fluorouracil has been researched along with Acute Lymphoid Leukemia in 15 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cultured P388 (murine) and CEM (human) leukemia cells were exposed to medium including either 5-fluorouracil (5-FU) or methotorexate (MTX)." | 3.70 | Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity. ( Sugimura, K; Sukemori, S, 1998) |
| "A 60-yr-old woman with breast cancer underwent breast-conserving surgery followed by 6 cycles of adjuvant chemotherapy (cyclophosphamide, epirubicin, and fluorouracil) and radiation therapy (dose, 5,040 cGy to the left breast and a 1,000 cGy boost to the tumor bed)." | 1.36 | A case of therapy-related ALL with MLL gene rearrangement following treatment of breast cancer. ( Cho, J; Hur, M; Lee, CH; Lee, HG; Moon, HW; Yun, YM, 2010) |
| "LV-6S exhibits pharmacokinetic patterns similar to those obtained with LV-6R,S whatever the route used, oral or intravenous." | 1.29 | Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin. ( Zittoun, J, 1993) |
| "We established a novel human acute lymphoblastic leukemia cell line made resistant to two folate analogues, trimetrexate (TMQ) and N10-propargyl-5,8-dideazafolic acid (CB3717), by sequential exposure of the 200-fold TMQ-resistant cells (MOLT-3/TMQ200) to CB3717." | 1.28 | A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717). ( Miyachi, H; Ohnuma, T; Sekiguchi, S; Takemura, Y, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (46.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deenen, MJ | 1 |
| Henricks, LM | 1 |
| Sonke, GS | 1 |
| Schellens, JH | 1 |
| Meulendijks, D | 1 |
| Wang, D | 1 |
| Chen, Y | 1 |
| Fang, H | 1 |
| Zheng, L | 1 |
| Li, Y | 1 |
| Yang, F | 1 |
| Xu, Y | 1 |
| Du, L | 1 |
| Zhou, BS | 1 |
| Li, H | 1 |
| Zhao, XQ | 1 |
| Cao, WJ | 1 |
| Yang, HP | 1 |
| Yang, XW | 1 |
| Tang, P | 1 |
| Sun, L | 1 |
| Gao, X | 1 |
| Ashavaid, TF | 1 |
| Raghavan, R | 1 |
| Shah, S | 1 |
| Kapadia, A | 1 |
| Almel, S | 1 |
| Desai, D | 1 |
| Cho, J | 1 |
| Hur, M | 1 |
| Moon, HW | 1 |
| Yun, YM | 1 |
| Lee, CH | 1 |
| Lee, HG | 1 |
| Mathews, CK | 1 |
| Bonneterre, JM | 1 |
| Merlin, F | 1 |
| Prochilo, T | 1 |
| Kildani, B | 1 |
| Tucci, A | 1 |
| Ferrari, S | 1 |
| Rossi, G | 1 |
| D'Adda, P | 1 |
| Beretta, GD | 1 |
| Zittoun, J | 1 |
| Sukemori, S | 1 |
| Sugimura, K | 1 |
| Chen, J | 1 |
| Jiang, S | 1 |
| Li, J | 1 |
| Guglielmi, C | 2 |
| Amadori, S | 2 |
| Martelli, M | 2 |
| Papa, G | 2 |
| Mandelli, F | 2 |
| Takemura, Y | 1 |
| Ohnuma, T | 1 |
| Miyachi, H | 1 |
| Sekiguchi, S | 1 |
| Kau, B | 1 |
| Rieger, M | 1 |
| Sauer, H | 1 |
2 reviews available for fluorouracil and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Secondary acute lymphoblastic leukaemia following oxaliplatin for adjuvant chemotherapy in colon cancer.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protoc | 2008 |
[Effects of chemotherapy on the changes of histology and function of the ovary].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Daunorubicin; Female; Fluorouracil; Human | 1998 |
2 trials available for fluorouracil and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Long-term efficacy and toxicity of the FEC100 regimen.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cost-Benefit Analysis | 2004 |
F-MACHOP in advanced aggressive lymphoma.
Topics: Actuarial Analysis; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Do | 1992 |
11 other studies available for fluorouracil and Acute Lymphoid Leukemia
| Article | Year |
|---|---|
Letter regarding Zhao et al. entitled " DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia".
Topics: Antimetabolites, Antineoplastic; Child; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Po | 2017 |
Increase of PRPP enhances chemosensitivity of PRPS1 mutant acute lymphoblastic leukemia cells to 5-Fluorouracil.
Topics: Animals; Apoptosis; Cell Survival; DNA Damage; Fluorouracil; Gene Expression Regulation, Leukemic; H | 2018 |
DPYD gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Dihydrouracil Dehydrogenase | 2016 |
TPMT and DPD polymorphisms: Efficient screening method for Indian patients considering taking Thiopurine and 5-FU drugs.
Topics: Antineoplastic Agents; Base Sequence; Dihydrouracil Dehydrogenase (NADP); DNA Primers; Fluorouracil; | 2009 |
A case of therapy-related ALL with MLL gene rearrangement following treatment of breast cancer.
Topics: Antibiotics, Antineoplastic; Blood Cell Count; Bone Marrow; Breast Neoplasms; Chemotherapy, Adjuvant | 2010 |
DNA synthesis as a therapeutic target: the first 65 years.
Topics: Aminopterin; Antimetabolites, Antineoplastic; DNA Replication; Fluorouracil; Folic Acid; Folic Acid | 2012 |
Pharmacokinetics and in vitro studies of l-leucovorin. Comparison with the d and d,l-leucovorin.
Topics: Drug Synergism; Fluorouracil; Humans; Leucovorin; Male; Methotrexate; Pediococcus; Precursor Cell Ly | 1993 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutam | 1998 |
A human leukemia cell line made resistant to two folate analogues, trimetrexate and N10-propargyl-5,8-dideazafolic acid (CB3717).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell | 1991 |
The F-MACHOP regimen in advanced diffuse aggressive lymphomas: summary of ten years' experience at a single institution.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Fluoroura | 1991 |
[Modulation of the biochemical effect of 5-fluorouracil (5-FU) by leucovorin measured by thymidylate synthase activity and nucleoside incorporation into DNA].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; DNA Replication; Drug Syne | 1990 |