fluorouracil has been researched along with Anticipation, Genetic in 1 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Anticipation, Genetic: The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres." | 1.33 | Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. ( Armanios, M; Feldser, DM; Greider, CW; Hao, LY; Huso, D; Karim, B; Strong, MA, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hao, LY | 1 |
| Armanios, M | 1 |
| Strong, MA | 1 |
| Karim, B | 1 |
| Feldser, DM | 1 |
| Huso, D | 1 |
| Greider, CW | 1 |
1 other study available for fluorouracil and Anticipation, Genetic
| Article | Year |
|---|---|
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity.
Topics: Animals; Anticipation, Genetic; Blood Cell Count; Bone Marrow Transplantation; Crosses, Genetic; Dys | 2005 |