Page last updated: 2024-10-27

fluorouracil and Acute Liver Injury, Drug-Induced

fluorouracil has been researched along with Acute Liver Injury, Drug-Induced in 91 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"An electronic search was undertaken to identify randomized controlled trials comparing raltitrexed-based regimen to 5-fluorouracil-based regimen in patients with advanced colorectal cancer."8.90Raltitrexed-based chemotherapy for advanced colorectal cancer. ( Hong, W; Huang, Q; Liu, Y; Sun, X; Wu, J; Wu, W, 2014)
"To assess if CT texture analysis (TA) can serve as a biomarker of liver toxicity in patients with colorectal cancer treated with 5-fluorouracil (5-FU)-based chemotherapy."7.915-Fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker. ( Alessandrino, F; Cruz, G; Meyerhardt, JA; Qin, L; Rosenthal, MH; Sahu, S; Shinagare, AB, 2019)
"Assessment of oxaliplatin-associated hepatotoxicity in patients receiving oxaliplatin, fluorouracil and leucovorin chemotherapy (FOLFOX) for colorectal cancer remains controversial."7.81Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate and is an Indicator Of Hepatotoxicity In Patients Receiving FOLFOX for Colorectal Cancer. ( Fujino, S; Hosokawa, Y; Katsumata, K; Makino, H; Maruno, K; Mushiake, H; Sugiyama, Y; Watanabe, M, 2015)
"We have described fatty liver, diagnosed by computed tomography scanning (CT) in more than 30% of patients with breast cancer who received tamoxifen."7.70Toremifene-induced fatty liver and NASH in breast cancer patients with breast-conservation treatment. ( Hamada, N; Inomata, T; Kariya, S; Murata, Y; Nishioka, A; Ogawa, Y; Saibara, T; Terashima, M; Yoshida, S, 2000)
"Liver function tests from 194 breast cancer patients who received adjuvant chemotherapy with or without tamoxifen (TAM) were reviewed."6.68Hepatic toxicity caused by adjuvant CMF/CNF in breast cancer patients and reversal by tamoxifen. ( Hirvikoski, PP; Johansson, RT; Kumpulainen, EJ, 1997)
"5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1."5.36Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010)
" Following intravenous administration of S-1, the blood concentration-time profiles of CDHP were similar between control rats and rats with hepatic dysfunction, but the half-life of tegafur was significantly prolonged."5.35Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. ( Chikamoto, J; Kanie, S; Nagayama, S; Nishimura, T; Yoshisue, K, 2009)
"An electronic search was undertaken to identify randomized controlled trials comparing raltitrexed-based regimen to 5-fluorouracil-based regimen in patients with advanced colorectal cancer."4.90Raltitrexed-based chemotherapy for advanced colorectal cancer. ( Hong, W; Huang, Q; Liu, Y; Sun, X; Wu, J; Wu, W, 2014)
"To assess if CT texture analysis (TA) can serve as a biomarker of liver toxicity in patients with colorectal cancer treated with 5-fluorouracil (5-FU)-based chemotherapy."3.915-Fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker. ( Alessandrino, F; Cruz, G; Meyerhardt, JA; Qin, L; Rosenthal, MH; Sahu, S; Shinagare, AB, 2019)
"Assessment of oxaliplatin-associated hepatotoxicity in patients receiving oxaliplatin, fluorouracil and leucovorin chemotherapy (FOLFOX) for colorectal cancer remains controversial."3.81Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate and is an Indicator Of Hepatotoxicity In Patients Receiving FOLFOX for Colorectal Cancer. ( Fujino, S; Hosokawa, Y; Katsumata, K; Makino, H; Maruno, K; Mushiake, H; Sugiyama, Y; Watanabe, M, 2015)
"Assessment of oxaliplatin-associated hepatotoxicity in patients receiving oxaliplatin, fluorouracil and leucovorin chemotherapy (FOLFOX) for colorectal cancer remains controversial."3.81Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate. ( Fujino, S; Hosokawa, Y; Katsumata, K; Makino, H; Maruno, K; Mushiake, H; Sugiyama, Y; Watanabe, M, 2015)
"Atorvastatin prevented mucosal damage and inflammation associated with 5-FU-induced OM, but the association of a higher dose of ATV with 5-FU induced hepatotoxicity and amplified leukopenia."3.77Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis. ( Alencar, NM; Barboza, DR; Brito, GA; Gomes, AS; Leitão, RF; Macedo, RN; Medeiros, CA; Nogueira, NA; Ribeiro, RA, 2011)
"Bevacizumab (Avastin) in combination with intravenous 5-fluorouracil-based chemotherapy as first-line as well as second-line treatment of metastatic colorectal cancer improves survival."3.73Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response. ( Gotlib, V; Khaled, S; Lapko, I; Mar, N; Saif, MW, 2006)
"We have described fatty liver, diagnosed by computed tomography scanning (CT) in more than 30% of patients with breast cancer who received tamoxifen."3.70Toremifene-induced fatty liver and NASH in breast cancer patients with breast-conservation treatment. ( Hamada, N; Inomata, T; Kariya, S; Murata, Y; Nishioka, A; Ogawa, Y; Saibara, T; Terashima, M; Yoshida, S, 2000)
" In the present study the therapeutic effect and metabolism of 5-FU and its masked compounds: FT, UFT (uracil + FT), HCFU (Carmofur), 5'-DFUR (Doxifluridine) were assessed by using MOPC-104E plasmacytoma transplanted subcutaneously in BALB/c mice with CCl4-induced chronic liver dysfunction."3.68[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction]. ( Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M, 1990)
"As adverse reactions to the combination treatment by the digestive system, we observed the occurrence of nausea and vomiting in 15% of the cases who received FTP treatment consisting of 5-FU, toyomicin and prednisone, 25% of the cases who received MFU treatment consisting of MMC, 5-FU and ACNU, and in 64% of the cases who received PPQ treatment consisting of CDDP, Carboquone (CQ) and prednisone."3.67[Adverse reactions to carcinostatics and countermeasures]. ( Nakao, I, 1989)
"5 mg/kg of mitomycin-C (Mit-C) resulted in 70% (n = 20) and 71% (n = 14) mortality, respectively, from 2 to 7 days after perfusion, with extensive, patchy necrosis and infarction seen on histologic examination and markedly elevated levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) at 6 and 24 hours after perfusion."3.66Reversal of lethal, chemotherapeutically induced acute hepatic necrosis in rats by regenerating liver cytosol. ( Falk, JA; Falk, RE; Falk, W; Makowka, L; Miyazaki, M; Venturi, D, 1983)
"Patients with Stage II/III gastric cancer after surgery were recruited."2.76Postoperative chemoradiotherapy in gastric cancer: a phase I study of radiotherapy with dose escalation of oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX regimen). ( Bi, F; Cao, D; Gou, HF; He, B; Li, Q; Li, ZP; Liao, ZY; Liu, JY; Luo, DY; Qiu, M; Shen, YL; Wang, X; Wang, Y; Xu, F; Yang, Y; Yi, C, 2011)
"Liver function tests from 194 breast cancer patients who received adjuvant chemotherapy with or without tamoxifen (TAM) were reviewed."2.68Hepatic toxicity caused by adjuvant CMF/CNF in breast cancer patients and reversal by tamoxifen. ( Hirvikoski, PP; Johansson, RT; Kumpulainen, EJ, 1997)
"Fifty-seven Dukes C colorectal cancer patients were given 5-fluorouracil-interferon-alpha 2b adjuvant treatment from October 1986 to September 1990."2.675-Fluorouracil-interferon-alpha 2b adjuvant treatment of Dukes C colorectal cancer. ( Cremone, L; Espinosa, A; Faiella, F; Frasci, G; Leone, F; Monaco, M; Persico, G; Sapio, U, 1994)
"5-fluorouracil (5-FU) is a widely used chemotherapeutic drug, but its hepatotoxicity challenges its clinical use."1.72Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats. ( Abdalla, AM; Abdelbaky, FAF; Abdelzaher, WY; Hafez, SMNA; Khalaf, HM; Welson, NN, 2022)
"5- Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC."1.72Sulfonamide-Functionalized Polymeric Nanoparticles for Enhanced In Vivo Colorectal Cancer Therapy. ( Andrade, SP; Campos, PP; Gontijo, SML; Guimarães, PPG; Pereira, L; Santos, RAS; Sinisterra, RD; Viana, CTR, 2022)
"Juglone has been showed to exert a direct cytotoxic effect on tumor cells."1.51Juglone eliminates MDSCs accumulation and enhances antitumor immunity. ( Cui, Y; E, F; Gao, X; Qiu, Z; Wang, H; Yu, Y; Zhang, H; Zhao, W; Zou, C, 2019)
"Two cohorts of metastatic colorectal cancer (CRC) were analyzed: a nonrandomized exploratory cohort of 184 patients treated at a single institution from 2003 to 2010 and a confirmatory cohort of 200 patients from a multi-institutional randomized trial (NO16966)."1.48The Addition of Bevacizumab to Oxaliplatin-Based Chemotherapy: Impact Upon Hepatic Sinusoidal Injury and Thrombocytopenia. ( Ferrarotto, R; George, B; Hobbs, B; Hoff, PM; Kopetz, S; Loyer, EM; Machado, KK; Mazard, T; Overman, MJ; Qiao, W; Raghav, K; Saltz, LB; Vauthey, JN, 2018)
"5-Fluorouracil (5-FU) is a pyrimidine analog widely used for the treatment of various cancers, but often causes hepatic damage in clinical practice."1.43Taurine as a protective agent for 5-fluorouracil-induced hepatic damage related to oxidative stress. ( Fukuno, S; Konishi, H; Nagai, K; Suzuki, H; Yoshida, S, 2016)
"Chemotherapy-induced toxic liver injury is a relevant issue in the clinical management of patients affected with metastatic colorectal cancer (mCRC)."1.42Liver toxicity in colorectal cancer patients treated with first-line FOLFIRI-containing regimen: a single institution experience. ( Fausti, V; Gallo, P; Imperatori, M; Picardi, A; Santini, D; Spalato Ceruso, M; Tonini, G; Vespasiani Gentilucci, U; Vincenzi, B, 2015)
"Close monitoring and prompt discontinuation of the drugs with high volume of distribution and metabolized through the liver are necessary to avoid drug-drug interaction in liver transplant patients."1.40Liver injury possibly related to drug interaction after liver transplant: a case report. ( Jiang, WT; Liu, YH; Pan, C; Thian, Y; Zhu, LQ, 2014)
"Patients undergoing liver resection for colorectal cancer liver metastasis (CRCLM) are often treated with chemotherapy before surgery."1.39Preoperative chemotherapy and the risk of hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience. ( Allen, PJ; Bao, F; D'Angelica, MI; DeMatteo, RP; Fong, Y; Gönen, M; Jarnagin, WR; Kemeny, N; Kingham, TP; Park, JO; Shia, J; Wolf, PS, 2013)
" The incidences of grade 3 or 4 adverse events and grade 2 or greater histopathological sinusoidal injury were significantly higher in the SVI ≥ +30% than in the SVI < +30% group."1.37Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy. ( Arai, T; Kobayashi, S; Koike, J; Koizumi, S; Makizumi, R; Miura, K; Miyajima, N; Nakano, H; Otsubo, T; Sakurai, J; Shimamura, T; Yamada, K, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
"5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1."1.36Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010)
" Following intravenous administration of S-1, the blood concentration-time profiles of CDHP were similar between control rats and rats with hepatic dysfunction, but the half-life of tegafur was significantly prolonged."1.35Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats. ( Chikamoto, J; Kanie, S; Nagayama, S; Nishimura, T; Yoshisue, K, 2009)
"The subjects were 13 colorectal cancer patients who had undergone resection of the primary tumor, and showed multiple, unresectable liver metastases and severe liver dysfunction."1.35[Combination of hepatic arterial infusion therapy and FOLFOX for colorectal cancer with multiple unresectable liver metastases causing severe liver dysfunction]. ( Iizawa, H; Ikeda, E; Ishiyama, K; Mori, N; Saito, K; Sakurai, N; Sato, T; Suto, T; Takano, N, 2009)
"All patients died from neoplastic disease progression despite further chemotherapy at 6, 17 and 31 months following the diagnosis of NRH."1.34Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases? ( Canon, JL; Ceratti, A; Gigot, JF; Horsmans, Y; Hubert, C; Humblet, Y; Machiels, JP; Rahier, J; Sempoux, C, 2007)
" However, it was repeatedly shown that the sequence of 5-FU followed by CDDP is more active and less toxic in tumor-bearing animals."1.33Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice. ( Fujimoto, S, 2006)
"In the patients with squamous cell carcinoma, 100 mg/m2 of cisplatin was infused intravenously, followed immediately by five consecutive daily administrations of 5-fluorouracil, 1,000 mg/m2/day, each infused intravenously over 24 hr."1.31Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors. ( Kim, GE; Kim, SN; Kim, SW; Park, TK; Suh, CO, 2000)

Research

Studies (91)

TimeframeStudies, this research(%)All Research%
pre-199018 (19.78)18.7374
1990's14 (15.38)18.2507
2000's9 (9.89)29.6817
2010's47 (51.65)24.3611
2020's3 (3.30)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Liu, Z1
Shi, Q1
Ding, D1
Kelly, R1
Fang, H1
Tong, W2
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG1
Stahl, S1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Chen, M1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Khalaf, HM1
Hafez, SMNA1
Abdalla, AM1
Welson, NN1
Abdelzaher, WY1
Abdelbaky, FAF1
Shindoh, J1
Kobayashi, Y1
Kinowaki, K1
Mise, Y1
Gonoi, W1
Yoshida, S3
Tani, K1
Matoba, S1
Kuroyanagi, H1
Hashimoto, M1
Sarathy, V1
Kothandath Shankar, RK1
Mufti, SS1
Naik, R1
Guimarães, PPG1
Viana, CTR1
Pereira, L1
Gontijo, SML1
Campos, PP1
Andrade, SP1
Santos, RAS1
Sinisterra, RD1
Duwe, G1
Knitter, S1
Pesthy, S1
Beierle, AS1
Bahra, M1
Schmelzle, M1
Schmuck, RB1
Lohneis, P1
Raschzok, N1
Öllinger, R1
Sinn, M1
Struecker, B1
Sauer, IM1
Pratschke, J1
Andreou, A1
Overman, MJ1
Ferrarotto, R1
Raghav, K1
George, B1
Qiao, W1
Machado, KK1
Saltz, LB1
Mazard, T1
Vauthey, JN1
Hoff, PM1
Hobbs, B1
Loyer, EM1
Kopetz, S1
Akindele, AJ1
Oludadepo, GO1
Amagon, KI1
Singh, D1
Osiagwu, DD1
Ünal, E1
Karaosmanoğlu, AD1
Ozmen, MN1
Akata, D1
Karcaaltincaba, M1
Fukuno, S1
Nagai, K1
Suzuki, H1
Konishi, H1
Hajj, A1
Ghosn, M1
Mourad, D1
Hojaiban, K1
Mousallem, P1
Khabbaz, LR1
Hubert, C2
Lucidi, V1
Weerts, J1
Dili, A1
Demetter, P1
Massart, B1
Komuta, M1
Navez, J1
Reding, R1
Gigot, JF2
Sempoux, C2
Li, PJ1
Mo, HY1
Luo, DH1
Hu, WH1
Jin, T1
Munakata, C1
Fuchigami, Y1
Hiroishi, S1
Haraguchi, A1
Hagimori, M1
Enomoto, H1
Tachiki, H1
Kodama, Y1
Sasaki, H1
Kawakami, S1
Limaiem, F1
Bouraoui, S1
Wang, H1
Zou, C2
Zhao, W1
Yu, Y1
Cui, Y1
Zhang, H1
E, F1
Qiu, Z1
Gao, X1
Alessandrino, F1
Qin, L1
Cruz, G1
Sahu, S1
Rosenthal, MH1
Meyerhardt, JA1
Shinagare, AB1
Robinson, SM2
Mann, J2
Manas, DM2
Mann, DA2
White, SA2
Gurzu, S1
Jung, I1
Comsulea, M1
Kadar, Z1
Azamfirei, L1
Molnar, C1
Oakley, F1
Liu, Y1
Wu, W1
Hong, W1
Sun, X1
Wu, J1
Huang, Q1
Han, NY1
Park, BJ1
Sung, DJ1
Kim, MJ1
Cho, SB1
Lee, CH1
Jang, YJ1
Kim, SY1
Kim, DS1
Um, SH1
Won, NH1
Yang, KS1
Zhu, LQ1
Jiang, WT1
Pan, C1
Liu, YH1
Thian, Y1
Poornima, K1
Chella Perumal, P1
Gopalakrishnan, VK1
Yan, Y1
Mo, Y1
Zhang, D1
Vincenzi, B3
Imperatori, M1
Picardi, A3
Vespasiani Gentilucci, U1
Gallo, P1
Fausti, V1
Spalato Ceruso, M1
Santini, D2
Tonini, G3
Hosokawa, Y2
Watanabe, M2
Makino, H2
Mushiake, H2
Katsumata, K2
Maruno, K2
Fujino, S2
Sugiyama, Y2
Hiroshima, Y1
Shuto, K1
Yamazaki, K1
Kawaguchi, D1
Yamada, M1
Kikuchi, Y1
Kasahara, K1
Murakami, T1
Hirano, A1
Mori, M1
Kosugi, C1
Matsuo, K1
Ishida, Y1
Koda, K1
Tanaka, K1
Suto, T1
Sato, T1
Mori, N1
Takano, N1
Ishiyama, K1
Sakurai, N1
Saito, K1
Iizawa, H1
Ikeda, E1
Yoshisue, K1
Kanie, S1
Nishimura, T1
Chikamoto, J1
Nagayama, S1
Nagata, M1
Hidaka, Y1
Hidaka, M1
Kawano, Y1
Iwakiri, T1
Okumura, M1
Arimori, K1
Medeiros, CA1
Leitão, RF1
Macedo, RN1
Barboza, DR1
Gomes, AS1
Nogueira, NA1
Alencar, NM1
Ribeiro, RA1
Brito, GA1
Mikalauskas, S1
Mikalauskiene, L1
Bruns, H1
Nickkholgh, A1
Hoffmann, K1
Longerich, T1
Strupas, K1
Büchler, MW1
Schemmer, P1
Wang, X1
Wang, Y1
Qiu, M1
Li, Q1
Li, ZP1
He, B1
Xu, F1
Shen, YL1
Gou, HF1
Yang, Y1
Cao, D1
Yi, C1
Liu, JY1
Luo, DY1
Liao, ZY1
Bi, F1
Krieger, PM1
Tamandl, D1
Herberger, B1
Faybik, P1
Fleischmann, E1
Maresch, J1
Gruenberger, T1
Daniele, S1
Frezza, AM2
Berti, P2
Vespasiani, U2
Miura, K1
Nakano, H1
Sakurai, J1
Kobayashi, S1
Koizumi, S1
Arai, T1
Shimamura, T1
Makizumi, R1
Yamada, K1
Miyajima, N1
Otsubo, T1
Koike, J1
Pilgrim, CH1
Brettingham-Moore, K1
Pham, A1
Murray, W1
Link, E1
Smith, M1
Usatoff, V1
Evans, PM1
Banting, S1
Thomson, BN1
Michael, M1
Phillips, WA1
Ramachandran, S1
Mandal, M1
Vietor, NO1
George, BJ1
Wolf, PS1
Park, JO1
Bao, F1
Allen, PJ1
DeMatteo, RP1
Fong, Y1
Jarnagin, WR1
Kingham, TP1
Gönen, M1
Kemeny, N1
Shia, J1
D'Angelica, MI1
Tzeng, CW1
Aloia, TA1
Makino, S1
Murata, K1
Murakami, M1
Wada, Y1
Kato, R1
Nishigaki, T1
Owada, Y1
Okada, K1
Yanagisawa, T1
Okamura, S1
Ebisui, C1
Yokouchi, H1
Kinuta, M1
Nakagomi, N1
Tamai, M1
Gotlib, V1
Khaled, S1
Lapko, I1
Mar, N1
Saif, MW1
Fujimoto, S1
Horsmans, Y1
Rahier, J1
Humblet, Y1
Machiels, JP1
Ceratti, A1
Canon, JL1
Miyazaki, M1
Makowka, L1
Falk, RE1
Falk, JA1
Falk, W1
Venturi, D1
Schlangen, J1
Wils, J1
Savrin, RA1
Martin, EW1
Frasci, G1
Leone, F1
Monaco, M1
Cremone, L1
Sapio, U1
Faiella, F1
Espinosa, A1
Persico, G1
Klotz, HP1
Weder, W1
Largiadèr, F1
Moertel, CG1
Fleming, TR1
Macdonald, JS1
Haller, DG1
Laurie, JA1
Uchino, J1
Une, Y1
Sato, Y1
Gondo, H1
Nakajima, Y1
Sato, N1
Hirvikoski, PP1
Kumpulainen, EJ1
Johansson, RT1
Valik, D1
Kimura, Y1
Okuda, H1
Locatelli, M1
Colleoni, M1
Noberasco, C1
Nolé, F1
Orlando, L1
Munzone, E1
Peruzzotti, G1
Goldhirsch, A1
Yamano, T1
Takayasu, Y1
Nakao, N1
Kubota, A1
Soori, GS1
Oldham, RK1
Dobbs, TW1
Bury, MJ1
Church, CK1
DePriest, C1
Park, TK1
Kim, SN1
Kim, SW1
Kim, GE1
Suh, CO1
Hamada, N1
Ogawa, Y1
Saibara, T1
Murata, Y1
Kariya, S1
Nishioka, A1
Terashima, M1
Inomata, T1
Chabner, BA1
Myers, CE2
Coleman, CN1
Johns, DG1
Stenram, U1
Kemeny, NE1
Harada, M1
Koga, K1
Miura, I1
Nishitani, H1
Tsubono, M2
Nio, Y2
Imai, S2
Shiraishi, T2
Morimoto, H2
Tseng, CC2
Kawabata, K1
Fukumoto, M1
Tobe, T2
Schlag, P1
Yi, J1
Friedl, P1
Hull, W1
Berger, M1
Nakao, I1
Lorenz, M1
Hottenrott, C1
Inglis, R1
Kirkowa-Reimann, M1
Patakfalvi, A2
Gelencsér, E2
Sípos, J2
Caruso, U1
Elli, M1
Cravotto, E1
Tisone, G1
Lombardo, PA1
Silvaroli, M1
Ficorella, C1
Cortesi, E1
Casciani, CU1
Sugarbaker, PH1
Gianola, FJ1
Speyer, JL1
Wesley, R1
Barofsky, I1
Kitamura, M1
Tominaga, T1
Hayashi, K1
Takahashi, I1
Kosaki, G1
Kemeny, MM1
Goldberg, DA1
Browning, S1
Metter, GE1
Miner, PJ1
Terz, JJ1
Gorgun, B1
Watne, AL1
Poliak, NR1
Vestfrid, MA1
Castelleto, L1
Giménez, PO1
Tsoĭ, AI1
Dement'eva, NI1
Sulaeva, LS1
Ambre, JJ1
Fischer, LJ1
Pivniuk, VM1
Buklina, ZP1
Ezerskaia, LIa1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Placebo-controlled, Double-blind Multicenter Phase II Study to Investigate the Protectivity and Efficacy of Metformin Against Steatosis in Combination With FOLFIRI and Cetuximab in Subjects With First-line Palliative Treated, KRAS-Wild-Type,[NCT01523639]Phase 28 participants (Actual)Interventional2012-04-30Terminated (stopped due to Prematurely due to slow recruitment (07/08/2013). Newly defined study end=LPLV=05/11/2013. ABCSG guaranteed completed treatment period for ethical reasons.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for fluorouracil and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
Hepatotoxicity following systemic therapy for colorectal liver metastases and the impact of chemotherapy-associated liver injury on outcomes after curative liver resection.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2017, Volume: 43, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Cetuximab; Chemical and D

2017
Hepatobiliary phase liver MR imaging findings after Oxaliplatin-based chemotherapy in cancer patients.
    Abdominal radiology (New York), 2018, Volume: 43, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemical and Dru

2018
Raltitrexed-based chemotherapy for advanced colorectal cancer.
    Clinics and research in hepatology and gastroenterology, 2014, Volume: 38, Issue:2

    Topics: Alopecia; Anemia; Antineoplastic Combined Chemotherapy Protocols; Asthenia; Chemical and Drug Induce

2014
Oxaliplatin-induced hepatocellular injury and ototoxicity: a review of the literature and report of unusual side effects of a commonly used chemotherapeutic agent.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2012, Volume: 18, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Inju

2012
Colorectal liver metastases.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Catheter Ablati

2013
The clinical pharmacology of antineoplastic agents (first of two parts).
    The New England journal of medicine, 1975, May-22, Volume: 292, Issue:21

    Topics: Animals; Antineoplastic Agents; Asparaginase; Binding Sites; Biological Transport; Chemical and Drug

1975
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
    Important advances in oncology, 1992

    Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Fl

1992

Trials

13 trials available for fluorouracil and Acute Liver Injury, Drug-Induced

ArticleYear
[Magnesium isoglycyrrhizinate prevention of chemotherapy-induced liver damage during initial treatment of patients with gastrointestinal tumors].
    Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2015, Volume: 23, Issue:3

    Topics: Alanine Transaminase; Alkaline Phosphatase; Antineoplastic Combined Chemotherapy Protocols; Aspartat

2015
Postoperative chemoradiotherapy in gastric cancer: a phase I study of radiotherapy with dose escalation of oxaliplatin, 5-fluorouracil, and leucovorin (FOLFOX regimen).
    Medical oncology (Northwood, London, England), 2011, Volume: 28 Suppl 1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chemo

2011
5-Fluorouracil-interferon-alpha 2b adjuvant treatment of Dukes C colorectal cancer.
    Diseases of the colon and rectum, 1994, Volume: 37, Issue:7

    Topics: Aged; Chemical and Drug Induced Liver Injury; Chemotherapy, Adjuvant; Colonic Neoplasms; Confidence

1994
Local and systemic toxicity of intra-hepato-arterial chemotherapy for treatment of unresectable liver metastases of colorectal cancer with 5-Fluorouracil and high dose Leucovorin.
    Helvetica chirurgica acta, 1993, Volume: 60, Issue:1-2

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Colore

1993
Hepatic toxicity associated with fluorouracil plus levamisole adjuvant therapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1993, Volume: 11, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biopsy; Chemical and Drug Induced Liver Injury; Chem

1993
Chemohormonal therapy of unresectable hepatocellular carcinoma.
    American journal of clinical oncology, 1993, Volume: 16, Issue:3

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepato

1993
Hepatic toxicity caused by adjuvant CMF/CNF in breast cancer patients and reversal by tamoxifen.
    Breast cancer research and treatment, 1997, Volume: 44, Issue:3

    Topics: Acetyltransferases; Adult; Alkaline Phosphatase; Antineoplastic Agents, Hormonal; Antineoplastic Com

1997
Chemo-biotherapy with 5-fluorouracil, leucovorin, and alpha interferon in metastatic carcinoma of the colon--a Cancer Biotherapy Research Group [CBRG] phase II study.
    Cancer biotherapy & radiopharmaceuticals, 2000, Volume: 15, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury;

2000
Is hepatic infusion of chemotherapy effective treatment for liver metastases? Yes!
    Important advances in oncology, 1992

    Topics: Actuarial Analysis; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dexamethasone; Fl

1992
Prevention of extrahepatic disease during intraarterial floxuridine of colorectal liver metastases by simultaneous systemic 5-fluorouracil treatment? A prospective multicenter study.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:12

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Inju

1989
Prospective randomized trial of intravenous v intraperitoneal 5-FU in patients with advanced primary colon or rectal cancer.
    Seminars in oncology, 1985, Volume: 12, Issue:3 Suppl 4

    Topics: Adult; Catheters, Indwelling; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Colo

1985
[Preliminary report of adjuvant chemo-endocrine therapy for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1985, Volume: 12, Issue:1

    Topics: Adult; Anorexia; Breast Neoplasms; Chemical and Drug Induced Liver Injury; Combined Modality Therapy

1985
Experience with continuous regional chemotherapy and hepatic resection as treatment of hepatic metastases from colorectal primaries. A prospective randomized study.
    Cancer, 1985, Mar-15, Volume: 55, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Cholestasis; Colonic Neoplasms; Combined Modality Therapy; F

1985

Other Studies

71 other studies available for fluorouracil and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:26

    Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Chemical and Drug Induced

2022
Dynamic Changes in Normal Liver Parenchymal Volume During Chemotherapy for Colorectal Cancer: Liver Atrophy as an Alternate Marker of Chemotherapy-Associated Liver Injury.
    Annals of surgical oncology, 2019, Volume: 26, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Atrophy; Bevacizumab

2019
FOLFOX and capecitabine-induced hepatic granuloma mimicking metastasis in a rectal cancer patient.
    BMJ case reports, 2020, Mar-04, Volume: 13, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemi

2020
Sulfonamide-Functionalized Polymeric Nanoparticles for Enhanced In Vivo Colorectal Cancer Therapy.
    Current drug delivery, 2022, Volume: 19, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Colonic Neoplasms; Drug Carriers; Drug Delivery Systems; Flu

2022
The Addition of Bevacizumab to Oxaliplatin-Based Chemotherapy: Impact Upon Hepatic Sinusoidal Injury and Thrombocytopenia.
    Journal of the National Cancer Institute, 2018, 08-01, Volume: 110, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Chemica

2018
Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
    Pharmacology research & perspectives, 2018, Volume: 6, Issue:1

    Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Carbazoles; Carvedilol; Chemical and Drug

2018
Taurine as a protective agent for 5-fluorouracil-induced hepatic damage related to oxidative stress.
    Die Pharmazie, 2016, Sep-01, Volume: 71, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Chemical and Drug Induced Liver Injury; Dose-Response Rela

2016
Lethal hepatotoxicity following 5-fluorouracil/cisplatin chemotherapy: a relevant case report.
    Personalized medicine, 2017, Volume: 14, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cisplatin; Drug-Related Side Effects and Adverse React

2017
Impact of biological agents on the prevalence of chemotherapy associated liver injury (CALI): Multicentric study of patients operated for colorectal liver metastases.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2018, Volume: 44, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocol

2018
The efficacy of induction chemotherapy in the treatment of stage II nasopharyngeal carcinoma in intensity modulated radiotherapy era.
    Oral oncology, 2018, Volume: 85

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chemo

2018
Evaluation of miR-122 to Predict High Dose Acetaminophen-Induced Liver Injury in Mice: The Combination Uses of 5-Fluorouracil.
    Biological & pharmaceutical bulletin, 2018, Volume: 41, Issue:11

    Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antimetabolites, Antineoplas

2018
Chemotherapy-induced liver injury in metastatic colorectal cancer: about 48 cases.
    The Pan African medical journal, 2018, Volume: 30

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury;

2018
Juglone eliminates MDSCs accumulation and enhances antitumor immunity.
    International immunopharmacology, 2019, Volume: 73

    Topics: Animals; Antineoplastic Agents; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chemical and Drug Indu

2019
5-Fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker.
    Abdominal radiology (New York), 2019, Volume: 44, Issue:9

    Topics: Aged; Antimetabolites, Antineoplastic; Biomarkers; Chemical and Drug Induced Liver Injury; Colorecta

2019
An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2013, Volume: 15, Issue:8

    Topics: Adenosine Triphosphatases; Animals; Antineoplastic Combined Chemotherapy Protocols; Cation Transport

2013
Lethal cardiotoxicity, steatohepatitis, chronic pancreatitis, and acute enteritis induced by capecitabine and oxaliplatin in a 36-year-old woman.
    Diagnostic pathology, 2013, Sep-16, Volume: 8

    Topics: Acute Disease; Adenocarcinoma; Adult; Ampulla of Vater; Antineoplastic Combined Chemotherapy Protoco

2013
The potential contribution of tumour-related factors to the development of FOLFOX-induced sinusoidal obstruction syndrome.
    British journal of cancer, 2013, Oct-29, Volume: 109, Issue:9

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Chemical and Drug Induced

2013
Chemotherapy-induced focal hepatopathy in patients with gastrointestinal malignancy: gadoxetic acid--enhanced and diffusion-weighted MR imaging with clinical-pathologic correlation.
    Radiology, 2014, Volume: 271, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Chemica

2014
Liver injury possibly related to drug interaction after liver transplant: a case report.
    Journal of clinical pharmacy and therapeutics, 2014, Volume: 39, Issue:4

    Topics: Adult; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Chemical and Drug Induced Live

2014
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
    BioMed research international, 2014, Volume: 2014

    Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi

2014
Liver toxicity in colorectal cancer patients treated with first-line FOLFIRI-containing regimen: a single institution experience.
    Expert review of anticancer therapy, 2015, Volume: 15, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemic

2015
Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate and is an Indicator Of Hepatotoxicity In Patients Receiving FOLFOX for Colorectal Cancer.
    Hepato-gastroenterology, 2015, Volume: 62, Issue:139

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Chemical and Drug Induced Liver In

2015
Serum Type IV Collagen Concentration Correlates with Indocyanine Green Retention Rate.
    Hepato-gastroenterology, 2015, Volume: 62, Issue:140

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Cohort

2015
Fractal Dimension of Tc-99m DTPA GSA Estimates Pathologic Liver Injury due to Chemotherapy in Liver Cancer Patients.
    Annals of surgical oncology, 2016, Volume: 23, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemic

2016
[Combination of hepatic arterial infusion therapy and FOLFOX for colorectal cancer with multiple unresectable liver metastases causing severe liver dysfunction].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury;

2009
Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats.
    The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:12

    Topics: Animals; Antineoplastic Agents; Area Under Curve; Chemical and Drug Induced Liver Injury; Dihydroura

2009
Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:5

    Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Inju

2010
Effect of atorvastatin on 5-fluorouracil-induced experimental oral mucositis.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Atorvastatin; Bac

2011
Dietary glycine protects from chemotherapy-induced hepatotoxicity.
    Amino acids, 2011, Volume: 40, Issue:4

    Topics: Animals; Antineoplastic Agents; Camptothecin; Chemical and Drug Induced Liver Injury; Colorectal Neo

2011
Evaluation of chemotherapy-associated liver injury in patients with colorectal cancer liver metastases using indocyanine green clearance testing.
    Annals of surgical oncology, 2011, Volume: 18, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopl

2011
The role of S-adenosylmethionine in preventing oxaliplatin-induced liver toxicity: a retrospective analysis in metastatic colorectal cancer patients treated with bevacizumab plus oxaliplatin-based regimen.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012, Volume: 20, Issue:1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Cape

2012
Splenomegaly in FOLFOX-naïve stage IV or recurrent colorectal cancer patients due to chemotherapy-associated hepatotoxicity can be predicted by the aspartate aminotransferase to platelet ratio before chemotherapy.
    International journal of clinical oncology, 2011, Volume: 16, Issue:3

    Topics: Adenocarcinoma; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Comb

2011
The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen.
    Expert opinion on drug safety, 2011, Volume: 10, Issue:3

    Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Aspartate Aminotr

2011
mRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury.
    HPB : the official journal of the International Hepato Pancreato Biliary Association, 2011, Volume: 13, Issue:11

    Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Colorectal Neoplasms; Dihydrouracil D

2011
Induction of apoptosis of azurin synthesized from P. aeruginosa MTCC 2453 against Dalton's lymphoma ascites model.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2011, Volume: 65, Issue:7

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Pro

2011
Preoperative chemotherapy and the risk of hepatotoxicity and morbidity after liver resection for metastatic colorectal cancer: a single institution experience.
    Journal of the American College of Surgeons, 2013, Volume: 216, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopla

2013
[Liver damage detected after a hepatectomy for liver metastasis after 12 courses of mFOLFOX6 therapy as an adjuvant chemotherapy for colorectal cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2012, Volume: 39, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Chemical and Drug Induced Liver Injury; C

2012
Skin rash secondary to bevacizumab in a patient with advanced colorectal cancer and relation to response.
    Anti-cancer drugs, 2006, Volume: 17, Issue:10

    Topics: Adenocarcinoma; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Com

2006
Schedule-dependent antitumor activity and toxicity of combinations of 5-fluorouracil and cisplatin/carboplatin against L1210 leukemia-bearing mice.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:11

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Ascites; Carboplatin

2006
Nodular regenerative hyperplasia: a deleterious consequence of chemotherapy for colorectal liver metastases?
    Liver international : official journal of the International Association for the Study of the Liver, 2007, Volume: 27, Issue:7

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Chemot

2007
Reversal of lethal, chemotherapeutically induced acute hepatic necrosis in rats by regenerating liver cytosol.
    Surgery, 1983, Volume: 94, Issue:2

    Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytosol; Fluorouracil; Hyperthermia,

1983
Liver calcifications following hepatic artery infusion with 5-fluorouracil, adriamycin and mitomycin C (FAM).
    RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1984, Volume: 140, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Calcinosis; Chemical and Drug Induced Liver Injury;

1984
The relationship of the possible hepatic toxicity of chemotherapeutic drugs and carcinoembryonic antigen elevation.
    Cancer, 1981, Feb-01, Volume: 47, Issue:3

    Topics: Adenocarcinoma; Biopsy; Carcinoembryonic Antigen; Chemical and Drug Induced Liver Injury; Fluorourac

1981
Encephalopathy, lactic acidosis, hyperammonaemia and 5-fluorouracil toxicity.
    British journal of cancer, 1998, Volume: 77, Issue:10

    Topics: Acidosis, Lactic; Ammonia; Brain Diseases; Chemical and Drug Induced Liver Injury; Citric Acid Cycle

1998
Prevention by carp extract of myelotoxicity and gastrointestinal toxicity induced by 5-fluorouracil without loss of antitumor activity in mice.
    Journal of ethnopharmacology, 1999, Dec-15, Volume: 68, Issue:1-3

    Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Bone Marrow Diseases; Carps; Chemical and Dru

1999
Hepatic toxicity from cyclophosphamide, methotrexate, fluorouracil (CMF regimen)
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:11

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver In

1999
[Evaluation of hepatic toxicity following high-dose 5-FU arterial infusion chemotherapy: analysis of 42 cases of colorectal liver metastases].
    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica, 2000, Volume: 60, Issue:3

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Atrophy; Chemical and Drug Induced Liver Injury; Color

2000
Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors.
    Journal of Korean medical science, 2000, Volume: 15, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma,

2000
Toremifene-induced fatty liver and NASH in breast cancer patients with breast-conservation treatment.
    International journal of oncology, 2000, Volume: 17, Issue:6

    Topics: Alanine Transaminase; Alcohol Drinking; Antineoplastic Agents, Hormonal; Antineoplastic Combined Che

2000
Hepatotoxicity of fluorouracil with N-phosphonacetyl-L-aspartate.
    Annals of internal medicine, 1992, Jul-01, Volume: 117, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Chemical and Drug Induced Liver Injur

1992
A new method for the evaluation of the liver injury by 19F MRS of 5-fluorouracil.
    Magnetic resonance in medicine, 1991, Volume: 22, Issue:2

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fluorouracil; Liver

1991
Low uracil concentration in the liver might be responsible for the decreased antineoplastic activity of fluoropyrimidines in mice with CCl4-induced chronic liver dysfunction.
    Oncology, 1991, Volume: 48, Issue:3

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Resistance; Fi

1991
[Animal experiment studies of the toxicity of fluorodeoxyuridine (FUDR) and 5-fluorouracil (FU) within the scope of regional liver infusion chemotherapy].
    Langenbecks Archiv fur Chirurgie, 1990, Volume: 375, Issue:2

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Female; Floxuridine; Fluorouracil; Inactivati

1990
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
    Nihon Gan Chiryo Gakkai shi, 1990, Mar-20, Volume: 25, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride

1990
[Adverse reactions to carcinostatics and countermeasures].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-1

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Carbazilquinone; Chemical and Drug Indu

1989
Drug hepatitis of cholestatic type in association with a FAC-regimen for breast cancer.
    Acta medica Hungarica, 1987, Volume: 44, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced L

1987
[Liver damage following combined cytostatic therapy of breast cancer].
    Orvosi hetilap, 1986, Oct-19, Volume: 127, Issue:42

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemical and Drug Induced Liver In

1986
Colorectal cancer (Duke's group B2, C1, C2): adjuvant chemotherapy and toxicity.
    The Mount Sinai journal of medicine, New York, 1985, Volume: 52, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Chemical and Drug Induced

1985
Infusion chemotherapy in hepatoma and metastatic liver tumors.
    American journal of surgery, 1967, Volume: 113, Issue:3

    Topics: Adenocarcinoma; Adolescent; Aged; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury;

1967
[Use of vitamin B-15 in experimental tumor chemotherapy].
    Voprosy onkologii, 1970, Volume: 16, Issue:8

    Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride Poisoning; Carcinoma; Chemical and Drug Induced

1970
[Diffuse liver necrosis in treatment with 5-fluorouracil].
    Revista clinica espanola, 1972, Jun-30, Volume: 125, Issue:6

    Topics: Adult; Chemical and Drug Induced Liver Injury; Fluorouracil; Humans; Liver; Male; Mesothelioma; Necr

1972
[The functional state of the liver during conservative treatment of oncologic patients].
    Klinicheskaia meditsina, 1972, Volume: 50, Issue:6

    Topics: Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Esophageal Neoplasms; Fluorouracil; H

1972
The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats.
    The Journal of laboratory and clinical medicine, 1971, Volume: 78, Issue:3

    Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical

1971
[Hematopoietic changes following use of fluorouracil in animals with toxic hepatitis].
    Voprosy onkologii, 1970, Volume: 16, Issue:6

    Topics: Anemia, Aplastic; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; F

1970