Page last updated: 2024-10-27

fluorouracil and Acute Kidney Injury

fluorouracil has been researched along with Acute Kidney Injury in 20 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
" Because previous studies showed that long-term telbivudine treatment improved renal function in chronic hepatitis B virus (HBV) infected patients, we conducted a case-control study to evaluate the clinical outcome of telbivudine preemptive therapy in HBV-related advanced HCC patients treated by combination chemotherapy comprising 5-fluorouracil, mitoxantrone and cisplatin (FMP)."5.19Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study. ( Chang, ML; Chen, YC; Chien, RN; Hsu, CW; Lin, CL; Yeh, C; Yeh, CT, 2014)
"Although combination chemotherapy with docetaxel, cisplatin and 5-fluorouracil demonstrates high response rates in esophageal squamous cell carcinoma, patients treated with docetaxel, cisplatin and 5-fluorouracil frequently experience acute kidney injury."3.83Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer. ( Doki, Y; Kurokawa, Y; Makino, T; Miyata, H; Miyazaki, Y; Mori, M; Nakajima, K; Takahashi, T; Takiguchi, S; Yamasaki, M; Yanagimoto, Y, 2016)
" We report a case of acute kidney injury (AKI) after treatment with a combination of oxaliplatin, folinic acid and 5-fluorouracil or capecitabine."3.78A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. ( Imai, E; Ito, I; Ito, Y; Kosugi, T; Maruyama, S; Matsuo, S; Mizuno, M; Ozaki, T; Sato, W; Suzuki, Y; Tsuboi, N; Yasuda, K; Yasuda, Y, 2012)
"Fourteen patients with adenocarcinoma of the gastrointestinal tract and pancreas treated with mitomycin C(MMC) and 5-fluorouracil (5-FU) had renal impairment 6-11 months from the beginning of MMC therapy."3.66Renal disease after mitomycin C therapy. ( Hanna, WT; Krauss, S; Murphy, WM; Regester, RF, 1981)
"Pantoprazole prevented the increase in acute kidney injury biomarkers in cisplatin-treated patients."3.01Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial. ( El-Haggar, S; Ghonaim, E; Gohar, S, 2021)
" Nephrotoxicity that developed within 14 days following CDDP administration was evaluated in accordance with Common Terminology Criteria for Adverse Events ver."1.46Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study. ( Enokiya, T; Ikemura, K; Ishinaga, H; Iwamoto, T; Katayama, N; Mizuno, T; Muraki, Y; Oda, H; Okamoto, A; Okuda, M; Oshima, K; Takeuchi, K, 2017)
"Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker."1.42Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury. ( Babacan, NA; Deveci, K; Kacan, T; Sancakdar, E; Seker, A; Seker, MM; Turesin, AK; Yilmaz, A, 2015)
"Based on laboratory data, we diagnosed acute renal failure caused by MTX and added the infusion of Ringer and LV."1.33[A case of head and neck squamous cell carcinoma suffering from acute renal failure after methotrexate administrator]. ( Matsuda, H; Mikami, Y; Nagao, J; Sakuma, N; Tsukuda, M; Yoshida, T, 2005)
"Uric acid nephrolithiasis developed in a 75-year-old man who had received a large cumulative dose of streptozotocin for treatment of metastatic islet cell carcinoma of the pancreas."1.27Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity. ( Goldsmith, GH; Hricik, DE, 1988)
"A 45-year-old man with hepatocellular carcinoma who developed intravascular coagulation following complete tumor regression by chemotherapy is described."1.26Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report. ( Harada, T; Makisaka, Y; Nishimura, H; Okuda, K, 1978)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19905 (25.00)18.7374
1990's1 (5.00)18.2507
2000's1 (5.00)29.6817
2010's12 (60.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Ghonaim, E1
El-Haggar, S1
Gohar, S1
Ikemura, K1
Oshima, K1
Enokiya, T1
Okamoto, A1
Oda, H1
Mizuno, T1
Ishinaga, H1
Muraki, Y1
Iwamoto, T1
Takeuchi, K1
Katayama, N1
Okuda, M1
Akindele, AJ1
Oludadepo, GO1
Amagon, KI1
Singh, D1
Osiagwu, DD1
Iwazu, Y1
Kotani, K1
Yamada, T1
Lin, CL1
Chien, RN1
Yeh, C1
Hsu, CW1
Chang, ML1
Chen, YC1
Yeh, CT1
Seker, MM1
Deveci, K1
Seker, A1
Sancakdar, E1
Yilmaz, A1
Turesin, AK1
Kacan, T1
Babacan, NA1
Yanagimoto, Y1
Takiguchi, S1
Miyazaki, Y1
Makino, T1
Takahashi, T1
Kurokawa, Y1
Yamasaki, M1
Miyata, H1
Nakajima, K1
Mori, M1
Doki, Y1
Xiong, Y1
Shang, B1
Xu, S1
Zhao, R1
Gou, H1
Wang, C1
Yousef, HN1
Aboelwafa, HR1
Ulusakarya, A1
Misra, S1
Haydar, M1
Habert, H1
Castagne, V1
Gumus, Y1
Delmas-Marsalet, B1
Machover, D1
Di Mizio, G1
Gallelli, L1
Barbieri, V1
Loiacono, D1
Colosimo, F1
Rende, P1
Di Nunzio, C1
Ricci, P1
Ito, I1
Ito, Y1
Mizuno, M1
Suzuki, Y1
Yasuda, K1
Ozaki, T1
Kosugi, T1
Yasuda, Y1
Sato, W1
Tsuboi, N1
Maruyama, S1
Imai, E1
Matsuo, S1
Márquez, E1
Rodríguez, E1
Pascual, J1
Nagao, J1
Tsukuda, M1
Yoshida, T1
Sakuma, N1
Matsuda, H1
Mikami, Y1
Hanna, WT1
Krauss, S1
Regester, RF1
Murphy, WM1
Birembaut, P1
Parjoie, R1
Ploton, D1
Rebaiz, K1
Wolf, C1
Harada, T1
Makisaka, Y1
Nishimura, H1
Okuda, K1
Brillet, G1
Deray, G1
Baumelou, A1
Jacobs, C1
Hricik, DE1
Goldsmith, GH1
Ellison, NM1
Servi, RJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Observational, Single-center Post-marketing Surveillance Study of Telbivudine in Chronic Hepatitis B Adults With HBeAg Positive/Negative.[NCT00970216]160 participants (Actual)Observational2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

HBV-DNA < 300 Copies/mL in 48 Weeks

(NCT00970216)
Timeframe: 48 weeks

Interventionparticipants (Number)
Chronic Hepatitis B79

Reviews

1 review available for fluorouracil and Acute Kidney Injury

ArticleYear
[Acute Kidney Injury in a Patient with Diarrhea and Vomiting Undergoing Chemotherapy for Colorectal Cancer].
    Rinsho byori. The Japanese journal of clinical pathology, 2016, Volume: 64, Issue:5

    Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Diarrhea; Fluoroura

2016

Trials

2 trials available for fluorouracil and Acute Kidney Injury

ArticleYear
Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial.
    Medical oncology (Northwood, London, England), 2021, Aug-06, Volume: 38, Issue:9

    Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Female; F

2021
Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study.
    Scandinavian journal of gastroenterology, 2014, Volume: 49, Issue:12

    Topics: Acute Kidney Injury; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

2014

Other Studies

17 other studies available for fluorouracil and Acute Kidney Injury

ArticleYear
Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study.
    Cancer chemotherapy and pharmacology, 2017, Volume: 79, Issue:5

    Topics: Acute Kidney Injury; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineopla

2017
Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
    Pharmacology research & perspectives, 2018, Volume: 6, Issue:1

    Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Carbazoles; Carvedilol; Chemical and Drug

2018
Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury.
    Asian Pacific journal of cancer prevention : APJCP, 2015, Volume: 16, Issue:2

    Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Aged; Antineoplastic Combined Chemotherapy Protoco

2015
Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer.
    Japanese journal of clinical oncology, 2016, Volume: 46, Issue:5

    Topics: Acute Kidney Injury; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Creatinine; Do

2016
Protective effect of Bu-zhong-yi-qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced renal injury in mice.
    Renal failure, 2016, Volume: 38, Issue:8

    Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal

2016
The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2017, Jun-14, Volume: 69, Issue:5

    Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Fluorouracil; Kidney; Male; Rats; Taurine

2017
Acute renal failure related to oxaliplatin-induced intravascular hemolysis.
    Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:4

    Topics: Acute Kidney Injury; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combi

2010
Capecitabine-induced, rapid decrease of renal function due to drug dispensing error in a hospital pharmacy.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:1

    Topics: Acute Kidney Injury; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouraci

2011
A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin.
    Clinical and experimental nephrology, 2012, Volume: 16, Issue:3

    Topics: Acute Kidney Injury; Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocols;

2012
Inadvertent severe acute kidney injury and oxaliplatin.
    International urology and nephrology, 2013, Volume: 45, Issue:1

    Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorecta

2013
[A case of head and neck squamous cell carcinoma suffering from acute renal failure after methotrexate administrator].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2005, Volume: 32, Issue:6

    Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cispl

2005
Renal disease after mitomycin C therapy.
    Cancer, 1981, Dec-15, Volume: 48, Issue:12

    Topics: Acute Kidney Injury; Adenocarcinoma; Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Creatinine; F

1981
[Renal lesions after irradiation and chemotherapy with adriamycin, vincristin and 5-fluoro-uracil (author's transl)].
    Nephrologie, 1981, Volume: 2, Issue:1

    Topics: Acute Kidney Injury; Adult; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Ki

1981
Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report.
    Cancer, 1978, Volume: 42, Issue:1

    Topics: Acute Kidney Injury; Antineoplastic Agents; Carcinoma, Hepatocellular; Disseminated Intravascular Co

1978
Acute cardiac and renal failure after 5-FU and cisplatin treatment.
    Nephron, 1991, Volume: 59, Issue:4

    Topics: Acute Kidney Injury; Adult; Cardiac Output, Low; Cisplatin; Female; Fluorouracil; Humans; Uterine Ne

1991
Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity.
    The American journal of medicine, 1988, Volume: 84, Issue:1

    Topics: Acute Kidney Injury; Adenoma, Islet Cell; Aged; Fluorouracil; Humans; Kidney Calculi; Male; Pancreat

1988
Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration.
    Cancer treatment reports, 1985, Volume: 69, Issue:3

    Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic N

1985