fluorouracil has been researched along with Astrocytoma, Grade IV in 57 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous preclinical studies suggested that concurrent capecitabine and radiation could be an effective new treatment modality for glioblastoma (GBM)." | 9.14 | Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome. ( Cantor, A; Fathallah-Shaykh, HM; Fiveash, J; Grunda, JM; Johnson, MR; Nabors, LB; Palmer, CA, 2010) |
| " In this study, this method was used to provide localized and sustained delivery of 5-fluorouracil (5-FU) after the surgical resection of glioblastoma." | 9.09 | Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: a pilot study. ( Benoit, JP; Fournier, D; Gamelin, E; Guy, G; Hayek, G; Jadaud, E; Menei, P; Mercier, P; Saint-André, JP; Venier, MC, 1999) |
| "Fourteen patients with malignant gliomas were entered on a phase II study of 5-fluorouracil 300-370 mg/m2 plus folinic acid 200 mg/m2 x 5 days q4 weeks." | 9.08 | A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults. ( Dahrouge, S; Soltys, K; Stewart, DJ, 1995) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 7.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "The Neuro-oncology Service of the University of California Brain Tumor Research Center conducted a nonrandomized phase II study to evaluate, in patients with recurrent malignant glioma, the benefit of a four-drug combination (BFHM) consisting of carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea), 5-fluorouracil, hydroxyurea, and 6-mercaptopurine." | 7.67 | Phase II study of combined carmustine, 5-fluorouracil, hydroxyurea, and 6-mercaptopurine (BFHM) for the treatment of malignant gliomas. ( Berger, M; Chamberlain, M; Choucair, A; Da Silva, V; Davis, RL; Levin, VA; Liu, HC; Murovic, J; Phuphanich, S; Seager, M, 1986) |
| "5-Fluorouracil (5-FU) is a potent antimetabolite used for chemotherapy of gastrointestinal (GI), breast, and head and neck malignancies." | 5.31 | Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. ( Buchsbaum, DJ; Gillespie, GY; Miller, CR; Williams, CR, 2002) |
| "Previous preclinical studies suggested that concurrent capecitabine and radiation could be an effective new treatment modality for glioblastoma (GBM)." | 5.14 | Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome. ( Cantor, A; Fathallah-Shaykh, HM; Fiveash, J; Grunda, JM; Johnson, MR; Nabors, LB; Palmer, CA, 2010) |
| "A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)." | 5.12 | Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007) |
| " In this study, this method was used to provide localized and sustained delivery of 5-fluorouracil (5-FU) after the surgical resection of glioblastoma." | 5.09 | Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: a pilot study. ( Benoit, JP; Fournier, D; Gamelin, E; Guy, G; Hayek, G; Jadaud, E; Menei, P; Mercier, P; Saint-André, JP; Venier, MC, 1999) |
| "Fourteen patients with malignant gliomas were entered on a phase II study of 5-fluorouracil 300-370 mg/m2 plus folinic acid 200 mg/m2 x 5 days q4 weeks." | 5.08 | A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults. ( Dahrouge, S; Soltys, K; Stewart, DJ, 1995) |
| "In an attempt to improve the primary treatment of malignant gliomas we used a concomitant 6-week course of chemoradiotherapy with 5 fluorouracil (5 FU) and hydroxyurea (HU) in 24 adults with anaplastic astrocytoma (AA) (7 cases) or glioblastomas (GLB) (17 cases)." | 5.07 | Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas. ( Armand, JP; Cioloca, C; Constans, JP; Cvitkovic, FB; Haie-Meder, C; Maugis, N; Papadimitrakopoulou, V, 1993) |
| "From August 1987 through September 1989, 25 patients with either anaplastic astrocytoma (8 patients) or glioblastoma multiforme (17 patients) were entered into a Phase I trial of combined intra-arterial 5-fluorouracil (5-FU) and external beam radiation therapy." | 5.07 | Phase I/II trial of superselective arterial 5-FU infusion with concomitant external beam radiation for patients with either anaplastic astrocytoma or glioblastoma multiforme. ( Constable, WC; Ferguson, R; Jane, JA; Kersh, CR; Kline, P; Larner, JM; Short, R, 1991) |
| "Twenty-eight evaluable children with the diagnosis of brain stem glioma were treated with 5-fluorouracil and CCNU before posterior fossa irradiation (5500 rads); during irradiation, the children received hydroxyurea and misonidazole." | 3.67 | 5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group. ( Allen, J; Edwards, MS; Levin, VA; Ortega, J; Vestnys, P; Wara, WM, 1984) |
| "The Neuro-oncology Service of the University of California Brain Tumor Research Center conducted a nonrandomized phase II study to evaluate, in patients with recurrent malignant glioma, the benefit of a four-drug combination (BFHM) consisting of carmustine (1,3-bis (2-chloroethyl)-1-nitrosourea), 5-fluorouracil, hydroxyurea, and 6-mercaptopurine." | 3.67 | Phase II study of combined carmustine, 5-fluorouracil, hydroxyurea, and 6-mercaptopurine (BFHM) for the treatment of malignant gliomas. ( Berger, M; Chamberlain, M; Choucair, A; Da Silva, V; Davis, RL; Levin, VA; Liu, HC; Murovic, J; Phuphanich, S; Seager, M, 1986) |
| " This study demonstrates that the combination of apoptosis and fluorescence imaging is an excellent method for optimizing dosing and treatment schedules in preclinical cancer models." | 1.39 | Noninvasive monitoring of pharmacodynamics and kinetics of a death receptor 5 antibody and its enhanced apoptosis induction in sequential application with doxorubicin. ( Galbán, S; Pöschinger, T; Rehemtulla, A; Scheuer, W; Weber, TG, 2013) |
| "Human pancreatic cancer cells revealed high and relatively moderate MUC1 levels for Capan-1 and HPAF-II, respectively, compared to MUC1 negative control (U-87 MG glioblastoma) that showed relatively non-specific anti-MUC1 uptake." | 1.34 | Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain. ( Campbell, RB; Kalra, AV, 2007) |
| "In the United States, tumors of the central nervous system remain the third leading cancer-related cause of death in young adults with a median survival time of < 1 year." | 1.31 | Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation. ( Bharara, S; Blanquicett, C; Buchsbaum, DJ; Diasio, RB; Gillespie, GY; Johnson, MR; Miller, CR; Nabors, LB, 2002) |
| "5-Fluorouracil (5-FU) is a potent antimetabolite used for chemotherapy of gastrointestinal (GI), breast, and head and neck malignancies." | 1.31 | Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas. ( Buchsbaum, DJ; Gillespie, GY; Miller, CR; Williams, CR, 2002) |
| "Nineteen patients with brain tumors were orally administered 300 mg of UFT (a combination of FT and uracil with a molar ratio being 1:4) before operation and the concentrations of FT, 5-FU and Uracil in tumors and serum were measured by chemical assay." | 1.27 | [5-FU concentration in brain tumors after co-administration of FT and uracil]. ( Matsumoto, S; Nogaki, H; Tamaki, N; Taomoto, K, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (35.09) | 18.7374 |
| 1990's | 13 (22.81) | 18.2507 |
| 2000's | 12 (21.05) | 29.6817 |
| 2010's | 10 (17.54) | 24.3611 |
| 2020's | 2 (3.51) | 2.80 |
| Authors | Studies |
|---|---|
| Huff, S | 1 |
| Kummetha, IR | 1 |
| Zhang, L | 1 |
| Wang, L | 1 |
| Bray, W | 1 |
| Yin, J | 1 |
| Kelley, V | 1 |
| Wang, Y | 1 |
| Rana, TM | 1 |
| Hawkins, CC | 1 |
| Jones, AB | 1 |
| Gordon, ER | 1 |
| Williford, SE | 1 |
| Harsh, Y | 1 |
| Ziebro, JK | 1 |
| Landis, CJ | 1 |
| Gc, S | 1 |
| Crossman, DK | 1 |
| Cooper, SJ | 1 |
| Ramanadham, S | 1 |
| Doan, N | 1 |
| Hjelmeland, AB | 1 |
| Lakkadwala, S | 1 |
| Singh, J | 1 |
| Kazlauskas, A | 1 |
| Darinskas, A | 1 |
| Meškys, R | 1 |
| Tamašauskas, A | 1 |
| Urbonavičius, J | 1 |
| Weber, TG | 1 |
| Pöschinger, T | 1 |
| Galbán, S | 1 |
| Rehemtulla, A | 1 |
| Scheuer, W | 1 |
| Kim, EY | 1 |
| Yechieli, R | 1 |
| Kim, JK | 1 |
| Mikkelsen, T | 1 |
| Kalkanis, SN | 1 |
| Rock, J | 1 |
| Rosenblum, M | 1 |
| Ryu, S | 1 |
| Gmeiner, WH | 1 |
| Lema-Tome, C | 1 |
| Gibo, D | 1 |
| Jennings-Gee, J | 1 |
| Milligan, C | 1 |
| Debinski, W | 1 |
| Chockalingam, S | 1 |
| Ghosh, SS | 1 |
| Kutlu, C | 1 |
| Çakmak, AS | 1 |
| Gümüşderelioğlu, M | 1 |
| Grunda, JM | 1 |
| Fiveash, J | 1 |
| Palmer, CA | 1 |
| Cantor, A | 1 |
| Fathallah-Shaykh, HM | 1 |
| Nabors, LB | 2 |
| Johnson, MR | 2 |
| Hlavaty, J | 1 |
| Jandl, G | 1 |
| Liszt, M | 1 |
| Petznek, H | 1 |
| König-Schuster, M | 1 |
| Sedlak, J | 1 |
| Egerbacher, M | 1 |
| Weissenberger, J | 1 |
| Salmons, B | 1 |
| Günzburg, WH | 1 |
| Renner, M | 1 |
| Walbert, T | 1 |
| Gilbert, MR | 1 |
| Groves, MD | 1 |
| Puduvalli, VK | 1 |
| Yung, WK | 2 |
| Conrad, CA | 1 |
| Bobustuc, GC | 1 |
| Colman, H | 1 |
| Hsu, SH | 1 |
| Bekele, BN | 1 |
| Qiao, W | 1 |
| Levin, VA | 7 |
| Blanquicett, C | 1 |
| Gillespie, GY | 2 |
| Miller, CR | 2 |
| Bharara, S | 1 |
| Buchsbaum, DJ | 2 |
| Diasio, RB | 1 |
| Beech, DJ | 1 |
| Madan, AK | 1 |
| Aliabadi-Wahle, S | 1 |
| Hays, AN | 1 |
| Long, WP | 1 |
| HELSPER, JT | 1 |
| DEMOSS, EV | 1 |
| Menei, P | 2 |
| Benoit, JP | 2 |
| Yount, G | 1 |
| Taft, R | 1 |
| West, J | 1 |
| Moore, D | 1 |
| Mahyar-Roemer, M | 1 |
| Fritzsche, C | 1 |
| Wagner, S | 1 |
| Laue, M | 1 |
| Roemer, K | 1 |
| Yao, Y | 1 |
| Kubota, T | 2 |
| Sato, K | 1 |
| Takeuchi, H | 1 |
| Kitai, R | 1 |
| Matsukawa, S | 1 |
| Bourbeau, D | 1 |
| Lau, CJ | 1 |
| Jaime, J | 1 |
| Koty, Z | 1 |
| Zehntner, SP | 1 |
| Lavoie, G | 1 |
| Mes-Masson, AM | 1 |
| Nalbantoglu, J | 1 |
| Massie, B | 1 |
| Kalra, AV | 1 |
| Campbell, RB | 1 |
| Pyrko, P | 1 |
| Schönthal, AH | 1 |
| Hofman, FM | 1 |
| Chen, TC | 1 |
| Lee, AS | 1 |
| Hau, P | 1 |
| Kunz-Schughart, L | 1 |
| Bogdahn, U | 1 |
| Baumgart, U | 1 |
| Hirschmann, B | 1 |
| Weimann, E | 1 |
| Muhleisen, H | 1 |
| Ruemmele, P | 1 |
| Steinbrecher, A | 1 |
| Reichle, A | 1 |
| Edwards, MS | 1 |
| Wara, WM | 1 |
| Allen, J | 1 |
| Ortega, J | 1 |
| Vestnys, P | 1 |
| Mortimer, JE | 1 |
| Hewlett, JS | 1 |
| Bay, J | 1 |
| Livingston, RB | 1 |
| Nogaki, H | 1 |
| Taomoto, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Sueyoshi, K | 1 |
| Majima, H | 1 |
| Stewart, DJ | 1 |
| Dahrouge, S | 1 |
| Soltys, K | 1 |
| Larner, JM | 2 |
| Phillips, CD | 1 |
| Dion, JE | 1 |
| Jensen, ME | 1 |
| Newman, SA | 1 |
| Jane, JA | 2 |
| Cvitkovic, FB | 1 |
| Haie-Meder, C | 1 |
| Papadimitrakopoulou, V | 1 |
| Armand, JP | 1 |
| Cioloca, C | 1 |
| Maugis, N | 1 |
| Constans, JP | 1 |
| Vokes, EE | 1 |
| Dolan, ME | 1 |
| Krishnasamy, S | 1 |
| Mick, R | 1 |
| Ratain, MJ | 1 |
| Berezin, F | 1 |
| Brachman, D | 1 |
| Whitman, G | 1 |
| Schilsky, RL | 1 |
| Charette, J | 1 |
| Haberkorn, U | 2 |
| Oberdorfer, F | 2 |
| Gebert, J | 1 |
| Morr, I | 1 |
| Haack, K | 1 |
| Weber, K | 1 |
| Lindauer, M | 2 |
| van Kaick, G | 1 |
| Schackert, HK | 2 |
| Rowley, S | 1 |
| Gebert, JF | 1 |
| Moebius, U | 1 |
| Herfarth, C | 1 |
| Bolla, M | 1 |
| Vincent, P | 1 |
| Benabid, A | 1 |
| Mousseau, M | 1 |
| de Rougemont, J | 1 |
| Vrousos, C | 1 |
| Kolodié, H | 1 |
| Vincent, F | 1 |
| Pasquier, B | 1 |
| Heise, C | 1 |
| Sampson-Johannes, A | 1 |
| Williams, A | 1 |
| McCormick, F | 1 |
| Von Hoff, DD | 1 |
| Kirn, DH | 1 |
| Brem, H | 1 |
| Lawson, HC | 1 |
| Venier, MC | 1 |
| Gamelin, E | 1 |
| Saint-André, JP | 1 |
| Hayek, G | 1 |
| Jadaud, E | 1 |
| Fournier, D | 1 |
| Mercier, P | 1 |
| Guy, G | 1 |
| Noble, M | 1 |
| Hess, KR | 1 |
| Wong, ET | 1 |
| Jaeckle, KA | 1 |
| Kyritsis, AP | 1 |
| Prados, MD | 2 |
| Williams, CR | 1 |
| Hoffman, WF | 1 |
| Pischer, TL | 1 |
| Seager, ML | 1 |
| Boldrey, EB | 1 |
| Wilson, CB | 2 |
| Kersh, CR | 1 |
| Constable, WC | 1 |
| Kline, P | 1 |
| Ferguson, R | 1 |
| Short, R | 1 |
| Kawano, H | 1 |
| Hayashi, M | 1 |
| Yamamoto, S | 1 |
| Yamashima, T | 1 |
| Itoh, H | 1 |
| Kobayashi, H | 1 |
| Handa, Y | 1 |
| Kabuto, M | 1 |
| Ishikura, A | 1 |
| Decker, DA | 1 |
| Kinzie, J | 1 |
| Evans, R | 1 |
| Abu-Zahra, H | 1 |
| Al-Sarraf, M | 1 |
| Phuphanich, S | 1 |
| Liu, HC | 1 |
| Da Silva, V | 1 |
| Murovic, J | 1 |
| Choucair, A | 1 |
| Chamberlain, M | 1 |
| Berger, M | 1 |
| Seager, M | 1 |
| Davis, RL | 1 |
| Broder, LE | 1 |
| Rall, DP | 1 |
| Sehrbundt, HJ | 1 |
| Müller, W | 1 |
| Gentile, SL | 1 |
| Ringkjob, R | 1 |
| Takeuchi, K | 1 |
| Hoshino, T | 1 |
| Foltz, EL | 1 |
| Kirsch, WM | 2 |
| Leitner, JW | 1 |
| Schulz, D | 2 |
| Van Buskirk, J | 1 |
| Sheflin, J | 1 |
| Komatsu, K | 1 |
| Hiratsuka, H | 1 |
| Takahashi, S | 1 |
| Kamisasa, A | 1 |
| Inaba, Y | 1 |
| Van Buskirk, JJ | 1 |
| Young, HE | 1 |
| Heiss, WD | 1 |
| Kroiss, A | 1 |
| Kühböck, J | 1 |
| Profanter, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TS Overexpression in SCLC: Mechanism and Therapeutic Targeting[NCT03741829] | 12 participants (Actual) | Observational | 2017-06-14 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fluorouracil and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?
Topics: Animals; Brain Neoplasms; Cell Movement; Combined Modality Therapy; Cytosine Deaminase; Flucytosine; | 2000 |
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
Chemotherapy of brain tumors.
Topics: Adult; Antineoplastic Agents; Azaguanine; Bleomycin; Brain Neoplasms; Child; Cyclophosphamide; Drug | 1972 |
10 trials available for fluorouracil and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Rationally designed pharmacogenomic treatment using concurrent capecitabine and radiotherapy for glioblastoma; gene expression profiles associated with outcome.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Brain Neoplasms; Capecitabine; Combined Mo | 2010 |
Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents; Biological Availability; Brain Neoplasms; C | 2003 |
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin | 2007 |
A phase II study of 5-fluorouracil plus folinic acid in malignant gliomas in adults.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Female; Fluorouracil; Glioblastoma; Glioma; Humans; Infus | 1995 |
A phase 1-2 trial of superselective carboplatin, low-dose infusional 5-fluorouracil and concurrent radiation for high-grade gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat | 1995 |
Pilot study of 6 weeks of chemoradiotherapy with 5 FU and hydroxyurea in malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Combined | 1993 |
5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemotherapy, Adjuvant; Dr | 1993 |
Local and sustained delivery of 5-fluorouracil from biodegradable microspheres for the radiosensitization of glioblastoma: a pilot study.
Topics: Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Biodegradation, Environmental; Brain Neopl | 1999 |
Response and progression in recurrent malignant glioma.
Topics: Actuarial Analysis; Adolescent; Adult; Aged; Aged, 80 and over; Alitretinoin; Antineoplastic Combine | 1999 |
Phase I/II trial of superselective arterial 5-FU infusion with concomitant external beam radiation for patients with either anaplastic astrocytoma or glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Drug Admini | 1991 |
44 other studies available for fluorouracil and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Rational Design and Optimization of m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Antineoplastic Agents; Glioblastoma; Human | 2022 |
Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling.
Topics: Acid Ceramidase; Cell Line, Tumor; Cell Movement; Ceramides; Fluorouracil; Glioblastoma; Humans; Pro | 2022 |
Dual Functionalized 5-Fluorouracil Liposomes as Highly Efficient Nanomedicine for Glioblastoma Treatment as Assessed in an In Vitro Brain Tumor Model.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Drug Delivery Systems | 2018 |
Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Caco-2 Cells; Cell Line, | 2019 |
Noninvasive monitoring of pharmacodynamics and kinetics of a death receptor 5 antibody and its enhanced apoptosis induction in sequential application with doxorubicin.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting | 2013 |
Patterns of failure after radiosurgery to two different target volumes of enhancing lesions with and without FLAIR abnormalities in recurrent glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carboplatin; Disease-F | 2014 |
Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Caspase | 2014 |
Amelioration of cancer stem cells in macrophage colony stimulating factor-expressing U87MG-human glioblastoma upon 5-fluorouracil therapy.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Cycle; Cell Proliferation; Drug | 2013 |
Double-effective chitosan scaffold-PLGA nanoparticle system for brain tumour therapy: in vitro study.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Chitosan; Drug Carriers; Fluorou | 2014 |
Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma.
Topics: Animals; Brain Neoplasms; Bystander Effect; Cytosine Deaminase; Disease Models, Animal; Drug Evaluat | 2011 |
Combination of 6-thioguanine, capecitabine, and celecoxib with temozolomide or lomustine for recurrent high-grade glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Capecitabine; Celecoxi | 2011 |
Induction of thymidine phosphorylase in both irradiated and shielded, contralateral human U87MG glioma xenografts: implications for a dual modality treatment using capecitabine and irradiation.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Capecitabine; Combined Modality Therapy; Cyt | 2002 |
Synchronous occurrence of glioblastoma multiforme and esophageal adenocarcinoma.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cisplat | 2003 |
REGIONAL INTRA-ARTERIAL INFUSION OF 5-FLUOROURACIL FOR CANCER.
Topics: Adenocarcinoma; Adenocarcinoma, Scirrhous; Carcinoma, Squamous Cell; Female; Fluorouracil; Glioblast | 1964 |
Possible influence of infrasound on glioma cell response to chemotherapy: a pilot study.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Division; Cell Line, Tumor; Combined Modality | 2004 |
Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; Doxorubicin; Flow Cytome | 2004 |
Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cell Lin | 2005 |
Improvement of antitumor activity by gene amplification with a replicating but nondisseminating adenovirus.
Topics: Adenoviridae; Animals; Cell Line, Tumor; Cytosine Deaminase; Flucytosine; Fluorouracil; Gene Amplifi | 2007 |
Mucin impedes cytotoxic effect of 5-FU against growth of human pancreatic cancer cells: overcoming cellular barriers for therapeutic gain.
Topics: Acetylgalactosamine; Antimetabolites, Antineoplastic; Benzyl Compounds; Cell Proliferation; Fluoresc | 2007 |
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Camptothecin; Caspase 7; Catechin; | 2007 |
5-Fluorouracil and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) followed by hydroxyurea, misonidazole, and irradiation for brain stem gliomas: a pilot study of the Brain Tumor Research Center and the Childrens Cancer Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Bra | 1984 |
High dose BCNU with autologous bone marrow rescue in the treatment of recurrent malignant gliomas.
Topics: Adult; Bone Marrow Transplantation; Brain Neoplasms; Carmustine; Combined Modality Therapy; Dose-Res | 1983 |
[5-FU concentration in brain tumors after co-administration of FT and uracil].
Topics: Brain Neoplasms; Drug Therapy, Combination; Fluorouracil; Glioblastoma; Humans; Meningeal Neoplasms; | 1983 |
[Cerebrospinal fluid distributions of systemically administered fluorinated pyrimidines].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Female; Fluorouracil; Glioblastoma; | 1983 |
Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine.
Topics: Chromatography, High Pressure Liquid; Cytosine Deaminase; Flucytosine; Fluorouracil; Genetic Therapy | 1996 |
Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer.
Topics: Base Sequence; Cell Death; Cloning, Molecular; Colorectal Neoplasms; Cytosine Deaminase; Escherichia | 1996 |
[Association of 5-FU, CDDP and hypofractionated radiotherapy in recurrences of subtentorial astrocytomas and malignant gliomas in adults].
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; | 1990 |
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.
Topics: Adenoviridae; Adenovirus E1B Proteins; Antigens, Viral; Capsid; Capsid Proteins; Cells, Cultured; Ch | 1997 |
The development of new brain tumor therapy utilizing the local and sustained delivery of chemotherapeutic agents from biodegradable polymers.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biodegradation, Environmental; Brain Neoplas | 1999 |
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
Topics: Adenoviridae; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cytosine Deaminase; Flucyto | 2002 |
BCNU-5-fluorouracil combination therapy for recurrent malignant brain tumors.
Topics: Astrocytoma; Bone Marrow; Brain Neoplasms; Carmustine; Drug Therapy, Combination; Fluorouracil; Glio | 1978 |
Treatment of recurrent gliomas and metastatic brain tumors with a polydrug protocol designed to combat nitrosourea resistance.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Cycle | 1992 |
[Evaluation of ACNU and 5-FU in the treatment of gliomas].
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biological Products; Brain Neoplasms; C | 1986 |
Pilot study of combination 5-fluorouracil, cisdiamminedichloroplatinum II, and radiation therapy for grade III and IV astrocytomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; | 1987 |
Phase II study of combined carmustine, 5-fluorouracil, hydroxyurea, and 6-mercaptopurine (BFHM) for the treatment of malignant gliomas.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine | 1986 |
[Cytometric studies on tumor cells following 5-fluorouracil treatment].
Topics: Culture Techniques; Fluorouracil; Glioblastoma; HeLa Cells; Humans; Neoplasm Proteins; Neoplasms, Ex | 1967 |
Treatment of intracranial gliomas and metastatic carcinomas by local application of cytostatic agents.
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Carcinoma; Female; Fluorouracil; Glioblastoma; | 1968 |
[Chemotherapy of brain tumors].
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Carotid Arteries; Catheterization; Child; Ependymom | 1968 |
Current trends in the chemotherapy of brain tumors with special reference to glioblastomas.
Topics: Alkaloids; Antibiotics, Antineoplastic; Antineoplastic Agents; Azaguanine; Blood Vessel Prosthesis; | 1969 |
Neurologic surgery.
Topics: Animals; Brain Neoplasms; Cats; Dogs; Fluorouracil; Glioblastoma; Humans; Hypothermia, Induced; Lami | 1970 |
Energy metabolism of the glioblastoma: chemotherapeutic implications.
Topics: Brain; Brain Neoplasms; Drug Synergism; Fluorouracil; Glioblastoma; Glycolysis; Humans; Intracranial | 1969 |
Widespread extracranial metastases of glioblastoma multiforme. Report of case and clinicopathological review of cases in literature.
Topics: Adolescent; Autopsy; Biopsy; Bone Neoplasms; Brain Neoplasms; Carotid Arteries; Cauda Equina; Cerebr | 1972 |
Effects of sodium warfarin and other carcinostatic agents on malignant cells: a study of drug synergy.
Topics: Animals; Carbon Radioisotopes; Carcinoma, Bronchogenic; Carcinoma, Hepatocellular; Carcinoma, Squamo | 1974 |
[Combined cytostatic treatment of malignant brain tumors (author's transl)].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; C | 1974 |