fluorouracil has been researched along with Acne Vulgaris in 10 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Acne Vulgaris: A chronic disorder of the pilosebaceous apparatus associated with an increase in sebum secretion. It is characterized by open comedones (blackheads), closed comedones (whiteheads), and pustular nodules. The cause is unknown, but heredity and age are predisposing factors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Vitamin A acid and benzoyl peroxide have brought significant advances in the topical treatment of acne." | 3.66 | [Advances in topical therapy of skin diseases (author's transl)]. ( Happle, R, 1979) |
| " No serious adverse reactions and good tolerability were reported in the included studies." | 3.01 | Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review. ( Bekkers, VZ; Bik, L; Prens, EP; van Doorn, MBA; van Huijstee, JC; Wolkerstorfer, A, 2023) |
| "Hypertrophic scars and keloids may complicate wound healing secondary to trauma or surgery." | 2.69 | Treatment of inflamed hypertrophic scars using intralesional 5-FU. ( Fitzpatrick, RE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Y | 1 |
| Li, Z | 1 |
| Hu, J | 1 |
| Zhan, S | 1 |
| Wang, M | 1 |
| Wang, L | 1 |
| Bekkers, VZ | 1 |
| Bik, L | 1 |
| van Huijstee, JC | 1 |
| Wolkerstorfer, A | 1 |
| Prens, EP | 1 |
| van Doorn, MBA | 1 |
| Milstein, HG | 1 |
| Yoshinaga, K | 1 |
| Kanzaki, T | 1 |
| Draelos, ZD | 1 |
| Fitzpatrick, RE | 1 |
| Rees, RB | 2 |
| Happle, R | 1 |
| Dickinson, JT | 1 |
| Rooker, DW | 1 |
| Leonard, JR | 1 |
4 reviews available for fluorouracil and Acne Vulgaris
| Article | Year |
|---|---|
Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review.
Topics: Acne Vulgaris; Dermatology; Fluorouracil; Humans; Keloid; Treatment Outcome; Triamcinolone Acetonide | 2023 |
Therapeutic skin care in the mature patient.
Topics: Acne Vulgaris; Fluorouracil; Humans; Hydrogen-Ion Concentration; Retinoids; Skin Aging; Skin Care; S | 1997 |
Current dermatologic therapy.
Topics: Acne Vulgaris; Administration, Topical; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antifungal A | 1976 |
Newer treatment in dermatology.
Topics: Acne Vulgaris; Adrenal Cortex Hormones; Antifungal Agents; Antineoplastic Agents; Carotenoids; Derma | 1975 |
1 trial available for fluorouracil and Acne Vulgaris
| Article | Year |
|---|---|
Treatment of inflamed hypertrophic scars using intralesional 5-FU.
Topics: Acne Vulgaris; Adult; Aged; Anti-Inflammatory Agents; Antimetabolites; Cicatrix; Female; Fluorouraci | 1999 |
5 other studies available for fluorouracil and Acne Vulgaris
| Article | Year |
|---|---|
Treatment of acne by subcutaneous injection of low-concentration 5-Fluorouracil.
Topics: Acne Vulgaris; Fluorouracil; Humans; Injections, Intralesional; Injections, Subcutaneous; Keloid | 2022 |
5-Fluorouracil as an aid in management of acne and melasma.
Topics: Acne Vulgaris; Administration, Topical; Fluorouracil; Humans; Melanosis | 1981 |
Topical 5-fluorouracil ointment for senile comedones: a case report.
Topics: Acne Vulgaris; Administration, Topical; Aged; Antimetabolites; Fluorouracil; Humans; Male | 1995 |
[Advances in topical therapy of skin diseases (author's transl)].
Topics: Acne Vulgaris; Administration, Topical; Alopecia; Benzoyl Peroxide; Dinitrochlorobenzene; Fluocortol | 1979 |
Minor surgery for benign and malignant facial lesions.
Topics: Acne Vulgaris; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cicatrix; Cortisone; Curettage; Cyst | 1974 |