fluorouracil has been researched along with Abnormalities, Multiple in 7 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy." | 3.73 | Combined chemotherapy and teratogenicity. ( de Camargo Pinto, LL; Gazzola Zen, PR; Graziadio, C; Paskulin, GA; Rosa, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paskulin, GA | 1 |
| Gazzola Zen, PR | 1 |
| de Camargo Pinto, LL | 1 |
| Rosa, R | 1 |
| Graziadio, C | 1 |
| Stephens, JD | 1 |
| Golbus, MS | 1 |
| Miller, TR | 1 |
| Wilber, RR | 1 |
| Epstein, CJ | 1 |
| Baden, HP | 1 |
| Rex, IH | 1 |
| Forsthoefel, PF | 1 |
| Wilson, JG | 1 |
| Pinsky, L | 1 |
| Fraser, FC | 1 |
| Dagg, CP | 1 |
1 review available for fluorouracil and Abnormalities, Multiple
| Article | Year |
|---|---|
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
6 other studies available for fluorouracil and Abnormalities, Multiple
| Article | Year |
|---|---|
Combined chemotherapy and teratogenicity.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo | 2005 |
Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Bone and Bones; Digestive System Abnorm | 1980 |
Linear ichthyosis associated with skeletal abnormalities.
Topics: Abnormalities, Multiple; Bone and Bones; Child; Female; Fluocinolone Acetonide; Fluorouracil; Hand D | 1970 |
The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Cleft Palate; Embryo, | 1972 |
Atypical malformation syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Chromosome Aberrations; Environment; Fluoroura | 1972 |
Independent effects of fluorouracil and two mutant genes in mouse embryos.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fluorouracil; Genes; Genotype | 1972 |