Page last updated: 2024-10-27

fluorouracil and Acantholysis Bullosa

fluorouracil has been researched along with Acantholysis Bullosa in 3 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Research Excerpts

ExcerptRelevanceReference
"Dystrophic epidermolysis bullosa is associated with a high incidence of cutaneous squamous cell carcinoma."2.38Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy. ( Lentz, SR; Marion, JM; Orlowski, EP; Raish, RJ, 1990)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Has, C1
Burger, B1
Volz, A1
Kohlhase, J1
Bruckner-Tuderman, L1
Itin, P1
Lentz, SR1
Raish, RJ1
Orlowski, EP1
Marion, JM1
Niehoff, M1

Reviews

1 review available for fluorouracil and Acantholysis Bullosa

ArticleYear
Squamous cell carcinoma in epidermolysis bullosa. Treatment with systemic chemotherapy.
    Cancer, 1990, Sep-15, Volume: 66, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Catheterization, Ce

1990

Other Studies

2 other studies available for fluorouracil and Acantholysis Bullosa

ArticleYear
Mild clinical phenotype of Kindler syndrome associated with late diagnosis and skin cancer.
    Dermatology (Basel, Switzerland), 2010, Volume: 221, Issue:4

    Topics: Aged; Aminoquinolines; Antineoplastic Agents; Basement Membrane; Blister; Carcinoma, Basal Cell; Cry

2010
[Case demonstration: Papillomatosis cutis carcinoides (Gottron) in epidermolysis bullosa dystrophica].
    Zeitschrift fur Hautkrankheiten, 1974, Jul-01, Volume: 49, Issue:13

    Topics: Adult; Bleomycin; Epidermolysis Bullosa; Female; Fluorouracil; Foot; Hand; Humans; Leg; Lymphadeniti

1974