fluorouracil has been researched along with Acute Confusional Senile Dementia in 3 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the design of a series of tacrine-phenolic heterodimers in order to tackle the multifactorial nature of the disease." | 1.51 | Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors. ( Bartolini, M; Bolognesi, ML; Fernández-Bolaños, JG; Franconetti, A; Hicke, J; Lagunes, I; López, Ó; Maya, I; Monti, B; Naldi, M; Padrón, JM; Petralla, S; Poeta, E; Roldán-Peña, JM; Romero-Real, V, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Candia, M | 1 |
| Zaetta, G | 1 |
| Denora, N | 1 |
| Tricarico, D | 1 |
| Majellaro, M | 1 |
| Cellamare, S | 1 |
| Altomare, CD | 1 |
| Roldán-Peña, JM | 2 |
| Alejandre-Ramos, D | 1 |
| López, Ó | 2 |
| Maya, I | 2 |
| Lagunes, I | 2 |
| Padrón, JM | 2 |
| Peña-Altamira, LE | 1 |
| Bartolini, M | 2 |
| Monti, B | 2 |
| Bolognesi, ML | 2 |
| Fernández-Bolaños, JG | 2 |
| Romero-Real, V | 1 |
| Hicke, J | 1 |
| Franconetti, A | 1 |
| Petralla, S | 1 |
| Poeta, E | 1 |
| Naldi, M | 1 |
3 other studies available for fluorouracil and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.
Topics: Alzheimer Disease; Azepines; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Hum | 2017 |
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antineoplastic Agents; Anti | 2017 |
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antineoplastic Agents; Butyrylcholinesterase; Cell | 2019 |