Page last updated: 2024-10-27

fluorouracil and Alzheimer Disease

fluorouracil has been researched along with Alzheimer Disease in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research Excerpts

ExcerptRelevanceReference
"Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the design of a series of tacrine-phenolic heterodimers in order to tackle the multifactorial nature of the disease."1.51Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors. ( Bartolini, M; Bolognesi, ML; Fernández-Bolaños, JG; Franconetti, A; Hicke, J; Lagunes, I; López, Ó; Maya, I; Monti, B; Naldi, M; Padrón, JM; Petralla, S; Poeta, E; Roldán-Peña, JM; Romero-Real, V, 2019)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Candia, M1
Zaetta, G1
Denora, N1
Tricarico, D1
Majellaro, M1
Cellamare, S1
Altomare, CD1
Roldán-Peña, JM2
Alejandre-Ramos, D1
López, Ó2
Maya, I2
Lagunes, I2
Padrón, JM2
Peña-Altamira, LE1
Bartolini, M2
Monti, B2
Bolognesi, ML2
Fernández-Bolaños, JG2
Romero-Real, V1
Hicke, J1
Franconetti, A1
Petralla, S1
Poeta, E1
Naldi, M1

Other Studies

3 other studies available for fluorouracil and Alzheimer Disease

ArticleYear
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.
    European journal of medicinal chemistry, 2017, Jan-05, Volume: 125

    Topics: Alzheimer Disease; Azepines; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Hum

2017
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Anti

2017
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
    European journal of medicinal chemistry, 2019, Nov-01, Volume: 181

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antineoplastic Agents; Butyrylcholinesterase; Cell

2019