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fluorouracil and Arrhythmias, Cardiac

fluorouracil has been researched along with Arrhythmias, Cardiac in 23 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effect of low-dose carvedilol combined with candesartan in the prevention of acute and chronic cardiotoxicity of anthracycline drugs in adjuvant chemotherapy of breast cancer."9.17[Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer]. ( Han, YL; Liang, XF; Liu, L; Liu, YY; Liu, ZZ; Xie, XD; Zheng, ZD, 2013)
"5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens."5.30Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998)
"To investigate cardiac toxicity associated with breast radiation therapy (RT) at 10-year follow-up in BCIRG-001, a phase 3 trial comparing adjuvant anthracycline chemotherapy (fluorouracil, doxorubicin, and cyclophosphamide) with anthracycline-taxane chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) in women with lymph node-positive early breast cancer."5.24Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up. ( Gerber, NK; Perez, CA; Tam, M; Vega, RM; Wu, SP, 2017)
"To investigate the effect of low-dose carvedilol combined with candesartan in the prevention of acute and chronic cardiotoxicity of anthracycline drugs in adjuvant chemotherapy of breast cancer."5.17[Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer]. ( Han, YL; Liang, XF; Liu, L; Liu, YY; Liu, ZZ; Xie, XD; Zheng, ZD, 2013)
" Nine patients had symptoms resembling myocardial ischemia, one patient died due to assumed myocardial infarction related closely to fluorouracil treatment, four patients had supraventricular arrhythmia, and one patient had congestive heart failure."3.68Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer. ( Bokemeyer, C; Harstrick, A; Hiddemann, W; Köhne-Wömpner, CH; Mügge, A; Papageorgiou, E; Poliwoda, H; Schöber, C; Stahl, M; Wilke, H, 1993)
"The most common cardiotoxic effects of 5-fluorouracil (5-FU) are chest pain and ischemic ECG abnormalities."3.68Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil. ( Albertsson, M; Eskilsson, J, 1990)
"The toxic effects of 5-fluorouracil - an antimitotic drug widely used in the treatment of cancer - mainly affect the digestive tract and the blood."2.37[Cardiac toxicity of 5-fluorouracil. Review of the literature, 5 new cases]. ( Clavel, M; Grivet, B; Siméone, P, 1988)
"5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens."1.30Supraventricular arrhythmia: a complication of 5-fluorouracil therapy. ( Ahmad, M; Aziz, SA; Iqbal, K; Jalal, S; Mohi-ud-Din, K; Tramboo, NA, 1998)
"5-Fluorouracil is widely known to be toxic to the hematopoietic and gastrointestinal systems."1.29Clinical cardiotoxicity of 5-fluorouracil. ( Keefe, DL; Pierri, MK; Roistacher, N, 1993)
"Pericarditis and cardiac arrhythmias developed, but the patient did not have cardiac tamponade."1.28Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter. ( Cathcart-Rake, WF; Mowery, WE, 1991)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19907 (30.43)18.7374
1990's10 (43.48)18.2507
2000's4 (17.39)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wu, SP1
Tam, M1
Vega, RM1
Perez, CA1
Gerber, NK1
Liu, L1
Liu, ZZ1
Liu, YY1
Zheng, ZD1
Liang, XF1
Han, YL1
Xie, XD1
Zhang, GQ1
Han, F1
Sun, W1
Pang, ZL1
SiKanDaer, AB1
Wang, HJ1
Dalzell, JR1
Samuel, LM1
Hrovatin, E1
Viel, E1
Lestuzzi, C1
Tartuferi, L1
Zardo, F1
Brieda, M1
Dametto, E1
Piazza, R1
Antonini-Canterin, F1
Vaccher, E1
Meneguzzo, N1
Nicolosi, GL1
Bottoni, P1
Bobba, L1
Ranieri, MG1
Croce, M1
Zaietta, P1
Provera, F1
Ciubra-Niczewska, E1
Keefe, DL1
Roistacher, N1
Pierri, MK1
Schöber, C1
Papageorgiou, E1
Harstrick, A1
Bokemeyer, C1
Mügge, A1
Stahl, M1
Wilke, H1
Poliwoda, H1
Hiddemann, W1
Köhne-Wömpner, CH1
Harris, LN1
Ragaz, J1
Muc, M1
Baranowski, M1
Braczkowski, R1
Zubelewicz, B1
Kozowicz, A1
Aziz, SA1
Tramboo, NA1
Mohi-ud-Din, K1
Iqbal, K1
Jalal, S1
Ahmad, M1
Belpomme, D1
Gauthier, S1
Pujade-Lauraine, E1
Facchini, T1
Goudier, MJ1
Krakowski, I1
Netter-Pinon, G1
Frenay, M1
Gousset, C1
Marié, FN1
Benmiloud, M1
Sturtz, F1
Ferrari, E1
Taillan, B1
Tibi, T1
Darmon, JP1
Gibelin, P1
Chichmanian, RM1
Dujardin, P1
Morand, P1
Cathcart-Rake, WF1
Mowery, WE1
Jeremic, B1
Jevremovic, S1
Djuric, L1
Mijatovic, L1
Eskilsson, J3
Albertsson, M3
May, D1
Wandl, U1
Becher, R1
Niederle, N1
Schmidt, CG1
Fournier, C1
Benahmed, M1
Blondeau, M1
Clavel, M1
Siméone, P1
Grivet, B1
Weiss, RB1
Valagussa, P1
Moliterni, A1
Zambetti, M1
Buzzoni, R1
Bonadonna, G1
Mercke, C1

Reviews

2 reviews available for fluorouracil and Arrhythmias, Cardiac

ArticleYear
The spectrum of 5-fluorouracil cardiotoxicity.
    Anti-cancer drugs, 2009, Volume: 20, Issue:1

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Arr

2009
[Cardiac toxicity of 5-fluorouracil. Review of the literature, 5 new cases].
    Presse medicale (Paris, France : 1983), 1988, Oct-01, Volume: 17, Issue:33

    Topics: Arrhythmias, Cardiac; Female; Fluorouracil; Heart Diseases; Humans; Male; Middle Aged; Neoplasms; Ri

1988

Trials

5 trials available for fluorouracil and Arrhythmias, Cardiac

ArticleYear
Effect of Breast Irradiation on Cardiac Disease in Women Enrolled in BCIRG-001 at 10-Year Follow-Up.
    International journal of radiation oncology, biology, physics, 2017, 11-01, Volume: 99, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Card

2017
[Preventive effect of low-dose carvedilol combined with candesartan on the cardiotoxicity of anthracycline drugs in the adjuvant chemotherapy of breast cancer].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:12

    Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antineoplastic Co

2013
[Impact of different extents of lymph node dissection on the survival in stage III esophageal cancer patients].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2008, Volume: 30, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Carcinoma, Squamous Cell

2008
Verapamil increases the survival of patients with anthracycline-resistant metastatic breast carcinoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:11

    Topics: Administration, Oral; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc

2000
Adjuvant chemotherapy after conservative surgery plus irradiation versus modified radical mastectomy. Analysis of drug dosing and toxicity.
    The American journal of medicine, 1987, Volume: 83, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Breast Neoplasms; Clinical Tri

1987

Other Studies

16 other studies available for fluorouracil and Arrhythmias, Cardiac

ArticleYear
Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin.
    Journal of cardiovascular medicine (Hagerstown, Md.), 2006, Volume: 7, Issue:8

    Topics: Adult; Antimetabolites, Antineoplastic; Arrhythmias, Cardiac; Cisplatin; Electrocardiography; Fluoro

2006
[Asymptomatic electrocardiographic abnormalities during antiblastic chemotherapy].
    Minerva medica, 1983, Oct-06, Volume: 74, Issue:38

    Topics: Aged; Antineoplastic Agents; Arrhythmias, Cardiac; Breast Neoplasms; Cardiac Complexes, Premature; C

1983
[Cardiotoxicity of drugs used in the treatment of malignant neoplasms].
    Polski tygodnik lekarski (Warsaw, Poland : 1960), 1983, Jan-03, Volume: 38, Issue:1

    Topics: Antineoplastic Agents; Arrhythmias, Cardiac; Cyclophosphamide; Doxorubicin; Drug Therapy, Combinatio

1983
Clinical cardiotoxicity of 5-fluorouracil.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:11

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Electrocardiography; Female; Fluorouracil; Heart Arr

1993
Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer.
    Cancer, 1993, Oct-01, Volume: 72, Issue:7

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Coronary Disease;

1993
Ventricular arrhythmia and adrenal insufficiency after fluorouracil: new side effects of an old drug.
    Journal of the National Cancer Institute, 1993, Feb-17, Volume: 85, Issue:4

    Topics: Adrenal Insufficiency; Adult; Arrhythmias, Cardiac; Breast Neoplasms; Electrocardiography; Female; F

1993
[Cardiotoxic effect of the herec-TNF alpha preparation given intravenously to patients with advanced neoplasms].
    Przeglad lekarski, 1996, Volume: 53, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac; Female; Fluoroura

1996
Supraventricular arrhythmia: a complication of 5-fluorouracil therapy.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1998, Volume: 10, Issue:6

    Topics: Adenocarcinoma; Adult; Antimetabolites, Antineoplastic; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atr

1998
[Cardiac toxicity of fluoro-uracil. Typical and atypical aspects. Apropos of 8 cases].
    Annales de cardiologie et d'angeiologie, 1992, Volume: 41, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Cardiomyopathies; Coronary Disease; Fluorouracil; Heart Diseases;

1992
Intrapericardial infusion of 5-fluorouracil. An unusual complication of a Hickman catheter.
    Cancer, 1991, Feb-01, Volume: 67, Issue:3

    Topics: Adenocarcinoma; Arrhythmias, Cardiac; Catheterization, Central Venous; Colonic Neoplasms; Female; Fl

1991
Cardiotoxicity during chemotherapy treatment with 5-fluorouracil and cisplatin.
    Journal of chemotherapy (Florence, Italy), 1990, Volume: 2, Issue:4

    Topics: Arrhythmias, Cardiac; Carcinoma, Squamous Cell; Chest Pain; Cisplatin; Electrocardiography; Esophage

1990
Failure of preventing 5-fluorouracil cardiotoxicity by prophylactic treatment with verapamil.
    Acta oncologica (Stockholm, Sweden), 1990, Volume: 29, Issue:8

    Topics: Adult; Aged; Arrhythmias, Cardiac; Chest Pain; Female; Fluorouracil; Heart; Humans; Male; Middle Age

1990
[Cardiac side effects of 5-fluorouracil].
    Deutsche medizinische Wochenschrift (1946), 1990, Apr-20, Volume: 115, Issue:16

    Topics: Aged; Arrhythmias, Cardiac; Colorectal Neoplasms; Electrocardiography; Female; Fluorouracil; Heart;

1990
[Cardiac toxicity of 5-fluorouracil].
    Annales de cardiologie et d'angeiologie, 1989, Volume: 38, Issue:2

    Topics: Aged; Arrhythmias, Cardiac; Coronary Vasospasm; Fluorouracil; Humans; Laryngeal Neoplasms; Male; Voc

1989
Adverse cardiac effects during induction chemotherapy treatment with cis-platin and 5-fluorouracil.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1988, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Arrhythmias, Cardiac

1988
[Severe adverse cardiac effects during treatment with cisplatin and 5-fluorouracil].
    Lakartidningen, 1988, Aug-31, Volume: 85, Issue:35

    Topics: Angina Pectoris; Arrhythmias, Cardiac; Cisplatin; Fluorouracil; Humans

1988