Page last updated: 2024-10-27

fluorouracil and Animal Mammary Carcinoma

fluorouracil has been researched along with Animal Mammary Carcinoma in 21 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Adjuvant chemotherapy is used for human breast cancer patients, even after curative surgery of primary tumor, to prevent tumor recurrence primarily as a form of metastasis."5.48Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung. ( Baba, T; Matsugo, S; Mukaida, N; Muranaka, H; Sasaki, S; Takahashi, C; Tanabe, Y, 2018)
"Most breast cancers originate in the epithelial cells lining the breast ducts."2.76Preclinical and clinical evaluation of intraductally administered agents in early breast cancer. ( Brown, RJ; Gabrielson, E; Huso, DL; Jacobs, LK; Jeter, S; Khouri, NF; Kominsky, SL; Lange, JR; Mori, T; Powers, P; Rudek, MA; Stearns, V; Sukumar, S; Tarpinian, K; Tsangaris, TN; Yoshida, T; Zhang, Z, 2011)
"Adjuvant chemotherapy is used for human breast cancer patients, even after curative surgery of primary tumor, to prevent tumor recurrence primarily as a form of metastasis."1.48Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung. ( Baba, T; Matsugo, S; Mukaida, N; Muranaka, H; Sasaki, S; Takahashi, C; Tanabe, Y, 2018)
"CRF has been detected in breast cancer tissues; however, the biological effects reported in the literature are sparse and variable."1.40Corticotropin-releasing factor reduces tumor volume, halts further growth, and enhances the effect of chemotherapy in 4T1 mammary carcinoma in mice. ( Reed, RK; Stuhr, LE; Wei, ET, 2014)
" In this study, we investigated the efficiency of transgene delivery and the cytotoxic effects of alphaviral vector in combination with 5-fluorouracil (5-FU) in a mouse mammary tumor model (4 T1)."1.40High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model. ( Kozlovska, T; Plotniece, A; Skrastina, D; Spaks, A; Vasilevska, J; Zajakina, A; Zhulenkovs, D, 2014)
"Capecitabine is a novel fluoropyrimidine carbamate, which has a broader spectrum of antitumor activity than other fluoropyrimidines, such as 5-FU, DFUR, or UFT; it has proved effective over a wide dose range."1.35Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice. ( Kang, X; Wang, J; Yang, B; Yang, F; Zhang, Q, 2008)
"DISC-hGMCSF was able to infect all breast carcinoma cell lines and the majority of primary breast carcinoma cultures with high efficiency, although culture-to-culture variability in infectability was noted in the latter."1.32Preclinical evaluation of DISC-GMCSF for the treatment of breast carcinoma. ( Curry, J; Hoogstraten, C; Leigh Shaw, M; Loudon, PT; Martin, G; McLean, CS; Osanto, S; Verdegaal, E, 2003)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's3 (14.29)18.2507
2000's5 (23.81)29.6817
2010's6 (28.57)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Abu-Serie, MM1
Abdelfattah, EZA1
Farboudi, A1
Nouri, A1
Shirinzad, S1
Sojoudi, P1
Davaran, S1
Akrami, M1
Irani, M1
Baboli, M1
Winters, KV1
Freed, M1
Zhang, J1
Kim, SG1
Zhou, B1
Zhang, D1
Pei, SM1
Zhang, H1
Du, HC1
Jin, YP1
Lin, DG1
Sasaki, S1
Baba, T1
Muranaka, H1
Tanabe, Y1
Takahashi, C1
Matsugo, S1
Mukaida, N1
Stuhr, LE1
Wei, ET1
Reed, RK1
Zajakina, A1
Vasilevska, J1
Zhulenkovs, D1
Skrastina, D1
Spaks, A1
Plotniece, A1
Kozlovska, T1
Schem, C1
Tower, RJ1
Kneissl, P1
Rambow, AC1
Campbell, GM1
Desel, C1
Damm, T1
Heilmann, T1
Fuchs, S1
Zuhayra, M1
Trauzold, A1
Glüer, CC1
Schott, S1
Tiwari, S1
Zhang, Q1
Kang, X1
Yang, B1
Wang, J1
Yang, F1
Stearns, V1
Mori, T1
Jacobs, LK1
Khouri, NF1
Gabrielson, E1
Yoshida, T1
Kominsky, SL1
Huso, DL1
Jeter, S1
Powers, P1
Tarpinian, K1
Brown, RJ1
Lange, JR1
Rudek, MA1
Zhang, Z1
Tsangaris, TN1
Sukumar, S1
Loudon, PT1
McLean, CS1
Martin, G1
Curry, J1
Leigh Shaw, M1
Hoogstraten, C1
Verdegaal, E1
Osanto, S1
CRANSTON, EM1
STROUD, AN1
MCDONALD, GO1
SVOBODA, BR1
BRUES, AM1
MCALISTER, WH1
DIPAOLO, JA1
Kossoy, G1
Ben-Hur, H1
Avinoach, I1
Alhayany, A1
Shneider, DF1
Zusman, I1
Sasaki, T1
Fujimori, M1
Hamaji, Y1
Hama, Y1
Ito, K1
Amano, J1
Taniguchi, S1
Stolfi, RL2
Colofiore, JR1
Nord, LD1
Martin, DS3
Koutcher, JA1
Alfieri, AA1
Thaler, H1
Matei, C1
Karayannopoulou, M1
Kaldrymidou, E1
Constantinidis, TC1
Dessiris, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled, Parallel-group Clinical Study to Evaluate the Efficacy and Safety of Ginsenoside Rg3 Capsule in Prevention of Postoperative Recurrence of Hepatocellular Carcinoma[NCT01717066]480 participants (Actual)Interventional2012-04-30Completed
A Phase I Study Assessing the Feasibility and Safety of Intraductal Administration of Pegylated Liposomal Doxorubicin (Doxil) in Women With Breast Cancer[NCT00290732]Phase 120 participants (Actual)Interventional2005-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Maximum Tolerated Dose (MTD)

Maximum tolerated dose (MTD) of administering pegylated liposomal doxorubicin (PLD) into one duct of women with breast cancer awaiting mastectomy. MTD reflects highest dose of drug that did not cause Dose Limiting Toxicity (DLT) in more than 30% of patients. (NCT00290732)
Timeframe: Until up to 30 days after PLD administration

Interventionmilligrams (Number)
Intraductal Arm10

Concentrations of Doxorubicin in Blood (Plasma) at Definitive Surgery

Due to the limited number of samples and detectable levels, the maximum concentration of doxorubicin in blood (plasma) across all the participants in each group is reported. (NCT00290732)
Timeframe: Baseline, 4 hrs, day2/24 hrs, day 8, day of surgery/biopsy

,,,,
InterventionnM (Number)
Doxorubicin, maxDoxorubicinol, max
Intraductal Arm- 0 mg PLD00
Intraductal Arm- 10 mg PLD902.036.9
Intraductal Arm- 2 mg PLD28.50
Intraductal Arm- 5 mg PLD18.30
Intravenous Arm793008090

Concentrations of Doxorubicin in Tissue at Definitive Surgery

Due to the limited number of samples and detectable levels, the maximum concentration of doxorubicin in tissue across all the participants in each group is reported. (NCT00290732)
Timeframe: Day of surgery/biopsy

,,,,
Interventionnmol/g (Number)
Doxorubicin, maxDoxorubicinol, max
Intraductal Arm- 0 mg PLD00
Intraductal Arm- 10 mg PLD10.825.26
Intraductal Arm- 2 mg PLD00
Intraductal Arm- 5 mg PLD1.730.09
Intravenous Arm0.210

Trials

1 trial available for fluorouracil and Animal Mammary Carcinoma

ArticleYear
Preclinical and clinical evaluation of intraductally administered agents in early breast cancer.
    Science translational medicine, 2011, Oct-26, Volume: 3, Issue:106

    Topics: Adult; Animals; Antineoplastic Agents; Breast Neoplasms; Carboplatin; Doxorubicin; Drug Administrati

2011

Other Studies

20 other studies available for fluorouracil and Animal Mammary Carcinoma

ArticleYear
A comparative study of smart nanoformulations of diethyldithiocarbamate with Cu
    Scientific reports, 2023, 03-02, Volume: 13, Issue:1

    Topics: Aldehyde Dehydrogenase; Animals; Ditiocarb; Female; Fetal Hypoxia; Fluorouracil; Humans; Liver Neopl

2023
Synthesis of magnetic gold coated poly (ε-caprolactonediol) based polyurethane/poly(N-isopropylacrylamide)-grafted-chitosan core-shell nanofibers for controlled release of paclitaxel and 5-FU.
    International journal of biological macromolecules, 2020, May-01, Volume: 150

    Topics: Acrylic Resins; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chitosan;

2020
Evaluation of metronomic chemotherapy response using diffusion and dynamic contrast-enhanced MRI.
    PloS one, 2020, Volume: 15, Issue:11

    Topics: Administration, Metronomic; Animals; Antimetabolites, Antineoplastic; Case-Control Studies; Contrast

2020
Establishment of 5-Fluorouracil-resistant canine mammary tumor cell line.
    Polish journal of veterinary sciences, 2017, Mar-28, Volume: 20, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Dog Diseases; Dogs; Drug Resistance, Neo

2017
Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
    Molecular cancer therapeutics, 2018, Volume: 17, Issue:7

    Topics: Animals; Breast Neoplasms; Cell Proliferation; Chemokine CXCL1; Chemokine CXCL2; Cyclophosphamide; D

2018
Corticotropin-releasing factor reduces tumor volume, halts further growth, and enhances the effect of chemotherapy in 4T1 mammary carcinoma in mice.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:2

    Topics: Animals; Apoptosis; Breast Neoplasms; Corticotropin-Releasing Hormone; Female; Fluorouracil; Humans;

2014
High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model.
    BMC cancer, 2014, Jun-20, Volume: 14

    Topics: Alphavirus; Animals; Cell Line; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal;

2014
Pharmacologically Inactive Bisphosphonates as an Alternative Strategy for Targeting Osteoclasts: In Vivo Assessment of 5-Fluorodeoxyuridine-Alendronate in a Preclinical Model of Breast Cancer Bone Metastases.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017, Volume: 32, Issue:3

    Topics: Alendronate; Animals; Apoptosis; Biomarkers, Tumor; Bone Neoplasms; Bone Resorption; Caspases; Cell

2017
Antiangiogenic effect of capecitabine combined with ginsenoside Rg3 on breast cancer in mice.
    Cancer biotherapy & radiopharmaceuticals, 2008, Volume: 23, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; D

2008
Preclinical evaluation of DISC-GMCSF for the treatment of breast carcinoma.
    The journal of gene medicine, 2003, Volume: 5, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Separation; Centr

2003
Ineffectiveness of five compounds on spontaneous mammary tumors of mice.
    Cancer chemotherapy reports, 1963, Volume: 27

    Topics: Animals; Chlorprothixene; Fluorouracil; Hydrocarbons; Mammary Neoplasms, Animal; Mice; Naphthoquinon

1963
UTILIZATION OF DNA AND RNA PRECURSORS AS INDICATORS OF DRUG EFFECT ON CANCER CELLS. ANL-6723.
    ANL, 1963

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dactinomycin; DNA; DNA, Neoplasm; Fluorour

1963
COMPARISON OF THE EFFECTS OF CHEMOTHERAPY AND LOCAL IRRADIATION ON THE VASCULARITY OF A TRANSPLANTED MOUSE MAMMARY ADENOCARCINOMA AND A PLEOMORPHIC SARCOMA.
    Radiology, 1965, Volume: 84

    Topics: Adenocarcinoma; Angiography; Animals; Blood Vessels; Fluorouracil; Mammary Neoplasms, Animal; Mammar

1965
IN VITRO TEST SYSTEMS FOR CANCER CHEMOTHERAPY. 3. PRELIMINARY STUDIES OF SPONTANEOUS MAMMARY TUMORS IN MICE.
    Cancer chemotherapy reports, 1965, Volume: 44

    Topics: Alkylating Agents; Animals; Carcinoma, Ehrlich Tumor; Dactinomycin; Fluorouracil; Hydrocortisone; In

1965
Human soluble tumor-associated antigens promote the suppression of rat mammary tumors by 5-fluorouracil and stimulate the functional activity of immune organs: Experimental and morphological studies.
    International journal of molecular medicine, 2003, Volume: 12, Issue:5

    Topics: Animals; Antigens, Neoplasm; Female; Fluorouracil; Lymph Nodes; Mammary Neoplasms, Animal; Rats; Rat

2003
Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats.
    Cancer science, 2006, Volume: 97, Issue:7

    Topics: Animals; Antigens, Bacterial; Antimetabolites, Antineoplastic; Bifidobacterium; Cytosine Deaminase;

2006
Enhanced antitumor activity of an adriamycin + 5-fluorouracil combination when preceded by biochemical modulation.
    Anti-cancer drugs, 1996, Volume: 7, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemo

1996
Radiation enhancement by biochemical modulation and 5-fluorouracil.
    International journal of radiation oncology, biology, physics, 1997, Dec-01, Volume: 39, Issue:5

    Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Di

1997
Adjuvant post-operative chemotherapy in bitches with mammary cancer.
    Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 2001, Volume: 48, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Carcinosarcoma; Chemotherapy, Ad

2001
Chemotherapeutic activity of L-histidinol against spontaneous, autochthonous murine breast tumors.
    Chemotherapy, 1990, Volume: 36, Issue:6

    Topics: Animals; DNA, Neoplasm; Female; Fluorouracil; Histidinol; Mammary Neoplasms, Animal; Mice; RNA, Neop

1990