fluorouracil has been researched along with Ataxia in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A cerebral demyelinating disease developed in 3 patients during adjuvant therapy with 5-fluorouracil and levamisole for adenocarcinoma of the colon." | 3.68 | Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole. ( Forsyth, PA; Hook, CC; Kimmel, DW; Kvols, LK; Moertel, CG; Rodriguez, M; Rubin, J; Scheithauer, BW, 1992) |
| "Fluorouracil can cause both acute and delayed neurotoxicity." | 1.31 | Fluorouracil-induced neurotoxicity. ( Ali, II; Dafer, RM; Pirzada, NA, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shimizu, T | 1 |
| MOERTEL, CG | 3 |
| REITEMEIER, RJ | 1 |
| BOLTON, CF | 1 |
| SHORTER, RG | 1 |
| Fry, MM | 1 |
| Forman, MA | 1 |
| Guilloton, L | 1 |
| Michaud, A | 1 |
| Potier, V | 1 |
| Le Berre, J | 1 |
| Drouet, A | 1 |
| Felten, D | 1 |
| Hamberg, P | 1 |
| De Jong, FA | 1 |
| Brandsma, D | 1 |
| Verweij, J | 1 |
| Sleijfer, S | 1 |
| O'Connell, MJ | 1 |
| Rubin, J | 2 |
| Hahn, RG | 1 |
| Kvols, LK | 2 |
| Schutt, AJ | 1 |
| Stuart, K | 1 |
| Tessitore, J | 1 |
| Huberman, M | 1 |
| Pirzada, NA | 1 |
| Ali, II | 1 |
| Dafer, RM | 1 |
| Harvey, HJ | 1 |
| MacEwen, EG | 1 |
| Hayes, AA | 1 |
| Lokich, JJ | 1 |
| Pitman, SW | 1 |
| Skarin, AT | 1 |
| Nichols, M | 1 |
| Bergevin, PR | 1 |
| Vyas, AC | 1 |
| Hamilin, R | 1 |
| Hook, CC | 1 |
| Kimmel, DW | 1 |
| Scheithauer, BW | 1 |
| Forsyth, PA | 1 |
| Rodriguez, M | 1 |
| Piro, AJ | 1 |
| Wilson, RE | 1 |
| Hall, TC | 1 |
| Aliapoulios, MA | 1 |
| Nevinny, HB | 1 |
| Moore, FD | 1 |
1 review available for fluorouracil and Ataxia
| Article | Year |
|---|---|
Irinotecan-induced central nervous system toxicity. Report on two cases and review of the literature.
Topics: Adult; Antiemetics; Antineoplastic Agents, Phytogenic; Ataxia; Camptothecin; Capecitabine; Central N | 2008 |
12 other studies available for fluorouracil and Ataxia
| Article | Year |
|---|---|
[Ataxia].
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antipsychotic Agents; Ataxia; Fluorouracil; Humans | 2012 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasm | 1964 |
5-fluorouracil toxicity with severe bone marrow suppression in a dog.
Topics: Animals; Antimetabolites, Antineoplastic; Ataxia; Blood Chemical Analysis; Bone Marrow; Diagnosis, D | 2004 |
[Ataxia and confusion after treatment with 5 Fluorouracile].
Topics: Antimetabolites, Antineoplastic; Ataxia; Colonic Neoplasms; Confusion; Fluorouracil; Humans; Wernick | 2005 |
Clinical trial of sequential N-phosphonacetyl-L-aspartate, thymidine, and 5-fluorouracil in advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Ataxia; Colonic Neoplasm | 1984 |
5-Fluorouracil and alpha-interferon in hepatocellular carcinoma.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Ataxia; Carcinoma, Hepatocellular; Disease P | 1996 |
Fluorouracil-induced neurotoxicity.
Topics: Aged; Antimetabolites, Antineoplastic; Ataxia; Confusion; Esophageal Neoplasms; Fluorouracil; Humans | 2000 |
Neurotoxicosis associated with use of 5-fluorouracil in five dogs and one cat.
Topics: Animals; Ataxia; Blindness; Cat Diseases; Cats; Dog Diseases; Dogs; Female; Fluorouracil; Male; Nerv | 1977 |
Combined 5-fluorouracil and hydroxyurea therapy for gastrointestinal cancer.
Topics: Administration, Oral; Ataxia; Colonic Neoplasms; Drug Therapy, Combination; Fluorouracil; Gastrointe | 1975 |
Neurotoxicity from 5-fluorouracil (NSC-19893) administration reproduced by mitomycin C (NSC-26980).
Topics: Adenocarcinoma; Aged; Ataxia; Blood-Brain Barrier; Cerebellar Ataxia; Colonic Neoplasms; Fluorouraci | 1976 |
Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Biopsy; Brain; Chemoth | 1992 |
Toxicity studies of fluorouracil used with adrenalectomy in breast cancer.
Topics: Adrenalectomy; Adult; Aged; Alopecia; Ataxia; Blood Platelet Disorders; Breast Neoplasms; Diarrhea; | 1972 |