Page last updated: 2024-10-27

fluorouracil and Angioedema

fluorouracil has been researched along with Angioedema in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Angioedema: Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.

Research Excerpts

ExcerptRelevanceReference
"An allergic reaction consisting of angioneurotic edema secondary to continuous infusion 5-fluorouracil occurred in a patient with recurrent carcinoma of the oral cavity, cirrhosis, and cisplatin-induced impaired renal function."3.67Allergic reaction to 5-fluorouracil infusion. ( Sridhar, KS, 1986)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cohen, PR1
Maughan, C1
Lear, W1
Sridhar, KS1

Reviews

1 review available for fluorouracil and Angioedema

ArticleYear
Topical application of 5-fluorouracil 5 percent cream associated with severe neutropenia: discussion of a case and review of systemic reactions after topical treatment with 5-fluorouracil.
    Dermatology online journal, 2018, Apr-15, Volume: 24, Issue:4

    Topics: Administration, Cutaneous; Aged; Angioedema; Antimetabolites, Antineoplastic; Cheilitis; Fluorouraci

2018

Other Studies

2 other studies available for fluorouracil and Angioedema

ArticleYear
Acute angioedema response to topical 5-fluorouracil therapy.
    Dermatology online journal, 2013, Mar-15, Volume: 19, Issue:3

    Topics: Administration, Topical; Aged; Angioedema; Angiotensin-Converting Enzyme Inhibitors; Antimetabolites

2013
Allergic reaction to 5-fluorouracil infusion.
    Cancer, 1986, Aug-15, Volume: 58, Issue:4

    Topics: Angioedema; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Dru

1986