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fluorouracil and Abnormalities, Drug-Induced

fluorouracil has been researched along with Abnormalities, Drug-Induced in 49 studies

Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

ExcerptRelevanceReference
"Fifty-seven pregnant breast cancer patients were treated on a single-arm, multidisciplinary, institutional review board-approved protocol with FAC (5-fluorouracil, doxorubicin, cyclophosphamide) in the adjuvant (n = 32) or neoadjuvant (n = 25) setting."5.12Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. ( Gordon, N; Hahn, KM; Hortobagyi, GN; Johnson, PH; Kuerer, H; Middleton, L; Perkins, G; Ramirez, M; Theriault, RL; Yang, W, 2006)
" His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy."3.73Combined chemotherapy and teratogenicity. ( de Camargo Pinto, LL; Gazzola Zen, PR; Graziadio, C; Paskulin, GA; Rosa, R, 2005)
"5-Fluorouracil is an antineoplastic drug, which has not been adequately studied."1.33Teratogenic effects of 5-fluorouracil on rat brain. ( Dubey, AK; Kumar, S; Lobo, SW; Pandey, SK, 2006)
"Biologically based dose-response (BBDR) modeling represents a novel approach for quantitative assessment of health risk by incorporating pharmacokinetic and pharmacodynamic characteristics of a chemical and by relating the immediate cellular responses to a cascade of aberrant biological actions that leads to detectable adverse outcomes."1.31Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report. ( Andersen, ME; Crawford-Brown, DJ; Kavlock, RJ; Kimmel, CA; Knudsen, TB; Lau, C; Muneoka, K; Rogers, JM; Setzer, RW; Smith, G; Tyl, R, 2000)
"Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment."1.31Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data. ( Cameron, AM; Copeland, MF; Ellis, DH; Kavlock, RJ; Lau, C; Logsdon, TR; Merriman, J; Mole, ML; Rogers, JM; Setzer, RW; Shuey, DL, 2001)
"Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments."1.31Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct. ( Copeland, MF; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW, 2001)

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-199038 (77.55)18.7374
1990's4 (8.16)18.2507
2000's6 (12.24)29.6817
2010's1 (2.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Isidori, M1
Piscitelli, C1
Russo, C1
Smutná, M1
Bláha, L1
DIPAOLO, JA1
WILSON, JG3
Paskulin, GA1
Gazzola Zen, PR1
de Camargo Pinto, LL1
Rosa, R1
Graziadio, C1
Kumar, S1
Lobo, SW1
Dubey, AK1
Pandey, SK1
Hahn, KM1
Johnson, PH1
Gordon, N1
Kuerer, H1
Middleton, L1
Ramirez, M1
Yang, W1
Perkins, G1
Hortobagyi, GN1
Theriault, RL1
Puchkov, VF2
Dagg, CP4
Imagawa, S1
Katagiri, N1
Yasuda, M1
Nakamura, H1
Stephens, JD1
Golbus, MS1
Miller, TR1
Wilber, RR1
Epstein, CJ1
Shah, RM2
Wong, DT1
Kavlock, RJ4
Setzer, RW4
Kuwagata, M1
Takashima, H1
Nagao, T1
Lau, C3
Andersen, ME1
Crawford-Brown, DJ1
Kimmel, CA1
Knudsen, TB1
Muneoka, K1
Rogers, JM3
Smith, G1
Tyl, R1
Mole, ML2
Copeland, MF2
Shuey, DL1
Cameron, AM1
Ellis, DH1
Logsdon, TR1
Merriman, J1
Forsthoefel, PF2
Williams, ML1
Eifinger, FF1
Köhler, F1
Holmes, LB1
Montenegro, MA1
Cubillo, P1
Palomino, H1
Van Le, L1
Pizzuti, DJ1
Greenberg, M1
Reid, R1
Otaño, L1
Amestoy, G1
Paz, J1
Gadow, EC1
Chen, YP1
Burdett, DN1
Grafton, TF1
Bazare, JJ1
Hansen, DK1
Sheehan, DM1
Aracena, M1
Leiva, W1
Selman, E1
Muñoz, R1
Mancinelli, S1
Dawson, DA1
Bantle, JA1
Sauerbier, I1
Kury, G1
Craig, JM1
Williams, JP1
Long, SY1
Johnson, EM1
Jusko, WJ1
von Kreybig, T1
Pinsky, L1
Fraser, FC1
Rizki, RM1
Rizki, TM1
Hara, H2
Lauro, V1
Giornelli, C1
Santilli Giornelli, FE1
Fanelli, A1
Yoshihara, H1
Jordan, RL1
Schumacher, H1
Aita, M2
Conti, G2
Doerr, A2
Offutt, C1
Schlager, G1

Reviews

3 reviews available for fluorouracil and Abnormalities, Drug-Induced

ArticleYear
The road to embryologically based dose-response models.
    Environmental health perspectives, 1996, Volume: 104 Suppl 1

    Topics: Abnormalities, Drug-Induced; Animals; Computer Simulation; Dose-Response Relationship, Drug; Embryo,

1996
Abnormalities of intrauterine development in non-human primates.
    Acta endocrinologica. Supplementum, 1972, Volume: 166

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic

1972
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology].
    Arzneimittel-Forschung, 1970, Volume: 20, Issue:5

    Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cycloph

1970

Trials

1 trial available for fluorouracil and Abnormalities, Drug-Induced

ArticleYear
Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero.
    Cancer, 2006, Sep-15, Volume: 107, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms

2006

Other Studies

45 other studies available for fluorouracil and Abnormalities, Drug-Induced

ArticleYear
Teratogenic effects of five anticancer drugs on Xenopus laevis embryos.
    Ecotoxicology and environmental safety, 2016, Volume: 133

    Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Biological Assay; Capecitabine; Cisplat

2016
POLYDACTYLISM IN THE OFFSPRING OF MICE INJECTED WITH 5-BROMODEOXYURIDINE.
    Science (New York, N.Y.), 1964, Jul-31, Volume: 145, Issue:3631

    Topics: Abnormalities, Drug-Induced; Animals; Blood Chemical Analysis; Bromodeoxyuridine; Family; Female; Fl

1964
[CURRENT PROGRESS IN THE FIELD OF TERATOLOGY WITH SPECIAL REFERENCE TO THE APPLICATION OF 2 OR MORE KINDS OF AGENTS].
    Saishin igaku. Modern medicine, 1965, Volume: 20

    Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dactinomycin; Fluorouracil; Humans; Mercaptop

1965
Combined chemotherapy and teratogenicity.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:9

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo

2005
Teratogenic effects of 5-fluorouracil on rat brain.
    Nepal Medical College journal : NMCJ, 2006, Volume: 8, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites, Antineoplastic; Brain; Female; Fluorouracil;

2006
[Sensitivity to fluorouracil applied locally in ovo in chick embryo incubated two days].
    Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 51, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil; Methods; Time Factors

1966
Combined action of fluorouracil and two mutant genes on limb development in the mouse.
    The Journal of experimental zoology, 1967, Volume: 164, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Fluorouracil; Genes; Mice; Mutation; Pregnancy; Pregna

1967
Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice.
    Hiroshima journal of medical sciences, 1980, Volume: 29, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy;

1980
Vascular pattern and limb development. 1. Normal development of the hindlimb vasculature in the mouse and its aberrations induced by 5-fluorouracil.
    Hiroshima journal of medical sciences, 1983, Volume: 32, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Extremities; Female; Fluorouracil; Mice; Mice,

1983
Pathogenesis of limb malformations in mice: an electron microscopic study.
    Progress in clinical and biological research, 1983, Volume: 110 Pt A

    Topics: Abnormalities, Drug-Induced; Animals; Cell Communication; Cell Survival; Ectoderm; Extremities; Fema

1983
Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester.
    American journal of obstetrics and gynecology, 1980, Jul-15, Volume: 137, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Bone and Bones; Digestive System Abnorm

1980
Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
    Journal of embryology and experimental morphology, 1980, Volume: 57

    Topics: Abnormalities, Drug-Induced; Animals; Biometry; Cleft Palate; Cricetinae; Fluorouracil; Mesocricetus

1980
A comparison of the in vivo and in vitro response of rat embryos to 5-fluorouracil.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Embryo, Mammalian; Embryonic and Fetal Developme

1998
Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report.
    Regulatory toxicology and pharmacology : RTP, 2000, Volume: 31, Issue:2 Pt 1

    Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Education; Fluorouracil; Hum

2000
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 59, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Cell Cycle; Deoxyribonucleotides; DNA; Dose-Response Relations

2001
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 59, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Deoxyribonucleotides; Dose-Response Relation

2001
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
    Teratology, 1975, Volume: 11, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Deat

1975
[Comparative teratological studies with organic fluroine compounds, their bases and amines].
    Deutsche zahnarztliche Zeitschrift, 1977, Volume: 32, Issue:11

    Topics: Abnormalities, Drug-Induced; Amines; Animals; Deoxycytidine; Female; Fluorides; Fluorides, Topical;

1977
Penetrance and expressivity of limb malformations.
    Birth defects original article series, 1979, Volume: 15, Issue:5B

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Breech Presentation; Congenital Abnormalities; Extrachr

1979
[Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)].
    Revista medica de Chile, 1976, Volume: 104, Issue:9

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Food Deprivation; Maternal

1976
Accidental use of low-dose 5-fluorouracil in pregnancy.
    The Journal of reproductive medicine, 1991, Volume: 36, Issue:12

    Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adolescent; Adult; Female; Fluorouracil;

1991
Periconceptional exposure to topical 5-fluorouracil.
    American journal of obstetrics and gynecology, 1992, Volume: 166, Issue:1 Pt 1

    Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Female; Fertilization; Fluorouracil; Hu

1992
Palatal shelf reorientation in hamster embryos following treatment with 5-fluorouracil.
    Histology and histopathology, 1989, Volume: 4, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; DNA; Embryo, Mammalian; Epithelial Cells; Female;

1989
The in vitro embryotoxicity of 5-fluorouracil in rat embryos.
    Teratology, 1987, Volume: 36, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fl

1987
[Embryopathy caused by antineoplastic agents].
    Revista medica de Chile, 1986, Volume: 114, Issue:9

    Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Chemical Phenomena; Chemistry; Cyclophosphamide; Fema

1986
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
    Teratology, 1987, Volume: 35, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, N

1987
Circadian modification of 5-fluorouracil-induced teratogenesis in mice.
    Chronobiology international, 1986, Volume: 3, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Circadian Rhythm; Female; Fluorouracil; Gestational Age; Pregn

1986
Congenital malformations produced in chickens by fluorinated pyrimidines.
    Archives of pathology, 1966, Volume: 81, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Chick Embryo; Floxuridine; Fluorouracil; Pyri

1966
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
    Research communications in chemical pathology and pharmacology, 1971, Volume: 2, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; E

1971
Enzyme ontogeny in normal and hemimelic limbs of mice.
    Journal of embryology and experimental morphology, 1968, Volume: 20, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Electrophoresis; Embryo, Mammalian; Esterases; Fem

1968
The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers.
    Teratology, 1972, Volume: 6, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Cleft Palate; Embryo,

1972
Pharmacodynamic principles in chemical teratology: dose-effect relationships.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 183, Issue:3

    Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re

1972
Atypical malformation syndromes.
    The Journal of pediatrics, 1972, Volume: 80, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Chromosome Aberrations; Environment; Fluoroura

1972
Morphogenic effects of halogenated thymidine analogs on Drosophila. 3. 5-Iododeoxyuridine.
    Experientia, 1972, Mar-15, Volume: 28, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Centrifugation, Density Gradient; Deoxyuridine; DNA; Drosophil

1972
Independent effects of fluorouracil and two mutant genes in mouse embryos.
    Teratology, 1972, Volume: 5, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fluorouracil; Genes; Genotype

1972
[Disturbances of development and differentiation induced in the amphibian embryo by 5-fluorouracil. (Histological and histoautoradiographic examinations)].
    Beitrage zur pathologischen Anatomie und zur allgemeinen Pathologie, 1970, Volume: 140, Issue:4

    Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Anura; Autoradiography; Brain; Cell Nucleus; DNA;

1970
[Abnormalities of the Triturus embryo caused by 5-fluorouracil].
    Die Naturwissenschaften, 1970, Volume: 57, Issue:3

    Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Fluorouracil; Metamorphosis, Biological

1970
[The teratogenic effect of aminopterin and 5-fluorouracil on 4 to 23-somite embryonic chicks following their application in ovo].
    Biulleten' eksperimental'noi biologii i meditsiny, 1967, Volume: 63, Issue:7

    Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chick Embryo; Fluorouracil; Microcephaly; Microph

1967
[Experimental studies of the effects of administration of fluorouracil in the early stages of pregnancy. I. Treatment of gravid rats with fluorouracil].
    Archivio di ostetricia e ginecologia, 1968, Volume: 73, Issue:2

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Extraembryonic Membranes; Female; Fetus

1968
The effect of 5-fluorouracil on the development of tail vertebrae of mice in organ culture.
    Teratology, 1968, Volume: 1, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Fetus; Fluorouracil; Mice; Tail; Time Fact

1968
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
    Teratology, 1969, Volume: 2, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergis

1969
[On the effects of 5-fluorouracil injected into the chick embryo in the advanced stages of incubation].
    Experientia, 1965, Dec-15, Volume: 21, Issue:12

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil

1965
Incorporation of 5-fluorouracil-2-C-14 by mouse embryos.
    Biologia neonatorum. Neo-natal studies, 1966, Volume: 10, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fluorouracil; Maternal-Fetal Exchan

1966
Polygenic control of the teratogenicity of 5-fluorouracil in mice.
    Genetics, 1966, Volume: 53, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Foot Deformities, Congenit

1966
[On the effect of different doses of 5-fluoruracil injected into the chicken embryo in the course of its development].
    Archives de biologie, 1966, Volume: 77, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil

1966