fluorouracil has been researched along with Apoplexy in 11 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan." | 9.41 | Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023) |
| " CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan." | 5.41 | Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023) |
| "5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors." | 1.62 | Case report on 5-fluorouracil induced cerebrovascular accident. ( Ashok, AM; Babu, CM; Karthikeyan, K; Madhu, CS; Shaji, S, 2021) |
| "Fluorouracil (5-FU) is a commonly used chemotherapeutic agent in many cancers." | 1.62 | 5-Fluorouracil associated neurovascular toxicities. ( Dumas, B; Horta, L; Ozer, M; Sadrzadeh, H, 2021) |
| "Patients with cerebrovascular accidents were excluded." | 1.35 | Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. ( Baehring, JM; Fulbright, RK, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Yuwono, KA | 1 |
| Hutajulu, SH | 1 |
| Gofir, A | 1 |
| Nugroho, DB | 1 |
| Karthikeyan, K | 1 |
| Babu, CM | 1 |
| Shaji, S | 1 |
| Ashok, AM | 1 |
| Madhu, CS | 1 |
| Ozer, M | 1 |
| Dumas, B | 1 |
| Horta, L | 1 |
| Sadrzadeh, H | 1 |
| Nguyen, MT | 1 |
| Stoianovici, R | 1 |
| Brunetti, L | 1 |
| Kinno, R | 1 |
| Kii, Y | 1 |
| Uchiyama, M | 1 |
| Owan, Y | 1 |
| Yamazaki, T | 1 |
| Fukui, T | 1 |
| Fleming, GF | 1 |
| Li, Y | 2 |
| Mao, WW | 2 |
| Zhang, CG | 1 |
| Wan, L | 1 |
| Jing, CH | 1 |
| Hua, XM | 2 |
| Li, ST | 1 |
| Cheng, J | 2 |
| Chen, CH | 1 |
| Yin, Y | 1 |
| Redana, S | 1 |
| Sharp, A | 1 |
| Lote, H | 1 |
| Mohammed, K | 1 |
| Papadimitraki, E | 1 |
| Capelan, M | 1 |
| Ring, A | 1 |
| Baehring, JM | 1 |
| Fulbright, RK | 1 |
| Schaefer, U | 1 |
| Micke, O | 1 |
| Schueller, P | 1 |
| Willich, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma[NCT03694262] | Phase 2 | 30 participants (Actual) | Interventional | 2019-07-19 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fluorouracil and Apoplexy
| Article | Year |
|---|---|
Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebral Infarction; Colorectal Neoplasms; Fluoroura | 2023 |
Second-Line Therapy for Endometrial Cancer: The Need for Better Options.
Topics: Adenocarcinoma; Amines; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials | 2015 |
9 other studies available for fluorouracil and Apoplexy
| Article | Year |
|---|---|
Case report on 5-fluorouracil induced cerebrovascular accident.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal N | 2021 |
5-Fluorouracil associated neurovascular toxicities.
Topics: Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Nervous Sys | 2021 |
Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Brain Dise | 2017 |
5-fluorouracil-induced leukoencephalopathy with acute stroke-like presentation fulfilling criteria for recombinant tissue plasminogen activator therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Fibrinolytic Agents; Fluorouracil; Humans; Infusions | 2014 |
Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Brain Ischemia; Cell Survival; Disea | 2016 |
Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
Topics: Analysis of Variance; Animals; Antigens, CD; Brain Ischemia; Chemokine CXCL12; Cytokines; Disease Mo | 2016 |
Rates of major complications during neoadjuvant and adjuvant chemotherapy for early breast cancer: An off study population.
Topics: Acute Coronary Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas | 2016 |
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytid | 2008 |
Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy-results of a prospective study.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P | 2000 |