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fluorouracil and Age-Related Memory Disorders

fluorouracil has been researched along with Age-Related Memory Disorders in 7 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats."1.56Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. ( Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P, 2020)
"thioTEPA was found to yield a pronounced dose-related inhibition in cell proliferation, while 5-fluorouracil did not."1.33Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. ( Mignone, RG; Weber, ET, 2006)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's4 (57.14)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Sirichoat, A1
Suwannakot, K1
Chaisawang, P2
Pannangrong, W2
Aranarochana, A1
Wigmore, P2
Welbat, JU2
Winocur, G1
Wojtowicz, JM1
Tannock, IF1
Rendeiro, C1
Sheriff, A1
Bhattacharya, TK1
Gogola, JV1
Baxter, JH1
Chen, H1
Helferich, WG1
Roy, EJ1
Rhodes, JS1
ElBeltagy, M1
Mustafa, S1
Umka, J1
Lyons, L1
Salman, A1
Chur-yoe, GT1
Bhalla, N1
Bennett, G1
Wigmore, PM1
Mignone, RG1
Weber, ET1
Reiriz, AB1
Reolon, GK1
Preissler, T1
Rosado, JO1
Henriques, JA1
Roesler, R1
Schwartsmann, G1

Other Studies

7 other studies available for fluorouracil and Age-Related Memory Disorders

ArticleYear
Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats.
    Life sciences, 2020, May-01, Volume: 248

    Topics: Animals; Antimetabolites; Biomarkers; Cell Proliferation; Cognitive Dysfunction; Dentate Gyrus; Doub

2020
Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model.
    Nutrients, 2018, Aug-09, Volume: 10, Issue:8

    Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Behavior, Animal; Cell Cycle Checkpoints; Di

2018
Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis.
    Behavioural brain research, 2015, Mar-15, Volume: 281

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Discrimination Learning; Female; Fl

2015
Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer.
    Behavioural brain research, 2016, 12-15, Volume: 315

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Count; Cell Differentiation; Cell Proliferati

2016
Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.
    Behavioural brain research, 2010, Mar-17, Volume: 208, Issue:1

    Topics: Analysis of Variance; Animals; Cell Proliferation; Disease Models, Animal; Exploratory Behavior; Flu

2010
Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA.
    Brain research, 2006, Sep-21, Volume: 1111, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Ce

2006
Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-15, Volume: 12, Issue:16

    Topics: Animals; Cognition Disorders; Cyclophosphamide; Fluorouracil; Hippocampus; Male; Memory; Memory Diso

2006