fluorouracil has been researched along with Acquired Immunodeficiency Syndrome in 9 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mucositis is a common toxicity of cancer chemotherapy." | 6.68 | Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. ( Anderson, PM; Skubitz, KM, 1996) |
| "Mucositis is a common toxicity of cancer chemotherapy." | 2.68 | Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study. ( Anderson, PM; Skubitz, KM, 1996) |
| "Among them, three patients had acquired immunodeficiency syndrome (AIDS)." | 1.29 | Squamous-cell carcinoma of the anus in HIV-positive patients. ( Berson, A; Chadha, M; Malamud, S; Pisch, J; Rosenblatt, EA, 1994) |
| "Seven patients had HIV, four of whom had acquired immunodeficiency syndrome." | 1.29 | Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy. ( Holland, JM; Swift, PS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fleming, TR | 1 |
| Prentice, RL | 1 |
| Pepe, MS | 1 |
| Glidden, D | 1 |
| Chadha, M | 1 |
| Rosenblatt, EA | 1 |
| Malamud, S | 1 |
| Pisch, J | 1 |
| Berson, A | 1 |
| Holland, JM | 1 |
| Swift, PS | 1 |
| Skubitz, KM | 1 |
| Anderson, PM | 1 |
| Podzamczer, D | 1 |
| Miralles, P | 1 |
| La Calle Md, Md | 1 |
| Zarco, C | 1 |
| Berenguer, J | 1 |
| López Aldeguer, J | 1 |
| Valencia, E | 1 |
| Rubio, R | 1 |
| Ribera, JM | 1 |
| Reiter, Z | 1 |
| Ozes, ON | 1 |
| Tomson, S | 1 |
| Blatt, LM | 1 |
| Taylor, MW | 1 |
| Sillman, FH | 2 |
| Sedlis, A | 2 |
| Boyce, JG | 1 |
| Shoemaker, JP | 1 |
3 reviews available for fluorouracil and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
[Recommendations of GESIDA/Spanish National Plan of AIDS on diagnosis and treatment of Kaposi's sarcoma and cervical cancer in HIV-infected patients].
Topics: Acquired Immunodeficiency Syndrome; Algorithms; Antimetabolites, Antineoplastic; Antineoplastic Agen | 2002 |
Anogenital papillomavirus infection and neoplasia in immunodeficient women.
Topics: Acquired Immunodeficiency Syndrome; Combined Modality Therapy; Female; Fluorouracil; Genital Neoplas | 1987 |
A review of lower genital intraepithelial neoplasia and the use of topical 5-fluorouracil.
Topics: Acquired Immunodeficiency Syndrome; Administration, Topical; Adult; Anal Canal; Anus Neoplasms; Carc | 1985 |
2 trials available for fluorouracil and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Surrogate and auxiliary endpoints in clinical trials, with potential applications in cancer and AIDS research.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Ad | 1994 |
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antineoplastic Combined Chemotherapy Proto | 1996 |
4 other studies available for fluorouracil and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Squamous-cell carcinoma of the anus in HIV-positive patients.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Anu | 1994 |
Tolerance of patients with human immunodeficiency virus and anal carcinoma to treatment with combined chemotherapy and radiation therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Combined Chemotherapy Protocols; Anus Neop | 1994 |
A dual anti-tumor effect of a combination of interferon-alpha and 5-flurouracil or 2-chlorodeoxyadenosine on natural killer (NK) cell mediated cytotoxicity.
Topics: 2-Chloroadenosine; Acquired Immunodeficiency Syndrome; Antimetabolites, Antineoplastic; Cell Divisio | 1991 |
Treatment for AIDS and other retrovirus-caused diseases.
Topics: Acquired Immunodeficiency Syndrome; Animals; Chloroquine; Drug Therapy, Combination; Fluorouracil; H | 1988 |