Page last updated: 2024-10-27

fluorouracil and Anoxemia

fluorouracil has been researched along with Anoxemia in 25 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment."7.91Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019)
"Radiosensitization by vorinostat under hypoxia was studied in four colorectal carcinoma cell lines and in one colorectal carcinoma xenograft model by analysis of clonogenic survival and tumor growth delay, respectively."7.78Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma. ( Flatmark, K; Fleten, KG; Furre, T; Hektoen, HH; Kristian, A; Ree, AH; Saelen, MG, 2012)
"The antitumor effect and bone marrow toxicity of 5-fluorouracil (5FU) in combination with the hypoxia-selective cytotoxins NLCQ-1 or tirapazamine (TPZ) were investigated in vivo."7.71Therapeutic advantage from combining 5-fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo; comparison with tirapazamine. ( Bloomer, WD; Ji, M; Ji, X; Papadopoulou, MV, 2002)
" We undertook a retrospective study comparing the incidences of hand-foot syndrome in 67 patients with metastatic colorectal cancer who took capecitabine (Xeloda) with or without celecoxib."7.71Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. ( Ayers, GD; Lin, E; Morris, JS, 2002)
"Plasma erythropoietin levels during continuous exposure to hypobaric hypoxia in mice with marrow aplasia induced by whole body X-irradiation of 5-fluorouracil injection were higher than in control mice similarly exposed."7.66Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection. ( Barceló, AC; Bozzini, CE, 1982)
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug."5.91Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023)
"Avascular-differentiated regions in squamous cell carcinoma offer sanctuary to some hypoxic but viable tumor cells (carbonic anhydrase IX and Ki67 positive) that escape therapy because of limited drug delivery."5.32Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy. ( Azrak, R; Bhattacharya, A; Cao, S; Durrani, FA; Mazurchuk, R; Pendyala, L; Rustum, YM; Slocum, HK; Spernyak, JA; Tóth, K, 2004)
" This study aims to investigate the role of the hypoxia-induced miR-675-5p in 5-Fluorouracil (5-FU) resistance on colorectal cancer (CRC) cells."4.12Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells. ( Alessandro, R; Barreca, MM; Conigliaro, A; Cordaro, A; Corrado, C; Zichittella, C, 2022)
" In this context, tumor-associated macrophages (TAM) have been related to chemoresistance to 5-fluorouracil (5-FU), the first-line chemotherapeutic agent used in treating colorectal cancers."4.02Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer. ( Decaens, T; Gharzeddine, K; Laverriere, MH; Malier, M; Marsili, S; Millet, A; Roth, G; Thomas, F, 2021)
"5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment."3.91Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. ( Kim, CW; Kim, HG; Lee, DH; Lee, JS; Oh, ET; Park, HJ, 2019)
"Radiosensitization by vorinostat under hypoxia was studied in four colorectal carcinoma cell lines and in one colorectal carcinoma xenograft model by analysis of clonogenic survival and tumor growth delay, respectively."3.78Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma. ( Flatmark, K; Fleten, KG; Furre, T; Hektoen, HH; Kristian, A; Ree, AH; Saelen, MG, 2012)
"The antitumor effect and bone marrow toxicity of 5-fluorouracil (5FU) in combination with the hypoxia-selective cytotoxins NLCQ-1 or tirapazamine (TPZ) were investigated in vivo."3.71Therapeutic advantage from combining 5-fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo; comparison with tirapazamine. ( Bloomer, WD; Ji, M; Ji, X; Papadopoulou, MV, 2002)
" We undertook a retrospective study comparing the incidences of hand-foot syndrome in 67 patients with metastatic colorectal cancer who took capecitabine (Xeloda) with or without celecoxib."3.71Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. ( Ayers, GD; Lin, E; Morris, JS, 2002)
"Plasma erythropoietin levels during continuous exposure to hypobaric hypoxia in mice with marrow aplasia induced by whole body X-irradiation of 5-fluorouracil injection were higher than in control mice similarly exposed."3.66Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection. ( Barceló, AC; Bozzini, CE, 1982)
"Chloroquine (CQ) is an effective and safe antimalarial drug that is also used as a disease-modifying antirheumatic drug."1.91Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia. ( Ju, S; Jung, Y; Kang, C; Kim, J, 2023)
"However, chemically induced anoxia induced Ser(392)-site phosphorylation as well as stabilization of both p53 and HIF-1 proteins."1.32Hypoxia attenuates the p53 response to cellular damage. ( Achison, M; Hupp, TR, 2003)
"Avascular-differentiated regions in squamous cell carcinoma offer sanctuary to some hypoxic but viable tumor cells (carbonic anhydrase IX and Ki67 positive) that escape therapy because of limited drug delivery."1.32Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy. ( Azrak, R; Bhattacharya, A; Cao, S; Durrani, FA; Mazurchuk, R; Pendyala, L; Rustum, YM; Slocum, HK; Spernyak, JA; Tóth, K, 2004)
"longum accumulated in hypoxic solid tumors."1.31Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors. ( Amano, J; Fujimori, M; Kano, Y; Nakamura, T; Sasaki, T; Taniguchi, S; Yazawa, K, 2002)
"Hypoxia in tumors is associated with malignant progression, metastatic spread, and increased resistance to radiotherapy and chemotherapy."1.31Nitric oxide-mediated regulation of chemosensitivity in cancer cells. ( Adams, MA; Gofton, TE; Graham, CH; Matthews, NE; Maxwell, LR, 2001)
"A case of metastatic carcinoid syndrome with hypoxaemia is described."1.29Intrapulmonary shunting causing hypoxaemia in a case of carcinoid syndrome. ( Bloom, SR; Greaves, JD; Hammond, PJ; Hughes, JM; Hussain, A; Wallis, SC; Young, ET, 1994)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19904 (16.00)18.7374
1990's4 (16.00)18.2507
2000's8 (32.00)29.6817
2010's6 (24.00)24.3611
2020's3 (12.00)2.80

Authors

AuthorsStudies
Malier, M1
Gharzeddine, K1
Laverriere, MH1
Marsili, S1
Thomas, F1
Decaens, T1
Roth, G1
Millet, A1
Zichittella, C1
Barreca, MM1
Cordaro, A1
Corrado, C1
Alessandro, R1
Conigliaro, A1
Kang, C2
Ju, S2
Kim, J2
Jung, Y2
Kim, HG1
Kim, CW1
Lee, DH1
Lee, JS1
Oh, ET1
Park, HJ1
Li, JQ1
Wu, X1
Gan, L1
Yang, XL1
Miao, ZH1
Foucher, ED1
Ghigo, C1
Chouaib, S1
Galon, J1
Iovanna, J1
Olive, D1
Limani, P1
Linecker, M1
Kachaylo, E1
Tschuor, C1
Kron, P1
Schlegel, A1
Ungethuem, U1
Jang, JH1
Georgiopoulou, S1
Nicolau, C1
Lehn, JM1
Graf, R1
Humar, B1
Clavien, PA1
Shah, SM1
Drage, MG1
Lichtman, AH1
Haddad, RI1
Saelen, MG1
Ree, AH1
Kristian, A1
Fleten, KG1
Furre, T1
Hektoen, HH1
Flatmark, K1
Papadopoulou, MV1
Ji, M1
Ji, X1
Bloomer, WD1
Nakamura, T1
Sasaki, T1
Fujimori, M1
Yazawa, K1
Kano, Y1
Amano, J1
Taniguchi, S1
Lin, E1
Morris, JS1
Ayers, GD1
Achison, M1
Hupp, TR1
Bhattacharya, A1
Tóth, K1
Mazurchuk, R1
Spernyak, JA1
Slocum, HK1
Pendyala, L1
Azrak, R1
Cao, S1
Durrani, FA1
Rustum, YM1
Kinuya, S1
Yokoyama, K1
Fukuoka, M1
Mori, H1
Shiba, K1
Watanabe, N1
Shuke, N1
Michigishi, T1
Tonami, N1
Lee, CH1
Wu, CL1
Shiau, AL1
Barceló, AC1
Bozzini, CE1
Hussain, A1
Young, ET1
Greaves, JD1
Hammond, PJ1
Hughes, JM1
Wallis, SC1
Bloom, SR1
Ben-Ari, GY1
McSheehy, PM1
Robinson, SP1
Ojugo, AS1
Aboagye, EO1
Cannell, MB1
Leach, MO1
Judson, IR1
Griffiths, JR1
Ehrnrooth, E1
von der Maase, H1
Sørensen, BS1
Poulsen, JH1
Horsman, MR1
Matthews, NE1
Adams, MA1
Maxwell, LR1
Gofton, TE1
Graham, CH1
Kaplan, HS1
Kelly, JP1
Hannam, TW1
Giles, GR1
Bengmark, S1
Puntis, M1
Jeppsson, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine: A Randomized Controlled Trial.[NCT05641246]Phase 266 participants (Anticipated)Interventional2022-12-08Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fluorouracil and Anoxemia

ArticleYear
Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Albumins; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Pancreatic Ductal; Cell Cycle C

2018
1977 Henry H. Janeway lecture: fundamental mechanisms in combined modality therapy of cancer.
    AJR. American journal of roentgenology, 1977, Volume: 129, Issue:3

    Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Dactinomycin; DNA Repair; DNA, Neoplasm; Electron

1977

Other Studies

23 other studies available for fluorouracil and Anoxemia

ArticleYear
Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer.
    Cancer research, 2021, 12-01, Volume: 81, Issue:23

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Colorect

2021
Mir-675-5p supports hypoxia-induced drug resistance in colorectal cancer cells.
    BMC cancer, 2022, May-20, Volume: 22, Issue:1

    Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Fluorouraci

2022
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Carcinoma; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Colo

2023
Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer.
    International journal of molecular sciences, 2019, Sep-05, Volume: 20, Issue:18

    Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm;

2019
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells.
    Acta pharmacologica Sinica, 2017, Volume: 38, Issue:12

    Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; DNA Breaks, Double-Stranded; Dose-Response Re

2017
Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-01, Volume: 22, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Colonic Neoplasms; Disease Model

2016
Metastatic human papillomavirus-positive nasopharyngeal carcinoma with an unusual pattern of aggressive hematogenous spread.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Nov-10, Volume: 30, Issue:32

    Topics: Alphapapillomavirus; Antineoplastic Combined Chemotherapy Protocols; Axilla; Biomarkers, Tumor; Carb

2012
Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma.
    Radiation oncology (London, England), 2012, Sep-27, Volume: 7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycy

2012
Therapeutic advantage from combining 5-fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo; comparison with tirapazamine.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Drug Synergism; Female; Fluoro

2002
Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:11

    Topics: Antimetabolites, Antineoplastic; Bifidobacterium; Blotting, Western; Cloning, Molecular; Cytosine De

2002
Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity.
    Oncology (Williston Park, N.Y.), 2002, Volume: 16, Issue:12 Suppl N

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Capecitabine; Celecoxib; Colorectal Neoplasms;

2002
Hypoxia attenuates the p53 response to cellular damage.
    Oncogene, 2003, May-29, Volume: 22, Issue:22

    Topics: Apoptosis; Cell Survival; Down-Regulation; Fluorouracil; Humans; Hypoxia; Phosphorylation; Tumor Cel

2003
Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Dec-01, Volume: 10, Issue:23

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Camptothecin; Carcinoma,

2004
Anti-angiogenic therapy and chemotherapy affect 99mTc sestamibi and 99mTc-HL91 accumulation differently in tumour xenografts.
    Nuclear medicine communications, 2005, Volume: 26, Issue:12

    Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Estradiol; Fluorouracil; Hum

2005
Hypoxia-induced cytosine deaminase gene expression for cancer therapy.
    Human gene therapy, 2007, Volume: 18, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Lewis Lung; Cell Line, Tumor; Cytosine Deaminas

2007
Erythropoietin formation during hypoxia in mice with impaired responsiveness to erythropoietin induced by irradiation or 5-fluorouracil injection.
    Experientia, 1982, Apr-15, Volume: 38, Issue:4

    Topics: Animals; Erythrocytes; Erythropoiesis; Erythropoietin; Female; Fluorouracil; Hypoxia; Iron; Mice

1982
Intrapulmonary shunting causing hypoxaemia in a case of carcinoid syndrome.
    Clinical endocrinology, 1994, Volume: 41, Issue:4

    Topics: Adult; Carcinoid Tumor; Drug Therapy, Combination; Fluorouracil; Humans; Hypoxia; Liver Neoplasms; L

1994
Treatment of abdominal malignancies using total abdominal stop-flow infusion and hypoxic perfusion.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:12

    Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy,

1997
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
    Cancer research, 1998, Mar-15, Volume: 58, Issue:6

    Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentratio

1998
The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo.
    International journal of radiation biology, 1999, Volume: 75, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Base Sequence; DNA Primers; Drug Resistance; Female; Fluor

1999
Nitric oxide-mediated regulation of chemosensitivity in cancer cells.
    Journal of the National Cancer Institute, 2001, Dec-19, Volume: 93, Issue:24

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell

2001
The cytocidal action of metronidazole in combination with other antineoplastic agents.
    Cancer treatment reviews, 1979, Volume: 6 Suppl

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; D

1979
Hepatic dearterialization in cancer: new perspectives.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1986, Volume: 18, Issue:3-4

    Topics: Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Combined Modality Therapy; Fluorour

1986