fluorouracil has been researched along with Airway Obstruction in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Airway Obstruction: Any hindrance to the passage of air into and out of the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with tracheal or major airway obstruction owing to inoperable carcinomas are at risk of developing respiratory failure or postobstructive pneumonia." | 6.71 | Intratumoural chemotherapy with 5-fluorouracil for palliation of bronchial cancer in patients with severe airway obstruction. ( Celikoğlu, F; Celikoğlu, SI, 2003) |
| "Patients with tracheal or major airway obstruction owing to inoperable carcinomas are at risk of developing respiratory failure or postobstructive pneumonia." | 2.71 | Intratumoural chemotherapy with 5-fluorouracil for palliation of bronchial cancer in patients with severe airway obstruction. ( Celikoğlu, F; Celikoğlu, SI, 2003) |
| "Between 1998 and 2012, 56 patients with squamous cell carcinoma were treated at our institution and included in the analysis." | 1.40 | [Results of definitive radiotherapy for squamous cell carcinomas of the larynx patients with subglottic extension]. ( Blanchard, P; Bourhis, J; Daly-Schveitzer, N; Janot, F; Lévy, A; Tao, Y; Temam, S, 2014) |
| "Patients with tracheal or major airway obstruction due to inoperable carcinomas are at a high risk of developing respiratory failure or post-obstructive pneumonia, or both." | 1.30 | Direct injection of anti-cancer drugs into endobronchial tumours for palliation of major airway obstruction. ( Cağatay, T; Celikoğlu, F; Celikoğlu, SI; Demirci, S; Karayel, T, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lévy, A | 1 |
| Blanchard, P | 1 |
| Janot, F | 1 |
| Temam, S | 1 |
| Bourhis, J | 1 |
| Daly-Schveitzer, N | 1 |
| Tao, Y | 1 |
| Celikoğlu, F | 2 |
| Celikoğlu, SI | 2 |
| Karayel, T | 1 |
| Demirci, S | 1 |
| Cağatay, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intratumoral Cancer Chemotherapy Through a Flexible Bronchoscope as an Adjunct to Brachytherapy[NCT00379665] | Phase 2 | 25 participants (Actual) | Interventional | 2005-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fluorouracil and Airway Obstruction
| Article | Year |
|---|---|
Intratumoural chemotherapy with 5-fluorouracil for palliation of bronchial cancer in patients with severe airway obstruction.
Topics: Adult; Aged; Aged, 80 and over; Airway Obstruction; Antimetabolites, Antineoplastic; Bronchoscopy; F | 2003 |
2 other studies available for fluorouracil and Airway Obstruction
| Article | Year |
|---|---|
[Results of definitive radiotherapy for squamous cell carcinomas of the larynx patients with subglottic extension].
Topics: Adult; Aged; Aged, 80 and over; Airway Obstruction; Antibodies, Monoclonal, Humanized; Antineoplasti | 2014 |
Direct injection of anti-cancer drugs into endobronchial tumours for palliation of major airway obstruction.
Topics: Adult; Aged; Aged, 80 and over; Airway Obstruction; Antineoplastic Agents; Bleomycin; Bronchial Neop | 1997 |