fluorouracil has been researched along with Atrial Fibrillation in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature." | 7.72 | Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003) |
| "A 77-year-old man with colon cancer and multiple metastases to the liver and lungs underwent resection of the primary tumor and D3 lymph node dissection." | 5.39 | [A case of advanced colon cancer with atrial fibrillation and the use of dabigatran for safe chemotherapy using fluoropyrimidine-based antitumor agents]. ( Adachi, A; Nakajima, M; Uchisako, H; Uchiyama, T, 2013) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 5.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| "We describe an 80-year-old woman who presented with rectal bleeding and an increased INR due to the concomitant use of acenocoumarol and capecitabine for atrial fibrillation and metastatic cecal cancer, respectively." | 3.78 | [Increased INR from concomitant use of acenocoumarol and capecitabine]. ( Smorenburg, CH; Tomlow, B; Voll, ML, 2012) |
| "5-Fluorouracil, a widely used drug in cancer treatment, is known to have cardiotoxic effects: chest pain with ECG changes, arrhythmias, arterial hypertension or hypotension, myocardial infarction, cardiogenic shock and sudden death have been described in the literature." | 3.72 | Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases. ( Alberti, A; Corrada, E; Ferrari, S; Mafrici, A; Marenna, B, 2003) |
| "We evaluated esophageal cancer patients treated between 2006 and 2014 with preoperative IMRT chemoradiation to a dose of 50." | 1.46 | Dose escalated neoadjuvant chemoradiotherapy with dose-painting intensity-modulated radiation therapy and improved pathologic complete response in locally advanced esophageal cancer. ( Abuodeh, Y; Almhanna, K; Fontaine, JP; Frakes, JM; Hoffe, SE; Meredith, KL; Naghavi, AO; Pimiento, JM; Shridhar, R; Venkat, PS, 2017) |
| "A 77-year-old man with colon cancer and multiple metastases to the liver and lungs underwent resection of the primary tumor and D3 lymph node dissection." | 1.39 | [A case of advanced colon cancer with atrial fibrillation and the use of dabigatran for safe chemotherapy using fluoropyrimidine-based antitumor agents]. ( Adachi, A; Nakajima, M; Uchisako, H; Uchiyama, T, 2013) |
| "The incidence of 5-fluorouracil (5-FU)-related cardiotoxicity seems to be dosage and schedule dependent." | 1.33 | Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up. ( Alakavuklar, MN; Barutca, S; Kundak, I; Meydan, N; Oztop, I; Yavuzsen, T; Yilmaz, U, 2005) |
| "Cardiotoxicity is a rare but serious side effect of 5-flourouracil (5-FU)." | 1.31 | Cardiotoxicity of 5-flourouracil: two case reports. ( Ayanoğlu, E; Caymaz, O; Duman, D; Inanli, S; Tutkun, A, 2001) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 1.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Venkat, PS | 1 |
| Shridhar, R | 1 |
| Naghavi, AO | 1 |
| Hoffe, SE | 1 |
| Almhanna, K | 1 |
| Pimiento, JM | 1 |
| Fontaine, JP | 1 |
| Abuodeh, Y | 1 |
| Meredith, KL | 1 |
| Frakes, JM | 1 |
| Hayashi, Y | 1 |
| Iijima, H | 1 |
| Isohashi, F | 1 |
| Tsujii, Y | 1 |
| Fujinaga, T | 1 |
| Nagai, K | 1 |
| Yoshii, S | 1 |
| Sakatani, A | 1 |
| Hiyama, S | 1 |
| Shinzaki, S | 1 |
| Makino, T | 1 |
| Yamasaki, M | 1 |
| Ogawa, K | 1 |
| Doki, Y | 1 |
| Takehara, T | 1 |
| Nakajima, M | 1 |
| Uchiyama, T | 1 |
| Adachi, A | 1 |
| Uchisako, H | 1 |
| Tomlow, B | 1 |
| Voll, ML | 1 |
| Smorenburg, CH | 1 |
| Mafrici, A | 1 |
| Alberti, A | 1 |
| Corrada, E | 1 |
| Ferrari, S | 1 |
| Marenna, B | 1 |
| Meydan, N | 1 |
| Kundak, I | 1 |
| Yavuzsen, T | 1 |
| Oztop, I | 1 |
| Barutca, S | 1 |
| Yilmaz, U | 1 |
| Alakavuklar, MN | 1 |
| Aziz, SA | 1 |
| Tramboo, NA | 1 |
| Mohi-ud-Din, K | 1 |
| Iqbal, K | 1 |
| Jalal, S | 1 |
| Ahmad, M | 1 |
| Tutkun, A | 1 |
| Inanli, S | 1 |
| Caymaz, O | 1 |
| Ayanoğlu, E | 1 |
| Duman, D | 1 |
8 other studies available for fluorouracil and Atrial Fibrillation
| Article | Year |
|---|---|
Dose escalated neoadjuvant chemoradiotherapy with dose-painting intensity-modulated radiation therapy and improved pathologic complete response in locally advanced esophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibrillation; | 2017 |
The heart's exposure to radiation increases the risk of cardiac toxicity after chemoradiotherapy for superficial esophageal cancer: a retrospective cohort study.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibrillation; Cardiotoxicity; Chemoradi | 2019 |
[A case of advanced colon cancer with atrial fibrillation and the use of dabigatran for safe chemotherapy using fluoropyrimidine-based antitumor agents].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibrillation; Benzimidazoles; Colonic N | 2013 |
[Increased INR from concomitant use of acenocoumarol and capecitabine].
Topics: Acenocoumarol; Aged, 80 and over; Anticoagulants; Antimetabolites, Antineoplastic; Atrial Fibrillati | 2012 |
Management of patients with persistent chest pain and ST-segment elevation during 5-fluorouracil treatment: report about two cases.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antimetabolites, Antineoplas | 2003 |
Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up.
Topics: Acute Disease; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrial Fibri | 2005 |
Supraventricular arrhythmia: a complication of 5-fluorouracil therapy.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atr | 1998 |
Cardiotoxicity of 5-flourouracil: two case reports.
Topics: Angina Pectoris; Atrial Fibrillation; Female; Fluorouracil; Heart; Humans; Male; Middle Aged; Myocar | 2001 |