Page last updated: 2024-10-27

fluorouracil and Alopecia Areata

fluorouracil has been researched along with Alopecia Areata in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Alopecia Areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.

Research Excerpts

ExcerptRelevanceReference
"We report the results of a pilot study of topical 5% 5-fluorouracil (FU) cream for the treatment of alopecia areata, an immunologically modulated disorder of hair growth."7.72Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata. ( Kaplan, AL; Olsen, EA, 2004)
"We report the results of a pilot study of topical 5% 5-fluorouracil (FU) cream for the treatment of alopecia areata, an immunologically modulated disorder of hair growth."3.72Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata. ( Kaplan, AL; Olsen, EA, 2004)
"5-Fluorouracil (5-FU) cream is a common human topical chemotherapy agent with potentially fatal neurotoxic effects on dogs if accidentally ingested."1.72Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog. ( Goodman, IH; Immelman, LM; Keller, N, 2022)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's1 (33.33)2.80

Authors

AuthorsStudies
Immelman, LM1
Goodman, IH1
Keller, N1
Kaplan, AL1
Olsen, EA1
Rietschel, RL1
Madorsky, DD1

Other Studies

3 other studies available for fluorouracil and Alopecia Areata

ArticleYear
Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog.
    Australian veterinary journal, 2022, Volume: 100, Issue:6

    Topics: Aftercare; Alopecia Areata; Animals; Antineoplastic Agents; Dog Diseases; Dogs; Female; Fluorouracil

2022
Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata.
    Journal of the American Academy of Dermatology, 2004, Volume: 50, Issue:6

    Topics: Administration, Topical; Adult; Aged; Alopecia Areata; Antidepressive Agents, Tricyclic; Female; Flu

2004
Male pattern alopecia regrowth following topical fluorouracil therapy.
    JAMA, 1977, Sep-12, Volume: 238, Issue:11

    Topics: Alopecia; Alopecia Areata; Fluorouracil; Humans; Keratosis; Male; Middle Aged

1977