fluorouracil has been researched along with Altered Level of Consciousness in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of hyperammonemia induced by chemotherapy, including high-dose fluorouracil(5-FU), for advanced unresectable large intestinal cancer has been reported." | 7.91 | [Case of Hyperammonemia Induced by High-Dose Fluorouracil]. ( Abe, M; Hagiwara, A; Kusakabe, A; Mafune, K; Saito, M, 2019) |
| "Hyperammonemia induced by 5-fluorouracil(5-FU)is known as a rare adverse event, but there are few reports of hyperammonemia occurring during FP(5-FU plus CDDP)treatment for esophageal cancer." | 4.31 | [A Case of Esophageal Cancer with Consciousness Disorder Due to Hyperammonemia during FP Treatment]. ( Chiba, T; Hayashi, M; Iseki, H; Matsui, T; Miura, T; Noguchi, N; Ryotokuji, T; Tsunemi, A; Yamasaki, Y; Yokosuka, T, 2023) |
| "A case of hyperammonemia induced by chemotherapy, including high-dose fluorouracil(5-FU), for advanced unresectable large intestinal cancer has been reported." | 3.91 | [Case of Hyperammonemia Induced by High-Dose Fluorouracil]. ( Abe, M; Hagiwara, A; Kusakabe, A; Mafune, K; Saito, M, 2019) |
| "A cerebral demyelinating disease developed in 3 patients during adjuvant therapy with 5-fluorouracil and levamisole for adenocarcinoma of the colon." | 3.68 | Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole. ( Forsyth, PA; Hook, CC; Kimmel, DW; Kvols, LK; Moertel, CG; Rodriguez, M; Rubin, J; Scheithauer, BW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Yamasaki, Y | 1 |
| Ryotokuji, T | 1 |
| Matsui, T | 1 |
| Miura, T | 1 |
| Chiba, T | 2 |
| Hayashi, M | 1 |
| Yokosuka, T | 1 |
| Noguchi, N | 1 |
| Tsunemi, A | 1 |
| Iseki, H | 1 |
| Fukuda, M | 1 |
| Nabeta, M | 1 |
| Muta, T | 1 |
| Cho, T | 1 |
| Shimamatsu, Y | 1 |
| Shimotsuura, Y | 1 |
| Fukami, K | 1 |
| Takasu, O | 1 |
| Tamura, T | 1 |
| Taniguchi, N | 1 |
| Otsuki, K | 1 |
| Narai, T | 1 |
| Kawasaki, M | 1 |
| Fujii, N | 1 |
| Doi, R | 1 |
| Kodani, I | 1 |
| Hagiwara, A | 1 |
| Abe, M | 1 |
| Mafune, K | 1 |
| Saito, M | 1 |
| Kusakabe, A | 1 |
| Endo, C | 1 |
| Takagawa, R | 1 |
| Kawamoto, M | 1 |
| Konishi, T | 1 |
| Honma, Y | 1 |
| Minami, Y | 1 |
| Watanabe, J | 1 |
| Morita, T | 1 |
| Mogaki, M | 1 |
| Masui, H | 1 |
| Toyokawa, A | 1 |
| Nakajima, T | 1 |
| Inui, K | 1 |
| Yamashita, H | 1 |
| Gon, H | 1 |
| Kanemitsu, K | 1 |
| Tanaka, K | 1 |
| Tsukamoto, T | 1 |
| Hamabe, Y | 1 |
| Ishida, T | 1 |
| Motoori, M | 1 |
| Tsujinaka, T | 1 |
| Hasuike, Y | 1 |
| Fujitani, K | 1 |
| Takeda, Y | 1 |
| Kikkawa, N | 1 |
| Greenwald, ES | 1 |
| Hook, CC | 1 |
| Kimmel, DW | 1 |
| Kvols, LK | 1 |
| Scheithauer, BW | 1 |
| Forsyth, PA | 1 |
| Rubin, J | 1 |
| Moertel, CG | 1 |
| Rodriguez, M | 1 |
2 reviews available for fluorouracil and Altered Level of Consciousness
| Article | Year |
|---|---|
[A Case of Consciousness Disorder Induced by the Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Cisplatin and 5-Fluorouracil Chemotherapy in a Patient with Tongue Cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisplatin; Conscious | 2018 |
[A case of consciousness disorder induced by the syndrome of inappropriate secretion of antidiuretic hormone following cisplatin and 5-fluorouracil chemotherapy in a patient with esophageal cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Consciousness Disorders; Esophageal | 2013 |
7 other studies available for fluorouracil and Altered Level of Consciousness
| Article | Year |
|---|---|
[A Case of Esophageal Cancer with Consciousness Disorder Due to Hyperammonemia during FP Treatment].
Topics: Antineoplastic Combined Chemotherapy Protocols; Consciousness Disorders; Esophageal Neoplasms; Fluor | 2023 |
Disturbance of consciousness due to hyperammonemia and lactic acidosis during mFOLFOX6 regimen: Case report.
Topics: Acidosis, Lactic; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protoc | 2020 |
[Case of Hyperammonemia Induced by High-Dose Fluorouracil].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Consciousness Disorders; Female; | 2019 |
[A case of hyperammonemia with encephalopathy related to FOLFIRI chemotherapy for advanced colon cancer].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Che | 2009 |
[Two cases of chemotherapy related death associated with acute depression of consciousness complicating hepatic arterial infusion chemotherapy (5-FU and CDDP) for liver metastases from gastric cancer].
Topics: Acute Disease; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Consciousness Disord | 2000 |
Letter: Organic mental changes with fluorouracil therapy.
Topics: Aged; Cognition Disorders; Colonic Neoplasms; Consciousness Disorders; Female; Fluorouracil; Humans; | 1976 |
Multifocal inflammatory leukoencephalopathy with 5-fluorouracil and levamisole.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Ataxia; Biopsy; Brain; Chemoth | 1992 |