Page last updated: 2024-10-27

fluorouracil and Acute Myelogenous Leukemia

fluorouracil has been researched along with Acute Myelogenous Leukemia in 44 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
" We observed 10 cases of such t-AML over a 7-year-period in breast cancer patients treated with mitoxantrone combined with fluorouracil, cyclophosphamide and regional radiotherapy, and in three cases with vindesine."7.70Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy. ( Barin, C; Benboubker, L; Binet, C; Brémond, JL; Calais, G; Cartron, G; Colombat, P; Delain, M; Georget, MT; Lamagnère, JP; Leloup, R; Letortorec, S; Linassier, C; Petit, A; Raban, N, 2000)
"Therapy-related acute non-lymphocytic leukemia or preleukemia was observed in five of 71 patients with advanced breast cancer treated with combination chemotherapy comprising prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen."7.68High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer. ( Andersson, M; Pedersen-Bjergaard, J; Philip, P, 1990)
"A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen)."3.73Oxaliplatin-related acute myelogenous leukemia. ( Carneiro, BA; Eldibany, M; Kaminer, L; Kaul, K; Locker, GY; Sreekantaiah, C, 2006)
" We observed 10 cases of such t-AML over a 7-year-period in breast cancer patients treated with mitoxantrone combined with fluorouracil, cyclophosphamide and regional radiotherapy, and in three cases with vindesine."3.70Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy. ( Barin, C; Benboubker, L; Binet, C; Brémond, JL; Calais, G; Cartron, G; Colombat, P; Delain, M; Georget, MT; Lamagnère, JP; Leloup, R; Letortorec, S; Linassier, C; Petit, A; Raban, N, 2000)
"Therapy-related acute non-lymphocytic leukemia or preleukemia was observed in five of 71 patients with advanced breast cancer treated with combination chemotherapy comprising prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen."3.68High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer. ( Andersson, M; Pedersen-Bjergaard, J; Philip, P, 1990)
"Interestingly, rare balanced chromosomal abnormalities were observed in the present cases, thus providing new insights into the leukemogenesis of therapy-related leukemia."1.36Therapy-related leukemia following chemoradiotherapy for esophageal cancer. ( Ise, M; Kumagai, K; Mimura, N; Nagata, M; Sakai, C; Takagi, T; Tsujimura, H, 2010)
"Dissociated cancer cells are exposed to antineoplastic drugs (5 X 10(4) viable cells/drug for 1 hr or continuously) and cultured for 4 to 6 days in liquid medium."1.27A novel dye exclusion method for testing in vitro chemosensitivity of human tumors. ( Dill, PL; Macaluso, CK; Marsden, JA; Weisenthal, LM, 1983)
" With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor."1.275'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983)
"Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0."1.26Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199020 (45.45)18.7374
1990's6 (13.64)18.2507
2000's6 (13.64)29.6817
2010's12 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, K1
Yang, K1
Zheng, L1
Li, Y1
Wang, Q1
Lin, R1
He, D1
Cantor, JR1
Abu-Remaileh, M1
Kanarek, N1
Freinkman, E1
Gao, X1
Louissaint, A1
Lewis, CA1
Sabatini, DM1
Taylor, SJ1
Duyvestyn, JM1
Dagger, SA1
Dishington, EJ1
Rinaldi, CA1
Dovey, OM1
Vassiliou, GS1
Grove, CS1
Langdon, WY1
Kenswil, KJG1
Jaramillo, AC1
Ping, Z1
Chen, S1
Hoogenboezem, RM1
Mylona, MA1
Adisty, MN1
Bindels, EMJ1
Bos, PK1
Stoop, H1
Lam, KH1
van Eerden, B1
Cupedo, T1
Raaijmakers, MHGP1
Maurer, S1
Salih, HR1
Smirnow, I1
Lauer, UM1
Berchtold, S1
Jafek, JL1
Shakya, A1
Tai, PY1
Ibarra, A1
Kim, H1
Maddox, J1
Chumley, J1
Spangrude, GJ1
Miles, RR1
Kelley, TW1
Tantin, D1
Puissant, A1
Fenouille, N1
Alexe, G1
Pikman, Y1
Bassil, CF1
Mehta, S1
Du, J1
Kazi, JU1
Luciano, F1
Rönnstrand, L1
Kung, AL1
Aster, JC1
Galinsky, I1
Stone, RM1
DeAngelo, DJ1
Hemann, MT1
Stegmaier, K1
Song, K1
Li, M1
Xu, XJ1
Xuan, L1
Huang, GN1
Song, XL1
Liu, QF1
Rashidi, A1
Amarillo, I1
Fisher, SI1
Tansley, S1
Gibbons, S1
Mimura, N1
Tsujimura, H1
Ise, M1
Sakai, C1
Takagi, T1
Nagata, M1
Kumagai, K1
Damodaran, S1
Bellavia, T1
Sait, SN1
Wang, ES1
Wetzler, M1
Khushalani, NI1
Park, HJ1
Choi, JH1
Lee, KA1
Kim, HC1
Nam, YS1
Oh, YH1
Lee, WS1
Weldon, CB1
Jaffe, BM1
Kahn, MJ1
Carneiro, BA1
Kaminer, L1
Eldibany, M1
Sreekantaiah, C1
Kaul, K1
Locker, GY1
Patel, S1
Liu, D1
Caron, P1
Seiter, K1
Weisenthal, LM1
Marsden, JA1
Dill, PL1
Macaluso, CK1
Armstrong, RD1
Cadman, E1
Tanaka, M1
Kimura, K1
Yoshida, S1
Kato, M1
Saji, S1
Furuta, T1
Tanemura, H1
Azuma, S1
Nishina, T1
Kuno, T1
Takahashi, K1
Sica, S1
Salutari, P1
Ciarli, M1
Piccirillo, N1
Laurenti, L1
Menichella, G1
Leone, G1
Kuntz, BM1
Schöttler, B1
Brüster, HT1
Linassier, C1
Barin, C1
Calais, G1
Letortorec, S1
Brémond, JL1
Delain, M1
Petit, A1
Georget, MT1
Cartron, G1
Raban, N1
Benboubker, L1
Leloup, R1
Binet, C1
Lamagnère, JP1
Colombat, P1
Pitini, V1
Arrigo, C1
Aloi, G1
Righi, M1
Falduto, M1
Teti, D1
Reimer, RR1
Hoover, R1
Fraumeni, JF1
Young, RC1
Bouillet, T1
Lepage, E1
Gisselbrecht, C1
Boiron, M1
Zampa, G1
Andriani, A1
Beni, A1
Patino, N1
Rinaldi, P1
Andersson, M1
Philip, P1
Pedersen-Bjergaard, J1
Kane, MA1
Roth, E1
Raptis, G1
Schreiber, C1
Waxman, S1
Elias, L2
Crissman, HA2
Geller, RB1
Boone, LB1
Karp, JE1
Davidson, N1
Selonick, SE1
Edwards, J1
Burke, PJ1
Ermens, AA1
Lindemans, J1
Abels, J1
Keniry, M1
Benz, C1
Shafer, RH1
James, TL1
Mendoza, EA1
Thomas, LC1
Sutherland, CM1
Wood, A1
Ratliff, R1
Grignani, F1
Martelli, M1
Tonato, M1
Danieli, G1
Davis, HL1
Prout, MN1
McKenna, PJ1
Cole, DR1
Korbitz, BC1
Frei, E1
Schabel, FM1
Goldin, A1
Kaslow, RA1
Wisch, N1
Glass, JL1
Goldfinger, D1
McGinniss, MH1
Aoki, Y1
Moore, GE1
Vogler, WR1
Horwitz, S1
Groth, DP1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088]Phase 1/Phase 282 participants (Anticipated)Interventional2022-12-15Not yet recruiting
A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer[NCT00001428]Phase 265 participants Interventional1995-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for fluorouracil and Acute Myelogenous Leukemia

ArticleYear
Remission induction in childhood leukemia with second course vincristine (NSC-67574) and prednisone (NSC-10023) therapy.
    Cancer chemotherapy reports, 1970, Volume: 54, Issue:2

    Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Colonic

1970

Other Studies

43 other studies available for fluorouracil and Acute Myelogenous Leukemia

ArticleYear
Anti-acute myeloid leukemia activity of 2-chloro-3-alkyl-1,4-naphthoquinone derivatives through inducing mtDNA damage and GSH depletion.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; DNA Damage; DNA, Mitoc

2018
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
    Cell, 2017, Apr-06, Volume: 169, Issue:2

    Topics: Aged; Animals; Cell Culture Techniques; Cell Line, Tumor; Culture Media; Fluorouracil; Glucose; Huma

2017
Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib.
    Science translational medicine, 2017, Aug-09, Volume: 9, Issue:402

    Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Fluorouracil; fms-Like Tyrosine

2017
Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor.
    Cell reports, 2018, 01-16, Volume: 22, Issue:3

    Topics: Adult; Aged; Animals; Bone Marrow; Cell Differentiation; Endothelial Cells; Fluorouracil; Hematopoie

2018
Suicide gene‑armed measles vaccine virus for the treatment of AML.
    International journal of oncology, 2019, Volume: 55, Issue:2

    Topics: Adult; Aged; Combined Modality Therapy; Female; Flucytosine; Fluorouracil; Follow-Up Studies; Genes,

2019
Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
    Experimental hematology, 2019, Volume: 76

    Topics: Animals; Bone Marrow; Bone Marrow Failure Disorders; CDX2 Transcription Factor; Cell Transformation,

2019
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
    Cancer cell, 2014, Feb-10, Volume: 25, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Proliferation; Cell Tra

2014
HIF-1α and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:4

    Topics: Adult; Antibiotics, Antineoplastic; Bone Marrow Cells; Cell Line, Tumor; Doxorubicin; Drug Resistanc

2014
BRCA2-associated therapy-related acute myeloid leukemia.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Duct

2015
Capecitabine-induced acute myeloid leukaemia.
    The New Zealand medical journal, 2009, May-08, Volume: 122, Issue:1294

    Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Hu

2009
Therapy-related leukemia following chemoradiotherapy for esophageal cancer.
    European journal of haematology, 2010, Volume: 85, Issue:4

    Topics: Aged; Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 5; Combined Modality T

2010
Acute myeloid leukemia secondary to oxaliplatin treatment for esophageal cancer.
    Clinical colorectal cancer, 2012, Volume: 11, Issue:2

    Topics: Abnormal Karyotype; Adenocarcinoma; Antineoplastic Agents; Capecitabine; Clinical Trials, Phase II a

2012
A case of therapy-related acute myeloid leukemia following 5-fluorouracil chemotherapy.
    The Korean journal of internal medicine, 2012, Volume: 27, Issue:1

    Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone

2012
Therapy-induced leukemias and myelodysplastic syndromes after breast cancer treatment: an underemphasized clinical problem.
    Annals of surgical oncology, 2002, Volume: 9, Issue:8

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Carci

2002
Oxaliplatin-related acute myelogenous leukemia.
    The oncologist, 2006, Volume: 11, Issue:3

    Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C

2006
Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
    Leukemia & lymphoma, 2007, Volume: 48, Issue:5

    Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Fluorouracil; H

2007
A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.
    Cancer research, 1983, Volume: 43, Issue:2

    Topics: Antineoplastic Agents; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Eosine Y

1983
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
    Cancer research, 1983, Volume: 43, Issue:6

    Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine;

1983
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylat

1983
[A case of secondary leukemia induced by chemotherapy with a CDDP-based regimen for gastric cancer 5 years following radical resection].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans

1993
Secondary leukemia after autologous peripheral blood progenitor cell transplantation for breast cancer.
    Leukemia, 1997, Volume: 11, Issue:11

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyc

1997
[Resuscitation necessitated by a transfusion reaction after HLA mismatched platelets substitution].
    Beitrage zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine, 1994, Volume: 32

    Topics: Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Cyt

1994
Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:10

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality The

2000
Myelodysplastic syndrome/acute myelogenous leukaemia after adjuvant chemotherapy with pyrimidine anti-metabolites in three patients.
    Haematologica, 2001, Volume: 86, Issue:10

    Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Le

2001
Acute leukemia after alkylating-agent therapy of ovarian cancer.
    The New England journal of medicine, 1977, Jul-28, Volume: 297, Issue:4

    Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil;

1977
Acute non-lymphocytic leukemia following FAM combination adjuvant chemotherapy for gastric and lung adenocarcinoma.
    Nouvelle revue francaise d'hematologie, 1990, Volume: 32, Issue:3

    Topics: Adenocarcinoma; Aged; Anemia, Refractory, with Excess of Blasts; Antineoplastic Combined Chemotherap

1990
Acute non lymphoid leukemia following CMF treatment as adjuvant therapy in positive node breast cancer. Case report.
    Tumori, 1990, Apr-30, Volume: 76, Issue:2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Female; Fluoroura

1990
High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer.
    Cancer, 1990, Jun-01, Volume: 65, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Female;

1990
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
    Cancer research, 1987, Dec-15, Volume: 47, Issue:24 Pt 1

    Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Ce

1987
Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.
    Cancer research, 1988, Sep-01, Volume: 48, Issue:17

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Division; Drug Synergism; Floxuridine; Fluorou

1988
Secondary acute myelocytic leukemia after adjuvant therapy for early-stage breast carcinoma. A new complication of cyclophosphamide, methotrexate, and 5-fluorouracil therapy.
    Cancer, 1989, Aug-01, Volume: 64, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fl

1989
Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.
    British journal of cancer, 1988, Volume: 57, Issue:4

    Topics: Animals; Antineoplastic Agents; Deoxyuridine; DNA; Fluorouracil; Folic Acid; Folic Acid Antagonists;

1988
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
    Cancer research, 1986, Volume: 46, Issue:4 Pt 1

    Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectro

1986
Acute myelocytic leukemia following radiation and chemotherapy for esophageal carcinoma.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1987, Volume: 139, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combined Modality Therap

1987
Effects of conditioned medium upon proliferation, deoxynucleotide metabolism, and antimetabolite sensitivity of promyelocytic leukemic cells in vitro.
    Cancer research, 1985, Volume: 45, Issue:12 Pt 1

    Topics: Cell Cycle; Cell Differentiation; Cell Division; Culture Media; Deoxyribonucleotides; DNA Replicatio

1985
[Antimetabolites in the treatment of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. II].
    La Clinica terapeutica, 1974, Apr-30, Volume: 69, Issue:2

    Topics: Antimetabolites; Azacitidine; Azaguanine; Azauridine; Cell Membrane Permeability; Cytarabine; DNA, N

1974
[1973 treatment of acute leukemias].
    Minerva medica, 1974, Dec-15, Volume: 65, Issue:90

    Topics: Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Dru

1974
Acute leukemia complicating metastatic breast cancer.
    Cancer, 1973, Volume: 31, Issue:3

    Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil

1973
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
    Cancer research, 1974, Volume: 34, Issue:1

    Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara

1974
Acute leukemia following cytotoxic chemotherapy.
    JAMA, 1972, Volume: 219, Issue:1

    Topics: Adenocarcinoma; Adult; Female; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Methotrexate; Ovarian

1972
Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.
    The New England journal of medicine, 1971, Apr-29, Volume: 284, Issue:17

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibodies; Antibody Formation; Blood Group Incompatibili

1971
Comparative sensitivity to various antimetabolites of several established cell lines derived from the buffy coat of normal humans and patients with neoplastic diseases.
    Cancer research, 1969, Volume: 29, Issue:6

    Topics: Antimetabolites; Blood Cells; Cell Line; Culture Techniques; Cytarabine; Fluorouracil; Humans; Leuke

1969
Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism.
    Cancer research, 1969, Volume: 29, Issue:7

    Topics: Amidohydrolases; Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Cyclophosphamide; Cytarab

1969