Page last updated: 2024-10-27

fluorouracil and Aging

fluorouracil has been researched along with Aging in 40 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Our results encourage the use of 5-fluorouracil-treated planarians as a model system for studying mechanisms of resistance to genotoxicants, planarian stem cell heterogeneity and molecular cascades of tissue aging."7.965-Fluorouracil-treated planarians, a versatile model system for studying stem cell heterogeneity and tissue aging. ( Gambino, G; Ippolito, C; Modeo, L; Rossi, L; Salvetti, A, 2020)
" This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients."7.76Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. ( Kasapović, J; Pajović, SB; Pejić, S; Radošević-Jelić, L; Saičić, ZS; Stojiljković, V; Todorović, A, 2010)
"5-Fluorouracil was given at 2/3 of the usual dose."5.27Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance. ( Gelman, RS; Taylor, SG, 1984)
" This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients."3.76Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. ( Kasapović, J; Pajović, SB; Pejić, S; Radošević-Jelić, L; Saičić, ZS; Stojiljković, V; Todorović, A, 2010)
"Pancreatic cancer is the fourth leading cause of cancer death in the United States."2.45Medical management of pancreatic adenocarcinoma. ( Cunha, JE; Fernandes, Gdos S; Freitas, D; Hoff, PM, 2009)
"Most of the head and neck tumors are squamous cell carcinomas (SCCs), which are relatively sensitive to chemotherapeutic agents."1.33[Change of creatinine clearance rate in accordance with aging in Japanese patients with head and neck cancer]. ( Horiuchi, C; Kawakami, M; Kondo, N; Masuda, Y; Matsuda, H; Mikami, Y; Nagao, J; Nishimura, G; Taguchi, T; Tsukuda, M; Yabuki, K; Yoshida, T, 2006)
" Age and sex are among the host factors that have been implicated in the pharmacokinetic variability of drugs."1.28Influence of sex and age on fluorouracil clearance. ( Cassuto-Viguier, E; Demard, F; Etienne, MC; Frenay, M; Milano, G; Renee, N; Santini, J; Schneider, M; Thyss, A, 1992)
"5-Fluorouracil was given at 2/3 of the usual dose."1.27Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance. ( Gelman, RS; Taylor, SG, 1984)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-199012 (30.00)18.7374
1990's10 (25.00)18.2507
2000's5 (12.50)29.6817
2010's10 (25.00)24.3611
2020's3 (7.50)2.80

Authors

AuthorsStudies
Saçma, M1
Pospiech, J1
Bogeska, R1
de Back, W1
Mallm, JP1
Sakk, V1
Soller, K1
Marka, G1
Vollmer, A1
Karns, R1
Cabezas-Wallscheid, N1
Trumpp, A1
Méndez-Ferrer, S1
Milsom, MD1
Mulaw, MA1
Geiger, H1
Florian, MC1
Ganguly, R1
Anand, S1
Metkari, S1
Bhartiya, D1
Gambino, G1
Ippolito, C1
Modeo, L1
Salvetti, A1
Rossi, L1
Wu, HC1
Lin, WL1
Lin, CL1
Lin, CY1
Chen, SW1
Chen, YX1
Chen, CH1
Lee, SW1
Chen, SH1
Tsao, CJ1
Huang, WT1
Guo, HR1
He, L1
Beghi, F1
Baral, V1
Dépond, M1
Zhang, Y1
Joulin, V1
Rueda, BR1
Gonin, P1
Foudi, A1
Wittner, M1
Louache, F1
Saba, CF1
Schmiedt, CW1
Freeman, KG1
Edwards, GL1
Busch, K1
Klapproth, K1
Barile, M1
Flossdorf, M1
Holland-Letz, T1
Schlenner, SM1
Reth, M1
Höfer, T1
Rodewald, HR1
Russolillo, N1
Ratti, F1
Viganò, L1
Langella, S1
Cipriani, F1
Aldrighetti, L1
Ferrero, A1
Ruf, F1
Schreck, C1
Wagner, A1
Grziwok, S1
Pagel, C1
Romero, S1
Kieslinger, M1
Shimono, A1
Peschel, C1
Götze, KS1
Istvanffy, R1
Oostendorp, RA1
Groves, TR1
Farris, R1
Anderson, JE1
Alexander, TC1
Kiffer, F1
Carter, G1
Wang, J1
Boerma, M1
Allen, AR1
Freitas, D1
Fernandes, Gdos S1
Hoff, PM1
Cunha, JE1
Pal, SK1
Mortimer, J1
Kasapović, J1
Pejić, S1
Stojiljković, V1
Todorović, A1
Radošević-Jelić, L1
Saičić, ZS1
Pajović, SB1
Day, AC1
Machin, D1
Aung, T1
Gazzard, G1
Husain, R1
Chew, PT1
Khaw, PT1
Seah, SK1
Foster, PJ1
Tsuboi, I2
Harada, T2
Hirabayashi, Y2
Kanno, J2
Inoue, T2
Aizawa, S2
GOLDGRABER, MB1
KIRSNER, JB1
Biganzoli, L1
Goldhirsch, A1
Straehle, C1
Castiglione-Gertsch, M1
Therasse, P1
Aapro, M1
Minisini, A1
Piccart, MJ1
Nishimura, G1
Horiuchi, C1
Yoshida, T1
Kawakami, M1
Yabuki, K1
Taguchi, T1
Nagao, J1
Kondo, N1
Masuda, Y1
Matsuda, H1
Mikami, Y1
Tsukuda, M1
Koshinaga, M1
Kawamata, T1
Carter, DM1
Balin, AK1
Gelman, RS1
Taylor, SG1
Navarra, S1
Melita, P1
Di Mauro, S1
Higley, B1
Oakes, J1
De Mello, J1
Giles, GR1
Olsen, TW1
Edelhauser, HF1
Lim, JI1
Geroski, DH1
Nilsson, SK1
Bertoncello, I1
Tateishi, T1
Watanabe, M1
Nakura, H1
Tanaka, M1
Kumai, T1
Kobayashi, S1
Barnaby, JW1
Styles, AR1
Cockerell, CJ1
Krenacs, T1
Rosendaal, M1
Sekine, I1
Fukuda, H1
Kunitoh, H1
Saijo, N1
Stoop, MJ1
Dirksen, R1
Wobbes, T1
Hendriks, T1
Rudolph, KL1
Chang, S1
Lee, HW1
Blasco, M1
Gottlieb, GJ1
Greider, C1
DePinho, RA1
Holliday, R2
Cascinu, S1
Fedeli, A1
Luzi Fedeli, S1
Catalano, G1
Milano, G1
Etienne, MC1
Cassuto-Viguier, E1
Thyss, A1
Santini, J1
Frenay, M1
Renee, N1
Schneider, M1
Demard, F1
Baumgart, J1
Zhukovskaya, NV1
Anisimov, VN1
Lesnaia, NA1
Teller, MN1
Bowie, M1
Mountain, IM1
Richards, RN1
Spencer, SK1
Kierland, RR1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Trial of Adjuvant Chemotherapy With Standard Regimens, Cyclophosphamide, Methotrexate and Fluorouracil - (CMF) or Doxorubicin and Cyclophosphamide - (AC), Versus Capecitabine in Women 65 Years and Older With Node Positive or Node-Negative Bre[NCT00024102]Phase 3633 participants (Actual)Interventional2001-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Grade 3, 4 or 5 Adverse Event at Least Possibly Related to Treatment.

"The National Cancer Institute (NCI) Common Toxicity Criteria (CTC) Version 2.0 was used to evaluate toxicity.~Grade 1: Mild; Grade 2: Moderate; Grade 3: Severe; Grade 4: Life Threatening; Grade 5: Death." (NCT00024102)
Timeframe: Reported during protocol treatment after each cycle

Interventionparticipants (Number)
Standard Chemotherapy (CMF)92
Standard Chemotherapy (AC)109
Capecitabine101

Overall Survival Rate at 2.4 Years

Percentage of patients who were alive at 2.4 years. This rate was estimated using the Kaplan Meier method. (NCT00024102)
Timeframe: Time from registration to death (up to 15 years)

Interventionpercentage of participants (Number)
Standard Chemotherapy93
Capecitabine88

Relapse-free Survival Rates at 2.4 Years

"Percentage of participants who were alive and relapse-free at time of analysis were counted as Alive without relapse at 2.4 years. Participants who had a first local recurrence, first distant metastasis or death from any cause were counted as relapse, first occurrence. These rates were estimated using the Kaplan Meier method" (NCT00024102)
Timeframe: randomization until date of first event, or date last known to be event free if no event was reported (up to 5 years)

,
Interventionpercentage of participants (Number)
Relapse, first occurrenceAlive without relapse
Capecitabine2080
Standard Chemotherapy1189

Reviews

5 reviews available for fluorouracil and Aging

ArticleYear
Medical management of pancreatic adenocarcinoma.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009, Volume: 9, Issue:3

    Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Agents; Black People; Capecitabine; Deoxycytidine; Diabe

2009
Adjuvant chemotherapy for older adults with breast cancer: making the standard a standard.
    Women's health (London, England), 2009, Volume: 5, Issue:5

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Antibiotics, Antineoplastic; Antimetabolites, Antineopl

2009
Dermatological aspects of aging.
    The Medical clinics of North America, 1983, Volume: 67, Issue:2

    Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl

1983
Actinic keratoses. Differential diagnosis and treatment.
    Drugs & aging, 1997, Volume: 11, Issue:3

    Topics: Aging; Chemexfoliation; Combined Modality Therapy; Cryosurgery; Curettage; Dermabrasion; Diagnosis,

1997
Cancer chemotherapy in the elderly.
    Japanese journal of clinical oncology, 1998, Volume: 28, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neo

1998

Trials

2 trials available for fluorouracil and Aging

ArticleYear
Central corneal thickness and glaucoma in East Asian people.
    Investigative ophthalmology & visual science, 2011, Oct-28, Volume: 52, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Aging; Alkylating Agents; Asian People; Case-Control Studies; Cornea

2011
Treatment of elderly advanced gastric cancer patients with 5-fluorouracil and leucovorin combination.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:3

    Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female

1992

Other Studies

33 other studies available for fluorouracil and Aging

ArticleYear
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
    Nature cell biology, 2019, Volume: 21, Issue:11

    Topics: Aging; Animals; Bone Marrow; Capillaries; Cell Differentiation; Cell Division; Cell Polarity; Cell T

2019
Effect of Aging and 5-Fluorouracil Treatment on Bone Marrow Stem Cell Dynamics.
    Stem cell reviews and reports, 2020, Volume: 16, Issue:5

    Topics: Aging; Animals; Biomarkers; Bone Marrow Cells; Cell Differentiation; Colony-Forming Units Assay; DNA

2020
5-Fluorouracil-treated planarians, a versatile model system for studying stem cell heterogeneity and tissue aging.
    Biology of the cell, 2020, Volume: 112, Issue:11

    Topics: Aging; Animals; Cell Differentiation; DNA Damage; Fluorouracil; Planarians; Stem Cells

2020
Age as a modifier of the effects of chemoradiotherapy with infusional 5-fluorouracil after D2 dissection in gastric cancer.
    Aging, 2021, 07-05, Volume: 13, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antimetabolites, Antineoplastic; Chemoradiotherapy, Adjuvant;

2021
CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.
    Stem cell reports, 2019, 08-13, Volume: 13, Issue:2

    Topics: Aging; Animals; Antigens, CD34; Bone Marrow Cells; Cell Cycle Checkpoints; Cell Proliferation; Cycli

2019
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
    Veterinary and comparative oncology, 2013, Volume: 11, Issue:4

    Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NA

2013
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.
    Nature, 2015, Feb-26, Volume: 518, Issue:7540

    Topics: Aging; Animals; Animals, Newborn; Bone Marrow Transplantation; Cell Lineage; Cell Proliferation; Cel

2015
The Influence of Aging on Hepatic Regeneration and Early Outcome after Portal Vein Occlusion: A Case-Control Study.
    Annals of surgical oncology, 2015, Volume: 22, Issue:12

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Antineoplastic Combined Chemotherapy Protocols;

2015
Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool.
    Stem cells (Dayton, Ohio), 2016, Volume: 34, Issue:9

    Topics: Aging; Animals; Cell Proliferation; Cells, Cultured; Cellular Microenvironment; Cellular Senescence;

2016
5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.
    Behavioural brain research, 2017, 01-01, Volume: 316

    Topics: Aging; Animals; Dendrites; Dendritic Spines; Fluorouracil; Hippocampus; Immunosuppressive Agents; Ma

2017
Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide.
    Clinical biochemistry, 2010, Volume: 43, Issue:16-17

    Topics: Aged; Aging; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cyclophosphamide; Doxorubicin; F

2010
Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment.
    Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:11

    Topics: Aging; Animals; Femur; Fluorouracil; Gene Expression; Male; Mast Cells; Mice; Regeneration; S Phase;

2012
CARCINOMA OF THE COLON IN ULCERATIVE COLITIS.
    Cancer, 1964, Volume: 17

    Topics: Aged; Aging; Cell Biology; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Fluorouracil; Humans; Me

1964
Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG).
    Annals of oncology : official journal of the European Society for Medical Oncology, 2004, Volume: 15, Issue:2

    Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan

2004
[Change of creatinine clearance rate in accordance with aging in Japanese patients with head and neck cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Antineoplastic Combined Chemotherapy Protocols; Carboplatin;

2006
Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:6

    Topics: Aging; Animals; Antimetabolites; B-Lymphocytes; Blood Cells; Bone Marrow Cells; Colony-Forming Units

2008
Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:12

    Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality The

1984
[Immunotherapy in the treatment of colorectal cancers in the aged].
    Minerva medica, 1982, Apr-28, Volume: 73, Issue:18

    Topics: Aged; Aging; BCG Vaccine; Carmustine; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Middle

1982
Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.
    Gut, 1982, Volume: 23, Issue:12

    Topics: Adult; Aged; Aging; Female; Fluorouracil; Gastric Mucosa; Gastrointestinal Neoplasms; Humans; Intest

1982
Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning.
    Investigative ophthalmology & visual science, 1995, Volume: 36, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Water; Child; Child, Preschool; Cryosurgery;

1995
Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) mice.
    Experimental hematology, 1994, Volume: 22, Issue:4

    Topics: Aging; Animals; Bone Marrow; Cell Separation; Fluorouracil; Hematopoiesis; Mice; Mice, Mutant Strain

1994
Sex- or age-related differences were not detected in the activity of dihydropyrimidine dehydrogenase from rat liver.
    Pharmacological research, 1997, Volume: 35, Issue:2

    Topics: Aging; Animals; Body Weight; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Liver; Male;

1997
Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation.
    The American journal of pathology, 1998, Volume: 152, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Blotting, Northern; Bone Marrow; Cells,

1998
Effects of early postoperative 5-fluorouracil and ageing on the healing capacity of experimental intestinal anastomoses.
    The British journal of surgery, 1998, Volume: 85, Issue:11

    Topics: Aging; Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Ileum;

1998
Longevity, stress response, and cancer in aging telomerase-deficient mice.
    Cell, 1999, Mar-05, Volume: 96, Issue:5

    Topics: Aging; Alopecia; Animals; Body Weight; Bone Marrow Diseases; Fluorouracil; Hair Color; Longevity; Mi

1999
Testing the protein error theory of ageing: a reply to Baird, Samis, Massie and Zimmerman.
    Gerontologia, 1975, Volume: 21, Issue:1

    Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Cross Reactions; Cycloheximide; Depression

1975
Influence of sex and age on fluorouracil clearance.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Carcinoma, Squamous Cell; Female; Fluor

1992
Carcinogenesis and aging. VIII. Effect of host age on tumour growth, metastatic potential, and chemotherapeutic sensitivity to 1.4-benzoquinone-guanylhydrazonethiosemicarbazone (ambazone) and 5-fluorouracil in mice and rats.
    Experimental pathology, 1988, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Aging; Animals; Antineoplastic Agents; Cell Division; Female; Fluorouracil; Leukemia

1988
[Chronobiological approach in the experimental development of regimens for the combined chemotherapy of tumors].
    Vestnik Akademii meditsinskikh nauk SSSR, 1986, Issue:5

    Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Chronobiology Phenomena; Circadian R

1986
Influence of age of host on the chemotherapy of murine myeloma LCP-1.
    Journal of gerontology, 1974, Volume: 29, Issue:4

    Topics: Age Factors; Aging; Alkylating Agents; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide;

1974
The use of topical 5-fluorouracil in actinic keratoses.
    Canadian Medical Association journal, 1971, Dec-18, Volume: 105, Issue:12

    Topics: Adult; Aged; Aging; Biopsy; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Middle Aged;

1971
The aging skin: problems and their causes.
    Geriatrics, 1970, Volume: 25, Issue:4

    Topics: Aged; Aging; Arsenicals; Balanitis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorou

1970
Errors in protein synthesis and clonal senescence in fungi.
    Nature, 1969, Mar-29, Volume: 221, Issue:5187

    Topics: Adenine; Aging; Ascomycota; Culture Media; Fluorouracil; Genetic Code; Genetics, Microbial; Mutation

1969