fluorouracil has been researched along with Acute Myelogenous Leukemia in 44 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Excerpt | Relevance | Reference |
---|---|---|
" We observed 10 cases of such t-AML over a 7-year-period in breast cancer patients treated with mitoxantrone combined with fluorouracil, cyclophosphamide and regional radiotherapy, and in three cases with vindesine." | 7.70 | Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy. ( Barin, C; Benboubker, L; Binet, C; Brémond, JL; Calais, G; Cartron, G; Colombat, P; Delain, M; Georget, MT; Lamagnère, JP; Leloup, R; Letortorec, S; Linassier, C; Petit, A; Raban, N, 2000) |
"Therapy-related acute non-lymphocytic leukemia or preleukemia was observed in five of 71 patients with advanced breast cancer treated with combination chemotherapy comprising prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen." | 7.68 | High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer. ( Andersson, M; Pedersen-Bjergaard, J; Philip, P, 1990) |
"A 56-year-old woman diagnosed with a poorly differentiated cecal adenocarcinoma with metastases to ovaries, omentum, and sigmoid colon went into remission after 12 cycles of infusional 5-fluorouracil, luecovorin, and oxaliplatin (FOLFOX-4 regimen)." | 3.73 | Oxaliplatin-related acute myelogenous leukemia. ( Carneiro, BA; Eldibany, M; Kaminer, L; Kaul, K; Locker, GY; Sreekantaiah, C, 2006) |
" We observed 10 cases of such t-AML over a 7-year-period in breast cancer patients treated with mitoxantrone combined with fluorouracil, cyclophosphamide and regional radiotherapy, and in three cases with vindesine." | 3.70 | Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy. ( Barin, C; Benboubker, L; Binet, C; Brémond, JL; Calais, G; Cartron, G; Colombat, P; Delain, M; Georget, MT; Lamagnère, JP; Leloup, R; Letortorec, S; Linassier, C; Petit, A; Raban, N, 2000) |
"Therapy-related acute non-lymphocytic leukemia or preleukemia was observed in five of 71 patients with advanced breast cancer treated with combination chemotherapy comprising prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen." | 3.68 | High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer. ( Andersson, M; Pedersen-Bjergaard, J; Philip, P, 1990) |
"Interestingly, rare balanced chromosomal abnormalities were observed in the present cases, thus providing new insights into the leukemogenesis of therapy-related leukemia." | 1.36 | Therapy-related leukemia following chemoradiotherapy for esophageal cancer. ( Ise, M; Kumagai, K; Mimura, N; Nagata, M; Sakai, C; Takagi, T; Tsujimura, H, 2010) |
"Dissociated cancer cells are exposed to antineoplastic drugs (5 X 10(4) viable cells/drug for 1 hr or continuously) and cultured for 4 to 6 days in liquid medium." | 1.27 | A novel dye exclusion method for testing in vitro chemosensitivity of human tumors. ( Dill, PL; Macaluso, CK; Marsden, JA; Weisenthal, LM, 1983) |
" With use of these studies, a therapeutic ratio (concentration that prevented 25% clonal growth compared to untreated control of bone marrow divided by LD50 of tumor) was calculated for each drug in each tumor." | 1.27 | 5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow. ( Armstrong, RD; Cadman, E, 1983) |
"Thirteen cases of acute nonlymphocytic leukemia occurred among 5455 patients, as compared to 0." | 1.26 | Acute leukemia after alkylating-agent therapy of ovarian cancer. ( Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC, 1977) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 20 (45.45) | 18.7374 |
1990's | 6 (13.64) | 18.2507 |
2000's | 6 (13.64) | 29.6817 |
2010's | 12 (27.27) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Li, K | 1 |
Yang, K | 1 |
Zheng, L | 1 |
Li, Y | 1 |
Wang, Q | 1 |
Lin, R | 1 |
He, D | 1 |
Cantor, JR | 1 |
Abu-Remaileh, M | 1 |
Kanarek, N | 1 |
Freinkman, E | 1 |
Gao, X | 1 |
Louissaint, A | 1 |
Lewis, CA | 1 |
Sabatini, DM | 1 |
Taylor, SJ | 1 |
Duyvestyn, JM | 1 |
Dagger, SA | 1 |
Dishington, EJ | 1 |
Rinaldi, CA | 1 |
Dovey, OM | 1 |
Vassiliou, GS | 1 |
Grove, CS | 1 |
Langdon, WY | 1 |
Kenswil, KJG | 1 |
Jaramillo, AC | 1 |
Ping, Z | 1 |
Chen, S | 1 |
Hoogenboezem, RM | 1 |
Mylona, MA | 1 |
Adisty, MN | 1 |
Bindels, EMJ | 1 |
Bos, PK | 1 |
Stoop, H | 1 |
Lam, KH | 1 |
van Eerden, B | 1 |
Cupedo, T | 1 |
Raaijmakers, MHGP | 1 |
Maurer, S | 1 |
Salih, HR | 1 |
Smirnow, I | 1 |
Lauer, UM | 1 |
Berchtold, S | 1 |
Jafek, JL | 1 |
Shakya, A | 1 |
Tai, PY | 1 |
Ibarra, A | 1 |
Kim, H | 1 |
Maddox, J | 1 |
Chumley, J | 1 |
Spangrude, GJ | 1 |
Miles, RR | 1 |
Kelley, TW | 1 |
Tantin, D | 1 |
Puissant, A | 1 |
Fenouille, N | 1 |
Alexe, G | 1 |
Pikman, Y | 1 |
Bassil, CF | 1 |
Mehta, S | 1 |
Du, J | 1 |
Kazi, JU | 1 |
Luciano, F | 1 |
Rönnstrand, L | 1 |
Kung, AL | 1 |
Aster, JC | 1 |
Galinsky, I | 1 |
Stone, RM | 1 |
DeAngelo, DJ | 1 |
Hemann, MT | 1 |
Stegmaier, K | 1 |
Song, K | 1 |
Li, M | 1 |
Xu, XJ | 1 |
Xuan, L | 1 |
Huang, GN | 1 |
Song, XL | 1 |
Liu, QF | 1 |
Rashidi, A | 1 |
Amarillo, I | 1 |
Fisher, SI | 1 |
Tansley, S | 1 |
Gibbons, S | 1 |
Mimura, N | 1 |
Tsujimura, H | 1 |
Ise, M | 1 |
Sakai, C | 1 |
Takagi, T | 1 |
Nagata, M | 1 |
Kumagai, K | 1 |
Damodaran, S | 1 |
Bellavia, T | 1 |
Sait, SN | 1 |
Wang, ES | 1 |
Wetzler, M | 1 |
Khushalani, NI | 1 |
Park, HJ | 1 |
Choi, JH | 1 |
Lee, KA | 1 |
Kim, HC | 1 |
Nam, YS | 1 |
Oh, YH | 1 |
Lee, WS | 1 |
Weldon, CB | 1 |
Jaffe, BM | 1 |
Kahn, MJ | 1 |
Carneiro, BA | 1 |
Kaminer, L | 1 |
Eldibany, M | 1 |
Sreekantaiah, C | 1 |
Kaul, K | 1 |
Locker, GY | 1 |
Patel, S | 1 |
Liu, D | 1 |
Caron, P | 1 |
Seiter, K | 1 |
Weisenthal, LM | 1 |
Marsden, JA | 1 |
Dill, PL | 1 |
Macaluso, CK | 1 |
Armstrong, RD | 1 |
Cadman, E | 1 |
Tanaka, M | 1 |
Kimura, K | 1 |
Yoshida, S | 1 |
Kato, M | 1 |
Saji, S | 1 |
Furuta, T | 1 |
Tanemura, H | 1 |
Azuma, S | 1 |
Nishina, T | 1 |
Kuno, T | 1 |
Takahashi, K | 1 |
Sica, S | 1 |
Salutari, P | 1 |
Ciarli, M | 1 |
Piccirillo, N | 1 |
Laurenti, L | 1 |
Menichella, G | 1 |
Leone, G | 1 |
Kuntz, BM | 1 |
Schöttler, B | 1 |
Brüster, HT | 1 |
Linassier, C | 1 |
Barin, C | 1 |
Calais, G | 1 |
Letortorec, S | 1 |
Brémond, JL | 1 |
Delain, M | 1 |
Petit, A | 1 |
Georget, MT | 1 |
Cartron, G | 1 |
Raban, N | 1 |
Benboubker, L | 1 |
Leloup, R | 1 |
Binet, C | 1 |
Lamagnère, JP | 1 |
Colombat, P | 1 |
Pitini, V | 1 |
Arrigo, C | 1 |
Aloi, G | 1 |
Righi, M | 1 |
Falduto, M | 1 |
Teti, D | 1 |
Reimer, RR | 1 |
Hoover, R | 1 |
Fraumeni, JF | 1 |
Young, RC | 1 |
Bouillet, T | 1 |
Lepage, E | 1 |
Gisselbrecht, C | 1 |
Boiron, M | 1 |
Zampa, G | 1 |
Andriani, A | 1 |
Beni, A | 1 |
Patino, N | 1 |
Rinaldi, P | 1 |
Andersson, M | 1 |
Philip, P | 1 |
Pedersen-Bjergaard, J | 1 |
Kane, MA | 1 |
Roth, E | 1 |
Raptis, G | 1 |
Schreiber, C | 1 |
Waxman, S | 1 |
Elias, L | 2 |
Crissman, HA | 2 |
Geller, RB | 1 |
Boone, LB | 1 |
Karp, JE | 1 |
Davidson, N | 1 |
Selonick, SE | 1 |
Edwards, J | 1 |
Burke, PJ | 1 |
Ermens, AA | 1 |
Lindemans, J | 1 |
Abels, J | 1 |
Keniry, M | 1 |
Benz, C | 1 |
Shafer, RH | 1 |
James, TL | 1 |
Mendoza, EA | 1 |
Thomas, LC | 1 |
Sutherland, CM | 1 |
Wood, A | 1 |
Ratliff, R | 1 |
Grignani, F | 1 |
Martelli, M | 1 |
Tonato, M | 1 |
Danieli, G | 1 |
Davis, HL | 1 |
Prout, MN | 1 |
McKenna, PJ | 1 |
Cole, DR | 1 |
Korbitz, BC | 1 |
Frei, E | 1 |
Schabel, FM | 1 |
Goldin, A | 1 |
Kaslow, RA | 1 |
Wisch, N | 1 |
Glass, JL | 1 |
Goldfinger, D | 1 |
McGinniss, MH | 1 |
Aoki, Y | 1 |
Moore, GE | 1 |
Vogler, WR | 1 |
Horwitz, S | 1 |
Groth, DP | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Evaluation of the Safety and Efficacy of Esperanza Extract (Petiveria Alliacea) in Patients With Metastatic Gastrointestinal Tumors and Acute Leukemia[NCT05587088] | Phase 1/Phase 2 | 82 participants (Anticipated) | Interventional | 2022-12-15 | Not yet recruiting | ||
A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer[NCT00001428] | Phase 2 | 65 participants | Interventional | 1995-02-28 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
1 trial available for fluorouracil and Acute Myelogenous Leukemia
Article | Year |
---|---|
Remission induction in childhood leukemia with second course vincristine (NSC-67574) and prednisone (NSC-10023) therapy.
Topics: Adolescent; Antibiotics, Antineoplastic; Child; Child, Preschool; Clinical Trials as Topic; Colonic | 1970 |
43 other studies available for fluorouracil and Acute Myelogenous Leukemia
Article | Year |
---|---|
Anti-acute myeloid leukemia activity of 2-chloro-3-alkyl-1,4-naphthoquinone derivatives through inducing mtDNA damage and GSH depletion.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Proliferation; DNA Damage; DNA, Mitoc | 2018 |
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
Topics: Aged; Animals; Cell Culture Techniques; Cell Line, Tumor; Culture Media; Fluorouracil; Glucose; Huma | 2017 |
Preventing chemotherapy-induced myelosuppression by repurposing the FLT3 inhibitor quizartinib.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Cell Proliferation; Fluorouracil; fms-Like Tyrosine | 2017 |
Characterization of Endothelial Cells Associated with Hematopoietic Niche Formation in Humans Identifies IL-33 As an Anabolic Factor.
Topics: Adult; Aged; Animals; Bone Marrow; Cell Differentiation; Endothelial Cells; Fluorouracil; Hematopoie | 2018 |
Suicide gene‑armed measles vaccine virus for the treatment of AML.
Topics: Adult; Aged; Combined Modality Therapy; Female; Flucytosine; Fluorouracil; Follow-Up Studies; Genes, | 2019 |
Transcription factor Oct1 protects against hematopoietic stress and promotes acute myeloid leukemia.
Topics: Animals; Bone Marrow; Bone Marrow Failure Disorders; CDX2 Transcription Factor; Cell Transformation, | 2019 |
SYK is a critical regulator of FLT3 in acute myeloid leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Blotting, Western; Cell Proliferation; Cell Tra | 2014 |
HIF-1α and GLUT1 gene expression is associated with chemoresistance of acute myeloid leukemia.
Topics: Adult; Antibiotics, Antineoplastic; Bone Marrow Cells; Cell Line, Tumor; Doxorubicin; Drug Resistanc | 2014 |
BRCA2-associated therapy-related acute myeloid leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Duct | 2015 |
Capecitabine-induced acute myeloid leukaemia.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouracil; Hu | 2009 |
Therapy-related leukemia following chemoradiotherapy for esophageal cancer.
Topics: Aged; Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 5; Combined Modality T | 2010 |
Acute myeloid leukemia secondary to oxaliplatin treatment for esophageal cancer.
Topics: Abnormal Karyotype; Adenocarcinoma; Antineoplastic Agents; Capecitabine; Clinical Trials, Phase II a | 2012 |
A case of therapy-related acute myeloid leukemia following 5-fluorouracil chemotherapy.
Topics: Adult; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Bone | 2012 |
Therapy-induced leukemias and myelodysplastic syndromes after breast cancer treatment: an underemphasized clinical problem.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Carci | 2002 |
Oxaliplatin-related acute myelogenous leukemia.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2006 |
Acute myelogenous leukemia following irinotecan-based chemotherapy for adenocarcinoma of the small intestine.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Fluorouracil; H | 2007 |
A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Eosine Y | 1983 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; | 1983 |
Enhancement of the incorporation of 5-fluorodeoxyuridylate into DNA of HL-60 cells by metabolic modulations.
Topics: Cell Line; Deoxyuracil Nucleotides; DNA Replication; DNA, Neoplasm; Floxuridine; Fluorodeoxyuridylat | 1983 |
[A case of secondary leukemia induced by chemotherapy with a CDDP-based regimen for gastric cancer 5 years following radical resection].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastrectomy; Humans | 1993 |
Secondary leukemia after autologous peripheral blood progenitor cell transplantation for breast cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyc | 1997 |
[Resuscitation necessitated by a transfusion reaction after HLA mismatched platelets substitution].
Topics: Anaphylaxis; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Cyt | 1994 |
Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality The | 2000 |
Myelodysplastic syndrome/acute myelogenous leukaemia after adjuvant chemotherapy with pyrimidine anti-metabolites in three patients.
Topics: Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colonic Neoplasms; Fluorouracil; Humans; Le | 2001 |
Acute leukemia after alkylating-agent therapy of ovarian cancer.
Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; | 1977 |
Acute non-lymphocytic leukemia following FAM combination adjuvant chemotherapy for gastric and lung adenocarcinoma.
Topics: Adenocarcinoma; Aged; Anemia, Refractory, with Excess of Blasts; Antineoplastic Combined Chemotherap | 1990 |
Acute non lymphoid leukemia following CMF treatment as adjuvant therapy in positive node breast cancer. Case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Female; Fluoroura | 1990 |
High risk of therapy-related leukemia and preleukemia after therapy with prednimustine, methotrexate, 5-fluorouracil, mitoxantrone, and tamoxifen for advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Female; | 1990 |
Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Survival; Fluorouracil; Folic Acid; Glucose; Humans; KB Ce | 1987 |
Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergistic interactions with halogenated pyrimidine antimetabolites.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Division; Drug Synergism; Floxuridine; Fluorou | 1988 |
Secondary acute myelocytic leukemia after adjuvant therapy for early-stage breast carcinoma. A new complication of cyclophosphamide, methotrexate, and 5-fluorouracil therapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fl | 1989 |
Moderate antiproliferative effect of the antifolate CB3717 in the BN myeloid leukaemia model.
Topics: Animals; Antineoplastic Agents; Deoxyuridine; DNA; Fluorouracil; Folic Acid; Folic Acid Antagonists; | 1988 |
Noninvasive spectroscopic analysis of fluoropyrimidine metabolism in cultured tumor cells.
Topics: Animals; Cells, Cultured; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Magnetic Resonance Spectro | 1986 |
Acute myelocytic leukemia following radiation and chemotherapy for esophageal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combined Modality Therap | 1987 |
Effects of conditioned medium upon proliferation, deoxynucleotide metabolism, and antimetabolite sensitivity of promyelocytic leukemic cells in vitro.
Topics: Cell Cycle; Cell Differentiation; Cell Division; Culture Media; Deoxyribonucleotides; DNA Replicatio | 1985 |
[Antimetabolites in the treatment of acute human leukoses. Mechanism of action and conditioning factors in the cellular response to drugs. II].
Topics: Antimetabolites; Azacitidine; Azaguanine; Azauridine; Cell Membrane Permeability; Cytarabine; DNA, N | 1974 |
[1973 treatment of acute leukemias].
Topics: Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Doxorubicin; Dru | 1974 |
Acute leukemia complicating metastatic breast cancer.
Topics: Adult; Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil | 1973 |
Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Carmustine; Cyclohexanes; Cyclophosphamide; Cytara | 1974 |
Acute leukemia following cytotoxic chemotherapy.
Topics: Adenocarcinoma; Adult; Female; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Methotrexate; Ovarian | 1972 |
Rh-incompatible platelet transfusions--risks and consequences of sensitizing immunosuppressed patients.
Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antibodies; Antibody Formation; Blood Group Incompatibili | 1971 |
Comparative sensitivity to various antimetabolites of several established cell lines derived from the buffy coat of normal humans and patients with neoplastic diseases.
Topics: Antimetabolites; Blood Cells; Cell Line; Culture Techniques; Cytarabine; Fluorouracil; Humans; Leuke | 1969 |
Studies on the effects of hydroxyurea and other anticancer drugs upon pyrimidine metabolism.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Ascites; Carbon Isotopes; Cyclophosphamide; Cytarab | 1969 |