fluorouracil has been researched along with Anaplastic Ependymoma in 17 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a phase I study to examine the pharmacokinetics, safety, and recommended dosage of weekly intravenous bolus 5-fluorouracil (5-FU) in children and young adults with recurrent ependymoma." | 9.20 | Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma. ( Boulos, N; Daryani, VM; Gajjar, A; Gilbertson, RJ; Onar-Thomas, A; Orr, BA; Stewart, CF; Turner, DC; Wright, KD, 2015) |
| "We previously investigated novel therapies for pediatric ependymoma and found 5-fluorouracil (5-FU) i." | 7.83 | Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma. ( Atkinson, JM; Carcaboso, AM; Daryani, VM; Gajjar, A; Gilbertson, RJ; Patel, YT; Stewart, CF; Tagen, M; Turner, DC; Wright, KD, 2016) |
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 7.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| "We report a phase I study to examine the pharmacokinetics, safety, and recommended dosage of weekly intravenous bolus 5-fluorouracil (5-FU) in children and young adults with recurrent ependymoma." | 5.20 | Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma. ( Boulos, N; Daryani, VM; Gajjar, A; Gilbertson, RJ; Onar-Thomas, A; Orr, BA; Stewart, CF; Turner, DC; Wright, KD, 2015) |
| "We previously investigated novel therapies for pediatric ependymoma and found 5-fluorouracil (5-FU) i." | 3.83 | Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma. ( Atkinson, JM; Carcaboso, AM; Daryani, VM; Gajjar, A; Gilbertson, RJ; Patel, YT; Stewart, CF; Tagen, M; Turner, DC; Wright, KD, 2016) |
| "Twenty-one patients with recurrent malignant central nervous system gliomas were treated with a combination of 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine." | 3.67 | Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine. ( Edwards, MS; Fulton, D; Levin, V; Prados, M; Rodriguez, LA; Silver, P, 1988) |
| " Both dosage and releasing time can be adjusted." | 1.27 | [Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites]. ( Himuro, H; Inoue, N; Kaetsu, I; Kitamura, K; Kubo, O; Sakairi, M; Tajika, T; Tajika, Y; Tohyama, T; Yoshida, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (76.47) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grill, J | 1 |
| Wright, KD | 2 |
| Daryani, VM | 2 |
| Turner, DC | 2 |
| Onar-Thomas, A | 1 |
| Boulos, N | 2 |
| Orr, BA | 1 |
| Gilbertson, RJ | 3 |
| Stewart, CF | 3 |
| Gajjar, A | 3 |
| Patel, YT | 1 |
| Tagen, M | 1 |
| Carcaboso, AM | 2 |
| Atkinson, JM | 2 |
| Shelat, AA | 1 |
| Kranenburg, TA | 1 |
| Arnold, LA | 1 |
| Wright, K | 1 |
| Johnson, RA | 1 |
| Poppleton, H | 1 |
| Mohankumar, KM | 1 |
| Féau, C | 1 |
| Phoenix, T | 1 |
| Gibson, P | 1 |
| Zhu, L | 1 |
| Tong, Y | 1 |
| Eden, C | 1 |
| Ellison, DW | 1 |
| Priebe, W | 1 |
| Koul, D | 1 |
| Yung, WK | 1 |
| Guy, RK | 1 |
| Matsumoto, K | 1 |
| Tabuchi, K | 1 |
| Furuta, T | 1 |
| Fujiwara, T | 1 |
| Nakasone, S | 1 |
| Ohnishi, R | 1 |
| Moriya, Y | 1 |
| Nishimoto, A | 1 |
| Doi, A | 1 |
| Asari, S | 1 |
| Sueyoshi, K | 1 |
| Majima, H | 1 |
| Takeuchi, K | 2 |
| Wilkinson, HA | 1 |
| Kornblith, P | 1 |
| Weems, S | 1 |
| Yamashita, M | 1 |
| Hashimoto, T | 1 |
| Hirakawa, T | 1 |
| Fukushima, T | 1 |
| Tomonaga, M | 1 |
| Hara, Y | 1 |
| Kono, A | 1 |
| Tanaka, M | 1 |
| Levin, VA | 2 |
| Kubo, O | 1 |
| Himuro, H | 1 |
| Inoue, N | 1 |
| Tajika, Y | 1 |
| Tajika, T | 1 |
| Tohyama, T | 1 |
| Sakairi, M | 1 |
| Yoshida, M | 1 |
| Kaetsu, I | 1 |
| Kitamura, K | 1 |
| Kitahara, M | 1 |
| Katakura, R | 1 |
| Kanno, M | 1 |
| Niizuma, H | 1 |
| Yoshimoto, T | 1 |
| Suzuki, J | 1 |
| Mori, T | 1 |
| Wada, T | 1 |
| Rodriguez, LA | 1 |
| Prados, M | 1 |
| Fulton, D | 1 |
| Edwards, MS | 1 |
| Silver, P | 1 |
| Levin, V | 1 |
| Shapiro, WR | 2 |
| Chadwick, M | 1 |
| Little, AD | 1 |
1 review available for fluorouracil and Anaplastic Ependymoma
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Efl | 1985 |
1 trial available for fluorouracil and Anaplastic Ependymoma
| Article | Year |
|---|---|
Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Brain Neoplasms; Child; Child, Preschool; Dose-R | 2015 |
15 other studies available for fluorouracil and Anaplastic Ependymoma
| Article | Year |
|---|---|
Translating preclinical hopes into clinical reality for children with ependymoma.
Topics: Antimetabolites, Antineoplastic; Brain Neoplasms; Ependymoma; Fluorouracil; Humans | 2015 |
Translational Pharmacokinetic-Pharmacodynamic Modeling and Simulation: Optimizing 5-Fluorouracil Dosing in Children With Pediatric Ependymoma.
Topics: Animals; Antimetabolites, Antineoplastic; Blood Proteins; Child; Child, Preschool; Computer Simulati | 2016 |
An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma.
Topics: Animals; Boronic Acids; Bortezomib; Brain; Brain Neoplasms; Cell Proliferation; Centrosome; Drug Scr | 2011 |
[Combination chemotherapy of brain tumors with ACNU and 5-FU].
Topics: Astrocytoma; Biological Products; Brain Neoplasms; Combined Modality Therapy; Drug Therapy, Combinat | 1983 |
[Cerebrospinal fluid distributions of systemically administered fluorinated pyrimidines].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Female; Fluorouracil; Glioblastoma; | 1983 |
[Role of chemotherapy in long-term survival of malignant glioma (author's transl)].
Topics: Adolescent; Adult; Astrocytoma; Bleomycin; Brain Neoplasms; Ependymoma; Female; Fluorouracil; Glioma | 1975 |
Focal chemotherapy of brain tumours using semipermeable membranes.
Topics: Animals; Antineoplastic Agents; Bleomycin; Brain Neoplasms; Dactinomycin; Ependymoma; Fluorouracil; | 1977 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Epen | 1985 |
[Treatment of malignant brain tumors with slowly releasing anticancer drug-polymer composites].
Topics: Antineoplastic Agents; Brain Neoplasms; Combined Modality Therapy; Doxorubicin; Drug Implants; Dysge | 1986 |
[Results of combined radiochemotherapy of intracranial ependymoma].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cerebral Ventric | 1987 |
Treatment of recurrent brain stem gliomas and other central nervous system tumors with 5-fluorouracil, CCNU, hydroxyurea, and 6-mercaptopurine.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Brain Stem; Chil | 1988 |
Studies on the chemotherapy of experimental brain tumors: evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cyclophosphamide; Disease Models, Animal; Ependymom | 1971 |
Distribution of 5-fluorouracil-2- 14 C and its metabolites in a murine glioma.
Topics: Animals; Brain; Brain Neoplasms; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Thin | 1972 |
[Chemotherapy of brain tumors].
Topics: Adolescent; Adult; Astrocytoma; Brain Neoplasms; Carotid Arteries; Catheterization; Child; Ependymom | 1968 |
Further studies on chemotherapy of experimental brain tumors.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Ependymoma; Fluorouracil; Glioma; Mice; Neoplasms, | 1970 |