fluorouracil has been researched along with Aneuploid in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed at developing a more detailed understanding of cyclin D1 in early stage human breast cancer and defining the biologic profiles with different prognostic value correlating cyclin D1 gene amplification and chromosome 11 aneusomy with bio-pathologic variables of known clinical importance." | 7.74 | Bio-pathologic characteristics related to chromosome 11 aneusomy and cyclin D1 gene status in surgically resected stage I and II breast cancer: Identification of an adverse prognostic profile. ( Buglioni, S; Cianciulli, A; Cognetti, F; Di Benedetto, A; Merola, R; Mottolese, M; Orlandi, G; Perracchio, L; Pinnarò, P; Sperduti, I; Venturo, I, 2007) |
| " Additionally, functional studies indicated that over-expression of RAD51B promoted cell proliferation, aneuploidy, and drug resistance, while RAD51B knockdown led to G1 arrest and sensitized cells to 5-fluorouracil (5-FU)." | 3.83 | RAD51B as a potential biomarker for early detection and poor prognostic evaluation contributes to tumorigenesis of gastric cancer. ( Chen, X; Cheng, Y; Xi, Y; Yang, B, 2016) |
| "We aimed at developing a more detailed understanding of cyclin D1 in early stage human breast cancer and defining the biologic profiles with different prognostic value correlating cyclin D1 gene amplification and chromosome 11 aneusomy with bio-pathologic variables of known clinical importance." | 3.74 | Bio-pathologic characteristics related to chromosome 11 aneusomy and cyclin D1 gene status in surgically resected stage I and II breast cancer: Identification of an adverse prognostic profile. ( Buglioni, S; Cianciulli, A; Cognetti, F; Di Benedetto, A; Merola, R; Mottolese, M; Orlandi, G; Perracchio, L; Pinnarò, P; Sperduti, I; Venturo, I, 2007) |
"These specimens were evaluated for DNA aneuploidy (DI | 2.73 | Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial. ( Crook, W; Eifel, PJ; Gaffney, DK; Grigsby, PW; Krishan, A; Lucci, JA; Markoe, AM; Morris, M; Winter, K; Wolfson, AH, 2008) | |
| "19 advanced gastric cancer (AGC) patients were divided into the following groups: group A (n = 7): in addition to their oral intake, received a PNS for 5 days, which yielded 117 Kj." | 2.67 | [Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients]. ( Cao, WX; Xiao, HB; Yin, HR, 1994) |
| "MNi are formed as a consequence of chromosome breaks and aneuploidy." | 1.40 | Acute toxic and genotoxic activities of widely used cytostatic drugs in higher plants: Possible impact on the environment. ( Filipic, M; Knasmueller, S; Mišík, M; Nersesyan, A; Pichler, C; Rainer, B, 2014) |
| "Some degree of aneuploidy was detected in all primary carcinomas." | 1.31 | Markers of drug resistance in relapsing colon cancer. ( Davaris, PS; Kavantzas, NG; Lazaris, AC; Tsavaris, NV; Zorzos, HS, 2002) |
| "Histologically, aneuploidy was detected in 71." | 1.29 | [Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck]. ( Miyagi, M; Nakashima, T; Soda, T, 1994) |
| "Because DNA aneuploidy is an indirect measure of the proliferative activity of a cell population, a study was conducted to examine differences in tumor response to induction chemotherapy based on aDI values." | 1.29 | DNA content and tumor response to induction chemotherapy in patients with advanced laryngeal squamous cell carcinoma. ( Beals, TE; Fisher, SG; Gregg, CM; McClatchy, KM; Wolf, GT, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mišík, M | 1 |
| Pichler, C | 1 |
| Rainer, B | 1 |
| Filipic, M | 1 |
| Nersesyan, A | 1 |
| Knasmueller, S | 1 |
| Cheng, Y | 1 |
| Yang, B | 1 |
| Xi, Y | 1 |
| Chen, X | 1 |
| Mayhew, CN | 1 |
| Perkin, LM | 1 |
| Zhang, X | 1 |
| Sage, J | 1 |
| Jacks, T | 1 |
| Knudsen, ES | 1 |
| Mottolese, M | 1 |
| Orlandi, G | 1 |
| Sperduti, I | 1 |
| Merola, R | 1 |
| Buglioni, S | 1 |
| Di Benedetto, A | 1 |
| Pinnarò, P | 1 |
| Perracchio, L | 1 |
| Venturo, I | 1 |
| Cognetti, F | 1 |
| Cianciulli, A | 1 |
| Wolfson, AH | 1 |
| Winter, K | 1 |
| Crook, W | 1 |
| Krishan, A | 1 |
| Grigsby, PW | 1 |
| Markoe, AM | 1 |
| Morris, M | 1 |
| Gaffney, DK | 1 |
| Eifel, PJ | 1 |
| Lucci, JA | 1 |
| Stål, O | 1 |
| Stenmark Askmalm, M | 1 |
| Wingren, S | 1 |
| Rutqvist, LE | 1 |
| Skoog, L | 1 |
| Ferraud, L | 1 |
| Sullivan, S | 1 |
| Carstensen, J | 1 |
| Nordenskjöld, B | 1 |
| Daidone, MG | 1 |
| Silvestrini, R | 1 |
| Luisi, A | 1 |
| Mastore, M | 1 |
| Benini, E | 1 |
| Veneroni, S | 1 |
| Brambilla, C | 1 |
| Ferrari, L | 1 |
| Greco, M | 1 |
| Andreola, S | 1 |
| Miyagi, M | 1 |
| Soda, T | 1 |
| Nakashima, T | 1 |
| Cao, WX | 1 |
| Xiao, HB | 1 |
| Yin, HR | 1 |
| Gregg, CM | 1 |
| Beals, TE | 1 |
| McClatchy, KM | 1 |
| Fisher, SG | 1 |
| Wolf, GT | 1 |
| Lazaris, AC | 1 |
| Kavantzas, NG | 1 |
| Zorzos, HS | 1 |
| Tsavaris, NV | 1 |
| Davaris, PS | 1 |
| Tagawa, Y | 1 |
| Kawazoe, N | 1 |
| Nishida, T | 1 |
| Tomita, M | 1 |
| Kobayashi, M | 1 |
| Kuramoto, S | 1 |
| Ihara, O | 1 |
| Oohara, T | 1 |
| Carlson, PS | 1 |
4 trials available for fluorouracil and Aneuploid
| Article | Year |
|---|---|
Are increased tumor aneuploidy and heightened cell proliferation along with heterogeneity associated with patient outcome for carcinomas of the uterine cervix? A combined analysis of subjects treated in RTOG 9001 and a single-institution trial.
Topics: Adenocarcinoma; Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, | 2008 |
p53 expression and the result of adjuvant therapy of breast cancer.
Topics: Aneuploidy; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combi | 1995 |
Changes in biological markers after primary chemotherapy for breast cancers.
Topics: Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Breast Neoplasms; Cell Cycle | 1995 |
[Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients].
Topics: Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Chemotherapy, A | 1994 |
9 other studies available for fluorouracil and Aneuploid
| Article | Year |
|---|---|
Acute toxic and genotoxic activities of widely used cytostatic drugs in higher plants: Possible impact on the environment.
Topics: Allium; Aneuploidy; Chromosome Breakage; Cyclophosphamide; Cytostatic Agents; Etoposide; Fluorouraci | 2014 |
RAD51B as a potential biomarker for early detection and poor prognostic evaluation contributes to tumorigenesis of gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Carc | 2016 |
Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents.
Topics: Aneuploidy; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Fluorouracil; G1 Phase; | 2004 |
Bio-pathologic characteristics related to chromosome 11 aneusomy and cyclin D1 gene status in surgically resected stage I and II breast cancer: Identification of an adverse prognostic profile.
Topics: Adenocarcinoma; Adult; Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, | 2007 |
[Flow cytometric DNA analysis and chemosensitivity in squamous cell carcinoma of the head and neck].
Topics: Adult; Aged; Aged, 80 and over; Aneuploidy; Antineoplastic Agents; Carbazilquinone; Carcinoma, Squam | 1994 |
DNA content and tumor response to induction chemotherapy in patients with advanced laryngeal squamous cell carcinoma.
Topics: Aged; Aneuploidy; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplati | 1993 |
Markers of drug resistance in relapsing colon cancer.
Topics: Aneuploidy; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette | 2002 |
[Classification of DNA histogram perturbed with 5-FU and its clinical application].
Topics: Aneuploidy; Cell Division; Colonic Neoplasms; Diploidy; DNA Damage; DNA, Neoplasm; Flow Cytometry; F | 1991 |
Notes on the mechanism of action of gibberellic acid.
Topics: Amylases; Aneuploidy; Calcium; Diploidy; Edible Grain; Enzyme Induction; Fluorouracil; Genes; Geneti | 1972 |