fluorouracil has been researched along with Adhesions, Tissue in 28 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to improve the direct results of reconstructive surgery in patients operated on for complicated forms of colorectal cancer, by using 5-fluorouracil in the postoperative period." | 8.12 | The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer. ( Irimbetov, S; Osombaev, M; Zhakipbekov, S, 2022) |
| "To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits." | 7.72 | Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004) |
| "The aim of this study was to improve the direct results of reconstructive surgery in patients operated on for complicated forms of colorectal cancer, by using 5-fluorouracil in the postoperative period." | 4.12 | The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer. ( Irimbetov, S; Osombaev, M; Zhakipbekov, S, 2022) |
| "To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits." | 3.72 | Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits. ( Düzcan, E; Eşme, A; Ozden, S; Tatlipinar, S; Yaylali, V; Yildirim, C, 2004) |
| "The formation of adhesions and the leukocytosis on the anastomoses were significantly higher in the 2nd, 3rd and 4th group than in the 1st group (P < 0." | 1.37 | The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study. ( Despoudi, K; Kanellos, D; Koliakos, G; Lazaridis, H; Mantzoros, I; Pramateftakis, MG; Raptis, D; Zacharakis, E; Zaraboukas, T, 2011) |
| "Malondialdehyde levels were significantly higher in the 5-FU groups than in the 5-FU + AM groups." | 1.36 | Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing. ( Citgez, B; Ipcioglu, OM; Isgor, A; Kartal, A; Ozcan, O; Ozdilli, K; Polat, N; Torun, P; Uludag, M; Yetkin, G, 2010) |
| "The hydroxyproline levels were higher in the IGF-I and the IGF-I +5-FU groups as a result of the stimulating act of IGF-I." | 1.35 | Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment. ( Betsis, D; Demetriades, H; Kanellos, I; Koliakos, G; Lambrou, I; Pramateftakis, MG; Zacharakis, E; Zaraboukas, T, 2008) |
| "Capecitabine is a fluoropyrimidine carbamate with antineoplasmatic activity, recommended for the treatment of colorectal cancer." | 1.34 | The effect of capecitabine on the healing of colonic anastomoses in rats. ( Athanasiadou, ZS; Ballas, KD; Demertzidis, CI; Economou, LD; Konstantinidis, HD; Pissanidou, TT; Sakadamis, AK; Sioga, AC; Slavakis, AP, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Zhakipbekov, S | 1 |
| Osombaev, M | 1 |
| Irimbetov, S | 1 |
| Dinh, L | 1 |
| Hong, J | 1 |
| Min Kim, D | 1 |
| Lee, G | 1 |
| Jung Park, E | 1 |
| Hyuk Baik, S | 1 |
| Hwang, SJ | 1 |
| Fatemi, MJ | 1 |
| Shirani, S | 1 |
| Sobhani, R | 1 |
| Lebaschi, AH | 1 |
| Gharegozlou, MJ | 1 |
| Bagheri, T | 1 |
| Pedram, M | 1 |
| Saberi, M | 1 |
| Araghi, S | 1 |
| Fatemi, MA | 1 |
| Sabino, FD | 1 |
| Campos, CF | 1 |
| Caetano, CE | 1 |
| Trotte, MN | 1 |
| Oliveira, AV | 1 |
| Marques, RG | 1 |
| Duci, SB | 1 |
| Arifi, HM | 1 |
| Ahmeti, HR | 1 |
| Manxhuka-Kerliu, S | 1 |
| Neziri, B | 1 |
| Mekaj, AY | 1 |
| Lajqi, S | 1 |
| Shahini, L | 1 |
| Guo, M | 2 |
| Zhang, J | 2 |
| Tian, D | 2 |
| Zhang, Y | 1 |
| Peng, X | 1 |
| Wang, Z | 1 |
| Wu, J | 1 |
| Duan, Y | 1 |
| Dou, Z | 1 |
| Wang, C | 1 |
| Uludag, M | 1 |
| Ozdilli, K | 1 |
| Citgez, B | 1 |
| Yetkin, G | 1 |
| Ipcioglu, OM | 1 |
| Ozcan, O | 1 |
| Polat, N | 1 |
| Kartal, A | 1 |
| Torun, P | 1 |
| Isgor, A | 1 |
| Zhao, C | 1 |
| Zobitz, ME | 1 |
| Sun, YL | 1 |
| Predmore, KS | 1 |
| Amadio, PC | 1 |
| An, KN | 1 |
| Moran, SL | 2 |
| Sheng, J | 1 |
| Zeng, B | 1 |
| Jiang, P | 1 |
| Fan, C | 1 |
| Pramateftakis, MG | 4 |
| Kanellos, D | 2 |
| Mantzoros, I | 3 |
| Despoudi, K | 2 |
| Raptis, D | 2 |
| Angelopoulos, S | 1 |
| Koliakos, G | 4 |
| Zaraboukas, T | 4 |
| Lazaridis, C | 1 |
| Zacharakis, E | 3 |
| Lazaridis, H | 1 |
| McGonagle, L | 1 |
| Jones, MD | 1 |
| Dowson, D | 1 |
| Theobald, PS | 1 |
| Karaaltin, MV | 1 |
| Ozalp, B | 1 |
| Dadaci, M | 1 |
| Kayikcioglu, A | 1 |
| Kecik, A | 1 |
| Oner, F | 1 |
| Eşme, A | 1 |
| Yildirim, C | 1 |
| Tatlipinar, S | 1 |
| Düzcan, E | 1 |
| Yaylali, V | 1 |
| Ozden, S | 1 |
| Konstantinidis, HD | 1 |
| Slavakis, AP | 1 |
| Ballas, KD | 1 |
| Sioga, AC | 1 |
| Economou, LD | 1 |
| Demertzidis, CI | 1 |
| Pissanidou, TT | 1 |
| Athanasiadou, ZS | 1 |
| Sakadamis, AK | 1 |
| Vasiliadis, K | 1 |
| Blouhos, K | 1 |
| Kanellos, I | 2 |
| Demetriades, H | 2 |
| Alamdari, DH | 1 |
| Betsis, D | 2 |
| Lambrou, I | 1 |
| Sun, Y | 1 |
| Wang, LX | 1 |
| Wang, L | 1 |
| Sun, SX | 1 |
| Cao, XJ | 1 |
| Wang, P | 1 |
| Feng, L | 1 |
| Goldman, LI | 1 |
| Rosemond, GP | 1 |
| Kuzu, MA | 1 |
| Köksoy, C | 1 |
| Kale, T | 1 |
| Demirpençe, E | 1 |
| Renda, N | 1 |
| Akali, A | 3 |
| Khan, U | 2 |
| Khaw, PT | 1 |
| McGrouther, AD | 1 |
| Hwang, JM | 1 |
| Chang, BL | 1 |
| Ryan, CK | 1 |
| Orlando, GS | 1 |
| Pratt, CE | 1 |
| Michalko, KB | 1 |
| Kakar, S | 1 |
| Bentley, G | 1 |
| McGrouther, DA | 2 |
| Cerovac, S | 1 |
| Afoke, A | 1 |
| El-Malt, M | 1 |
| Ceelen, W | 1 |
| De Meerleer, G | 1 |
| Verstraete, A | 1 |
| Boterberg, T | 1 |
| Van Belle, S | 1 |
| de Hemptinne, B | 1 |
| De Neve, W | 1 |
| Pattyn, P | 1 |
| Doe, EA | 1 |
| Budenz, DL | 1 |
| Gedde, SJ | 1 |
| Imami, NR | 1 |
1 trial available for fluorouracil and Adhesions, Tissue
| Article | Year |
|---|---|
[Effects of 5-fluorouracil on tendon adhesion formation after flexor tendon repair].
Topics: Adult; Female; Finger Injuries; Fluorouracil; Humans; Male; Plastic Surgery Procedures; Tendon Injur | 2008 |
27 other studies available for fluorouracil and Adhesions, Tissue
| Article | Year |
|---|---|
The Effect of 5-Fluorouracil on the Adhesion Process in Patients Operated on for Colorectal Cancer.
Topics: Colorectal Neoplasms; Fluorouracil; Humans; Postoperative Complications; Quality of Life; Tissue Adh | 2022 |
A novel thermosensitive poloxamer-hyaluronic acid- kappa-carrageenan-based hydrogel anti-adhesive agent loaded with 5-fluorouracil: A preclinical study in Sprague-Dawley rats.
Topics: Animals; Carrageenan; Fluorouracil; Hyaluronic Acid; Hydrogels; Poloxamer; Rats; Rats, Sprague-Dawle | 2022 |
Prevention of Peritendinous Adhesion Formation After the Flexor Tendon Surgery in Rabbits: A Comparative Study Between Use of Local Interferon-α, Interferon-β, and 5-Fluorouracil.
Topics: Animals; Anti-Inflammatory Agents; Biomechanical Phenomena; Fluorouracil; Interferon-alpha; Interfer | 2018 |
Effects of TachoSil and 5-fluorouracil on colonic anastomotic healing.
Topics: Anastomosis, Surgical; Animals; Antimetabolites; Colon; Colorectal Neoplasms; Drug Combinations; Fib | 2014 |
Biomechanical and Macroscopic Evaluations of the Effects of 5-Fluorouracil on Partially Divided Flexor Tendon Injuries in Rabbits.
Topics: Animals; Fluorouracil; Male; Rabbits; Tendon Injuries; Tendons; Tissue Adhesions; Wound Healing | 2015 |
Covering the colon anastomoses with amniotic membrane prevents the negative effects of early intraperitoneal 5-FU administration on anastomotic healing.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Biological Dressings; Body Weight; | 2010 |
Surface treatment with 5-fluorouracil after flexor tendon repair in a canine in vivo model.
Topics: Administration, Topical; Animals; Antimetabolites; Dogs; Fluorouracil; Musculoskeletal Diseases; Ten | 2009 |
[Effect of local basic fibroblast growth factor and 5-fluorouracil on accelerating healing and preventing tendon adhesion after flexor tendon repair].
Topics: Animals; Biomechanical Phenomena; Chickens; Fibrin Tissue Adhesive; Fibroblast Growth Factor 2; Fluo | 2011 |
Intraperitoneally administered irinotecan with 5-fluorouracil impair wound healing of colonic anastomoses in a rat model: an experimental study.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Antimetabolites, Antineoplastic; Antineoplastic Ag | 2011 |
The effects of the intraperitoneal administration of oxaliplatin and 5-FU on the healing of colonic anastomoses: an experimental study.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colon; Fluor | 2011 |
The bio-tribological properties of anti-adhesive agents commonly used during tendon repair.
Topics: Animals; Carbohydrates; Cattle; Fluorouracil; Hyaluronic Acid; Polymers; Sodium Chloride; Synovial F | 2012 |
The effects of 5-fluorouracil on flexor tendon healing by using a biodegradable gelatin, slow releasing system: experimental study in a hen model.
Topics: Absorbable Implants; Animals; Antimetabolites, Antineoplastic; Casts, Surgical; Chickens; Delayed-Ac | 2013 |
Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits.
Topics: Animals; Cicatrix; Connective Tissue Diseases; Fluorouracil; Intraoperative Care; Mitomycin; Oculomo | 2004 |
The effect of capecitabine on the healing of colonic anastomoses in rats.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Capecitabine; Colon; Deoxycytidine; | 2007 |
Effect of iloprost on impaired anastomotic healing caused by 5-fluorouracil plus leucovorin.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Collagen; Colon; Female; Fibroblast | 2007 |
Effect of IGF-I on healing of colonic anastomoses in rats under 5-FU treatment.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Collagen; Colon; Colonic Neoplasms; | 2008 |
[An effect of 5-fluorouracil on tendon adhesion formation after flexor tendon repair in chickens].
Topics: Administration, Topical; Animals; Biomechanical Phenomena; Chickens; Fluorouracil; Male; Postoperati | 2007 |
A comparison of the effectiveness of mitomycin C and 5-fluorouracil in the prevention of peridural adhesion after laminectomy.
Topics: Animals; Antimetabolites, Antineoplastic; Dura Mater; Fluorouracil; Laminectomy; Lumbar Vertebrae; M | 2007 |
5-Fluorouracil inhibition of experimental peritoneal adhesions.
Topics: Animals; Fluorouracil; Peritoneal Diseases; Rats; Tissue Adhesions | 1967 |
Experimental study of the effect of preoperative 5-fluorouracil on the integrity of colonic anastomoses.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Colon; Fluorouracil; Hemoglobins; M | 1998 |
Decrease in adhesion formation by a single application of 5-fluorouracil after flexor tendon injury.
Topics: Animals; Antimetabolites; Fluorouracil; Foot; Hindlimb; Male; Postoperative Complications; Rabbits; | 1999 |
Combined effect of Interceed and 5-fluorouracil on delayed adjustable strabismus surgery.
Topics: Adaptation, Physiological; Animals; Antimetabolites; Cellulose, Oxidized; Chondroitin; Chondroitin S | 1999 |
Effects of 5-fluorouracil on flexor tendon repair.
Topics: Administration, Topical; Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Biomechanic | 2000 |
Modulation of the formation of adhesions during the healing of injured tendons.
Topics: Animals; Cell Count; Disease Models, Animal; Fibroblasts; Fluorouracil; Hindlimb; Immunosuppressive | 2000 |
Early breaking strength of repaired flexor tendon treated with 5-fluorouracil.
Topics: Animals; Fluorouracil; Male; Rabbits; Sutures; Tendon Injuries; Tensile Strength; Tissue Adhesions; | 2001 |
Influence of preoperative combined radiochemotherapy on surgical outcome and colonic anastomotic healing: experimental study in the rat.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Blood Cell Count; Colon; Combined M | 2001 |
Long-term surgical outcomes of patients with glaucoma secondary to the iridocorneal endothelial syndrome.
Topics: Adult; Antihypertensive Agents; Corneal Diseases; Endothelium, Corneal; Fluorouracil; Follow-Up Stud | 2001 |