fluorouracil has been researched along with Alloxan Diabetes in 6 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After intraperitoneal administration of carboplatin, each measured characteristics of bone marrow function was more significantly suppressed and the induced neutropenia was more serious in db/db mice than in the controls." | 7.81 | Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus. ( Aradi, J; Benkő, I; Géresi, K; Megyeri, A; Németh, J; Szabó, B; Szabó, Z, 2015) |
| "Starting 7 days after transplantation of colonic adenocarcinoma colon-26 cells, STZ-treated and control mice were intraperitoneally administered oxaliplatin, fluorouracil, and levofolinate (FOLFOX) every 2 weeks." | 3.85 | Effect of Hyperglycemia on Antitumor Activity and Survival in Tumor-bearing Mice Receiving Oxaliplatin and Fluorouracil. ( Hashida, T; Ikemura, M, 2017) |
| " Transplantation of bone marrow hematopoietic stem and progenitor cells from diabetic C57Bl/6 donor mice to recipient CBA mice with 5-fluorouracilinduced leukopenia accelerated regeneration of granulocytopoiesis in recipient mice." | 3.83 | Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus. ( Choinzonov, EL; Dygai, AM; Ellinidi, VN; Ermakova, NN; Ermolaeva, LA; Goldberg, VE; Kravtsov, VY; Krupin, VA; Pershina, OV; Reikhart, DV; Skurikhin, EG; Stakheeva, MN, 2016) |
| "After intraperitoneal administration of carboplatin, each measured characteristics of bone marrow function was more significantly suppressed and the induced neutropenia was more serious in db/db mice than in the controls." | 3.81 | Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus. ( Aradi, J; Benkő, I; Géresi, K; Megyeri, A; Németh, J; Szabó, B; Szabó, Z, 2015) |
| "The pharmacokinetic parameters of 5-fluorouracil were compared after intravenous administration at a dose of 30 mg/kg to control Sprague-Dawley rats and to rats with diabetes mellitus induced by streptozotocin (DMIS)." | 1.33 | Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin. ( Bae, SK; Choi, YH; Kim, SO; Lee, AK; Lee, MG, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikemura, M | 1 |
| Hashida, T | 1 |
| Westerweel, PE | 1 |
| Teraa, M | 1 |
| Rafii, S | 1 |
| Jaspers, JE | 1 |
| White, IA | 1 |
| Hooper, AT | 1 |
| Doevendans, PA | 1 |
| Verhaar, MC | 1 |
| Géresi, K | 1 |
| Megyeri, A | 1 |
| Szabó, B | 1 |
| Szabó, Z | 1 |
| Aradi, J | 1 |
| Németh, J | 1 |
| Benkő, I | 1 |
| Dygai, AM | 1 |
| Skurikhin, EG | 1 |
| Pershina, OV | 1 |
| Ermakova, NN | 1 |
| Krupin, VA | 1 |
| Ermolaeva, LA | 1 |
| Stakheeva, MN | 1 |
| Choinzonov, EL | 1 |
| Goldberg, VE | 1 |
| Reikhart, DV | 1 |
| Ellinidi, VN | 1 |
| Kravtsov, VY | 1 |
| Greń, A | 1 |
| Formicki, G | 1 |
| Choi, YH | 1 |
| Lee, AK | 1 |
| Bae, SK | 1 |
| Kim, SO | 1 |
| Lee, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Allogeneic Mesenchymal Stromal Cells for Angiogenesis and Neovascularization in No-option Ischemic Limbs; A Double-blind, Randomized, Placebo-controlled Trial[NCT03042572] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2018-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for fluorouracil and Alloxan Diabetes
| Article | Year |
|---|---|
Effect of Hyperglycemia on Antitumor Activity and Survival in Tumor-bearing Mice Receiving Oxaliplatin and Fluorouracil.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Glucose; Cell Line, T | 2017 |
Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus.
Topics: Animals; Antigens, CD34; Bone Marrow; Cell Count; Cell Movement; Cell Survival; Cells, Cultured; Coc | 2013 |
Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus.
Topics: Animals; Antineoplastic Agents; Bone Marrow Diseases; Carboplatin; Diabetes Mellitus, Experimental; | 2015 |
Role of Hematopoietic Stem Cells in Inflammation of the Pancreas during Diabetes Mellitus.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell- and Tissue-Based Therapy; Diabetes Mellitus, | 2016 |
Effects of iscador and vincristine and 5-fluorouracil on brain, liver, and kidney element levels in alloxan-induced diabetic mice.
Topics: Animals; Brain; Copper; Diabetes Mellitus, Experimental; Fluorouracil; Iron; Kidney; Liver; Magnesiu | 2013 |
Pharmacokinetics of 5-fluorouracil in rats with diabetes mellitus induced by streptozotocin.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Fluorouracil; Inject | 2005 |