fluorouracil has been researched along with Adrenocortical Carcinoma in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Adrenocortical Carcinoma: A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "No standard therapy for advanced adrenocortical carcinoma (ACC) is established by any randomized trial but a consensus conference 2003 recommended mitotane as monotherapy or combined with etoposide, doxorubicin and cisplatin or with streptozotocin as first-line systemic therapy." | 6.75 | Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma. ( Allolio, B; Fassnacht, M; Hahner, S; Johanssen, S; Kroiss, M; Quinkler, M; Ritter, C; Wortmann, S, 2010) |
| "No standard therapy for advanced adrenocortical carcinoma (ACC) is established by any randomized trial but a consensus conference 2003 recommended mitotane as monotherapy or combined with etoposide, doxorubicin and cisplatin or with streptozotocin as first-line systemic therapy." | 2.75 | Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma. ( Allolio, B; Fassnacht, M; Hahner, S; Johanssen, S; Kroiss, M; Quinkler, M; Ritter, C; Wortmann, S, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wortmann, S | 1 |
| Quinkler, M | 1 |
| Ritter, C | 1 |
| Kroiss, M | 1 |
| Johanssen, S | 1 |
| Hahner, S | 1 |
| Allolio, B | 1 |
| Fassnacht, M | 1 |
| Sperone, P | 1 |
| Ferrero, A | 1 |
| Daffara, F | 1 |
| Priola, A | 1 |
| Zaggia, B | 1 |
| Volante, M | 1 |
| Santini, D | 1 |
| Vincenzi, B | 1 |
| Badalamenti, G | 1 |
| Intrivici, C | 1 |
| Del Buono, S | 1 |
| De Francia, S | 1 |
| Kalomirakis, E | 1 |
| Ratti, R | 1 |
| Angeli, A | 1 |
| Dogliotti, L | 1 |
| Papotti, M | 1 |
| Terzolo, M | 1 |
| Berruti, A | 1 |
2 trials available for fluorouracil and Adrenocortical Carcinoma
| Article | Year |
|---|---|
Bevacizumab plus capecitabine as a salvage therapy in advanced adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Angiogenesis Inhibitors; Antibodies | 2010 |
Gemcitabine plus metronomic 5-fluorouracil or capecitabine as a second-/third-line chemotherapy in advanced adrenocortical carcinoma: a multicenter phase II study.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Antimetabolites, Antineoplastic; An | 2010 |