fluorouracil has been researched along with Anemia, Megaloblastic in 5 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Anemia, Megaloblastic: A disorder characterized by the presence of ANEMIA, abnormally large red blood cells (megalocytes or macrocytes), and MEGALOBLASTS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koizumi, M | 1 |
| Suzuki, T | 1 |
| Takahashi, S | 1 |
| Ogata, E | 1 |
| Hooton, JW | 3 |
| Hoffbrand, AV | 3 |
| Vilpo, JA | 1 |
1 review available for fluorouracil and Anemia, Megaloblastic
| Article | Year |
|---|---|
The DNA-repair enzyme uracil-DNA glycosylase in the human hematopoietic system.
Topics: Anemia, Megaloblastic; Bromodeoxyuridine; Cell Division; Chromosome Aberrations; DNA Glycosylases; D | 1988 |
4 other studies available for fluorouracil and Anemia, Megaloblastic
| Article | Year |
|---|---|
Transient splenic accumulation of Tc-99m HMDP caused by megaloblastic anemia.
Topics: Anemia, Megaloblastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neopla | 2000 |
DNA synthesis in isolated lymphocyte nuclei. Effects of megaloblastic anaemia due to folate or vitamin B-12 deficiency or antimetabolite drugs.
Topics: Adenosine Triphosphate; Adult; Aged; Anemia, Macrocytic; Anemia, Megaloblastic; Cell Nucleus; Cytara | 1977 |
[3H]Thymidine triphosphate incorporation into isolated nuclei.
Topics: Anemia, Megaloblastic; Cell Nucleus; DNA Replication; Fluorouracil; Folic Acid; Humans; Hydroxyurea; | 1976 |
Thymidine kinase in megaloblastic anaemia.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Female; Fluorouracil; Folic Acid; Folic Acid Deficiency; | 1976 |