fluorouracil has been researched along with Adiadochokinesis in 13 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of capecitabine-associated cerebellar ataxia is presented." | 7.74 | Capecitabine-associated cerebellar ataxia. ( Kaufman, DA; Lam, MS; Russin, MP, 2008) |
| "A case of capecitabine-associated cerebellar ataxia is presented." | 3.74 | Capecitabine-associated cerebellar ataxia. ( Kaufman, DA; Lam, MS; Russin, MP, 2008) |
| "Capecitabine is an oral prodrug of 5-fluorouracil used in the treatment of adenocarcinoma of the colon." | 3.73 | Capecitabine-induced cerebellar toxicity. ( Gill, S; Renouf, D, 2006) |
| "The role of cisplatin and alcohol abuse in this neurotoxic episode, can not yet completely be excluded." | 1.29 | [Acute cerebellar syndrome after treatment with 5-fluorouracil]. ( Barbieux, C; Cerf, I; de Parades, V; Patri, B, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lam, MS | 1 |
| Kaufman, DA | 1 |
| Russin, MP | 1 |
| Sucker, C | 1 |
| Lambers, C | 1 |
| Stockschläder, M | 1 |
| Dölken, G | 1 |
| MOERTEL, CG | 1 |
| REITEMEIER, RJ | 1 |
| BOLTON, CF | 1 |
| SHORTER, RG | 1 |
| Renouf, D | 1 |
| Gill, S | 1 |
| Mukesh, M | 1 |
| Murray, P | 1 |
| Barbieux, C | 1 |
| Patri, B | 1 |
| Cerf, I | 1 |
| de Parades, V | 1 |
| Noguerón, E | 1 |
| Berrocal, A | 1 |
| Albert, A | 1 |
| Camps, C | 1 |
| Vicent, JM | 1 |
| Faris, M | 1 |
| Abraham, J | 1 |
| Barrett-Lee, P | 1 |
| Nichols, M | 1 |
| Bergevin, PR | 1 |
| Vyas, AC | 1 |
| Hamilin, R | 1 |
| Gottlieb, JA | 1 |
| Luce, JK | 1 |
| Boileau, G | 1 |
| Piro, AJ | 1 |
| Lahiri, SR | 1 |
| Hall, TC | 1 |
| Koenig, H | 2 |
| Patel, A | 2 |
1 review available for fluorouracil and Adiadochokinesis
| Article | Year |
|---|---|
[Neurotoxicity of 5-fluorouracil].
Topics: Antimetabolites, Antineoplastic; Cerebellar Ataxia; Fluorouracil; Humans; Leukoencephalopathy, Progr | 2002 |
12 other studies available for fluorouracil and Adiadochokinesis
| Article | Year |
|---|---|
Capecitabine-associated cerebellar ataxia.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Cerebellar Ataxia; Deoxycytidine; Female; Fluor | 2008 |
CEREBELLAR ATAXIA ASSOCIATED WITH FLUORINATED PYRIMIDINE THERAPY.
Topics: Ataxia; Cerebellar Ataxia; Cerebellar Diseases; Floxuridine; Fluorouracil; Gastrointestinal Neoplasm | 1964 |
Capecitabine-induced cerebellar toxicity.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Cecal Neoplasms; Cerebellar Ata | 2006 |
Cerebellar toxicity with capecitabine in a patient with metastatic breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cerebellar Ataxia; Deoxycytidine; Female; Flu | 2008 |
[Acute cerebellar syndrome after treatment with 5-fluorouracil].
Topics: Alcoholism; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cerebellar Ata | 1996 |
[Acute cerebellar syndrome due to 5-fluorouracil].
Topics: Acute Disease; Antimetabolites, Antineoplastic; Cerebellar Ataxia; Fluorouracil; Headache; Humans; M | 1997 |
A patient with breast cancer and paraneoplastic cerebellar syndrome associated with anti-Purkinje cell antibodies: response to CMF chemotherapy.
Topics: Adult; Antibodies; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplasti | 1998 |
Neurotoxicity from 5-fluorouracil (NSC-19893) administration reproduced by mitomycin C (NSC-26980).
Topics: Adenocarcinoma; Aged; Ataxia; Blood-Brain Barrier; Cerebellar Ataxia; Colonic Neoplasms; Fluorouraci | 1976 |
Cerebellar ataxia with weekly 5-fluorouracil administration.
Topics: Adenocarcinoma; Cerebellar Ataxia; Colonic Neoplasms; Female; Fluorouracil; Humans; Middle Aged; Neo | 1971 |
Cerebellar ataxia during 5-fluorouracil (NSC-19893) therapy.
Topics: Aged; Breast Neoplasms; Castration; Cerebellar Ataxia; Diagnosis, Differential; Female; Fluorouracil | 1971 |
Biochemical basis of the acute cerebellar syndrome in 5-fluorouracil chemotherapy.
Topics: Animals; Cats; Cerebellar Ataxia; Citrates; Fluorouracil; Kidney; Liver; Neuroglia | 1969 |
The acute cerebellar syndrome in 5-fluorouracil chemotherapy: a manifestation of fluoroacetate intoxication.
Topics: Alanine; Animals; Brain Chemistry; Cats; Cerebellar Ataxia; Citrates; Citric Acid Cycle; Fluoroaceta | 1970 |