fluorouracil has been researched along with Anemia, Fanconi in 4 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In a new independent cohort of 191 breast cancer patients treated with adjuvant 5-fluorouracil, epirubicin, and cyclophosphamide, a positive assay result predicted 5-year relapse-free survival with a hazard ratio of 0." | 3.80 | Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer. ( Boyle, D; Bylesjo, M; Couch, FJ; Davison, TS; Deharo, S; Hill, LA; Irwin, G; James, CR; James, J; Johnston, PG; Keating, KE; Kennedy, RD; Kerr, P; Lindor, NM; McDyer, FA; Mullan, PB; Mulligan, JM; O'Brien, E; Paul Harkin, D; Proutski, V; Quinn, JE; Raji, OY; Salto-Tellez, M; Walker, SM, 2014) |
| " However, the optimal dosage of chemoradiotherapy and the treatment strategy for esophageal cancer in patients with Fanconi anemia remain unclear, and outcomes are generally extremely poor." | 1.36 | Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia. ( Hirashima, Y; Hosoya, Y; Jinbu, Y; Lefor, A; Muroi, K; Nakazawa, M; Nokubi, M; Yamaguti, T; Yasuda, Y, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voter, AF | 1 |
| Manthei, KA | 1 |
| Keck, JL | 1 |
| Mulligan, JM | 1 |
| Hill, LA | 1 |
| Deharo, S | 1 |
| Irwin, G | 1 |
| Boyle, D | 1 |
| Keating, KE | 1 |
| Raji, OY | 1 |
| McDyer, FA | 1 |
| O'Brien, E | 1 |
| Bylesjo, M | 1 |
| Quinn, JE | 1 |
| Lindor, NM | 1 |
| Mullan, PB | 1 |
| James, CR | 1 |
| Walker, SM | 1 |
| Kerr, P | 1 |
| James, J | 1 |
| Davison, TS | 1 |
| Proutski, V | 1 |
| Salto-Tellez, M | 1 |
| Johnston, PG | 1 |
| Couch, FJ | 1 |
| Paul Harkin, D | 1 |
| Kennedy, RD | 1 |
| Du, W | 1 |
| Amarachintha, S | 1 |
| Erden, O | 1 |
| Wilson, A | 1 |
| Meetei, AR | 1 |
| Andreassen, PR | 1 |
| Namekawa, SH | 1 |
| Pang, Q | 1 |
| Hosoya, Y | 1 |
| Lefor, A | 1 |
| Hirashima, Y | 1 |
| Nokubi, M | 1 |
| Yamaguti, T | 1 |
| Jinbu, Y | 1 |
| Muroi, K | 1 |
| Nakazawa, M | 1 |
| Yasuda, Y | 1 |
4 other studies available for fluorouracil and Anemia, Fanconi
| Article | Year |
|---|---|
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc | 2016 |
Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer.
Topics: Adult; Aged; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemo | 2014 |
Fancb deficiency impairs hematopoietic stem cell function.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cell P | 2015 |
Successful treatment of esophageal squamous cell carcinoma in a patient with Fanconi anemia.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone Marrow Transplantation; Carcinom | 2010 |