fluorouracil has been researched along with Astrocytoma in 24 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen patients with malignant gliomas were entered on a phase II study of 5-fluorouracil 300-370 mg/m2 plus folinic acid 200 mg/m2 x 5 days q4 weeks." | 9.08 | A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults. ( Dahrouge, S; Soltys, K; Stewart, DJ, 1995) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 7.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "Fourteen patients with malignant gliomas were entered on a phase II study of 5-fluorouracil 300-370 mg/m2 plus folinic acid 200 mg/m2 x 5 days q4 weeks." | 5.08 | A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults. ( Dahrouge, S; Soltys, K; Stewart, DJ, 1995) |
| "In an attempt to improve the primary treatment of malignant gliomas we used a concomitant 6-week course of chemoradiotherapy with 5 fluorouracil (5 FU) and hydroxyurea (HU) in 24 adults with anaplastic astrocytoma (AA) (7 cases) or glioblastomas (GLB) (17 cases)." | 5.07 | Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas. ( Armand, JP; Cioloca, C; Constans, JP; Cvitkovic, FB; Haie-Meder, C; Maugis, N; Papadimitrakopoulou, V, 1993) |
| "From August 1987 through September 1989, 25 patients with either anaplastic astrocytoma (8 patients) or glioblastoma multiforme (17 patients) were entered into a Phase I trial of combined intra-arterial 5-fluorouracil (5-FU) and external beam radiation therapy." | 5.07 | Phase I/II trial of superselective arterial 5-FU infusion with concomitant external beam radiation for patients with either anaplastic astrocytoma or glioblastoma multiforme. ( Constable, WC; Ferguson, R; Jane, JA; Kersh, CR; Kline, P; Larner, JM; Short, R, 1991) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 3.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "Thirty patients with recurrent primary brain tumors were treated with a combination of 5-fluorouracil and leucovorin." | 2.68 | Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor. ( Buckner, JC; Cascino, TL; Goldberg, RM; Kuross, SA; Levitt, R; Morton, RF; O'Fallon, JR; Scheithauer, BW; Veeder, MH; Wiesenfeld, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (62.50) | 18.7374 |
| 1990's | 8 (33.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jurd, L | 1 |
| Narayanan, VL | 1 |
| Paull, KD | 1 |
| Levin, VA | 4 |
| Edwards, MS | 1 |
| Wara, WM | 1 |
| Allen, J | 1 |
| Ortega, J | 1 |
| Vestnys, P | 1 |
| Tsuchida, T | 1 |
| Watanabe, E | 1 |
| Nakayama, H | 1 |
| Sasaki, A | 1 |
| Nakamura, S | 1 |
| Sasaki, M | 1 |
| Fujiwara, T | 2 |
| Nemoto, S | 1 |
| Fujiwara, K | 1 |
| Yanagibashi, K | 1 |
| Hayakawa, I | 1 |
| Nomura, K | 1 |
| Matsumoto, K | 1 |
| Tabuchi, K | 1 |
| Furuta, T | 1 |
| Nakasone, S | 1 |
| Ohnishi, R | 1 |
| Moriya, Y | 1 |
| Nishimoto, A | 1 |
| Doi, A | 1 |
| Asari, S | 1 |
| Stewart, DJ | 1 |
| Dahrouge, S | 1 |
| Soltys, K | 1 |
| Larner, JM | 2 |
| Phillips, CD | 1 |
| Dion, JE | 1 |
| Jensen, ME | 1 |
| Newman, SA | 1 |
| Jane, JA | 2 |
| Cvitkovic, FB | 1 |
| Haie-Meder, C | 1 |
| Papadimitrakopoulou, V | 1 |
| Armand, JP | 1 |
| Cioloca, C | 1 |
| Maugis, N | 1 |
| Constans, JP | 1 |
| Vokes, EE | 1 |
| Dolan, ME | 1 |
| Krishnasamy, S | 1 |
| Mick, R | 1 |
| Ratain, MJ | 1 |
| Berezin, F | 1 |
| Brachman, D | 1 |
| Whitman, G | 1 |
| Schilsky, RL | 1 |
| Charette, J | 1 |
| Bolla, M | 1 |
| Vincent, P | 1 |
| Benabid, A | 1 |
| Mousseau, M | 1 |
| de Rougemont, J | 1 |
| Vrousos, C | 1 |
| Kolodié, H | 1 |
| Vincent, F | 1 |
| Pasquier, B | 1 |
| Cascino, TL | 1 |
| Veeder, MH | 1 |
| Buckner, JC | 1 |
| O'Fallon, JR | 1 |
| Wiesenfeld, M | 1 |
| Levitt, R | 1 |
| Goldberg, RM | 1 |
| Kuross, SA | 1 |
| Morton, RF | 1 |
| Scheithauer, BW | 1 |
| Hess, KR | 1 |
| Wong, ET | 1 |
| Jaeckle, KA | 1 |
| Kyritsis, AP | 1 |
| Prados, MD | 1 |
| Yung, WK | 1 |
| Raut, V | 1 |
| Golchin, K | 1 |
| Anderson, N | 1 |
| Primrose, WJ | 1 |
| Takeuchi, K | 2 |
| Hoffman, WF | 1 |
| Pischer, TL | 1 |
| Seager, ML | 1 |
| Boldrey, EB | 1 |
| Wilson, CB | 1 |
| Apinis, TA | 1 |
| Zilbere, AM | 1 |
| Meĭrena, DV | 1 |
| Gilev, AP | 1 |
| Zhuk, RA | 1 |
| Baumanis, EA | 1 |
| Kalnina, IE | 1 |
| Brusovanik, VI | 1 |
| Iablonovskaia, LIa | 1 |
| Kersh, CR | 1 |
| Constable, WC | 1 |
| Kline, P | 1 |
| Ferguson, R | 1 |
| Short, R | 1 |
| Yamashita, M | 1 |
| Hashimoto, T | 1 |
| Hirakawa, T | 1 |
| Fukushima, T | 1 |
| Tomonaga, M | 1 |
| Hara, Y | 1 |
| Kono, A | 1 |
| Tanaka, M | 1 |
| Kawano, H | 1 |
| Kubota, T | 1 |
| Hayashi, M | 1 |
| Yamamoto, S | 1 |
| Yamashima, T | 1 |
| Itoh, H | 1 |
| Kobayashi, H | 1 |
| Handa, Y | 1 |
| Kabuto, M | 1 |
| Ishikura, A | 1 |
| Sano, K | 1 |
| Hoshino, T | 1 |
| Nagai, M | 1 |
| Ringkjob, R | 1 |
| Heiss, WD | 1 |
| Kroiss, A | 1 |
| Kühböck, J | 1 |
| Profanter, W | 1 |
1 review available for fluorouracil and Astrocytoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
7 trials available for fluorouracil and Astrocytoma
| Article | Year |
|---|---|
A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Female; Fluorouracil; Glioblastoma; Glioma; Humans; Infus | 1995 |
A phase 1-2 trial of superselective carboplatin, low-dose infusional 5-fluorouracil and concurrent radiation for high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat | 1995 |
Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined | 1993 |
5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemotherapy, Adjuvant; Dr | 1993 |
Phase II study of 5-fluorouracil and leucovorin in recurrent primary brain tumor.
Topics: Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Astrocytoma; Brain Neoplasms; Female; Fluor | 1996 |
Response and progression in recurrent malignant glioma.
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Aged, 80 and over; Alitretinoin; Antineoplastic Combine | 1999 |
Phase I/II trial of superselective arterial 5-FU infusion with concomitant external beam radiation for patients with either anaplastic astrocytoma or glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Drug Admini | 1991 |
16 other studies available for fluorouracil and Astrocytoma
| Article | Year |
|---|---|
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topois | 1987 |
5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bra | 1984 |
[FAR therapy in brain tumors--FT207-vitamin A-Radiation therapy (author's transl)].
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Child; Child, Preschool; Drug Therapy, Combination; | 1980 |
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat | 1983 |
[Association of 5-FU, CDDP and hypofractionated radiotherapy in recurrences of subtentorial astrocytomas and malignant gliomas in adults].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; | 1990 |
Metastatic astrocytoma in the parotid.
Topics: Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biopsy, Needle; Brain Neop | 2002 |
[Role of chemotherapy in long-term survival of malignant glioma (author's transl)].
Topics: Adolescent; Adult; Astrocytoma; Bleomycin; Brain Neoplasms; Ependymoma; Female; Fluorouracil; Glioma | 1975 |
BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors.
Topics: Astrocytoma; Bone Marrow; Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glio | 1978 |
[Clinical pharmacokinetics of 2-C14-ftorafur in patients with astrocytoma].
Topics: Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Cerebral Cortex; Fluorouracil; Humans; Injections | 1976 |
[Comparative study of the effect of inhibitors of monoamine oxidase and ftorafur on the growth of de-differentiated astrocytoma].
Topics: Animals; Astrocytoma; Cerebellar Neoplasms; Drug Evaluation; Fluorouracil; Monoamine Oxidase Inhibit | 1976 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Epen | 1985 |
[Evaluation of ACNU and 5-FU in the treatment of gliomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biological Products; Brain Neoplasms; C | 1986 |
Radiosensitization of brain tumor cells with a thymidine analogue (bromouridine).
Topics: Astrocytoma; Brain Neoplasms; Bromodeoxyuridine; Culture Techniques; DNA; Floxuridine; Fluorouracil; | 1968 |
Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Female; Fluorouracil; Glioblastoma; | 1968 |
[Chemotherapy of brain tumors].
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Carotid Arteries; Catheterization; Child; Ependymom | 1968 |
[Combined cytostatic treatment of malignant brain tumors (author's transl)].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; C | 1974 |