fluorouracil has been researched along with Alopecia Areata in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Alopecia Areata: Loss of scalp and body hair involving microscopically inflammatory patchy areas.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the results of a pilot study of topical 5% 5-fluorouracil (FU) cream for the treatment of alopecia areata, an immunologically modulated disorder of hair growth." | 7.72 | Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata. ( Kaplan, AL; Olsen, EA, 2004) |
| "We report the results of a pilot study of topical 5% 5-fluorouracil (FU) cream for the treatment of alopecia areata, an immunologically modulated disorder of hair growth." | 3.72 | Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata. ( Kaplan, AL; Olsen, EA, 2004) |
| "5-Fluorouracil (5-FU) cream is a common human topical chemotherapy agent with potentially fatal neurotoxic effects on dogs if accidentally ingested." | 1.72 | Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog. ( Goodman, IH; Immelman, LM; Keller, N, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Immelman, LM | 1 |
| Goodman, IH | 1 |
| Keller, N | 1 |
| Kaplan, AL | 1 |
| Olsen, EA | 1 |
| Rietschel, RL | 1 |
| Madorsky, DD | 1 |
3 other studies available for fluorouracil and Alopecia Areata
| Article | Year |
|---|---|
Transient chemotherapy-induced alopecia after successful reversal of 5-fluorouracil myelosuppression and neurotoxicosis in a 9-month-old dog.
Topics: Aftercare; Alopecia Areata; Animals; Antineoplastic Agents; Dog Diseases; Dogs; Female; Fluorouracil | 2022 |
Topical 5-fluorouracil is ineffective in the treatment of extensive alopecia areata.
Topics: Administration, Topical; Adult; Aged; Alopecia Areata; Antidepressive Agents, Tricyclic; Female; Flu | 2004 |
Male pattern alopecia regrowth following topical fluorouracil therapy.
Topics: Alopecia; Alopecia Areata; Fluorouracil; Humans; Keratosis; Male; Middle Aged | 1977 |