Page last updated: 2024-10-27

fluorouracil and Anasarca

fluorouracil has been researched along with Anasarca in 28 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment."8.31Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy. ( Xie, L, 2023)
"Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties."7.96Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis. ( Daduang, J; Damrongrungruang, T; Mahakunakorn, P; Panpitakkul, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P; Somudorn, J; Uthaiwat, P, 2020)
"The limiting toxicity of low dose continuous infusion 5-fluorouracil (200-300 mg/m2/day) is often palmar-plantar erythrodysesthesia (PPE)."7.68Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion. ( Dahlberg, S; Fabian, CJ; Giri, S; Molina, R; Slavik, M; Stephens, R, 1990)
"A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)."5.12Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007)
" She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment."4.31Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy. ( Xie, L, 2023)
"Glutaryl melatonin exhibited mild anti-candidiasis and anti-inflammatory properties."3.96Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis. ( Daduang, J; Damrongrungruang, T; Mahakunakorn, P; Panpitakkul, P; Panyatip, P; Priprem, A; Puthongking, P; Sangchart, P; Somudorn, J; Uthaiwat, P, 2020)
"The limiting toxicity of low dose continuous infusion 5-fluorouracil (200-300 mg/m2/day) is often palmar-plantar erythrodysesthesia (PPE)."3.68Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion. ( Dahlberg, S; Fabian, CJ; Giri, S; Molina, R; Slavik, M; Stephens, R, 1990)
" Increasing ascites requiring repeated paracentesis had not responded to chemotherapy including infusion of 5-fluorouracil and vincristine into the coeliac artery."3.65Carcinoid heart disease: successful tricuspid valve replacement. ( Honey, M; Paneth, M, 1975)
"There is concern that breast cancer patients treated with left-sided radiation therapy (XRT) and doxorubicin (DOX) may have an increased risk of cardiac toxicity."2.69Treatment-related toxicity from a randomized trial of the sequencing of doxorubicin and radiation therapy in patients treated for early stage breast cancer. ( Come, SE; Gelman, RS; Gollamudi, S; Hardenbergh, PH; Harris, JR; Hayes, DF; O'Neill, A; Recht, A; Shulman, LN; Silver, B, 1999)
"Oral mucositis is a frequent side-effect of cancer therapy."1.33Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters. ( Augusto, RF; Brito, GA; Cunha, FQ; Falcão, BA; Leitão, BT; Lima, V; Rebouças, CG; Ribeiro, RA; Souza, ML, 2005)
"Male breast cancer is very rare, especially inflammatory breast cancer, which is an aggressive, rapidly proliferating manifestation of primary breast carcinoma."1.33Inflammatory breast cancer in a male. ( Choueiri, MB; El Saghir, NS; El-Hajj, II; Otrock, ZK; Tawil, AN, 2005)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-19904 (14.29)18.7374
1990's5 (17.86)18.2507
2000's7 (25.00)29.6817
2010's9 (32.14)24.3611
2020's3 (10.71)2.80

Authors

AuthorsStudies
Sondhi, SM2
Rani, R2
Roy, P1
Agrawal, SK2
Saxena, AK2
Singh, J1
Gupta, PP1
Vendramini-Costa, DB1
de Castro, IB1
Ruiz, AL1
Marquissolo, C1
Pilli, RA1
de Carvalho, JE1
Liu, W1
Zhou, J1
Bensdorf, K1
Zhang, H1
Liu, H1
Wang, Y1
Qian, H1
Zhang, Y1
Wellner, A1
Rubner, G1
Huang, W1
Guo, C1
Gust, R1
Suthar, SK1
Jaiswal, V1
Lohan, S1
Bansal, S1
Chaudhary, A1
Tiwari, A1
Alex, AT1
Joesph, A1
Ovais, S1
Javed, K1
Yaseen, S1
Bashir, R1
Rathore, P1
Yaseen, R1
Hameed, AD1
Samim, M1
Panda, SS1
Girgis, AS1
Thomas, SJ1
Capito, JE1
George, RF1
Salman, A1
El-Manawaty, MA1
Samir, A1
Xie, L1
Damrongrungruang, T1
Panpitakkul, P1
Somudorn, J1
Sangchart, P1
Mahakunakorn, P1
Uthaiwat, P1
Daduang, J1
Panyatip, P1
Puthongking, P1
Priprem, A1
Sellick, MJ1
Michaud, M1
Wong, S1
Candler, D1
Watanabe, SM1
Domati, F1
Bonetti, LR1
Barresi, V1
Zizzo, M1
Manenti, A1
Wei, G1
Nie, MM1
Shen, XJ1
Xue, XC1
Ma, LY1
Du, CH1
Wang, SL1
Bi, JW1
Wang, PL1
Cheng, YB1
Kuerban, G1
Lima, V1
Brito, GA1
Cunha, FQ1
Rebouças, CG1
Falcão, BA1
Augusto, RF1
Souza, ML1
Leitão, BT1
Ribeiro, RA1
Choueiri, MB1
Otrock, ZK1
Tawil, AN1
El-Hajj, II1
El Saghir, NS1
Ewens, AD1
Mihich, E1
Ehrke, MJ1
Lemperle, G1
Rullan, PP1
Gauthier-Hazan, N1
Hau, P1
Kunz-Schughart, L1
Bogdahn, U1
Baumgart, U1
Hirschmann, B1
Weimann, E1
Muhleisen, H1
Ruemmele, P1
Steinbrecher, A1
Reichle, A1
Danoff, BF1
Goodman, RL1
Glick, JH1
Haller, DG1
Pajak, TF1
Lokich, JJ1
Moore, C1
Alekseenko, AV1
Iftodiĭ, AG1
Fedoriak, SS1
Reva, VB1
Luste, AO1
Goriachev, VV1
Austin, JR1
Wong, FC1
Kim, EE1
Hardenbergh, PH1
Recht, A1
Gollamudi, S1
Come, SE1
Hayes, DF1
Shulman, LN1
O'Neill, A1
Gelman, RS1
Silver, B1
Harris, JR1
Bos, AM1
van der Graaf, WT1
Willemse, PH1
Honey, M1
Paneth, M1
Bondarenko, NM1
Desiaterik, VI1
Kryshen', VP1
Fabian, CJ1
Molina, R1
Slavik, M1
Dahlberg, S1
Giri, S1
Stephens, R1
Mörsdorf, K1
Knippertz, T1
Rausch, KD1
Domenjoz, R1

Reviews

1 review available for fluorouracil and Anasarca

ArticleYear
Avoiding and treating dermal filler complications.
    Plastic and reconstructive surgery, 2006, Volume: 118, Issue:3 Suppl

    Topics: Adipose Tissue; Adrenal Cortex Hormones; Animals; Autoimmune Diseases; Biocompatible Materials; Catt

2006

Trials

3 trials available for fluorouracil and Anasarca

ArticleYear
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
    Oncology, 2007, Volume: 73, Issue:1-2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin

2007
[Use of intra-tissue electrophoresis and electrophonophoresis in the multimodal treatment of edematous forms of pancreatitis].
    Klinicheskaia khirurgiia, 1994, Issue:11

    Topics: Adolescent; Adult; Aged; Aminophylline; Anti-Ulcer Agents; Aprotinin; Combined Modality Therapy; Ede

1994
Treatment-related toxicity from a randomized trial of the sequencing of doxorubicin and radiation therapy in patients treated for early stage breast cancer.
    International journal of radiation oncology, biology, physics, 1999, Aug-01, Volume: 45, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Arm; Breast Neoplasms; Combined Modalit

1999

Other Studies

24 other studies available for fluorouracil and Anasarca

ArticleYear
Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.
    Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cell Line, Tumor; Drug Eval

2009
Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Acridines; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor;

2010
Effect of goniothalamin on the development of Ehrlich solid tumor in mice.
    Bioorganic & medicinal chemistry, 2010, Sep-15, Volume: 18, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Carrageenan; Cel

2010
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell S

2011
Novel quinolone substituted thiazolidin-4-ones as anti-inflammatory, anticancer agents: design, synthesis and biological screening.
    European journal of medicinal chemistry, 2013, Volume: 63

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Carcinoma, Ehrlich Tumor; Carra

2013
Synthesis, antiproliferative and anti-inflammatory activities of some novel 6-aryl-2-(p-(methanesulfonyl)phenyl)-4,5-dihydropyridazi-3(2H)-ones.
    European journal of medicinal chemistry, 2013, Volume: 67

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor; Cell Prolif

2013
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
    European journal of medicinal chemistry, 2020, Jun-15, Volume: 196

    Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An

2020
Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2023, Volume: 29, Issue:6

    Topics: Calcium; Cisplatin; Docetaxel; Edema; Female; Fluorouracil; Headache; Humans; Leucovorin; Middle Age

2023
Glutaryl Melatonin Niosome Gel for Topical Oral Mucositis: Anti- Inflammatory and Anticandidiasis.
    Current drug delivery, 2020, Volume: 17, Issue:3

    Topics: Administration, Topical; Anhydrides; Animals; Anti-Inflammatory Agents; Antifungal Agents; Candida a

2020
Subcutaneous Draining of Lower Extremity Edema in a Patient With Advanced Cancer Relieves Scrotal Swelling and Improves Mobility.
    Journal of oncology practice, 2018, Volume: 14, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drainage; Edema; Fluoroura

2018
Radiation therapy damages external anal sphincter and perineal muscle floor.
    Journal of surgical oncology, 2018, Volume: 118, Issue:4

    Topics: Anal Canal; Antineoplastic Combined Chemotherapy Protocols; Arterioles; Collagen; Dilatation, Pathol

2018
Experimental study on sustained-release 5-Fluorouracil implantation in canine peritoneum and para-aortic abdominalis.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Dogs; Drug Implants; Edema; Fluorouracil; Humans; Inflamma

2014
The clinical characteristic differences between thrombosis-related edema and lymphedema following radiotherapy or chemoradiotherapy for patients with cervical cancer.
    Journal of radiation research, 2012, Volume: 53, Issue:1

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy

2012
Effects of the tumour necrosis factor-alpha inhibitors pentoxifylline and thalidomide in short-term experimental oral mucositis in hamsters.
    European journal of oral sciences, 2005, Volume: 113, Issue:3

    Topics: Abscess; Animals; Antimetabolites, Antineoplastic; Cricetinae; Disease Models, Animal; Edema; Erythe

2005
Inflammatory breast cancer in a male.
    The New Zealand medical journal, 2005, Jul-15, Volume: 118, Issue:1218

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms, Male; Cyclophospha

2005
Fluorouracil plus leucovorin induces submandibular salivary gland enlargement in rats.
    Toxicologic pathology, 2005, Volume: 33, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Bone Marrow Cells; Dose-Response Relationship

2005
The effect of adjuvant chemotherapy on cosmesis and complications in patients with breast cancer treated by definitive irradiation.
    International journal of radiation oncology, biology, physics, 1983, Volume: 9, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Arm; Breast Neoplasms; Combined Modality Therapy; Cy

1983
Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome.
    Annals of internal medicine, 1984, Volume: 101, Issue:6

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule;

1984
Positron emission tomography in the detection of residual laryngeal carcinoma.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1995, Volume: 113, Issue:4

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Carcinoma,

1995
A new conservative approach to extravasation of anthracyclines with dimethylsulfoxide and dexrazoxane.
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C

2001
Carcinoid heart disease: successful tricuspid valve replacement.
    Thorax, 1975, Volume: 30, Issue:4

    Topics: Adult; Ascites; Carcinoid Heart Disease; Carcinoid Tumor; Cardiac Catheterization; Edema; Female; Fl

1975
[The effect of 5-fluorouracil on lipid metabolism in patients with acute pancreatitis].
    Vrachebnoe delo, 1990, Issue:1

    Topics: Acute Disease; Adult; Aged; Chromatography, Thin Layer; Edema; Fluorouracil; Humans; Lipids; Middle

1990
Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion.
    Investigational new drugs, 1990, Volume: 8, Issue:1

    Topics: Colonic Neoplasms; Edema; Erythema; Fluorouracil; Follow-Up Studies; Foot Dermatoses; Hand Dermatose

1990
Studies on the antiphlogistic activity of cytostatics.
    Pharmacology, 1972, Volume: 7, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antimetabolites; Carrageenan; Chloramphenicol; Cyclophosphamide;

1972
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