fluorouracil has been researched along with Adenoma, Prolactin-Secreting, Pituitary in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Uptake and metabolism of 5FU in both tumour models with or without host carbogen breathing was studied non-invasively using fluorine-19 magnetic resonance spectroscopy ((19)F-MRS), while plasma samples from Buffalo rats were used to construct a NONMEM pharmacokinetic model." | 1.33 | Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours. ( Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Peters, GJ; Port, RE; Robinson, SP; Rodrigues, LM; Stubbs, M; van der Borns, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lundgren, JA | 1 |
| Oldfield, EH | 1 |
| Marshall, JC | 1 |
| McSheehy, PM | 1 |
| Port, RE | 1 |
| Rodrigues, LM | 1 |
| Robinson, SP | 1 |
| Stubbs, M | 1 |
| van der Borns, K | 1 |
| Peters, GJ | 1 |
| Judson, IR | 1 |
| Leach, MO | 1 |
| Griffiths, JR | 1 |
2 other studies available for fluorouracil and Adenoma, Prolactin-Secreting, Pituitary
| Article | Year |
|---|---|
The longest stalk: preserved pituitary function after regression of a giant prolactinoma.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Fluorouracil; Humans; M | 2017 |
Investigations in vivo of the effects of carbogen breathing on 5-fluorouracil pharmacokinetics and physiology of solid rodent tumours.
Topics: Animals; Carbon Dioxide; Fluorouracil; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscop | 2005 |