fluorouracil has been researched along with Anastomotic Leak in 17 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Anastomotic Leak: Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The rates of anastomotic leakage and stenosis were calculated for each treatment arm." | 2.82 | Impact of Preoperative Radiotherapy on Anastomotic Leakage and Stenosis After Rectal Cancer Resection: Post Hoc Analysis of a Randomized Controlled Trial. ( Deng, Y; Ma, T; Qin, Q; Wang, H; Wang, J; Wang, L; Zheng, J; Zhou, Z, 2016) |
| "The prognostic impact of postoperative anastomotic leakage (AL) and pneumonia on survival was evaluated." | 1.91 | Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers. ( Doki, Y; Kakeji, Y; Kawakubo, H; Kitagawa, Y; Matsuda, S; Muto, M; Okamura, A; Okui, J; Takemura, R; Takeuchi, H; Watanabe, M, 2023) |
| "Three patients (25%) developed anastomotic leakage." | 1.56 | Induction chemoradiotherapy including docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal cancer. ( Fujiwara, T; Hashimoto, M; Katsui, K; Maeda, N; Nishizaki, M; Noma, K; Sakurama, K; Shirakawa, Y; Tanabe, S, 2020) |
| "Patients with pathological stage II/III gastric cancer undergoing LG with D2 lymphadenectomy (LG group: n = 74) were matched 1:1 with patients selected from 214 similar patients undergoing OG (OG group: n = 74), identically matching gender, age, pathological stage, and type of gastrectomy, and comparing AC initiation timing between the two groups." | 1.46 | Timing of initiation of adjuvant chemotherapy for gastric cancer: A case-matched comparison study of laparoscopic vs. open surgery. ( Kaito, A; Kinoshita, T; Nishida, T; Shibasaki, H; Shitara, K, 2017) |
| "No conversions or intraoperative complications occurred." | 1.43 | Robotic Right Colectomy with Modified Complete Mesocolic Excision: Long-Term Oncologic Outcomes. ( Bianchi, PP; Formisano, G; Lenti, LM; Marano, A; Priora, F; Ravazzoni, F; Spinoglio, G, 2016) |
| "Hydroxyproline levels were higher in group M than in group C." | 1.40 | The use of collagen content as determined by spectral domain polarization-sensitive optical coherence tomography to assess colon anastomosis healing in a rat model. ( Ahn, CB; Jeong, HW; Jung, WW; Kim, BM; Kim, HS; Kim, KT; Lee, SH; Lee, SK; Park, KY; Son, KH, 2014) |
| "Postoperative complications were graded according to the Clavien-Dindo classification." | 1.40 | Prognostic factors for postoperative morbidity and tumour response after neoadjuvant chemoradiation followed by resection for rectal cancer. ( Berkel, AE; Klaase, JM; van der Palen, J; Woutersen, DP, 2014) |
| "Fecal incontinence was assessed by patient self-reported data without the use of a validated score." | 1.39 | Cumulative incidence of permanent stoma after sphincter preserving low anterior resection of mid and low rectal cancer. ( Buchner, S; Dinnewitzer, A; Jäger, T; Nawara, C; Öfner, D; Wolfgang, H, 2013) |
| "Of all patients operated for rectal cancer, 27." | 1.39 | Intensified neoadjuvant radiochemotherapy for rectal cancer enhances surgical complications. ( Fietkau, R; Gock, M; Klar, E; Klautke, G; Prall, F; Rau, B; Schiffmann, L; Wedermann, N, 2013) |
| "Combined resection of colorectal cancer with surgery for synchronous liver metastases (LM) still remains controversial because of the possible higher morbidity rate, the necessity of an adequate abdominal approach for both resections and the impact on oncological results." | 1.39 | Laparoscopic resection of colorectal cancer facilitates simultaneous surgery of synchronous liver metastases. ( Belghiti, J; Bretagnol, F; Farges, O; Hatwell, C; Panis, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (88.24) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Matsuda, S | 1 |
| Kitagawa, Y | 1 |
| Okui, J | 1 |
| Okamura, A | 1 |
| Kawakubo, H | 1 |
| Takemura, R | 1 |
| Muto, M | 1 |
| Kakeji, Y | 1 |
| Takeuchi, H | 1 |
| Watanabe, M | 1 |
| Doki, Y | 1 |
| Hashimoto, M | 1 |
| Shirakawa, Y | 1 |
| Maeda, N | 1 |
| Tanabe, S | 1 |
| Noma, K | 1 |
| Sakurama, K | 1 |
| Katsui, K | 1 |
| Nishizaki, M | 1 |
| Fujiwara, T | 1 |
| Murphy, CC | 1 |
| Incalcaterra, JR | 1 |
| Albright, HW | 1 |
| Correa, AM | 1 |
| Swisher, SG | 1 |
| Hofstetter, WL | 1 |
| Dinnewitzer, A | 1 |
| Jäger, T | 1 |
| Nawara, C | 1 |
| Buchner, S | 1 |
| Wolfgang, H | 1 |
| Öfner, D | 1 |
| Schiffmann, L | 1 |
| Wedermann, N | 1 |
| Gock, M | 1 |
| Prall, F | 1 |
| Klautke, G | 1 |
| Fietkau, R | 1 |
| Rau, B | 1 |
| Klar, E | 1 |
| Curtis, NJ | 1 |
| Noble, F | 1 |
| Bailey, IS | 1 |
| Kelly, JJ | 1 |
| Byrne, JP | 1 |
| Underwood, TJ | 1 |
| Son, KH | 1 |
| Jeong, HW | 1 |
| Jung, WW | 1 |
| Kim, HS | 1 |
| Lee, SK | 1 |
| Kim, KT | 1 |
| Ahn, CB | 1 |
| Park, KY | 1 |
| Kim, BM | 1 |
| Lee, SH | 1 |
| Dorth, JA | 1 |
| Pura, JA | 1 |
| Palta, M | 1 |
| Willett, CG | 1 |
| Uronis, HE | 1 |
| D'Amico, TA | 1 |
| Czito, BG | 1 |
| Berkel, AE | 1 |
| Woutersen, DP | 1 |
| van der Palen, J | 1 |
| Klaase, JM | 1 |
| Qin, Q | 1 |
| Ma, T | 1 |
| Deng, Y | 1 |
| Zheng, J | 1 |
| Zhou, Z | 1 |
| Wang, H | 1 |
| Wang, L | 1 |
| Wang, J | 1 |
| Spinoglio, G | 1 |
| Marano, A | 1 |
| Bianchi, PP | 1 |
| Priora, F | 1 |
| Lenti, LM | 1 |
| Ravazzoni, F | 1 |
| Formisano, G | 1 |
| Kaito, A | 1 |
| Kinoshita, T | 1 |
| Shitara, K | 1 |
| Shibasaki, H | 1 |
| Nishida, T | 1 |
| Garant, A | 1 |
| Des Groseilliers, S | 1 |
| Martin, L | 1 |
| Ferland, É | 1 |
| Vuong, T | 1 |
| Pramateftakis, MG | 1 |
| Kanellos, D | 1 |
| Mantzoros, I | 1 |
| Despoudi, K | 1 |
| Raptis, D | 1 |
| Angelopoulos, S | 1 |
| Koliakos, G | 1 |
| Zaraboukas, T | 1 |
| Lazaridis, C | 1 |
| Wolthuis, AM | 1 |
| Penninckx, F | 1 |
| Haustermans, K | 1 |
| De Hertogh, G | 1 |
| Fieuws, S | 1 |
| Van Cutsem, E | 1 |
| D'Hoore, A | 1 |
| Hatwell, C | 1 |
| Bretagnol, F | 1 |
| Farges, O | 1 |
| Belghiti, J | 1 |
| Panis, Y | 1 |
| Lubezky, N | 1 |
| Winograd, E | 1 |
| Papoulas, M | 1 |
| Lahat, G | 1 |
| Shacham-Shmueli, E | 1 |
| Geva, R | 1 |
| Nakache, R | 1 |
| Klausner, J | 1 |
| Ben-Haim, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II/III Randomized Controlled Study of Neoadjuvant FOLFOX6 Treatment With or Without Radiation Compared to 5-Fu Based Chemoradiation in Treating Patients With Resectable Rectal Cancer[NCT01211210] | Phase 2/Phase 3 | 495 participants (Actual) | Interventional | 2010-06-30 | Active, not recruiting | ||
| Total Mesorectal Excision(TME) With Lateral Lymph Node Dissection Versus TME After Neoadjuvant Chemo-radiotherapy of Lower Rectal Cancer With Suspected Local Lymph Node Metastasis[NCT03587480] | 250 participants (Anticipated) | Interventional | 2018-12-17 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fluorouracil and Anastomotic Leak
| Article | Year |
|---|---|
Impact of Preoperative Radiotherapy on Anastomotic Leakage and Stenosis After Rectal Cancer Resection: Post Hoc Analysis of a Randomized Controlled Trial.
Topics: Adenocarcinoma; Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Antineoplastic Agents; Chemora | 2016 |
Impact of Preoperative Radiotherapy on Anastomotic Leakage and Stenosis After Rectal Cancer Resection: Post Hoc Analysis of a Randomized Controlled Trial.
Topics: Adenocarcinoma; Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Antineoplastic Agents; Chemora | 2016 |
Impact of Preoperative Radiotherapy on Anastomotic Leakage and Stenosis After Rectal Cancer Resection: Post Hoc Analysis of a Randomized Controlled Trial.
Topics: Adenocarcinoma; Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Antineoplastic Agents; Chemora | 2016 |
Impact of Preoperative Radiotherapy on Anastomotic Leakage and Stenosis After Rectal Cancer Resection: Post Hoc Analysis of a Randomized Controlled Trial.
Topics: Adenocarcinoma; Adult; Aged; Anastomosis, Surgical; Anastomotic Leak; Antineoplastic Agents; Chemora | 2016 |
16 other studies available for fluorouracil and Anastomotic Leak
| Article | Year |
|---|---|
Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers.
Topics: Aged; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; East A | 2023 |
Induction chemoradiotherapy including docetaxel, cisplatin, and 5-fluorouracil for locally advanced esophageal cancer.
Topics: Aged; Anastomotic Leak; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemo | 2020 |
Pretreatment patient comorbidity and tobacco use increase cost and risk of postoperative complications after esophagectomy at a high-volume cancer center.
Topics: Adenocarcinoma; Adult; Aged; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Cance | 2013 |
Cumulative incidence of permanent stoma after sphincter preserving low anterior resection of mid and low rectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anal Canal; Anastomosis, Surgical; Anastomotic Leak; | 2013 |
Intensified neoadjuvant radiochemotherapy for rectal cancer enhances surgical complications.
Topics: Adenocarcinoma; Aged; Anastomotic Leak; Antineoplastic Agents; Antineoplastic Combined Chemotherapy | 2013 |
The relevance of the Siewert classification in the era of multimodal therapy for adenocarcinoma of the gastro-oesophageal junction.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Antineoplastic Combined Chemothera | 2014 |
The use of collagen content as determined by spectral domain polarization-sensitive optical coherence tomography to assess colon anastomosis healing in a rat model.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Antineoplastic Agents; Collagen; Collagen Type I; | 2014 |
Patterns of recurrence after trimodality therapy for esophageal cancer.
Topics: Adenocarcinoma; Adult; Aged; Anastomotic Leak; Antineoplastic Agents; Antineoplastic Combined Chemot | 2014 |
Prognostic factors for postoperative morbidity and tumour response after neoadjuvant chemoradiation followed by resection for rectal cancer.
Topics: Adenocarcinoma; Adult; Age Factors; Aged; Aged, 80 and over; Anastomotic Leak; Antimetabolites, Anti | 2014 |
Robotic Right Colectomy with Modified Complete Mesocolic Excision: Long-Term Oncologic Outcomes.
Topics: Adult; Aged; Aged, 80 and over; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Ch | 2016 |
Timing of initiation of adjuvant chemotherapy for gastric cancer: A case-matched comparison study of laparoscopic vs. open surgery.
Topics: Abdominal Abscess; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Antineoplastic Combined Chemoth | 2017 |
Late anastomotic dehiscence during bevacizumab therapy for patients with colorectal cancer.
Topics: Adenocarcinoma; Anastomotic Leak; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemoth | 2011 |
Intraperitoneally administered irinotecan with 5-fluorouracil impair wound healing of colonic anastomoses in a rat model: an experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2011 |
Impact of interval between neoadjuvant chemoradiotherapy and TME for locally advanced rectal cancer on pathologic response and oncologic outcome.
Topics: Adenocarcinoma; Aged; Anastomotic Leak; Antimetabolites, Antineoplastic; Chemoradiotherapy, Adjuvant | 2012 |
Laparoscopic resection of colorectal cancer facilitates simultaneous surgery of synchronous liver metastases.
Topics: Adult; Aged; Anastomotic Leak; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy, Ad | 2013 |
Perioperative complications after neoadjuvant chemotherapy with and without bevacizumab for colorectal liver metastases.
Topics: Adult; Aged; Aged, 80 and over; Anastomotic Leak; Antibodies, Monoclonal, Humanized; Antineoplastic | 2013 |