fluorouracil has been researched along with Abnormalities, Drug-Induced in 49 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-seven pregnant breast cancer patients were treated on a single-arm, multidisciplinary, institutional review board-approved protocol with FAC (5-fluorouracil, doxorubicin, cyclophosphamide) in the adjuvant (n = 32) or neoadjuvant (n = 25) setting." | 5.12 | Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. ( Gordon, N; Hahn, KM; Hortobagyi, GN; Johnson, PH; Kuerer, H; Middleton, L; Perkins, G; Ramirez, M; Theriault, RL; Yang, W, 2006) |
| " His mother became pregnant while receiving chemotherapy (cyclophosphamide, 5-fluorouracil, and adriamycin) for breast cancer, and the fetus was exposed to these drugs from conception to the 16th week of pregnancy." | 3.73 | Combined chemotherapy and teratogenicity. ( de Camargo Pinto, LL; Gazzola Zen, PR; Graziadio, C; Paskulin, GA; Rosa, R, 2005) |
| "5-Fluorouracil is an antineoplastic drug, which has not been adequately studied." | 1.33 | Teratogenic effects of 5-fluorouracil on rat brain. ( Dubey, AK; Kumar, S; Lobo, SW; Pandey, SK, 2006) |
| "Biologically based dose-response (BBDR) modeling represents a novel approach for quantitative assessment of health risk by incorporating pharmacokinetic and pharmacodynamic characteristics of a chemical and by relating the immediate cellular responses to a cascade of aberrant biological actions that leads to detectable adverse outcomes." | 1.31 | Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report. ( Andersen, ME; Crawford-Brown, DJ; Kavlock, RJ; Kimmel, CA; Knudsen, TB; Lau, C; Muneoka, K; Rogers, JM; Setzer, RW; Smith, G; Tyl, R, 2000) |
| "Biologically based dose-response (BBDR) models represent an emerging approach to improving the current practice of human health-risk assessment." | 1.31 | Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data. ( Cameron, AM; Copeland, MF; Ellis, DH; Kavlock, RJ; Lau, C; Logsdon, TR; Merriman, J; Mole, ML; Rogers, JM; Setzer, RW; Shuey, DL, 2001) |
| "Biologically based dose-response (BBDR) models comprise one way to incorporate mechanistic information into a dose-response assessment to be used for risk assessments." | 1.31 | Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct. ( Copeland, MF; Kavlock, RJ; Lau, C; Mole, ML; Rogers, JM; Setzer, RW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (77.55) | 18.7374 |
| 1990's | 4 (8.16) | 18.2507 |
| 2000's | 6 (12.24) | 29.6817 |
| 2010's | 1 (2.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isidori, M | 1 |
| Piscitelli, C | 1 |
| Russo, C | 1 |
| Smutná, M | 1 |
| Bláha, L | 1 |
| DIPAOLO, JA | 1 |
| WILSON, JG | 3 |
| Paskulin, GA | 1 |
| Gazzola Zen, PR | 1 |
| de Camargo Pinto, LL | 1 |
| Rosa, R | 1 |
| Graziadio, C | 1 |
| Kumar, S | 1 |
| Lobo, SW | 1 |
| Dubey, AK | 1 |
| Pandey, SK | 1 |
| Hahn, KM | 1 |
| Johnson, PH | 1 |
| Gordon, N | 1 |
| Kuerer, H | 1 |
| Middleton, L | 1 |
| Ramirez, M | 1 |
| Yang, W | 1 |
| Perkins, G | 1 |
| Hortobagyi, GN | 1 |
| Theriault, RL | 1 |
| Puchkov, VF | 2 |
| Dagg, CP | 4 |
| Imagawa, S | 1 |
| Katagiri, N | 1 |
| Yasuda, M | 1 |
| Nakamura, H | 1 |
| Stephens, JD | 1 |
| Golbus, MS | 1 |
| Miller, TR | 1 |
| Wilber, RR | 1 |
| Epstein, CJ | 1 |
| Shah, RM | 2 |
| Wong, DT | 1 |
| Kavlock, RJ | 4 |
| Setzer, RW | 4 |
| Kuwagata, M | 1 |
| Takashima, H | 1 |
| Nagao, T | 1 |
| Lau, C | 3 |
| Andersen, ME | 1 |
| Crawford-Brown, DJ | 1 |
| Kimmel, CA | 1 |
| Knudsen, TB | 1 |
| Muneoka, K | 1 |
| Rogers, JM | 3 |
| Smith, G | 1 |
| Tyl, R | 1 |
| Mole, ML | 2 |
| Copeland, MF | 2 |
| Shuey, DL | 1 |
| Cameron, AM | 1 |
| Ellis, DH | 1 |
| Logsdon, TR | 1 |
| Merriman, J | 1 |
| Forsthoefel, PF | 2 |
| Williams, ML | 1 |
| Eifinger, FF | 1 |
| Köhler, F | 1 |
| Holmes, LB | 1 |
| Montenegro, MA | 1 |
| Cubillo, P | 1 |
| Palomino, H | 1 |
| Van Le, L | 1 |
| Pizzuti, DJ | 1 |
| Greenberg, M | 1 |
| Reid, R | 1 |
| Otaño, L | 1 |
| Amestoy, G | 1 |
| Paz, J | 1 |
| Gadow, EC | 1 |
| Chen, YP | 1 |
| Burdett, DN | 1 |
| Grafton, TF | 1 |
| Bazare, JJ | 1 |
| Hansen, DK | 1 |
| Sheehan, DM | 1 |
| Aracena, M | 1 |
| Leiva, W | 1 |
| Selman, E | 1 |
| Muñoz, R | 1 |
| Mancinelli, S | 1 |
| Dawson, DA | 1 |
| Bantle, JA | 1 |
| Sauerbier, I | 1 |
| Kury, G | 1 |
| Craig, JM | 1 |
| Williams, JP | 1 |
| Long, SY | 1 |
| Johnson, EM | 1 |
| Jusko, WJ | 1 |
| von Kreybig, T | 1 |
| Pinsky, L | 1 |
| Fraser, FC | 1 |
| Rizki, RM | 1 |
| Rizki, TM | 1 |
| Hara, H | 2 |
| Lauro, V | 1 |
| Giornelli, C | 1 |
| Santilli Giornelli, FE | 1 |
| Fanelli, A | 1 |
| Yoshihara, H | 1 |
| Jordan, RL | 1 |
| Schumacher, H | 1 |
| Aita, M | 2 |
| Conti, G | 2 |
| Doerr, A | 2 |
| Offutt, C | 1 |
| Schlager, G | 1 |
3 reviews available for fluorouracil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
The road to embryologically based dose-response models.
Topics: Abnormalities, Drug-Induced; Animals; Computer Simulation; Dose-Response Relationship, Drug; Embryo, | 1996 |
Abnormalities of intrauterine development in non-human primates.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Spontaneous; Animals; Antineoplastic | 1972 |
[Carcinogenesis and teratogenesis. Comparative studies from the viewpoint of teratology].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Cycloph | 1970 |
1 trial available for fluorouracil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero.
Topics: Abnormalities, Drug-Induced; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms | 2006 |
45 other studies available for fluorouracil and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Teratogenic effects of five anticancer drugs on Xenopus laevis embryos.
Topics: Abnormalities, Drug-Induced; Animals; Antineoplastic Agents; Biological Assay; Capecitabine; Cisplat | 2016 |
POLYDACTYLISM IN THE OFFSPRING OF MICE INJECTED WITH 5-BROMODEOXYURIDINE.
Topics: Abnormalities, Drug-Induced; Animals; Blood Chemical Analysis; Bromodeoxyuridine; Family; Female; Fl | 1964 |
[CURRENT PROGRESS IN THE FIELD OF TERATOLOGY WITH SPECIAL REFERENCE TO THE APPLICATION OF 2 OR MORE KINDS OF AGENTS].
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Dactinomycin; Fluorouracil; Humans; Mercaptop | 1965 |
Combined chemotherapy and teratogenicity.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Antibiotics, Antineoplastic; Antimetabo | 2005 |
Teratogenic effects of 5-fluorouracil on rat brain.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites, Antineoplastic; Brain; Female; Fluorouracil; | 2006 |
[Sensitivity to fluorouracil applied locally in ovo in chick embryo incubated two days].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil; Methods; Time Factors | 1966 |
Combined action of fluorouracil and two mutant genes on limb development in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fluorouracil; Genes; Mice; Mutation; Pregnancy; Pregna | 1967 |
Symbrachydactyly: pathogenesis of 5-fluorouracil induced model in mice.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Fluorouracil; Mice; Pregnancy; | 1980 |
Vascular pattern and limb development. 1. Normal development of the hindlimb vasculature in the mouse and its aberrations induced by 5-fluorouracil.
Topics: Abnormalities, Drug-Induced; Animals; Blood Vessels; Extremities; Female; Fluorouracil; Mice; Mice, | 1983 |
Pathogenesis of limb malformations in mice: an electron microscopic study.
Topics: Abnormalities, Drug-Induced; Animals; Cell Communication; Cell Survival; Ectoderm; Extremities; Fema | 1983 |
Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Bone and Bones; Digestive System Abnorm | 1980 |
Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Biometry; Cleft Palate; Cricetinae; Fluorouracil; Mesocricetus | 1980 |
A comparison of the in vivo and in vitro response of rat embryos to 5-fluorouracil.
Topics: Abnormalities, Drug-Induced; Animals; Anophthalmos; Embryo, Mammalian; Embryonic and Fetal Developme | 1998 |
Evaluation of biologically based dose-response modeling for developmental toxicity: a workshop report.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Education; Fluorouracil; Hum | 2000 |
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: acquisition of experimental data.
Topics: Abnormalities, Drug-Induced; Animals; Cell Cycle; Deoxyribonucleotides; DNA; Dose-Response Relations | 2001 |
Toward a biologically based dose-response model for developmental toxicity of 5-fluorouracil in the rat: a mathematical construct.
Topics: Abnormalities, Drug-Induced; Animals; Area Under Curve; Deoxyribonucleotides; Dose-Response Relation | 2001 |
The effects of 5-fluorouracil and 5-fluorodeoxyuridine used alone and in combination with normal nucleic acid precursors on development of mice in lines selected for low and high expression of Strong's luxoid gene.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cell Survival; Drug Synergism; Female; Fetal Deat | 1975 |
[Comparative teratological studies with organic fluroine compounds, their bases and amines].
Topics: Abnormalities, Drug-Induced; Amines; Animals; Deoxycytidine; Female; Fluorides; Fluorides, Topical; | 1977 |
Penetrance and expressivity of limb malformations.
Topics: Abnormalities, Drug-Induced; Adult; Animals; Breech Presentation; Congenital Abnormalities; Extrachr | 1979 |
[Induction of cleft palate in ball mice: the comparative effect of 5-fluorouracil, phenylbutazone and water and food deprivation (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Food Deprivation; Maternal | 1976 |
Accidental use of low-dose 5-fluorouracil in pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adolescent; Adult; Female; Fluorouracil; | 1991 |
Periconceptional exposure to topical 5-fluorouracil.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Female; Fertilization; Fluorouracil; Hu | 1992 |
Palatal shelf reorientation in hamster embryos following treatment with 5-fluorouracil.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; DNA; Embryo, Mammalian; Epithelial Cells; Female; | 1989 |
The in vitro embryotoxicity of 5-fluorouracil in rat embryos.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fl | 1987 |
[Embryopathy caused by antineoplastic agents].
Topics: Abnormalities, Drug-Induced; Breast Neoplasms; Chemical Phenomena; Chemistry; Cyclophosphamide; Fema | 1986 |
Coadministration of methylxanthines and inhibitor compounds potentiates teratogenicity in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Cycloheximide; Cytarabine; Drug Synergism; Embryo, N | 1987 |
Circadian modification of 5-fluorouracil-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Animals; Circadian Rhythm; Female; Fluorouracil; Gestational Age; Pregn | 1986 |
Congenital malformations produced in chickens by fluorinated pyrimidines.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Chick Embryo; Floxuridine; Fluorouracil; Pyri | 1966 |
Incorporation of thymidine after administration of fluorouracil and fluorouridine to adult and embryo mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Dose-Response Relationship, Drug; E | 1971 |
Enzyme ontogeny in normal and hemimelic limbs of mice.
Topics: Abnormalities, Drug-Induced; Animals; Ectromelia; Electrophoresis; Embryo, Mammalian; Esterases; Fem | 1968 |
The effects on mouse development of interactions of 5-fluorouracil with Strong's luxoid gene and its plus and minus modifiers.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Cleft Palate; Embryo, | 1972 |
Pharmacodynamic principles in chemical teratology: dose-effect relationships.
Topics: Abnormalities, Drug-Induced; Adsorption; Cyclophosphamide; Dose-Response Relationship, Drug; Drug-Re | 1972 |
Atypical malformation syndromes.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Chromosome Aberrations; Environment; Fluoroura | 1972 |
Morphogenic effects of halogenated thymidine analogs on Drosophila. 3. 5-Iododeoxyuridine.
Topics: Abnormalities, Drug-Induced; Animals; Centrifugation, Density Gradient; Deoxyuridine; DNA; Drosophil | 1972 |
Independent effects of fluorouracil and two mutant genes in mouse embryos.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fluorouracil; Genes; Genotype | 1972 |
[Disturbances of development and differentiation induced in the amphibian embryo by 5-fluorouracil. (Histological and histoautoradiographic examinations)].
Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Anura; Autoradiography; Brain; Cell Nucleus; DNA; | 1970 |
[Abnormalities of the Triturus embryo caused by 5-fluorouracil].
Topics: Abnormalities, Drug-Induced; Amphibians; Animals; Fluorouracil; Metamorphosis, Biological | 1970 |
[The teratogenic effect of aminopterin and 5-fluorouracil on 4 to 23-somite embryonic chicks following their application in ovo].
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Chick Embryo; Fluorouracil; Microcephaly; Microph | 1967 |
[Experimental studies of the effects of administration of fluorouracil in the early stages of pregnancy. I. Treatment of gravid rats with fluorouracil].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Animals; Extraembryonic Membranes; Female; Fetus | 1968 |
The effect of 5-fluorouracil on the development of tail vertebrae of mice in organ culture.
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Fetus; Fluorouracil; Mice; Tail; Time Fact | 1968 |
Potentiation of the teratogenic effects of 5-fluorouracil by natural pyrimidines. I. Biological aspects.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Carbon Tetrachloride Poisoning; Drug Synergis | 1969 |
[On the effects of 5-fluorouracil injected into the chick embryo in the advanced stages of incubation].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil | 1965 |
Incorporation of 5-fluorouracil-2-C-14 by mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Fluorouracil; Maternal-Fetal Exchan | 1966 |
Polygenic control of the teratogenicity of 5-fluorouracil in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Fluorouracil; Foot Deformities, Congenit | 1966 |
[On the effect of different doses of 5-fluoruracil injected into the chicken embryo in the course of its development].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Fluorouracil | 1966 |