fluorouracil has been researched along with Actinic Reticuloid Syndrome in 44 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several formulations and concentrations of topical fluorouracil have received US Food and Drug Administration (FDA) approval for the treatment of actinic keratosis (AK)." | 8.82 | Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. ( Carney, PS; Jorizzo, JL; Ko, WT; Robins, P; Weinkle, SH; Werschler, WP, 2004) |
| "A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp." | 8.82 | Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005) |
| "Several formulations and concentrations of topical fluorouracil have received US Food and Drug Administration (FDA) approval for the treatment of actinic keratosis (AK)." | 4.82 | Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule. ( Carney, PS; Jorizzo, JL; Ko, WT; Robins, P; Weinkle, SH; Werschler, WP, 2004) |
| "A cumulative meta-analysis was performed to determine the efficacy of imiquimod 5% cream, which presents a new alternative topical therapy for actinic keratosis, and to compare it to 5-fluorouracil for the treatment of actinic keratosis lesions of the face and scalp." | 4.82 | Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies. ( Davey, V; Gupta, AK; Mcphail, H, 2005) |
| "One day after sunbathing, a breast cancer patient received intravenous methotrexate, cyclophosphamide and 5-fluorouracil and had a recall of her UV erythema over the following week." | 3.67 | Recall of UVB-induced erythema in breast cancer patient receiving multiple drug chemotherapy. ( Andersen, KE; Lindskov, R, 1984) |
| "A photosensitive lichen planus-like eruption developed in a 63-year-old man during postoperative chemotherapy with 1-(2-tetrahydrofuryl)-5-fluorouracil." | 3.66 | Photosensitivity due to a fluorouracil derivative. ( Horio, T; Ikai, K; Murai, T, 1978) |
| "Actinic keratosis is currently believed to be an early stage in the evolution of squamous cell carcinoma." | 2.42 | Topical and light-based treatments for actinic keratoses. ( Alam, M; Goldberg, LH; Silapunt, S, 2003) |
| "Tretinoin application was discontinued, and she recovered." | 1.31 | Photosensitivity associated with fluorouracil, prochlorperazine, and topical tretinoin. ( Birner, AM; Meyer, LP, 2001) |
| "Four patients with Xeroderma pigmentosum are reported: 2 diagnosed following the development of multiple cutaneous tumours, and 2 at an earlier state." | 1.26 | Xeroderma pigmentosum--biochemical and therapeutic aspects. Case report. ( Bartholdson, L; Lija, J; Mobacken, H; Waldenström, J, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (47.73) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 17 (38.64) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ba, W | 1 |
| Yang, Y | 1 |
| Zheng, L | 1 |
| Lin, B | 1 |
| Zhao, Z | 1 |
| Li, C | 1 |
| Walker, G | 1 |
| Lane, N | 1 |
| Parekh, P | 1 |
| Menter, A | 2 |
| Vamvakias, G | 1 |
| Jorizzo, J | 1 |
| Has, C | 1 |
| Burger, B | 1 |
| Volz, A | 1 |
| Kohlhase, J | 1 |
| Bruckner-Tuderman, L | 1 |
| Itin, P | 1 |
| Willey, A | 1 |
| Glusac, EJ | 1 |
| Bolognia, JL | 1 |
| Levy, S | 2 |
| Furst, K | 2 |
| Chern, W | 1 |
| Weiss, J | 1 |
| Hevia, O | 1 |
| Jones, T | 1 |
| Ling, M | 1 |
| Rist, T | 1 |
| Roberts, J | 1 |
| Shavin, JS | 1 |
| Sklar, J | 1 |
| Webster, G | 1 |
| Connolly, M | 1 |
| Gupta, AK | 3 |
| Robins, P | 2 |
| Silapunt, S | 1 |
| Goldberg, LH | 1 |
| Alam, M | 1 |
| Jorizzo, JL | 1 |
| Carney, PS | 1 |
| Ko, WT | 1 |
| Weinkle, SH | 1 |
| Werschler, WP | 1 |
| Levine, N | 1 |
| Davey, V | 1 |
| Mcphail, H | 1 |
| Tsoussis, S | 1 |
| Vourliotaki, I | 1 |
| Ekonomidou, F | 1 |
| Apostolakis, S | 1 |
| Epstein, E | 2 |
| Berman, B | 1 |
| Bienstock, L | 1 |
| Kuritzky, L | 1 |
| Mayeaux, EJ | 1 |
| Tyring, SK | 1 |
| Hague, JS | 1 |
| Ilchyshyn, A | 1 |
| Chia, A | 1 |
| Moreno, G | 1 |
| Lim, A | 1 |
| Shumack, S | 1 |
| Sun, CC | 1 |
| Hsu, SC | 1 |
| Andersen, KE | 1 |
| Lindskov, R | 1 |
| Goette, DK | 1 |
| Casson, P | 1 |
| Sander, CA | 1 |
| Pfeiffer, C | 1 |
| Kligman, AM | 1 |
| Plewig, G | 1 |
| von Moos, R | 1 |
| Sauter, C | 1 |
| Dinehart, SM | 1 |
| Birner, AM | 1 |
| Meyer, LP | 1 |
| Rees, RB | 1 |
| Bartholdson, L | 1 |
| Lija, J | 1 |
| Mobacken, H | 1 |
| Waldenström, J | 1 |
| Horio, T | 1 |
| Murai, T | 1 |
| Ikai, K | 1 |
| Schreiber, MM | 1 |
| Simmonds, WL | 1 |
| Vukelja, SJ | 1 |
| Bonner, MW | 1 |
| McCollough, M | 1 |
| Cobb, PW | 1 |
| Gaule, DA | 1 |
| Fanucchi, PJ | 1 |
| Keeling, JH | 1 |
| Beani, JC | 1 |
| Gautron, R | 1 |
| Amblard, P | 1 |
| Bastrenta, F | 1 |
| Harrouch, L | 1 |
| Jardon, P | 1 |
| Reymond, JL | 1 |
| Levantine, A | 1 |
| Almeyda, J | 1 |
| Thompson, RP | 1 |
| Nicholson, DC | 1 |
| Farnan, T | 1 |
| Whitmore, DN | 1 |
| Williams, R | 1 |
| Anderson, L | 1 |
| Saltzer, EI | 1 |
| Soderquist, NA | 1 |
| Wilson, JW | 1 |
| Rossman, RE | 1 |
| Thivolet, J | 1 |
| Chabanon, M | 1 |
| Perrot, H | 1 |
| Kestel, J | 1 |
| Arnold, HL | 1 |
| Williams, RM | 1 |
| Kim, R | 1 |
| Ippen, H | 1 |
| Thiry, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TreatMent of ActInic KerAtosis Lesions : pharmacoepiDemiological Study of the Impact in Real Life of ingenOl Mebutate Gel (Picato®) on Patients Satisfaction[NCT04202445] | 1,218 participants (Actual) | Observational | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for fluorouracil and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
One-week treatment with once-daily fluorouracil cream 0.5% in participants with actinic keratoses.
Topics: Administration, Cutaneous; Drug Administration Schedule; Drug Carriers; Fluorouracil; Humans; Immuno | 2008 |
The use of topical fluorouracil to treat actinic keratosis.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Dermatologic Agents; Fluorouracil; Humans; | 2002 |
Topical and light-based treatments for actinic keratoses.
Topics: Adjuvants, Immunologic; Administration, Topical; Aminolevulinic Acid; Aminoquinolines; Antineoplasti | 2003 |
Fluorouracil 5% and 0.5% creams for the treatment of actinic keratosis: equivalent efficacy with a lower concentration and more convenient dosing schedule.
Topics: Administration, Cutaneous; Antimetabolites, Antineoplastic; Drug Administration Schedule; Emulsions; | 2004 |
Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the treatment of actinic keratosis: Critical review and meta-analysis of efficacy studies.
Topics: Adjuvants, Immunologic; Aminoquinolines; Clinical Trials, Phase III as Topic; Confidence Intervals; | 2005 |
Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel.
Topics: Administration, Cutaneous; Aminoquinolines; Antineoplastic Agents; Carcinoma, Squamous Cell; Consens | 2006 |
Actinic keratoses.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Australia; Cryotherapy; Diclofenac; Fluoro | 2007 |
Topical chemotherapy with 5-fluorouracil. A review.
Topics: Administration, Topical; Chemical Phenomena; Chemistry; Dermatitis, Atopic; Dermatitis, Contact; Fem | 1981 |
Newer treatment in dermatology.
Topics: Acne Vulgaris; Adrenal Cortex Hormones; Antifungal Agents; Antineoplastic Agents; Carotenoids; Derma | 1975 |
Unusual serpentine hyperpigmentation associated with 5-fluorouracil. Case report and review of cutaneous manifestations associated with systemic 5-fluorouracil.
Topics: Adenocarcinoma; Aged; Drug Eruptions; Fluorouracil; Humans; Infusions, Intravenous; Male; Photosensi | 1991 |
Drug reactions. XXIV. Cutaneous reactions to cytostatic agents.
Topics: Alopecia; Aminopterin; Antineoplastic Agents; Asparaginase; Azathioprine; Bleomycin; Busulfan; Chlor | 1974 |
3 trials available for fluorouracil and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
Effective treatment of actinic keratosis with 0.5% fluorouracil cream for 1, 2, or 4 weeks.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Double-Bli | 2002 |
Twice daily vs. four times daily 5-fluorouracil therapy for actinic keratoses: a split face study.
Topics: Aged; Antimetabolites; Drug Administration Schedule; Facial Dermatoses; Female; Fluorouracil; Humans | 2006 |
Management of actinic keratoses with topical 5-fluorouracil.
Topics: Administration, Topical; Adult; Aged; Clinical Trials as Topic; Female; Fluorouracil; Humans; Kerato | 1976 |
30 other studies available for fluorouracil and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
Erythema elevatum diutinum with pustule formation: An unusual finding.
Topics: Female; Fluorouracil; Humans; Middle Aged; Photosensitivity Disorders; Skin Pigmentation; Vasculitis | 2018 |
Photosensitive lichenoid drug eruption to capecitabine.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Drug Eruptions; Female; Fluorour | 2014 |
Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer.
Topics: Aged; Aminoquinolines; Antineoplastic Agents; Basement Membrane; Blister; Carcinoma, Basal Cell; Cry | 2010 |
Photoeruption in a patient treated with capecitabine (Xeloda) for metastatic breast cancer.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Fluorouracil | 2002 |
A novel 0.5% fluorouracil cream is minimally absorbed into the systemic circulation yet is as effective as 5% fluorouracil cream.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Cadaver; Fluorouracil; Humans; Photosensit | 2002 |
The management of actinic keratoses in the United States with topical fluorouracil: a pharmacoeconomic evaluation.
Topics: Administration, Topical; Antimetabolites, Antineoplastic; Cost-Benefit Analysis; Economics, Pharmace | 2002 |
Lower lip exhibits shiny, white, nonhealing lesions. Patient was heavy smoker in past, and has spent much time outdoors.
Topics: Administration, Topical; Cheilitis; Fluorouracil; Humans; Immunosuppressive Agents; Male; Middle Age | 2005 |
Capecitabine as an alternative in a case of fluorouracil-induced photodermatitis.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Female; Fluorouracil; Humans; Ph | 2006 |
Lichenoid photosensitive eruption due to capecitabine chemotherapy for metastatic breast cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Eruptions | 2007 |
Photosensitivity from oral administration of a fluorouracil derivative (FT 207).
Topics: Aged; Antimetabolites, Antineoplastic; Fluorouracil; Humans; Male; Photosensitivity Disorders; Tegaf | 1984 |
Recall of UVB-induced erythema in breast cancer patient receiving multiple drug chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Erythema; Female | 1984 |
Basal cell carcinoma.
Topics: Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Cryosurgery; Female; Fluorouracil; Humans; Male; N | 1980 |
Chemotherapy for disseminated actinic keratoses with 5-fluorouracil and isotretinoin.
Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Drug Therapy, Combination; F | 1997 |
[Photosensitization caused by 5-fluorouracil (5-FU)].
Topics: Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Diagnosis, Differential; Drug Eruptions; F | 1999 |
The treatment of actinic keratoses.
Topics: Administration, Topical; Antimetabolites; Cryosurgery; Curettage; Electrosurgery; Fluorouracil; Huma | 2000 |
Photosensitivity associated with fluorouracil, prochlorperazine, and topical tretinoin.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Dopamine Antagonists; Drug Interactions; Fem | 2001 |
Xeroderma pigmentosum--biochemical and therapeutic aspects. Case report.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Adult; Aminobenzoates; Child; DNA Repair; Female; Fluo | 1977 |
Photosensitivity due to a fluorouracil derivative.
Topics: Fluorouracil; Humans; Lichen Planus; Male; Middle Aged; Photosensitivity Disorders; Tegafur; Ultravi | 1978 |
Systemic fluorouracil photosensitivity.
Topics: Aged; Colonic Neoplasms; Female; Fluorouracil; Humans; Keratosis; Photosensitivity Disorders | 1978 |
Screening for drug photosensitization activity by measuring the variations in oxygen consumption of Bacillus subtilis.
Topics: Aspirin; Bacillus subtilis; Benzoyl Peroxide; Chlorpromazine; Erythromycin; Fluorouracil; Light; Met | 1985 |
Cutaneous porphyria due to a malignant primary hepatoma.
Topics: Aged; Carcinoma, Hepatocellular; Feces; Female; Fluorouracil; Humans; Liver Neoplasms; Photosensitiv | 1970 |
Actinic keratosis--the advent of fluorouracil.
Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Sunlight | 1973 |
Selectivity of fluorouracil in treatment of actinic keratoses.
Topics: Aged; Fluorouracil; Humans; Keratosis; Male; Photosensitivity Disorders; Skin Transplantation; Sunbu | 1968 |
Topical fluorouracil therapy.
Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Sunlight | 1969 |
Resistance to fluorouracil.
Topics: Fluorouracil; Humans; Keratosis; Male; Middle Aged; Photosensitivity Disorders | 1969 |
[Use of 5-fluorouracil ointment. Indications and limitations].
Topics: Carcinoma, Squamous Cell; Erythema; Fluorouracil; Humans; Keratosis; Ointments; Photosensitivity Dis | 1970 |
Treatment of actinic keratosis.
Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Ultraviolet Therapy | 1970 |
Topical 5-fluorouracil for actinic keratoses.
Topics: Fluorouracil; Humans; Keratosis; Photosensitivity Disorders; Propylene Glycols; Skin Absorption; Ski | 1968 |
[Investigations in cutaneous light physiology I. Erythema protection by external applied 5-fluorouracil].
Topics: Erythema; Fluorouracil; Humans; Photosensitivity Disorders; Skin; Skin Physiological Phenomena; Sunl | 1969 |
Viruses grown in the presence of base analogs: specific alteration of susceptibility to inactivation by radiations, mutagens, and protodyes.
Topics: Arboviruses; Coloring Agents; Fluorouracil; Guanine; Hydroxylamines; In Vitro Techniques; Light; Met | 1966 |