fluorouracil has been researched along with Arrhythmias, Cardiac in 23 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of low-dose carvedilol combined with candesartan in the prevention of acute and chronic cardiotoxicity of anthracycline drugs in adjuvant chemotherapy of breast cancer." | 9.17 | [Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer]. ( Han, YL; Liang, XF; Liu, L; Liu, YY; Liu, ZZ; Xie, XD; Zheng, ZD, 2013) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 5.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| "To investigate cardiac toxicity associated with breast radiation therapy (RT) at 10-year follow-up in BCIRG-001, a phase 3 trial comparing adjuvant anthracycline chemotherapy (fluorouracil, doxorubicin, and cyclophosphamide) with anthracycline-taxane chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) in women with lymph node-positive early breast cancer." | 5.24 | Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up. ( Gerber, NK; Perez, CA; Tam, M; Vega, RM; Wu, SP, 2017) |
| "To investigate the effect of low-dose carvedilol combined with candesartan in the prevention of acute and chronic cardiotoxicity of anthracycline drugs in adjuvant chemotherapy of breast cancer." | 5.17 | [Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer]. ( Han, YL; Liang, XF; Liu, L; Liu, YY; Liu, ZZ; Xie, XD; Zheng, ZD, 2013) |
| " Nine patients had symptoms resembling myocardial ischemia, one patient died due to assumed myocardial infarction related closely to fluorouracil treatment, four patients had supraventricular arrhythmia, and one patient had congestive heart failure." | 3.68 | Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. ( Bokemeyer, C; Harstrick, A; Hiddemann, W; Köhne-Wömpner, CH; Mügge, A; Papageorgiou, E; Poliwoda, H; Schöber, C; Stahl, M; Wilke, H, 1993) |
| "The most common cardiotoxic effects of 5-fluorouracil (5-FU) are chest pain and ischemic ECG abnormalities." | 3.68 | Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil. ( Albertsson, M; Eskilsson, J, 1990) |
| "The toxic effects of 5-fluorouracil - an antimitotic drug widely used in the treatment of cancer - mainly affect the digestive tract and the blood." | 2.37 | [Cardiac toxicity of 5-fluorouracil. Review of the literature, 5 new cases]. ( Clavel, M; Grivet, B; Siméone, P, 1988) |
| "5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens." | 1.30 | Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998) |
| "5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems." | 1.29 | Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993) |
| "Pericarditis and cardiac arrhythmias developed, but the patient did not have cardiac tamponade." | 1.28 | Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter. ( Cathcart-Rake, WF; Mowery, WE, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, SP | 1 |
| Tam, M | 1 |
| Vega, RM | 1 |
| Perez, CA | 1 |
| Gerber, NK | 1 |
| Liu, L | 1 |
| Liu, ZZ | 1 |
| Liu, YY | 1 |
| Zheng, ZD | 1 |
| Liang, XF | 1 |
| Han, YL | 1 |
| Xie, XD | 1 |
| Zhang, GQ | 1 |
| Han, F | 1 |
| Sun, W | 1 |
| Pang, ZL | 1 |
| SiKanDaer, AB | 1 |
| Wang, HJ | 1 |
| Dalzell, JR | 1 |
| Samuel, LM | 1 |
| Hrovatin, E | 1 |
| Viel, E | 1 |
| Lestuzzi, C | 1 |
| Tartuferi, L | 1 |
| Zardo, F | 1 |
| Brieda, M | 1 |
| Dametto, E | 1 |
| Piazza, R | 1 |
| Antonini-Canterin, F | 1 |
| Vaccher, E | 1 |
| Meneguzzo, N | 1 |
| Nicolosi, GL | 1 |
| Bottoni, P | 1 |
| Bobba, L | 1 |
| Ranieri, MG | 1 |
| Croce, M | 1 |
| Zaietta, P | 1 |
| Provera, F | 1 |
| Ciubra-Niczewska, E | 1 |
| Keefe, DL | 1 |
| Roistacher, N | 1 |
| Pierri, MK | 1 |
| Schöber, C | 1 |
| Papageorgiou, E | 1 |
| Harstrick, A | 1 |
| Bokemeyer, C | 1 |
| Mügge, A | 1 |
| Stahl, M | 1 |
| Wilke, H | 1 |
| Poliwoda, H | 1 |
| Hiddemann, W | 1 |
| Köhne-Wömpner, CH | 1 |
| Harris, LN | 1 |
| Ragaz, J | 1 |
| Muc, M | 1 |
| Baranowski, M | 1 |
| Braczkowski, R | 1 |
| Zubelewicz, B | 1 |
| Kozowicz, A | 1 |
| Aziz, SA | 1 |
| Tramboo, NA | 1 |
| Mohi-ud-Din, K | 1 |
| Iqbal, K | 1 |
| Jalal, S | 1 |
| Ahmad, M | 1 |
| Belpomme, D | 1 |
| Gauthier, S | 1 |
| Pujade-Lauraine, E | 1 |
| Facchini, T | 1 |
| Goudier, MJ | 1 |
| Krakowski, I | 1 |
| Netter-Pinon, G | 1 |
| Frenay, M | 1 |
| Gousset, C | 1 |
| Marié, FN | 1 |
| Benmiloud, M | 1 |
| Sturtz, F | 1 |
| Ferrari, E | 1 |
| Taillan, B | 1 |
| Tibi, T | 1 |
| Darmon, JP | 1 |
| Gibelin, P | 1 |
| Chichmanian, RM | 1 |
| Dujardin, P | 1 |
| Morand, P | 1 |
| Cathcart-Rake, WF | 1 |
| Mowery, WE | 1 |
| Jeremic, B | 1 |
| Jevremovic, S | 1 |
| Djuric, L | 1 |
| Mijatovic, L | 1 |
| Eskilsson, J | 3 |
| Albertsson, M | 3 |
| May, D | 1 |
| Wandl, U | 1 |
| Becher, R | 1 |
| Niederle, N | 1 |
| Schmidt, CG | 1 |
| Fournier, C | 1 |
| Benahmed, M | 1 |
| Blondeau, M | 1 |
| Clavel, M | 1 |
| Siméone, P | 1 |
| Grivet, B | 1 |
| Weiss, RB | 1 |
| Valagussa, P | 1 |
| Moliterni, A | 1 |
| Zambetti, M | 1 |
| Buzzoni, R | 1 |
| Bonadonna, G | 1 |
| Mercke, C | 1 |
2 reviews available for fluorouracil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
The spectrum of 5-fluorouracil cardiotoxicity.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr | 2009 |
[Cardiac toxicity of 5-fluorouracil. Review of the literature, 5 new cases].
Topics: Arrhythmias, Cardiac; Female; Fluorouracil; Heart Diseases; Humans; Male; Middle Aged; Neoplasms; Ri | 1988 |
5 trials available for fluorouracil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Card | 2017 |
[Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antineoplastic Co | 2013 |
[Impact of different extents of lymph node dissection on the survival in stage III esophageal cancer patients].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Carcinoma, Squamous Cell | 2008 |
Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma.
Topics: Administration, Oral; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2000 |
Adjuvant chemotherapy after conservative surgery plus irradiation versus modified radical mastectomy. Analysis of drug dosing and toxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Breast Neoplasms; Clinical Tri | 1987 |
16 other studies available for fluorouracil and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin.
Topics: Adult; Antimetabolites, Antineoplastic; Arrhythmias, Cardiac; Cisplatin; Electrocardiography; Fluoro | 2006 |
[Asymptomatic electrocardiographic abnormalities during antiblastic chemotherapy].
Topics: Aged; Antineoplastic Agents; Arrhythmias, Cardiac; Breast Neoplasms; Cardiac Complexes, Premature; C | 1983 |
[Cardiotoxicity of drugs used in the treatment of malignant neoplasms].
Topics: Antineoplastic Agents; Arrhythmias, Cardiac; Cyclophosphamide; Doxorubicin; Drug Therapy, Combinatio | 1983 |
Clinical cardiotoxicity of 5-fluorouracil.
Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr | 1993 |
Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Coronary Disease; | 1993 |
Ventricular arrhythmia and adrenal insufficiency after fluorouracil: new side effects of an old drug.
Topics: Adrenal Insufficiency; Adult; Arrhythmias, Cardiac; Breast Neoplasms; Electrocardiography; Female; F | 1993 |
[Cardiotoxic effect of the herec-TNF alpha preparation given intravenously to patients with advanced neoplasms].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Female; Fluoroura | 1996 |
Supraventricular arrhythmia: a complication of 5-fluorouracil therapy.
Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atr | 1998 |
[Cardiac toxicity of fluoro-uracil. Typical and atypical aspects. Apropos of 8 cases].
Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiomyopathies; Coronary Disease; Fluorouracil; Heart Diseases; | 1992 |
Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter.
Topics: Adenocarcinoma; Arrhythmias, Cardiac; Catheterization, Central Venous; Colonic Neoplasms; Female; Fl | 1991 |
Cardiotoxicity during chemotherapy treatment with 5-fluorouracil and cisplatin.
Topics: Arrhythmias, Cardiac; Carcinoma, Squamous Cell; Chest Pain; Cisplatin; Electrocardiography; Esophage | 1990 |
Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil.
Topics: Adult; Aged; Arrhythmias, Cardiac; Chest Pain; Female; Fluorouracil; Heart; Humans; Male; Middle Age | 1990 |
[Cardiac side effects of 5-fluorouracil].
Topics: Aged; Arrhythmias, Cardiac; Colorectal Neoplasms; Electrocardiography; Female; Fluorouracil; Heart; | 1990 |
[Cardiac toxicity of 5-fluorouracil].
Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Fluorouracil; Humans; Laryngeal Neoplasms; Male; Voc | 1989 |
Adverse cardiac effects during induction chemotherapy treatment with cis-platin and 5-fluorouracil.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac | 1988 |
[Severe adverse cardiac effects during treatment with cisplatin and 5-fluorouracil].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Cisplatin; Fluorouracil; Humans | 1988 |