Page last updated: 2024-10-27

fluorouracil and Apoplexy

fluorouracil has been researched along with Apoplexy in 11 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan."9.41Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023)
" CASE REPORT We report the case of a patient who was diagnosed with stage IV colorectal cancer and who underwent chemotherapy with a high dose of 5-FU as part of the FOLFIRI (Folinic Acid, Fluorouracil, Irinotecan) treatment plan."5.41Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review. ( Gofir, A; Hutajulu, SH; Nugroho, DB; Yuwono, KA, 2023)
"5-Fluorouracil is an antineoplastic agent generally used to treat various types of solid tumors."1.62Case report on 5-fluorouracil induced cerebrovascular accident. ( Ashok, AM; Babu, CM; Karthikeyan, K; Madhu, CS; Shaji, S, 2021)
"Fluorouracil (5-FU) is a commonly used chemotherapeutic agent in many cancers."1.625-Fluorouracil associated neurovascular toxicities. ( Dumas, B; Horta, L; Ozer, M; Sadrzadeh, H, 2021)
"Patients with cerebrovascular accidents were excluded."1.35Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients. ( Baehring, JM; Fulbright, RK, 2008)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's6 (54.55)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Yuwono, KA1
Hutajulu, SH1
Gofir, A1
Nugroho, DB1
Karthikeyan, K1
Babu, CM1
Shaji, S1
Ashok, AM1
Madhu, CS1
Ozer, M1
Dumas, B1
Horta, L1
Sadrzadeh, H1
Nguyen, MT1
Stoianovici, R1
Brunetti, L1
Kinno, R1
Kii, Y1
Uchiyama, M1
Owan, Y1
Yamazaki, T1
Fukui, T1
Fleming, GF1
Li, Y2
Mao, WW2
Zhang, CG1
Wan, L1
Jing, CH1
Hua, XM2
Li, ST1
Cheng, J2
Chen, CH1
Yin, Y1
Redana, S1
Sharp, A1
Lote, H1
Mohammed, K1
Papadimitraki, E1
Capelan, M1
Ring, A1
Baehring, JM1
Fulbright, RK1
Schaefer, U1
Micke, O1
Schueller, P1
Willich, N1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open Label, Non-Randomized Multisite Phase II Trial Combining Bevacizumab, Atezolizumab and Rucaparib for the Treatment of Previously Treated Recurrent and Progressive Endometrial Carcinoma[NCT03694262]Phase 230 participants (Actual)Interventional2019-07-19Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fluorouracil and Apoplexy

ArticleYear
Recurrent Reversible Stroke-Like Encephalopathy After 5-Fluorouracil (5-FU) Chemotherapy: A Case Report and Literature Review.
    The American journal of case reports, 2023, Apr-04, Volume: 24

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cerebral Infarction; Colorectal Neoplasms; Fluoroura

2023
Second-Line Therapy for Endometrial Cancer: The Need for Better Options.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015, Nov-01, Volume: 33, Issue:31

    Topics: Adenocarcinoma; Amines; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Clinical Trials

2015

Other Studies

9 other studies available for fluorouracil and Apoplexy

ArticleYear
Case report on 5-fluorouracil induced cerebrovascular accident.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:4

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colorectal N

2021
5-Fluorouracil associated neurovascular toxicities.
    Current problems in cancer, 2021, Volume: 45, Issue:6

    Topics: Adult; Antimetabolites, Antineoplastic; Female; Fluorouracil; Humans; Male; Middle Aged; Nervous Sys

2021
Chemotherapy induced stroke mimic: 5-Fluorouracil encephalopathy fulfilling criteria for tissue plasminogen activator therapy.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aphasia; Brain Dise

2017
5-fluorouracil-induced leukoencephalopathy with acute stroke-like presentation fulfilling criteria for recombinant tissue plasminogen activator therapy.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Fibrinolytic Agents; Fluorouracil; Humans; Infusions

2014
Neuroprotective effects of intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats on ischemic stroke.
    Behavioural brain research, 2016, Mar-15, Volume: 301

    Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Brain; Brain Ischemia; Cell Survival; Disea

2016
Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
    Neurological research, 2016, Volume: 38, Issue:10

    Topics: Analysis of Variance; Animals; Antigens, CD; Brain Ischemia; Chemokine CXCL12; Cytokines; Disease Mo

2016
Rates of major complications during neoadjuvant and adjuvant chemotherapy for early breast cancer: An off study population.
    Breast (Edinburgh, Scotland), 2016, Volume: 30

    Topics: Acute Coronary Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplas

2016
Delayed leukoencephalopathy with stroke-like presentation in chemotherapy recipients.
    Journal of neurology, neurosurgery, and psychiatry, 2008, Volume: 79, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Brain; Brain Edema; Capecitabine; Dementia, Vascular; Deoxycytid

2008
Recurrent head and neck cancer: retreatment of previously irradiated areas with combined chemotherapy and radiation therapy-results of a prospective study.
    Radiology, 2000, Volume: 216, Issue:2

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy P

2000