fluorouracil has been researched along with Acute Hepatic Failure in 2 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1." | 5.36 | Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010) |
| "5-Fluorouracil was infused for 15 min into the hepatic artery or the saphenous vein of rats at a dose of 1." | 1.36 | Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats. ( Arimori, K; Hidaka, M; Hidaka, Y; Iwakiri, T; Kawano, Y; Nagata, M; Okumura, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hajj, A | 1 |
| Ghosn, M | 1 |
| Mourad, D | 1 |
| Hojaiban, K | 1 |
| Mousallem, P | 1 |
| Khabbaz, LR | 1 |
| Nagata, M | 1 |
| Hidaka, Y | 1 |
| Hidaka, M | 1 |
| Kawano, Y | 1 |
| Iwakiri, T | 1 |
| Okumura, M | 1 |
| Arimori, K | 1 |
2 other studies available for fluorouracil and Acute Hepatic Failure
| Article | Year |
|---|---|
Lethal hepatotoxicity following 5-fluorouracil/cisplatin chemotherapy: a relevant case report.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cisplatin; Drug-Related Side Effects and Adverse React | 2017 |
Effect of acute hepatic failure on the hepatic first-pass effect of 5-fluorouracil in rats.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Inju | 2010 |