Page last updated: 2024-10-27

fluorouracil and Adrenal Cancer

fluorouracil has been researched along with Adrenal Cancer in 35 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"We examined the background, survival rates, median survival time and side effects of 15 cases in which systemic chemotherapy using carboplatin and 5-fluorouracil was done (chemotherapy group) and 59 cases in which chemotherapy was not done (non-chemotherapy group) out of a total of 74 cases of patients with extrahepatic metastasis from hepatocellular carcinoma."7.78Systemic chemotherapy using carboplatin and 5-fluorouracil for extrahepatic metastasis of hepatocellular carcinoma. ( Fukunaga, A; Hirano, G; Irie, M; Iwashita, H; Iwata, K; Kunimoto, H; Morihara, D; Sakamoto, M; Sakisaka, S; Sakurai, K; Shakado, S; Sohda, T; Takeyama, Y; Ueda, S; Yokoyama, K; Yotsumoto, K, 2012)
"A 53-year-old female patient was treated with combined radiochemotherapy with 5-fluorouracil (5-FU) because of adenocarcinoma of the lung."7.69[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?]. ( Härle, M; Jungius, KP; Maurer, U, 1996)
"Gemcitabine is an active antitumor agent in the treatment of advanced pancreatic cancer, and has shown potential synergistic activity with the oral fluoropyrimidine capecitabine in previous phase I/II trials."6.71Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial. ( Depisch, D; Haider, K; Kornek, GV; Kwasny, W; Lang, F; Raderer, M; Scheithauer, W; Schmid, K; Schneeweiss, B; Schüll, B; Ulrich-Pur, H, 2003)
"Two patients with metastatic pheochromocytoma received chemotherapy with 5-fluorouracil, cyclophosphamide, and streptozotocin."5.05Chemotherapy trials in malignant pheochromocytoma: report of two patients and review of the literature. ( Bukowski, RM; Vidt, DG, 1984)
"We examined the background, survival rates, median survival time and side effects of 15 cases in which systemic chemotherapy using carboplatin and 5-fluorouracil was done (chemotherapy group) and 59 cases in which chemotherapy was not done (non-chemotherapy group) out of a total of 74 cases of patients with extrahepatic metastasis from hepatocellular carcinoma."3.78Systemic chemotherapy using carboplatin and 5-fluorouracil for extrahepatic metastasis of hepatocellular carcinoma. ( Fukunaga, A; Hirano, G; Irie, M; Iwashita, H; Iwata, K; Kunimoto, H; Morihara, D; Sakamoto, M; Sakisaka, S; Sakurai, K; Shakado, S; Sohda, T; Takeyama, Y; Ueda, S; Yokoyama, K; Yotsumoto, K, 2012)
"A 53-year-old female patient was treated with combined radiochemotherapy with 5-fluorouracil (5-FU) because of adenocarcinoma of the lung."3.69[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?]. ( Härle, M; Jungius, KP; Maurer, U, 1996)
"In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission."3.65Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy. ( Ostuni, JA; Roginsky, MS, 1975)
"Gemcitabine is an active antitumor agent in the treatment of advanced pancreatic cancer, and has shown potential synergistic activity with the oral fluoropyrimidine capecitabine in previous phase I/II trials."2.71Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial. ( Depisch, D; Haider, K; Kornek, GV; Kwasny, W; Lang, F; Raderer, M; Scheithauer, W; Schmid, K; Schneeweiss, B; Schüll, B; Ulrich-Pur, H, 2003)
"Solitary adrenal metastasis of rectal cancer is comparatively rare condition and it is difficult to be diagnosed because it doesn't have any characteristic symptoms."2.52[A CASE OF SOLITARY ADRENAL TUMOR METASTASIZED FROM RECTAL CANCER]. ( Fukuda, H; Iida, S; Iizuka, J; Ikeda, T; Kondo, T; Omae, K; Takagi, T; Tanabe, K; Toda, N, 2015)
"Patients with malignancy may present with acute circulatory compromise requiring ICU monitoring and care."2.41Circulatory shock. ( Bogolioubov, A; Groeger, JS; Keefe, DL, 2001)
"Metastasis of colorectal cancer (CRC) in an adrenal gland develops in 1."1.42[Epinephros metastasis of colorectal cancer complicated by tumor thrombosis of inferior vena cava]. ( Andreĭtseva, OI; Gritsiuta, AI; Kalinin, DV; Kharazov, AF; Vishnevskiĭ, AV; Zhavoronkova, OI, 2015)
"Among them, 3 patients with bladder metastasis received intravesical chemotherapy of fluorouracil."1.40[Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis]. ( Feng, F; Ren, T; Wan, X; Wang, D; Xiang, Y; Yang, J, 2014)
"Sigmoidectomy was performed for sigmoid colon cancer in January 2002."1.36[A case of recurrent sigmoid colon cancer with adrenal and para-aortic lymph node metastasis successfully treated by operation and chemotherapy]. ( Doki, Y; Hirose, H; Ikeda, M; Kim, HM; Miyoshi, N; Mizushima, T; Mori, M; Okano, M; Sekimoto, M; Takemasa, I; Yamamoto, H; Yamashita, S, 2010)
"Patients with esophageal cancer often develop metastatic disease after esophageal resection and generally receive cisplatin-based chemotherapy or chemoradiotherapy."1.34Second-line combination chemotherapy with docetaxel for cisplatin-pretreated refractory metastatic esophageal cancer: a preliminary report of initial experience. ( Fujita, H; Mori, N; Nagano, T; Sasahara, H; Shirouzu, K; Sueyoshi, S; Tanaka, T; Tanaka, Y; Yamana, H, 2007)
"Treatment with metyrapone decreased her cortisol production and produced clinical remission of Cushing's syndrome."1.25The immunological hazard of Cushing's syndrome. ( Britton, S; Sjoberg, HE; Thorén, M, 1975)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19909 (25.71)18.7374
1990's5 (14.29)18.2507
2000's10 (28.57)29.6817
2010's11 (31.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
You, YN1
Shiozaki, H1
Lee, JE1
Passot, G1
Goumard, C1
Okuno, M1
Aloia, TA1
Eng, C1
Chang, G1
Vauthey, JN1
Conrad, C1
Murakami, K1
Takeno, A1
Masuzawa, T1
Tamura, S1
Kawai, K1
Sakamoto, T1
Inatome, J1
Naito, A1
Katsura, Y1
Ohmura, Y1
Kagawa, Y1
Egawa, C1
Takeda, Y1
Murata, K1
Lin, J1
Cao, Y1
Yu, L1
Lin, L1
Yang, J1
Ren, T1
Wang, D1
Feng, F1
Wan, X1
Xiang, Y1
Okano, M2
Yasui, M1
Nishino, M1
Hosoda, Y1
Nagai, K1
Kim, Y1
Tsujinaka, T1
Vishnevskiĭ, AV1
Andreĭtseva, OI1
Kharazov, AF1
Gritsiuta, AI1
Kalinin, DV1
Zhavoronkova, OI1
Ikeda, T1
Iida, S1
Toda, N1
Fukuda, H1
Omae, K1
Takagi, T1
Iizuka, J1
Kondo, T1
Tanabe, K1
Fernández Sarabia, MT1
Rodríguez García, JM1
Cardenal Escarcena, A1
Serrano Vicente, J1
García Bernardo, L1
Gutweiler, JR1
Yu, DC1
Kim, HB1
Kozakewich, HP1
Marcus, KJ1
Shamberger, RC1
Weldon, CB1
Bitik, B1
Kalpakci, Y1
Altan, E1
Dogan, E1
Altundag, K1
Bonfill, T1
Dotor, E1
Darnell, A1
Casalots, A1
Bombardó, J1
Saigí, E1
Pericay, C1
Nomura, M1
Sasano, H1
Okada, Y1
Watanabe, T1
Sakamoto, S1
Sakiyama, Y1
Sakamoto, R1
Abe, I1
Horiuchi, T1
Yanase, T1
Takayanagi, R1
Saito, H1
Shuto, K1
Ota, T1
Toma, T1
Ohira, G1
Natsume, T1
Uesato, M1
Akutsu, Y1
Kono, T1
Matsubara, H1
Kim, HM1
Ikeda, M1
Miyoshi, N1
Hirose, H1
Yamashita, S1
Takemasa, I1
Mizushima, T1
Yamamoto, H1
Sekimoto, M1
Doki, Y1
Mori, M1
Hirano, G1
Sakurai, K1
Sohda, T1
Kunimoto, H1
Yotsumoto, K1
Fukunaga, A1
Iwashita, H1
Ueda, S1
Yokoyama, K1
Morihara, D1
Takeyama, Y1
Sakamoto, M1
Irie, M1
Iwata, K1
Shakado, S1
Sakisaka, S1
Iqbal, MS1
Hardman, J1
Scheithauer, W1
Schüll, B1
Ulrich-Pur, H1
Schmid, K1
Raderer, M1
Haider, K1
Kwasny, W1
Depisch, D1
Schneeweiss, B1
Lang, F1
Kornek, GV1
Tanaka, T1
Fujita, H1
Sueyoshi, S1
Tanaka, Y1
Sasahara, H1
Mori, N1
Nagano, T1
Yamana, H1
Shirouzu, K1
Bukowski, RM1
Vidt, DG1
Habs, M1
Schmähl, D1
Lin, PZ1
Kattan, J1
Culine, S1
Theodore, C1
Droz, JP1
Okamoto, T1
Noguchi, Y1
Yoshikawa, T1
Nomura, K1
Fukuzawa, K1
Uranaka, Y1
Makino, T1
Tsuburaya, A1
Amano, T1
Matsumoto, A1
Maurer, U1
Härle, M1
Jungius, KP1
Bogolioubov, A1
Keefe, DL1
Groeger, JS1
Onishi, Y1
Yajima, Y1
Hayashi, C1
Sato, M1
Aoki, C1
Takahashi, N1
Miyazaki, A1
Eda, Y1
Ohira, S1
Oikawa, H1
Tsukioka, Y1
Matsumura, Y1
Hamaguchi, T1
Goto, M1
Muro, K1
Yamada, Y1
Shirao, K1
Visconti, EB1
Peters, RW1
Cangir, A1
Zorn, GL1
Fisher, S1
Britton, S1
Thorén, M1
Sjoberg, HE1
Ostuni, JA1
Roginsky, MS2
Chabner, BA1
Friedman, MA1
Srimuninnimit, V1
Wampler, GL1
Linder, GT1
Crook, JN1
Cohn, I1
Lokich, JJ1
Skarin, AT1
Schick, M2

Reviews

5 reviews available for fluorouracil and Adrenal Cancer

ArticleYear
Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review.
    Medicine, 2018, Volume: 97, Issue:39

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adrenal Glands; alpha-Fetoproteins; Antineoplastic Combined

2018
[A CASE OF SOLITARY ADRENAL TUMOR METASTASIZED FROM RECTAL CANCER].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 2015, Volume: 106, Issue:3

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Combined Chemotherapy P

2015
[A case of long-term survival after resection for postoperative solitary adrenal metastasis from esophageal adenocarcinoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antimetabolites, Antineoplastic; Antin

2010
Addisonian crisis secondary to bilateral adrenal metastases in rectal carcinoma: report of a rare case and literature review.
    Journal of gastrointestinal cancer, 2013, Volume: 44, Issue:2

    Topics: Addison Disease; Adenocarcinoma; Adrenal Gland Neoplasms; Antimetabolites, Antineoplastic; Capecitab

2013
Circulatory shock.
    Critical care clinics, 2001, Volume: 17, Issue:3

    Topics: Adrenal Gland Diseases; Adrenal Gland Neoplasms; Anthracyclines; Antineoplastic Agents; Carcinoid Tu

2001

Trials

3 trials available for fluorouracil and Adrenal Cancer

ArticleYear
Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2003, Volume: 14, Issue:1

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols

2003
Chemotherapy trials in malignant pheochromocytoma: report of two patients and review of the literature.
    Journal of surgical oncology, 1984, Volume: 27, Issue:2

    Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Clinical Trials as Topic; Cyclophosphamide; Drug The

1984
Phase II trial of ifosfamide, fluorouracil, and folinic acid (FIFO regimen) in relapsed and refractory urothelial cancer.
    Cancer investigation, 1995, Volume: 13, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms

1995

Other Studies

27 other studies available for fluorouracil and Adrenal Cancer

ArticleYear
Total Laparoscopic Management for Stage IV Colorectal Cancer Requiring Multivisceral Resection.
    Annals of surgical oncology, 2017, Volume: 24, Issue:9

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevaci

2017
[A Case of Metachronous Resection for Advanced Esophageal Cancer with Pheochromocytoma].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2017, Volume: 44, Issue:12

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel;

2017
[Analysis of the treatment and prognosis for gestational trophoblastic neoplasia patients with urinary system and adrenal glands metastasis].
    Zhonghua fu chan ke za zhi, 2014, Volume: 49, Issue:10

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Antineoplastic Combined Chemotherapy Protocols; China; Fema

2014
[A case report of the use of laparoscopic surgery to remove an adrenal tumor following resection of sigmoid colon cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:12

    Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy,

2014
[Epinephros metastasis of colorectal cancer complicated by tumor thrombosis of inferior vena cava].
    Khirurgiia, 2015, Issue:1

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Agents; Capecitabine; Colecto

2015
Adrenal metastasis of breast cancer with involvement of the inferior vena cava.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2008, Volume: 10, Issue:11

    Topics: Adrenal Gland Neoplasms; Adult; Anticoagulants; Antimetabolites, Antineoplastic; Antineoplastic Agen

2008
Hepatoblastoma presenting with focal nodular hyperplasia after treatment of neuroblastoma.
    Journal of pediatric surgery, 2008, Volume: 43, Issue:12

    Topics: Adrenal Gland Neoplasms; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplas

2008
Successful treatment of primary duodenal carcinoma with bilateral adrenal metastases with docetaxel-cisplatin-5-fluorouracil regimen.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:2

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Cisplatin;

2009
Synchronous isolated adrenal metastasis from rectum adenocarcinoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2009, Volume: 11, Issue:4

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Female; Flu

2009
Adrenal failure caused by a retroperitoneal malignant mesothelioma.
    Internal medicine (Tokyo, Japan), 2009, Volume: 48, Issue:24

    Topics: Adrenal Gland Neoplasms; Adrenal Insufficiency; Antineoplastic Combined Chemotherapy Protocols; Cisp

2009
[A case of recurrent sigmoid colon cancer with adrenal and para-aortic lymph node metastasis successfully treated by operation and chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2010, Volume: 37, Issue:12

    Topics: Adrenal Gland Neoplasms; Adrenalectomy; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies,

2010
Systemic chemotherapy using carboplatin and 5-fluorouracil for extrahepatic metastasis of hepatocellular carcinoma.
    Hepato-gastroenterology, 2012, Volume: 59, Issue:119

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Carbo

2012
Second-line combination chemotherapy with docetaxel for cisplatin-pretreated refractory metastatic esophageal cancer: a preliminary report of initial experience.
    Chemotherapy, 2007, Volume: 53, Issue:6

    Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Cispl

2007
Carcinogenic activity in rats of combined treatment with cyclophosphamide, methotrexate and 5-fluorouracil.
    International journal of cancer, 1981, Jul-15, Volume: 28, Issue:1

    Topics: Adrenal Gland Neoplasms; Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy,

1981
[Chemotherapy-induced thrombotic occlusion of mesenteric arteries--case report and review of the literature].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8

    Topics: Abdomen, Acute; Adrenal Gland Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisp

1994
[5-fluorouracil: cause of a fatal myocardial infarction in combined radiochemotherapy?].
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 1996, Volume: 172, Issue:5

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Antimetabolites, Antineoplastic; Fatal Outcome; Female; Flu

1996
[A case of advanced hepatocellular carcinoma (Vp3) with right adrenal gland metastasis successfully treated with repeated arterial infusion chemotherapy using low dose CDDP and 5-FU through an implanted reservoir].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2001, Volume: 98, Issue:9

    Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular;

2001
Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FU-resistant gastric cancer: a case report.
    Japanese journal of clinical oncology, 2001, Volume: 31, Issue:9

    Topics: Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy;

2001
Unusual case of adrenal cortical carcinoma in a female infant.
    Archives of disease in childhood, 1978, Volume: 53, Issue:4

    Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Cyclophosphamide; Dactinomycin; Female; Fluoroura

1978
The immunological hazard of Cushing's syndrome.
    British medical journal, 1975, Dec-20, Volume: 4, Issue:5998

    Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Cryptococcosis; Cushing Syndrome; Female; Fluorouracil; Hum

1975
Metastatic adrenal cortical carcinoma. Documented cure with combined chemotherapy.
    Archives of internal medicine, 1975, Volume: 135, Issue:9

    Topics: Adolescent; Adrenal Gland Neoplasms; Carcinoma; Drug Therapy, Combination; Female; Fluorouracil; Hum

1975
Progress against rare and not-so-rare cancers.
    The New England journal of medicine, 1992, Feb-20, Volume: 326, Issue:8

    Topics: Adenoma, Islet Cell; Adrenal Gland Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Carcin

1992
Case report of metastatic familial pheochromocytoma treated with cisplatin and 5-fluorouracil.
    Cancer chemotherapy and pharmacology, 1991, Volume: 28, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined

1991
Primary liver carcinoma.
    Cancer, 1974, Volume: 33, Issue:6

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biopsy; Bone Neoplasms; Carcinoma, Hepatocellular;

1974
Five-drug combination chemotherapy for disseminated adenocarcinoma.
    Cancer chemotherapy reports, 1972, Volume: 56, Issue:6

    Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Breast Neoplasms; Colonic Neoplasms; Cyclophosphamide; Drug

1972
Survival with adrenal carcinoma.
    JAMA, 1973, Jun-25, Volume: 224, Issue:13

    Topics: Adrenal Gland Neoplasms; Female; Fluorouracil; Humans; Mitotane; Neoplasm Metastasis

1973
Addison's disease following combined chemotherapy for hyperfunctioning adrenocortical carcinoma.
    Archives of internal medicine, 1966, Volume: 117, Issue:5

    Topics: Addison Disease; Adolescent; Adrenal Gland Neoplasms; Antineoplastic Agents; Dichlorodiphenyldichlor

1966