fluorouracil has been researched along with Age-Related Memory Disorders in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "As melatonin has been shown to enhance memory and hippocampal neurogenesis in animal models, this research investigated the neuroprotective effects of melatonin against spatial memory and hippocampal neurogenesis impairment in 5-fluorouracil (5-FU)-treated rats." | 1.56 | Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. ( Aranarochana, A; Chaisawang, P; Pannangrong, W; Sirichoat, A; Suwannakot, K; Welbat, JU; Wigmore, P, 2020) |
| "thioTEPA was found to yield a pronounced dose-related inhibition in cell proliferation, while 5-fluorouracil did not." | 1.33 | Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA. ( Mignone, RG; Weber, ET, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Sirichoat, A | 1 |
| Suwannakot, K | 1 |
| Chaisawang, P | 2 |
| Pannangrong, W | 2 |
| Aranarochana, A | 1 |
| Wigmore, P | 2 |
| Welbat, JU | 2 |
| Winocur, G | 1 |
| Wojtowicz, JM | 1 |
| Tannock, IF | 1 |
| Rendeiro, C | 1 |
| Sheriff, A | 1 |
| Bhattacharya, TK | 1 |
| Gogola, JV | 1 |
| Baxter, JH | 1 |
| Chen, H | 1 |
| Helferich, WG | 1 |
| Roy, EJ | 1 |
| Rhodes, JS | 1 |
| ElBeltagy, M | 1 |
| Mustafa, S | 1 |
| Umka, J | 1 |
| Lyons, L | 1 |
| Salman, A | 1 |
| Chur-yoe, GT | 1 |
| Bhalla, N | 1 |
| Bennett, G | 1 |
| Wigmore, PM | 1 |
| Mignone, RG | 1 |
| Weber, ET | 1 |
| Reiriz, AB | 1 |
| Reolon, GK | 1 |
| Preissler, T | 1 |
| Rosado, JO | 1 |
| Henriques, JA | 1 |
| Roesler, R | 1 |
| Schwartsmann, G | 1 |
7 other studies available for fluorouracil and Age-Related Memory Disorders
| Article | Year |
|---|---|
Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats.
Topics: Animals; Antimetabolites; Biomarkers; Cell Proliferation; Cognitive Dysfunction; Dentate Gyrus; Doub | 2020 |
Neuroprotective Properties of Asiatic Acid against 5-Fluorouracil Chemotherapy in the Hippocampus in an Adult Rat Model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Behavior, Animal; Cell Cycle Checkpoints; Di | 2018 |
Memory loss in chemotherapy-treated rats is exacerbated in high-interference conditions and related to suppression of hippocampal neurogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Discrimination Learning; Female; Fl | 2015 |
Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Count; Cell Differentiation; Cell Proliferati | 2016 |
Fluoxetine improves the memory deficits caused by the chemotherapy agent 5-fluorouracil.
Topics: Analysis of Variance; Animals; Cell Proliferation; Disease Models, Animal; Exploratory Behavior; Flu | 2010 |
Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Blood-Brain Barrier; Ce | 2006 |
Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice.
Topics: Animals; Cognition Disorders; Cyclophosphamide; Fluorouracil; Hippocampus; Male; Memory; Memory Diso | 2006 |