochrane database of systematic reviews, 2022, 09-26, Volume: 9

    Topics: Adrenal Cortex Hormones; Adult; Aluminum; Atrophy; Carbon Dioxide; Child; Cicatrix, Hypertrophic; Di

2022
The safety and efficacy of intralesional triamcinolone acetonide for keloids and hypertrophic scars: A systematic review and meta-analysis.
    Burns : journal of the International Society for Burn Injuries, 2021, Volume: 47, Issue:5

    Topics: Atrophy; Burns; Cicatrix, Hypertrophic; Culture Media; Fluorouracil; Humans; Injections, Intralesion

2021
A Combination Approach to Surgical Scars.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2016, Volume: 42 Suppl 2

    Topics: Adrenal Cortex Hormones; Antimetabolites, Antineoplastic; Atrophy; Cicatrix; Combined Modality Thera

2016

Other Studies

9 other studies available for fluorouracil and Atrophy

ArticleYear
Evaluation and validation of chemotherapy-specific diarrhoea and histopathology in rats.
    Basic & clinical pharmacology & toxicology, 2022, Volume: 131, Issue:6

    Topics: Animals; Antineoplastic Agents; Atrophy; Body Weight; Diarrhea; Doxorubicin; Fluorouracil; Idarubici

2022
Dynamic Changes in Normal Liver Parenchymal Volume During Chemotherapy for Colorectal Cancer: Liver Atrophy as an Alternate Marker of Chemotherapy-Associated Liver Injury.
    Annals of surgical oncology, 2019, Volume: 26, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Bevacizumab

2019
Renal atrophy secondary to chemoradiotherapy of abdominal malignancies.
    International journal of radiation oncology, biology, physics, 2010, Oct-01, Volume: 78, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; At

2010
Unilateral hand-foot syndrome: an extraordinary side effect of capecitabine.
    Cutaneous and ocular toxicology, 2010, Volume: 29, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Atrophy; Capecitabine; Deoxycytidine; Dihydropyrimidine Dehyd

2010
THE EFFECT OF FIVE-FLUOROURACIL ON RECTAL MUCOSA.
    Gastroenterology, 1965, Volume: 48

    Topics: Atrophy; Cell Division; Drug Therapy; Epithelium; Fluorouracil; Gastrointestinal Neoplasms; Mucous M

1965
[Glutamine dipeptide attenuate mucosal atrophic changes and preservation of gut barrier function following 5-FU intervention].
    Zhonghua wai ke za zhi [Chinese journal of surgery], 1996, Volume: 34, Issue:6

    Topics: Animals; Atrophy; Bacterial Translocation; Dipeptides; Fluorouracil; Intestinal Mucosa; Male; Parent

1996
[Evaluation of hepatic toxicity following high-dose 5-FU arterial infusion chemotherapy: analysis of 42 cases of colorectal liver metastases].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 2000, Volume: 60, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Atrophy; Chemical and Drug Induced Liver Injury; Color

2000
Induction of seminiferous tubular atrophy by single dose of 5-fluorouracil (5-FU) in Wistar rats.
    Indian journal of physiology and pharmacology, 2001, Volume: 45, Issue:1

    Topics: Animals; Antimetabolites; Atrophy; Epididymis; Fluorouracil; Germ Cells; Male; Organ Size; Rats; Rat

2001
[Effect on dentin mineralization following 5-fluorouracil administration in the rat. Fluorescence microscopy and scanning electron microscopy studies].
    Taehan Ch'ikkwa Uisa Hyophoe chi, 1985, Volume: 23, Issue:5

    Topics: Animals; Atrophy; Calcium; Dentin; Fluorouracil; Microscopy, Electron, Scanning; Microscopy, Fluores

1985