fluorouracil has been researched along with Arthritis, Rheumatoid in 8 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three women with breast carcinoma were treated with combination chemotherapy, including cyclophosphamide, 5-fluorouracil, and methotrexate, after mastectomy." | 1.29 | Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma. ( Kramer, N; Leitner, SP; Michaelson, RA; Rosenstein, ED, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jensen, AO | 1 |
| Mejer, J | 1 |
| Kopp, HG | 1 |
| Moerike, K | 1 |
| Kanz, L | 1 |
| Hartmann, JT | 1 |
| Katz, P | 1 |
| Rosenstein, ED | 1 |
| Kramer, N | 1 |
| Leitner, SP | 1 |
| Michaelson, RA | 1 |
| Bunch, TW | 1 |
| Erlichman, C | 1 |
| Luthra, HS | 1 |
| Matteson, EL | 1 |
| Blackburn, WD | 1 |
| Alarcón, GS | 1 |
| Steinberg, ME | 2 |
| Cohen, LD | 1 |
| Mccrae, CR | 2 |
| Bershelli, RA | 1 |
| Cram, B | 1 |
1 review available for fluorouracil and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Immunosuppressant therapy.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antilymphocyte Serum; Arthritis, Rheumatoid; Azathio | 1984 |
1 trial available for fluorouracil and Arthritis, Rheumatoid
| Article | Year |
|---|---|
An open-label, phase I/II study of 5-fluorouracil plus leucovorin in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunosuppressive Ag | 2002 |
6 other studies available for fluorouracil and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Remission of methotrexate-resistant rheumatoid arthritis after receiving 5-fluorouracil for colon cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antirheumatic Agents; Arthritis, Rheumatoid; Colonic Neoplasm | 2003 |
Leflunomide and peripheral neuropathy: a potential interaction between uracil/tegafur and leflunomide.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Comorbidity; Disease Progression; Drug Administra | 2005 |
Exacerbation of rheumatoid arthritis after termination of chemotherapy for breast carcinoma.
Topics: Adenocarcinoma; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Breast Neoplasms; Cyclophosphamid | 1996 |
Toxic response to topical fluorouracil in two rheumatoid arthritis patients receiving low-dose, weekly methotrexate.
Topics: Aged; Arthritis, Rheumatoid; Drug Eruptions; Drug Synergism; Fluorouracil; Humans; Keratosis; Male; | 1990 |
Intra-articular 5-fluorouracil (5-FU) in antigen-induced arthritis: effect of timing on response.
Topics: Animals; Antigens; Arthritis, Rheumatoid; Disease Models, Animal; Fluorouracil; Freund's Adjuvant; H | 1973 |
Intra-articular 5-fluorouracil in antigen-induced arthritis.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Fluorouracil; Knee Joint; Ovalbumin; Rabbits | 1971 |