fluorouracil has been researched along with Acute Kidney Injury in 20 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because previous studies showed that long-term telbivudine treatment improved renal function in chronic hepatitis B virus (HBV) infected patients, we conducted a case-control study to evaluate the clinical outcome of telbivudine preemptive therapy in HBV-related advanced HCC patients treated by combination chemotherapy comprising 5-fluorouracil, mitoxantrone and cisplatin (FMP)." | 5.19 | Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study. ( Chang, ML; Chen, YC; Chien, RN; Hsu, CW; Lin, CL; Yeh, C; Yeh, CT, 2014) |
| "Although combination chemotherapy with docetaxel, cisplatin and 5-fluorouracil demonstrates high response rates in esophageal squamous cell carcinoma, patients treated with docetaxel, cisplatin and 5-fluorouracil frequently experience acute kidney injury." | 3.83 | Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer. ( Doki, Y; Kurokawa, Y; Makino, T; Miyata, H; Miyazaki, Y; Mori, M; Nakajima, K; Takahashi, T; Takiguchi, S; Yamasaki, M; Yanagimoto, Y, 2016) |
| " We report a case of acute kidney injury (AKI) after treatment with a combination of oxaliplatin, folinic acid and 5-fluorouracil or capecitabine." | 3.78 | A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin. ( Imai, E; Ito, I; Ito, Y; Kosugi, T; Maruyama, S; Matsuo, S; Mizuno, M; Ozaki, T; Sato, W; Suzuki, Y; Tsuboi, N; Yasuda, K; Yasuda, Y, 2012) |
| "Fourteen patients with adenocarcinoma of the gastrointestinal tract and pancreas treated with mitomycin C(MMC) and 5-fluorouracil (5-FU) had renal impairment 6-11 months from the beginning of MMC therapy." | 3.66 | Renal disease after mitomycin C therapy. ( Hanna, WT; Krauss, S; Murphy, WM; Regester, RF, 1981) |
| "Pantoprazole prevented the increase in acute kidney injury biomarkers in cisplatin-treated patients." | 3.01 | Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial. ( El-Haggar, S; Ghonaim, E; Gohar, S, 2021) |
| " Nephrotoxicity that developed within 14 days following CDDP administration was evaluated in accordance with Common Terminology Criteria for Adverse Events ver." | 1.46 | Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study. ( Enokiya, T; Ikemura, K; Ishinaga, H; Iwamoto, T; Katayama, N; Mizuno, T; Muraki, Y; Oda, H; Okamoto, A; Okuda, M; Oshima, K; Takeuchi, K, 2017) |
| "Acute kidney injury is an important issue in chemotherapy receiving patients an neutrophil gelatinase-associated lipocalin has been proposed as a novel marker." | 1.42 | Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury. ( Babacan, NA; Deveci, K; Kacan, T; Sancakdar, E; Seker, A; Seker, MM; Turesin, AK; Yilmaz, A, 2015) |
| "Based on laboratory data, we diagnosed acute renal failure caused by MTX and added the infusion of Ringer and LV." | 1.33 | [A case of head and neck squamous cell carcinoma suffering from acute renal failure after methotrexate administrator]. ( Matsuda, H; Mikami, Y; Nagao, J; Sakuma, N; Tsukuda, M; Yoshida, T, 2005) |
| "Uric acid nephrolithiasis developed in a 75-year-old man who had received a large cumulative dose of streptozotocin for treatment of metastatic islet cell carcinoma of the pancreas." | 1.27 | Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity. ( Goldsmith, GH; Hricik, DE, 1988) |
| "A 45-year-old man with hepatocellular carcinoma who developed intravascular coagulation following complete tumor regression by chemotherapy is described." | 1.26 | Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report. ( Harada, T; Makisaka, Y; Nishimura, H; Okuda, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 12 (60.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghonaim, E | 1 |
| El-Haggar, S | 1 |
| Gohar, S | 1 |
| Ikemura, K | 1 |
| Oshima, K | 1 |
| Enokiya, T | 1 |
| Okamoto, A | 1 |
| Oda, H | 1 |
| Mizuno, T | 1 |
| Ishinaga, H | 1 |
| Muraki, Y | 1 |
| Iwamoto, T | 1 |
| Takeuchi, K | 1 |
| Katayama, N | 1 |
| Okuda, M | 1 |
| Akindele, AJ | 1 |
| Oludadepo, GO | 1 |
| Amagon, KI | 1 |
| Singh, D | 1 |
| Osiagwu, DD | 1 |
| Iwazu, Y | 1 |
| Kotani, K | 1 |
| Yamada, T | 1 |
| Lin, CL | 1 |
| Chien, RN | 1 |
| Yeh, C | 1 |
| Hsu, CW | 1 |
| Chang, ML | 1 |
| Chen, YC | 1 |
| Yeh, CT | 1 |
| Seker, MM | 1 |
| Deveci, K | 1 |
| Seker, A | 1 |
| Sancakdar, E | 1 |
| Yilmaz, A | 1 |
| Turesin, AK | 1 |
| Kacan, T | 1 |
| Babacan, NA | 1 |
| Yanagimoto, Y | 1 |
| Takiguchi, S | 1 |
| Miyazaki, Y | 1 |
| Makino, T | 1 |
| Takahashi, T | 1 |
| Kurokawa, Y | 1 |
| Yamasaki, M | 1 |
| Miyata, H | 1 |
| Nakajima, K | 1 |
| Mori, M | 1 |
| Doki, Y | 1 |
| Xiong, Y | 1 |
| Shang, B | 1 |
| Xu, S | 1 |
| Zhao, R | 1 |
| Gou, H | 1 |
| Wang, C | 1 |
| Yousef, HN | 1 |
| Aboelwafa, HR | 1 |
| Ulusakarya, A | 1 |
| Misra, S | 1 |
| Haydar, M | 1 |
| Habert, H | 1 |
| Castagne, V | 1 |
| Gumus, Y | 1 |
| Delmas-Marsalet, B | 1 |
| Machover, D | 1 |
| Di Mizio, G | 1 |
| Gallelli, L | 1 |
| Barbieri, V | 1 |
| Loiacono, D | 1 |
| Colosimo, F | 1 |
| Rende, P | 1 |
| Di Nunzio, C | 1 |
| Ricci, P | 1 |
| Ito, I | 1 |
| Ito, Y | 1 |
| Mizuno, M | 1 |
| Suzuki, Y | 1 |
| Yasuda, K | 1 |
| Ozaki, T | 1 |
| Kosugi, T | 1 |
| Yasuda, Y | 1 |
| Sato, W | 1 |
| Tsuboi, N | 1 |
| Maruyama, S | 1 |
| Imai, E | 1 |
| Matsuo, S | 1 |
| Márquez, E | 1 |
| RodrÃguez, E | 1 |
| Pascual, J | 1 |
| Nagao, J | 1 |
| Tsukuda, M | 1 |
| Yoshida, T | 1 |
| Sakuma, N | 1 |
| Matsuda, H | 1 |
| Mikami, Y | 1 |
| Hanna, WT | 1 |
| Krauss, S | 1 |
| Regester, RF | 1 |
| Murphy, WM | 1 |
| Birembaut, P | 1 |
| Parjoie, R | 1 |
| Ploton, D | 1 |
| Rebaiz, K | 1 |
| Wolf, C | 1 |
| Harada, T | 1 |
| Makisaka, Y | 1 |
| Nishimura, H | 1 |
| Okuda, K | 1 |
| Brillet, G | 1 |
| Deray, G | 1 |
| Baumelou, A | 1 |
| Jacobs, C | 1 |
| Hricik, DE | 1 |
| Goldsmith, GH | 1 |
| Ellison, NM | 1 |
| Servi, RJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Observational, Single-center Post-marketing Surveillance Study of Telbivudine in Chronic Hepatitis B Adults With HBeAg Positive/Negative.[NCT00970216] | 160 participants (Actual) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00970216)
Timeframe: 48 weeks
| Intervention | participants (Number) |
|---|---|
| Chronic Hepatitis B | 79 |
1 review available for fluorouracil and Acute Kidney Injury
| Article | Year |
|---|---|
[Acute Kidney Injury in a Patient with Diarrhea and Vomiting Undergoing Chemotherapy for Colorectal Cancer].
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Diarrhea; Fluoroura | 2016 |
2 trials available for fluorouracil and Acute Kidney Injury
| Article | Year |
|---|---|
Possible protective effect of pantoprazole against cisplatin-induced nephrotoxicity in head and neck cancer patients: a randomized controlled trial.
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Female; F | 2021 |
Significant renoprotective effect of telbivudine during preemptive antiviral therapy in advanced liver cancer patients receiving cisplatin-based chemotherapy: a case-control study.
Topics: Acute Kidney Injury; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 2014 |
17 other studies available for fluorouracil and Acute Kidney Injury
| Article | Year |
|---|---|
Co-administration of proton pump inhibitors ameliorates nephrotoxicity in patients receiving chemotherapy with cisplatin and fluorouracil: a retrospective cohort study.
Topics: Acute Kidney Injury; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineopla | 2017 |
Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Carbazoles; Carvedilol; Chemical and Drug | 2018 |
Predictive role of neutrophil gelatinase-associated lipocalin in early diagnosis of platin-induced renal injury.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Aged; Antineoplastic Combined Chemotherapy Protoco | 2015 |
Plasma ghrelin levels as a predictor of adverse renal events due to cisplatin-based chemotherapy in patients with esophageal cancer.
Topics: Acute Kidney Injury; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Creatinine; Do | 2016 |
Protective effect of Bu-zhong-yi-qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced renal injury in mice.
Topics: Acute Kidney Injury; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Drugs, Chinese Herbal | 2016 |
The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Fluorouracil; Kidney; Male; Rats; Taurine | 2017 |
Acute renal failure related to oxaliplatin-induced intravascular hemolysis.
Topics: Acute Kidney Injury; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combi | 2010 |
Capecitabine-induced, rapid decrease of renal function due to drug dispensing error in a hospital pharmacy.
Topics: Acute Kidney Injury; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Fluorouraci | 2011 |
A rare case of acute kidney injury associated with autoimmune hemolytic anemia and thrombocytopenia after long-term usage of oxaliplatin.
Topics: Acute Kidney Injury; Anemia, Hemolytic, Autoimmune; Antineoplastic Combined Chemotherapy Protocols; | 2012 |
Inadvertent severe acute kidney injury and oxaliplatin.
Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorecta | 2013 |
[A case of head and neck squamous cell carcinoma suffering from acute renal failure after methotrexate administrator].
Topics: Acute Kidney Injury; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cispl | 2005 |
Renal disease after mitomycin C therapy.
Topics: Acute Kidney Injury; Adenocarcinoma; Adult; Aged; Blood Pressure; Blood Urea Nitrogen; Creatinine; F | 1981 |
[Renal lesions after irradiation and chemotherapy with adriamycin, vincristin and 5-fluoro-uracil (author's transl)].
Topics: Acute Kidney Injury; Adult; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Ki | 1981 |
Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report.
Topics: Acute Kidney Injury; Antineoplastic Agents; Carcinoma, Hepatocellular; Disseminated Intravascular Co | 1978 |
Acute cardiac and renal failure after 5-FU and cisplatin treatment.
Topics: Acute Kidney Injury; Adult; Cardiac Output, Low; Cisplatin; Female; Fluorouracil; Humans; Uterine Ne | 1991 |
Uric acid nephrolithiasis and acute renal failure secondary to streptozotocin nephrotoxicity.
Topics: Acute Kidney Injury; Adenoma, Islet Cell; Aged; Fluorouracil; Humans; Kidney Calculi; Male; Pancreat | 1988 |
Acute renal failure and death following sequential intermediate-dose methotrexate and 5-FU: a possible adverse effect due to concomitant indomethacin administration.
Topics: Acute Kidney Injury; Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic N | 1985 |