fluorouracil has been researched along with Aging in 40 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our results encourage the use of 5-fluorouracil-treated planarians as a model system for studying mechanisms of resistance to genotoxicants, planarian stem cell heterogeneity and molecular cascades of tissue aging." | 7.96 | 5-Fluorouracil-treated planarians, a versatile model system for studying stem cell heterogeneity and tissue aging. ( Gambino, G; Ippolito, C; Modeo, L; Rossi, L; Salvetti, A, 2020) |
| " This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients." | 7.76 | Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. ( Kasapović, J; Pajović, SB; Pejić, S; Radošević-Jelić, L; Saičić, ZS; Stojiljković, V; Todorović, A, 2010) |
| "5-Fluorouracil was given at 2/3 of the usual dose." | 5.27 | Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance. ( Gelman, RS; Taylor, SG, 1984) |
| " This work evaluated the potential age-related effect of chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide (FAC) on the level of lipid hydroperoxides (LP), glutathione (GSH), AO enzyme activities of copper, zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) in breast cancer patients." | 3.76 | Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide. ( Kasapović, J; Pajović, SB; Pejić, S; Radošević-Jelić, L; Saičić, ZS; Stojiljković, V; Todorović, A, 2010) |
| "Pancreatic cancer is the fourth leading cause of cancer death in the United States." | 2.45 | Medical management of pancreatic adenocarcinoma. ( Cunha, JE; Fernandes, Gdos S; Freitas, D; Hoff, PM, 2009) |
| "Most of the head and neck tumors are squamous cell carcinomas (SCCs), which are relatively sensitive to chemotherapeutic agents." | 1.33 | [Change of creatinine clearance rate in accordance with aging in Japanese patients with head and neck cancer]. ( Horiuchi, C; Kawakami, M; Kondo, N; Masuda, Y; Matsuda, H; Mikami, Y; Nagao, J; Nishimura, G; Taguchi, T; Tsukuda, M; Yabuki, K; Yoshida, T, 2006) |
| " Age and sex are among the host factors that have been implicated in the pharmacokinetic variability of drugs." | 1.28 | Influence of sex and age on fluorouracil clearance. ( Cassuto-Viguier, E; Demard, F; Etienne, MC; Frenay, M; Milano, G; Renee, N; Santini, J; Schneider, M; Thyss, A, 1992) |
| "5-Fluorouracil was given at 2/3 of the usual dose." | 1.27 | Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance. ( Gelman, RS; Taylor, SG, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (30.00) | 18.7374 |
| 1990's | 10 (25.00) | 18.2507 |
| 2000's | 5 (12.50) | 29.6817 |
| 2010's | 10 (25.00) | 24.3611 |
| 2020's | 3 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Saçma, M | 1 |
| Pospiech, J | 1 |
| Bogeska, R | 1 |
| de Back, W | 1 |
| Mallm, JP | 1 |
| Sakk, V | 1 |
| Soller, K | 1 |
| Marka, G | 1 |
| Vollmer, A | 1 |
| Karns, R | 1 |
| Cabezas-Wallscheid, N | 1 |
| Trumpp, A | 1 |
| Méndez-Ferrer, S | 1 |
| Milsom, MD | 1 |
| Mulaw, MA | 1 |
| Geiger, H | 1 |
| Florian, MC | 1 |
| Ganguly, R | 1 |
| Anand, S | 1 |
| Metkari, S | 1 |
| Bhartiya, D | 1 |
| Gambino, G | 1 |
| Ippolito, C | 1 |
| Modeo, L | 1 |
| Salvetti, A | 1 |
| Rossi, L | 1 |
| Wu, HC | 1 |
| Lin, WL | 1 |
| Lin, CL | 1 |
| Lin, CY | 1 |
| Chen, SW | 1 |
| Chen, YX | 1 |
| Chen, CH | 1 |
| Lee, SW | 1 |
| Chen, SH | 1 |
| Tsao, CJ | 1 |
| Huang, WT | 1 |
| Guo, HR | 1 |
| He, L | 1 |
| Beghi, F | 1 |
| Baral, V | 1 |
| Dépond, M | 1 |
| Zhang, Y | 1 |
| Joulin, V | 1 |
| Rueda, BR | 1 |
| Gonin, P | 1 |
| Foudi, A | 1 |
| Wittner, M | 1 |
| Louache, F | 1 |
| Saba, CF | 1 |
| Schmiedt, CW | 1 |
| Freeman, KG | 1 |
| Edwards, GL | 1 |
| Busch, K | 1 |
| Klapproth, K | 1 |
| Barile, M | 1 |
| Flossdorf, M | 1 |
| Holland-Letz, T | 1 |
| Schlenner, SM | 1 |
| Reth, M | 1 |
| Höfer, T | 1 |
| Rodewald, HR | 1 |
| Russolillo, N | 1 |
| Ratti, F | 1 |
| Viganò, L | 1 |
| Langella, S | 1 |
| Cipriani, F | 1 |
| Aldrighetti, L | 1 |
| Ferrero, A | 1 |
| Ruf, F | 1 |
| Schreck, C | 1 |
| Wagner, A | 1 |
| Grziwok, S | 1 |
| Pagel, C | 1 |
| Romero, S | 1 |
| Kieslinger, M | 1 |
| Shimono, A | 1 |
| Peschel, C | 1 |
| Götze, KS | 1 |
| Istvanffy, R | 1 |
| Oostendorp, RA | 1 |
| Groves, TR | 1 |
| Farris, R | 1 |
| Anderson, JE | 1 |
| Alexander, TC | 1 |
| Kiffer, F | 1 |
| Carter, G | 1 |
| Wang, J | 1 |
| Boerma, M | 1 |
| Allen, AR | 1 |
| Freitas, D | 1 |
| Fernandes, Gdos S | 1 |
| Hoff, PM | 1 |
| Cunha, JE | 1 |
| Pal, SK | 1 |
| Mortimer, J | 1 |
| Kasapović, J | 1 |
| Pejić, S | 1 |
| Stojiljković, V | 1 |
| Todorović, A | 1 |
| Radošević-Jelić, L | 1 |
| Saičić, ZS | 1 |
| Pajović, SB | 1 |
| Day, AC | 1 |
| Machin, D | 1 |
| Aung, T | 1 |
| Gazzard, G | 1 |
| Husain, R | 1 |
| Chew, PT | 1 |
| Khaw, PT | 1 |
| Seah, SK | 1 |
| Foster, PJ | 1 |
| Tsuboi, I | 2 |
| Harada, T | 2 |
| Hirabayashi, Y | 2 |
| Kanno, J | 2 |
| Inoue, T | 2 |
| Aizawa, S | 2 |
| GOLDGRABER, MB | 1 |
| KIRSNER, JB | 1 |
| Biganzoli, L | 1 |
| Goldhirsch, A | 1 |
| Straehle, C | 1 |
| Castiglione-Gertsch, M | 1 |
| Therasse, P | 1 |
| Aapro, M | 1 |
| Minisini, A | 1 |
| Piccart, MJ | 1 |
| Nishimura, G | 1 |
| Horiuchi, C | 1 |
| Yoshida, T | 1 |
| Kawakami, M | 1 |
| Yabuki, K | 1 |
| Taguchi, T | 1 |
| Nagao, J | 1 |
| Kondo, N | 1 |
| Masuda, Y | 1 |
| Matsuda, H | 1 |
| Mikami, Y | 1 |
| Tsukuda, M | 1 |
| Koshinaga, M | 1 |
| Kawamata, T | 1 |
| Carter, DM | 1 |
| Balin, AK | 1 |
| Gelman, RS | 1 |
| Taylor, SG | 1 |
| Navarra, S | 1 |
| Melita, P | 1 |
| Di Mauro, S | 1 |
| Higley, B | 1 |
| Oakes, J | 1 |
| De Mello, J | 1 |
| Giles, GR | 1 |
| Olsen, TW | 1 |
| Edelhauser, HF | 1 |
| Lim, JI | 1 |
| Geroski, DH | 1 |
| Nilsson, SK | 1 |
| Bertoncello, I | 1 |
| Tateishi, T | 1 |
| Watanabe, M | 1 |
| Nakura, H | 1 |
| Tanaka, M | 1 |
| Kumai, T | 1 |
| Kobayashi, S | 1 |
| Barnaby, JW | 1 |
| Styles, AR | 1 |
| Cockerell, CJ | 1 |
| Krenacs, T | 1 |
| Rosendaal, M | 1 |
| Sekine, I | 1 |
| Fukuda, H | 1 |
| Kunitoh, H | 1 |
| Saijo, N | 1 |
| Stoop, MJ | 1 |
| Dirksen, R | 1 |
| Wobbes, T | 1 |
| Hendriks, T | 1 |
| Rudolph, KL | 1 |
| Chang, S | 1 |
| Lee, HW | 1 |
| Blasco, M | 1 |
| Gottlieb, GJ | 1 |
| Greider, C | 1 |
| DePinho, RA | 1 |
| Holliday, R | 2 |
| Cascinu, S | 1 |
| Fedeli, A | 1 |
| Luzi Fedeli, S | 1 |
| Catalano, G | 1 |
| Milano, G | 1 |
| Etienne, MC | 1 |
| Cassuto-Viguier, E | 1 |
| Thyss, A | 1 |
| Santini, J | 1 |
| Frenay, M | 1 |
| Renee, N | 1 |
| Schneider, M | 1 |
| Demard, F | 1 |
| Baumgart, J | 1 |
| Zhukovskaya, NV | 1 |
| Anisimov, VN | 1 |
| Lesnaia, NA | 1 |
| Teller, MN | 1 |
| Bowie, M | 1 |
| Mountain, IM | 1 |
| Richards, RN | 1 |
| Spencer, SK | 1 |
| Kierland, RR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial of Adjuvant Chemotherapy With Standard Regimens, Cyclophosphamide, Methotrexate and Fluorouracil - (CMF) or Doxorubicin and Cyclophosphamide - (AC), Versus Capecitabine in Women 65 Years and Older With Node Positive or Node-Negative Bre[NCT00024102] | Phase 3 | 633 participants (Actual) | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The National Cancer Institute (NCI) Common Toxicity Criteria (CTC) Version 2.0 was used to evaluate toxicity.~Grade 1: Mild; Grade 2: Moderate; Grade 3: Severe; Grade 4: Life Threatening; Grade 5: Death." (NCT00024102)
Timeframe: Reported during protocol treatment after each cycle
| Intervention | participants (Number) |
|---|---|
| Standard Chemotherapy (CMF) | 92 |
| Standard Chemotherapy (AC) | 109 |
| Capecitabine | 101 |
Percentage of patients who were alive at 2.4 years. This rate was estimated using the Kaplan Meier method. (NCT00024102)
Timeframe: Time from registration to death (up to 15 years)
| Intervention | percentage of participants (Number) |
|---|---|
| Standard Chemotherapy | 93 |
| Capecitabine | 88 |
"Percentage of participants who were alive and relapse-free at time of analysis were counted as Alive without relapse at 2.4 years. Participants who had a first local recurrence, first distant metastasis or death from any cause were counted as relapse, first occurrence. These rates were estimated using the Kaplan Meier method" (NCT00024102)
Timeframe: randomization until date of first event, or date last known to be event free if no event was reported (up to 5 years)
| Intervention | percentage of participants (Number) | |
|---|---|---|
| Relapse, first occurrence | Alive without relapse | |
| Capecitabine | 20 | 80 |
| Standard Chemotherapy | 11 | 89 |
5 reviews available for fluorouracil and Aging
| Article | Year |
|---|---|
Medical management of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Agents; Black People; Capecitabine; Deoxycytidine; Diabe | 2009 |
Adjuvant chemotherapy for older adults with breast cancer: making the standard a standard.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Antibiotics, Antineoplastic; Antimetabolites, Antineopl | 2009 |
Dermatological aspects of aging.
Topics: Adult; Aged; Aging; Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatitis; Female; Fl | 1983 |
Actinic keratoses. Differential diagnosis and treatment.
Topics: Aging; Chemexfoliation; Combined Modality Therapy; Cryosurgery; Curettage; Dermabrasion; Diagnosis, | 1997 |
Cancer chemotherapy in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neo | 1998 |
2 trials available for fluorouracil and Aging
| Article | Year |
|---|---|
Central corneal thickness and glaucoma in East Asian people.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alkylating Agents; Asian People; Case-Control Studies; Cornea | 2011 |
Treatment of elderly advanced gastric cancer patients with 5-fluorouracil and leucovorin combination.
Topics: Adenocarcinoma; Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female | 1992 |
33 other studies available for fluorouracil and Aging
| Article | Year |
|---|---|
Haematopoietic stem cells in perisinusoidal niches are protected from ageing.
Topics: Aging; Animals; Bone Marrow; Capillaries; Cell Differentiation; Cell Division; Cell Polarity; Cell T | 2019 |
Effect of Aging and 5-Fluorouracil Treatment on Bone Marrow Stem Cell Dynamics.
Topics: Aging; Animals; Biomarkers; Bone Marrow Cells; Cell Differentiation; Colony-Forming Units Assay; DNA | 2020 |
5-Fluorouracil-treated planarians, a versatile model system for studying stem cell heterogeneity and tissue aging.
Topics: Aging; Animals; Cell Differentiation; DNA Damage; Fluorouracil; Planarians; Stem Cells | 2020 |
Age as a modifier of the effects of chemoradiotherapy with infusional 5-fluorouracil after D2 dissection in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Aging; Antimetabolites, Antineoplastic; Chemoradiotherapy, Adjuvant; | 2021 |
CABLES1 Deficiency Impairs Quiescence and Stress Responses of Hematopoietic Stem Cells in Intrinsic and Extrinsic Manners.
Topics: Aging; Animals; Antigens, CD34; Bone Marrow Cells; Cell Cycle Checkpoints; Cell Proliferation; Cycli | 2019 |
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NA | 2013 |
Fundamental properties of unperturbed haematopoiesis from stem cells in vivo.
Topics: Aging; Animals; Animals, Newborn; Bone Marrow Transplantation; Cell Lineage; Cell Proliferation; Cel | 2015 |
The Influence of Aging on Hepatic Regeneration and Early Outcome after Portal Vein Occlusion: A Case-Control Study.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Antineoplastic Combined Chemotherapy Protocols; | 2015 |
Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool.
Topics: Aging; Animals; Cell Proliferation; Cells, Cultured; Cellular Microenvironment; Cellular Senescence; | 2016 |
5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.
Topics: Aging; Animals; Dendrites; Dendritic Spines; Fluorouracil; Hippocampus; Immunosuppressive Agents; Ma | 2017 |
Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages after chemotherapy with 5-fluorouracil, doxorubicin and cyclophosphamide.
Topics: Aged; Aging; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cyclophosphamide; Doxorubicin; F | 2010 |
Age-related decline of mast cell regeneration in senescence-accelerated mice (SAMP1) after chemical myeloablation due to senescent stromal cell impairment.
Topics: Aging; Animals; Femur; Fluorouracil; Gene Expression; Male; Mast Cells; Mice; Regeneration; S Phase; | 2012 |
CARCINOMA OF THE COLON IN ULCERATIVE COLITIS.
Topics: Aged; Aging; Cell Biology; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Fluorouracil; Humans; Me | 1964 |
Adjuvant chemotherapy in elderly patients with breast cancer: a survey of the Breast International Group (BIG).
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvan | 2004 |
[Change of creatinine clearance rate in accordance with aging in Japanese patients with head and neck cancer].
Topics: Adult; Aged; Aged, 80 and over; Aging; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; | 2006 |
Role of hematopoietic microenvironment in prolonged impairment of B cell regeneration in age-related stromal-cell-impaired SAMP1 mouse: effects of a single dose of 5-fluorouracil.
Topics: Aging; Animals; Antimetabolites; B-Lymphocytes; Blood Cells; Bone Marrow Cells; Colony-Forming Units | 2008 |
Cyclophosphamide, methotrexate, and 5-fluorouracil chemotherapy in women more than 65 years old with advanced breast cancer: the elimination of age trends in toxicity by using doses based on creatinine clearance.
Topics: Aged; Aging; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality The | 1984 |
[Immunotherapy in the treatment of colorectal cancers in the aged].
Topics: Aged; Aging; BCG Vaccine; Carmustine; Colonic Neoplasms; Female; Fluorouracil; Humans; Male; Middle | 1982 |
Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.
Topics: Adult; Aged; Aging; Female; Fluorouracil; Gastric Mucosa; Gastrointestinal Neoplasms; Humans; Intest | 1982 |
Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Body Water; Child; Child, Preschool; Cryosurgery; | 1995 |
Age-related changes in extramedullary hematopoiesis in the spleen of normal and perturbed osteopetrotic (op/op) mice.
Topics: Aging; Animals; Bone Marrow; Cell Separation; Fluorouracil; Hematopoiesis; Mice; Mice, Mutant Strain | 1994 |
Sex- or age-related differences were not detected in the activity of dihydropyrimidine dehydrogenase from rat liver.
Topics: Aging; Animals; Body Weight; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Liver; Male; | 1997 |
Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; Blotting, Northern; Bone Marrow; Cells, | 1998 |
Effects of early postoperative 5-fluorouracil and ageing on the healing capacity of experimental intestinal anastomoses.
Topics: Aging; Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Ileum; | 1998 |
Longevity, stress response, and cancer in aging telomerase-deficient mice.
Topics: Aging; Alopecia; Animals; Body Weight; Bone Marrow Diseases; Fluorouracil; Hair Color; Longevity; Mi | 1999 |
Testing the protein error theory of ageing: a reply to Baird, Samis, Massie and Zimmerman.
Topics: Aging; Amino Acids; Amino Acyl-tRNA Synthetases; Animals; Cross Reactions; Cycloheximide; Depression | 1975 |
Influence of sex and age on fluorouracil clearance.
Topics: Adult; Aged; Aged, 80 and over; Aging; Analysis of Variance; Carcinoma, Squamous Cell; Female; Fluor | 1992 |
Carcinogenesis and aging. VIII. Effect of host age on tumour growth, metastatic potential, and chemotherapeutic sensitivity to 1.4-benzoquinone-guanylhydrazonethiosemicarbazone (ambazone) and 5-fluorouracil in mice and rats.
Topics: Adenocarcinoma; Aging; Animals; Antineoplastic Agents; Cell Division; Female; Fluorouracil; Leukemia | 1988 |
[Chronobiological approach in the experimental development of regimens for the combined chemotherapy of tumors].
Topics: Aging; Animals; Antineoplastic Combined Chemotherapy Protocols; Chronobiology Phenomena; Circadian R | 1986 |
Influence of age of host on the chemotherapy of murine myeloma LCP-1.
Topics: Age Factors; Aging; Alkylating Agents; Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; | 1974 |
The use of topical 5-fluorouracil in actinic keratoses.
Topics: Adult; Aged; Aging; Biopsy; Carcinoma, Squamous Cell; Fluorouracil; Humans; Keratosis; Middle Aged; | 1971 |
The aging skin: problems and their causes.
Topics: Aged; Aging; Arsenicals; Balanitis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Fluorou | 1970 |
Errors in protein synthesis and clonal senescence in fungi.
Topics: Adenine; Aging; Ascomycota; Culture Media; Fluorouracil; Genetic Code; Genetics, Microbial; Mutation | 1969 |