fluorouracil has been researched along with Adenocarcinoma of Lung in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Adenocarcinoma of Lung: A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study is to investigate the efficacy and tolerability of erlotinib plus capecitabine as first-line treatment in older Chinese patients (≥ 65 years) with lung adenocarcinoma." | 9.20 | Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study. ( Chen, GY; Cheng, Y; Feng, JF; Gu, CP; Huang, Y; Li, XL; Ma, LX; Shi, MQ; Song, XQ; Zhang, L; Zhang, YP; Zhao, HY; Zhou, D, 2015) |
| " Thus, this study was aimed to investigate the potential cytotoxic, antiproliferative and apoptosis-triggering effects of a newly developed SLN-Carmofur compound on human lung adenocarcinoma A549 cells." | 8.02 | Toward stimulating apoptosis in human lung adenocarcinoma cells by novel nano-carmofur compound treatment. ( Çömlekçi, E; Kutlu, HM; Vejselova Sezer, C, 2021) |
| " We reported an advanced lung adenocarcinoma female patient, who developed a Grade 3 HFS after a third-line treatment with apatinib of 250 mg for 10 days, the patient developed intolerable pain with pruritus." | 7.96 | Apatinib-induced Grade 3 hand-foot syndrome in advanced lung adenocarcinoma successful treated with thalidomide: A case report. ( Du, LY; Jia, YM; Lei, KJ; Li, T; Qiu, Y; Ren, Y; Wang, SB, 2020) |
| "When we examine a patient with symptoms of acute enteritis in the course of chemotherapy with oral fluoropyrimidines such as uracil-tegafur (often referred to as UFT), we usually suspect 5-fluorouracil-induced enterocolitis." | 7.83 | Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur. ( Abe, N; Fujinaga, A; Hayashi, H; Hirata, K; Ito, K; Komatsu, Y; Matsuda, K; Uchida, T, 2016) |
| "To assess whether early lung cancer prediction might be informed by an mRNA assay for 5-fluorouracil pathway genes in peripheral blood mononuclear cells (PBMNCs), we examined specimens taken from 51 adenocarcinoma patients and 38 controls (including six patients with benign tumors)." | 7.77 | A pilot study of mRNA expressions of 5-fluorouracil pathway genes in peripheral blood mononuclear cells and tumor tissues in patients with lung adenocarcinoma. ( Aida, S; Fujita, Y; Hasegawa, S; Hiroi, S; Kawai, T; Mio, T; Nakanishi, K; Ogata, S; Ozeki, Y; Takeuchi, K; Tanaka, F; Tominaga, S; Wada, H, 2011) |
| "Ginsenoside Rg3 (Rg3) has a strong anticancer influence on colon cancer, breast cancer, lung cancer, and other malignant tumors." | 5.72 | Examination of Combined Treatment of Ginsenoside Rg3 and 5-Fluorouracil in Lung Adenocarcinoma Cells. ( Deng, Y; Du, Z; Shan, K; Yang, S; Yue, P, 2022) |
| " This study is to investigate the efficacy and tolerability of erlotinib plus capecitabine as first-line treatment in older Chinese patients (≥ 65 years) with lung adenocarcinoma." | 5.20 | Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study. ( Chen, GY; Cheng, Y; Feng, JF; Gu, CP; Huang, Y; Li, XL; Ma, LX; Shi, MQ; Song, XQ; Zhang, L; Zhang, YP; Zhao, HY; Zhou, D, 2015) |
| " Thus, this study was aimed to investigate the potential cytotoxic, antiproliferative and apoptosis-triggering effects of a newly developed SLN-Carmofur compound on human lung adenocarcinoma A549 cells." | 4.02 | Toward stimulating apoptosis in human lung adenocarcinoma cells by novel nano-carmofur compound treatment. ( Çömlekçi, E; Kutlu, HM; Vejselova Sezer, C, 2021) |
| " We reported an advanced lung adenocarcinoma female patient, who developed a Grade 3 HFS after a third-line treatment with apatinib of 250 mg for 10 days, the patient developed intolerable pain with pruritus." | 3.96 | Apatinib-induced Grade 3 hand-foot syndrome in advanced lung adenocarcinoma successful treated with thalidomide: A case report. ( Du, LY; Jia, YM; Lei, KJ; Li, T; Qiu, Y; Ren, Y; Wang, SB, 2020) |
| "When we examine a patient with symptoms of acute enteritis in the course of chemotherapy with oral fluoropyrimidines such as uracil-tegafur (often referred to as UFT), we usually suspect 5-fluorouracil-induced enterocolitis." | 3.83 | Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur. ( Abe, N; Fujinaga, A; Hayashi, H; Hirata, K; Ito, K; Komatsu, Y; Matsuda, K; Uchida, T, 2016) |
| "To assess whether early lung cancer prediction might be informed by an mRNA assay for 5-fluorouracil pathway genes in peripheral blood mononuclear cells (PBMNCs), we examined specimens taken from 51 adenocarcinoma patients and 38 controls (including six patients with benign tumors)." | 3.77 | A pilot study of mRNA expressions of 5-fluorouracil pathway genes in peripheral blood mononuclear cells and tumor tissues in patients with lung adenocarcinoma. ( Aida, S; Fujita, Y; Hasegawa, S; Hiroi, S; Kawai, T; Mio, T; Nakanishi, K; Ogata, S; Ozeki, Y; Takeuchi, K; Tanaka, F; Tominaga, S; Wada, H, 2011) |
| "Ginsenoside Rg3 (Rg3) has a strong anticancer influence on colon cancer, breast cancer, lung cancer, and other malignant tumors." | 1.72 | Examination of Combined Treatment of Ginsenoside Rg3 and 5-Fluorouracil in Lung Adenocarcinoma Cells. ( Deng, Y; Du, Z; Shan, K; Yang, S; Yue, P, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Mao, G | 1 |
| Mu, Z | 1 |
| Wu, DA | 1 |
| Shan, K | 1 |
| Deng, Y | 1 |
| Du, Z | 1 |
| Yue, P | 1 |
| Yang, S | 1 |
| Ren, Y | 1 |
| Li, T | 1 |
| Du, LY | 1 |
| Qiu, Y | 1 |
| Wang, SB | 1 |
| Lei, KJ | 1 |
| Jia, YM | 1 |
| Takahashi, K | 1 |
| Tanabe, R | 1 |
| Ehata, S | 1 |
| Kubota, SI | 1 |
| Morishita, Y | 1 |
| Ueda, HR | 1 |
| Miyazono, K | 1 |
| Çömlekçi, E | 1 |
| Kutlu, HM | 1 |
| Vejselova Sezer, C | 1 |
| Callebout, E | 1 |
| Ribeiro, SM | 1 |
| Laurent, S | 1 |
| De Man, M | 1 |
| Ferdinande, L | 1 |
| Claes, KBM | 1 |
| Van der Meulen, J | 1 |
| Geboes, KP | 1 |
| Benitez, JC | 1 |
| Mezquita, L | 1 |
| Colle, R | 1 |
| Tselikas, L | 1 |
| Botticella, A | 1 |
| Caramella, C | 1 |
| Besse, B | 1 |
| Izumi, H | 1 |
| Touge, H | 1 |
| Igishi, T | 1 |
| Makino, H | 1 |
| Nishii-Ito, S | 1 |
| Takata, M | 1 |
| Nakazaki, H | 1 |
| Ueda, Y | 1 |
| Matsumoto, S | 1 |
| Kodani, M | 1 |
| Kurai, J | 1 |
| Takeda, K | 1 |
| Sakamoto, T | 1 |
| Yanai, M | 1 |
| Tanaka, N | 1 |
| Nirodi, CS | 1 |
| Shimizu, E | 1 |
| Zhao, HY | 1 |
| Chen, GY | 1 |
| Huang, Y | 1 |
| Li, XL | 1 |
| Feng, JF | 1 |
| Shi, MQ | 1 |
| Cheng, Y | 1 |
| Ma, LX | 1 |
| Zhang, YP | 1 |
| Gu, CP | 1 |
| Song, XQ | 1 |
| Zhou, D | 1 |
| Zhang, L | 1 |
| Tseng, CL | 1 |
| Chen, JC | 1 |
| Wu, YC | 1 |
| Fang, HW | 1 |
| Lin, FH | 1 |
| Tang, TP | 1 |
| Hayashi, H | 1 |
| Komatsu, Y | 1 |
| Uchida, T | 1 |
| Abe, N | 1 |
| Ito, K | 1 |
| Hirata, K | 1 |
| Matsuda, K | 1 |
| Fujinaga, A | 1 |
| Nazim, UM | 1 |
| Rasheduzzaman, M | 1 |
| Lee, YJ | 1 |
| Seol, DW | 1 |
| Park, SY | 1 |
| Ogata, S | 1 |
| Ozeki, Y | 1 |
| Nakanishi, K | 1 |
| Fujita, Y | 1 |
| Tanaka, F | 1 |
| Hasegawa, S | 1 |
| Mio, T | 1 |
| Wada, H | 1 |
| Hiroi, S | 1 |
| Tominaga, S | 1 |
| Aida, S | 1 |
| Takeuchi, K | 1 |
| Kawai, T | 1 |
| Xie, T | 1 |
| Li, L | 1 |
| Li, DR | 1 |
| Mao, NQ | 1 |
| Liu, DS | 1 |
| Zuo, CT | 1 |
| Zhang, W | 1 |
| Huang, DM | 1 |
| Zhang, D | 1 |
| Ochi, N | 1 |
| Takigawa, N | 1 |
| Tanimoto, Y | 1 |
| Chen, Y | 1 |
| Ichihara, E | 1 |
| Hotta, K | 1 |
| Tabata, M | 1 |
| Tanimoto, M | 1 |
| Kiura, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Erlotinib in Combination With Capecitabine as First-line Treatment in Elderly Patients With Stage IIIB/IV Adenocarcinoma Non-small Cell Lung Cancer (NSCLC)[NCT00816868] | Phase 2 | 62 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for fluorouracil and Adenocarcinoma of Lung
| Article | Year |
|---|---|
Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chem | 2015 |
Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Agents; Biomarkers; Capecitabine; China | 2015 |
13 other studies available for fluorouracil and Adenocarcinoma of Lung
| Article | Year |
|---|---|
Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance.
Topics: A549 Cells; Adenocarcinoma of Lung; Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell | 2021 |
Examination of Combined Treatment of Ginsenoside Rg3 and 5-Fluorouracil in Lung Adenocarcinoma Cells.
Topics: Adenocarcinoma of Lung; Cell Line, Tumor; Fluorouracil; Ginsenosides; Humans; Lung Neoplasms | 2022 |
Apatinib-induced Grade 3 hand-foot syndrome in advanced lung adenocarcinoma successful treated with thalidomide: A case report.
Topics: Adenocarcinoma of Lung; Female; Fluorouracil; Hand-Foot Syndrome; Humans; Lung Neoplasms; Pyridines; | 2020 |
Visualization of the cancer cell cycle by tissue-clearing technology using the Fucci reporter system.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cell | 2021 |
Toward stimulating apoptosis in human lung adenocarcinoma cells by novel nano-carmofur compound treatment.
Topics: A549 Cells; Adenocarcinoma of Lung; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Fluorour | 2021 |
Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report.
Topics: Adenocarcinoma of Lung; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bevac | 2019 |
Hepatic Intra-Arterial Chemotherapy With Immunotherapy in NSCLC.
Topics: Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lu | 2019 |
Development of lattice-inserted 5-Fluorouracil-hydroxyapatite nanoparticles as a chemotherapeutic delivery system.
Topics: 3T3 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antimetabolites, Antineoplastic; Cell Li | 2015 |
Cytomegalovirus colitis in a patient undergoing postoperative adjuvant chemotherapy for lung adenocarcinoma with uracil-tegafur.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemot | 2016 |
Enhancement of TRAIL-induced apoptosis by 5-fluorouracil requires activating Bax and p53 pathways in TRAIL-resistant lung cancers.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; b | 2017 |
A pilot study of mRNA expressions of 5-fluorouracil pathway genes in peripheral blood mononuclear cells and tumor tissues in patients with lung adenocarcinoma.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Aged; Aged, 80 and over; Dihydrouracil Dehydrogenase (NADP); | 2011 |
[Isolation and identification of side population cells in human lung adenocarcinoma cell line A549].
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; ATP-Binding Cassette Transporters; Cell Cycle; Cell | 2011 |
Establishment of pemetrexed-resistant non-small cell lung cancer cell lines.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Ce | 2011 |